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41. 发明授权

US06376205B1 Screening methods for agents that modulate or inhibit tau association with tau or map2 失效
标题翻译：调节或抑制tau与tau或map2 tau结合的药剂的筛选方法
公开(公告)号：US06376205B1
公开(公告)日：2002-04-23
申请号：US08913915
申请日：1997-12-12
申请人： Claude Michel Wischik , Patricia Carol Edwards , Charles Robert Harrington , Martin Roth , Aaron Klug
发明人： Claude Michel Wischik , Patricia Carol Edwards , Charles Robert Harrington , Martin Roth , Aaron Klug
IPC分类号： G01N3353
CPC分类号： G01N33/502 , A61K31/54 , A61K31/5415 , C07K14/4711 , G01N33/5008 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2500/00 , G01N2800/28 , G01N2800/2821
摘要： The present invention relates to methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association. The methods of the present invention are particularly useful in screening substances for the prophylaxis and treatment of Alzheiemer's disease.
摘要翻译：本发明涉及检测能够调节或抑制病理性tau-tau蛋白缔合的物质的方法。本发明的方法在用于预防和治疗阿尔茨海默病的物质中特别有用。

42. 发明授权

US06194490B1 Curable composition comprising epoxidized natural oils 有权
标题翻译：包含环氧化天然油的可固化组合物
公开(公告)号：US06194490B1
公开(公告)日：2001-02-27
申请号：US09253162
申请日：1999-02-19
申请人： Martin Roth , Qian Tang , Roger Malherbe , Catherine Schoenenberger
发明人： Martin Roth , Qian Tang , Roger Malherbe , Catherine Schoenenberger
IPC分类号： C08K336
CPC分类号： C08L63/00 , C08G59/38 , C08G59/42 , C08G59/686
摘要： A composition, which comprises (a) a compound containing at least one epoxy group in inner position per molecule, obtained by epoxidation of a natural unsaturated oil or of its derivative; (b) an epoxy compound selected from the group consisting of glycidyl ethers, glycidyl esters and cycloaliphatic epoxides; (c) a polycarboxylic acid anhydride; (d) a compound of formula I, I, III or IV or an acid adduct of a compound of formula I, II, III or IV wherein R1 to R4 are each independently of one another hydrogen; C1-C18alkyl which is unsubstituted or substituted by one or more than one hydroxyl group amino group, halogen atom, cyano group, C1-C6alkoxy group or C1-C6cyanalkoxy group; C5-C14aryl, C6-C24aralkyl, C3-C14heteroaryl or C4-C14heteroaralkyl which are unsubstituted or substituted by one or more than one C1-C6alkyl group, C1-C6alkoxy group or halogen atom, n is an integer from 1 to 3, and R5 and R6 are each independently of the other C1-C6alkyl or, together with the nitrogen atom, form a five- or six-membered ring, and (e) 20-90% by weight, based on the entire composition, of a filler, the average diameter of the filler particles being from 0.1 &mgr;m to 5.0 mm, can be cured to products having a high Tg and are suitable in particular as encapsulating material for electrical and electronic components.
摘要翻译：一种组合物，其包含（a）通过天然不饱和油或其衍生物的环氧化获得的每分子含有至少一个内部位置的环氧基的化合物;（b）选自缩水甘油醚，缩水甘油酯和环脂族环氧化物;（c）多元羧酸酐;（d）式I，I，III或IV的化合物或式I，II，III或IV化合物的酸加合物，其中R 1至R 4各自独立于氢; 未被取代或被一个或多于一个羟基氨基，卤素原子，氰基，C 1 -C 6烷氧基或C 1 -C 6氰基烷氧基取代的C 1 -C 18烷基; 未被取代或被一个或多于一个C 1 -C 6烷基，C 1 -C 6烷氧基或卤素原子取代的C 5 -C 14芳基，C 6 -C 24芳烷基，C 3 -C 14杂芳基或C 4 -C 14杂芳烷基，n为1至3的整数，R 5 和R 6各自独立地为其它C 1 -C 6烷基，或者与氮原子一起形成五元或六元环，和（e）基于整个组合物的20-90重量％的填料，填料颗粒的平均直径为0.1μm至5.0mm，可以固化成具有高Tg的产品，并且特别适合用作电气和电子部件的包封材料。

43. 发明授权

US6073914A Release apparatus for a holddown device 失效
标题翻译：用于压紧装置的释放装置
公开(公告)号：US6073914A
公开(公告)日：2000-06-13
申请号：US980913
申请日：1997-12-01
申请人： Martin Roth , Robert Apfelbeck
发明人： Martin Roth , Robert Apfelbeck
IPC分类号： B64G1/22 , B64G1/44 , B64G1/64 , H01L31/042 , E21B19/00
CPC分类号： B64G1/443 , B64G1/222 , B64G1/645 , Y10T29/49874
摘要： A release element for a holddown device, on a solar generator, for example, with a retaining bolt which is under pretension in the direction of its lengthwise axis, releases the retaining bolt from its pretensioned position. Pretensioning force is exerted on the retaining bolt through thread located at the end of retaining bolt into a corresponding internal thread in the release device. Internal thread is located half in a housing of release device and half in an opener. Opener is inserted pivotably in a cutout of housing and held in place by a wire coil wound around housing and opener. To release retaining bolt, the wire coil is released by fuse elements and expands to a larger diameter, releasing the retaining bolt.
摘要翻译：用于压紧装置的释放元件在太阳能发电机上，例如具有在其纵向轴线方向上预张紧的固定螺栓将其从其预张紧位置释放。预紧力通过位于固定螺栓端部的螺纹施加在固定螺栓上，使其与释放装置中相应的内螺纹相同。内螺纹位于释放装置的壳体中，一半位于开启器中。开启器可枢转地插入壳体的切口中，并通过围绕壳体和开启器缠绕的线圈将其保持在适当位置。为了释放固定螺栓，线圈由保险丝元件释放并膨胀到更大的直径，释放固定螺栓。

44. 发明授权

US5911536A Joint for deploying and locking a solar panel or a reflection 失效
标题翻译：用于部署和锁定太阳能电池板或反射的接头
公开(公告)号：US5911536A
公开(公告)日：1999-06-15
申请号：US980906
申请日：1997-12-01
申请人： Martin Roth
发明人： Martin Roth
IPC分类号： F16C11/04 , B64G1/22 , B64G1/44 , F24J2/54 , G02B7/182 , G02B7/183 , H01L31/042
CPC分类号： G02B7/183 , B64G1/222 , B64G1/44 , F24J2/54 , G02B7/1822 , Y02E10/47 , Y02E10/52 , Y10T16/53826 , Y10T403/32606 , Y10T403/32819 , Y10T403/32827
摘要： A joint for deploying and locking a solar panel or a reflector has a fork which is pivotable through 180.degree. about a common pivot axis with a fixed bearing support. A disk mounted on the fixed bearing support has a sliding curve that terminates in a groove. A latching fork mounted rotatably on pivotable fork has a latching bolt and sliding roller which runs on the sliding curve when the pivotable fork deploys, and together with a latching bolt, engages the groove. A leg spring engages the latching bolt. The sliding curve has a shape such that during the first half of a deployment angle of the fork that is pivoted by the force of a coil spring, a decreasing portion of the coil spring moment is stored in leg spring. In the second half of the deployment angle, a moment 16 stored in leg spring 9 is again added increasingly to the movement, so that during deployment, an approximately constant corrected deployment moment is provided.
摘要翻译：用于部署和锁定太阳能电池板或反射器的接头具有叉，该叉可以围绕共同的枢转轴线与固定的轴承支撑件一起旋转180度。安装在固定轴承座上的盘具有终止于凹槽中的滑动曲线。可旋转地安装在可转动叉上的锁定叉具有一个锁定螺栓和一个滑动辊，当可枢转叉展开时，滑动辊在滑动曲线上延伸，并且与一个闭锁螺栓一起啮合槽。一个腿部弹簧接合锁紧螺栓。滑动曲线具有这样的形状，使得在由螺旋弹簧的力枢转的叉的展开角度的前半部分期间，螺旋弹簧力矩的减小部分被存储在腿弹簧中。在展开角度的后半部分中，存储在腿部弹簧9中的时刻16再次增加到运动中，使得在展开期间，提供大致恒定的校正展开力矩。

45. 发明授权

US5393018A Unfolding and locking joint for space elements 失效
标题翻译：展开和锁定空间元件的关节
公开(公告)号：US5393018A
公开(公告)日：1995-02-28
申请号：US149830
申请日：1993-11-10
申请人： Martin Roth , Helmut Kiendl
发明人： Martin Roth , Helmut Kiendl
IPC分类号： B64G1/22 , B64G1/44 , F16C11/10 , B64G1/46
CPC分类号： F16C11/103 , B64G1/222 , B64G1/443 , Y10S136/292 , Y10T16/540243
摘要： A joint is provided for the unfolding and locking of space elements, such as solar generator panels. On one joint half, a detent lever is swivellably connected having a clamping nose as well as a finger as the guiding element. During the unfolding operation, the finger slides on a guiding contour of the other joint half. Shortly before the fully unfolded condition is reached, the finger engages in a depression, and the clamping nose runs up onto a cam and clamps down on the latter under the effect of the spring tension directed to the common axis of rotation. A movable stop element, e.g. universal ball joint, simultaneously presses against a stop surface so that both joint halves are braced with respect to one another. An arrangement of high stiffness which is as free from play as possible results.
摘要翻译：提供用于空间元件（例如太阳能发电机面板）的展开和锁定的接头。在一个关节半部，止动杆可旋转地连接，具有夹紧鼻以及作为引导元件的手指。在展开操作期间，手指在另一个关节半部的引导轮廓上滑动。在完全展开状态达到之前，手指接合凹陷，并且夹紧鼻子向上运动到凸轮上，并在弹簧张力的作用下向下夹紧凸轮，该弹簧张力指向公共旋转轴线。可移动止动元件，例如万向球接头同时按压止动表面，使得两个接合部分相对于彼此支撑。高刚度的布置尽可能不发挥作用。

46. 发明授权

US5001243A Substituted naphthacene-5, 12-diones 失效
标题翻译：取代的并四苯-5,12-二酮
公开(公告)号：US5001243A
公开(公告)日：1991-03-19
申请号：US356828
申请日：1989-05-24
申请人： Walter Fischer , Marcus Baumann , Jurgen Finter , Vratislav Kvita , Carl W. Mayer , Manfred Rembold , Martin Roth
发明人： Walter Fischer , Marcus Baumann , Jurgen Finter , Vratislav Kvita , Carl W. Mayer , Manfred Rembold , Martin Roth
IPC分类号： C09K3/00 , B05D1/20 , C07C323/22 , C07C323/25 , C07C323/52 , C08F2/50 , C08G61/12 , C09B3/58 , C09K9/02 , G03C1/73 , G03F7/031 , H01B1/12
CPC分类号： B05D1/202 , B82Y30/00 , B82Y40/00 , C07C323/22 , C07C323/25 , C07C323/52 , C08G61/123 , C09K9/02 , G03C1/73 , G03F7/031 , H01B1/121 , C07C2103/44
摘要： Naphthacene-5,12-diones which are substituted by at least one organic thio radical are not only photoinitiators for the photopolymerization but also sensitizers for the photodimerization of ethylenically unsaturated compounds. Compositions made of these naphthacene-5,12-diones and ethylenically unsaturated compounds are suitable for the preparation of printing inks, paints, printing plates, resist materials or as image recording material.
摘要翻译：被至少一个有机硫基取代的并用的5-萘二氢-5,12-二酮不仅是用于光聚合的光引发剂，而且也是用于烯属不饱和化合物的光二聚化的敏化剂。由这些并四烯-5,12-二酮和烯键式不饱和化合物制成的组合物适用于印刷油墨，油漆，印刷版，抗蚀剂材料或图像记录材料的制备。

47. 发明授权

US4888402A Copolymes formed from N-hydroxyphenylmaleinimide (derivatives) and allyl compounds 失效
公开(公告)号：US4888402A
公开(公告)日：1989-12-19
申请号：US79056
申请日：1987-07-29
申请人： Martin Roth , Peter Flury , Sameer H. Eldin
发明人： Martin Roth , Peter Flury , Sameer H. Eldin
IPC分类号： C08F214/02 , C08F14/18 , C08F16/12 , C08F16/14 , C08F16/34 , C08F16/38 , C08F20/02 , C08F20/10 , C08F20/32 , C08F20/42 , C08F20/52 , C08F214/06 , C08F214/18 , C08F216/14 , C08F216/34 , C08F216/36 , C08F220/04 , C08F220/10 , C08F220/32 , C08F220/50 , C08F220/54 , C08F222/00 , C08F222/40 , C08G59/62 , C08L63/00 , G03F7/023 , G03F7/037 , G03F7/038
CPC分类号： G03F7/0388 , C08F222/40 , C08G59/62 , C08L63/00 , G03F7/0233
摘要： The invention relates to copolymers consisting of 30-100 mol %, relative to the total polymer, of structural units of the formulae I and II, the proportion of structural units of the formula I, relative to the proportion of I and II, being 5 to 95 mol %, ##STR1## in which R.sup.1 is C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 alkoxy or halogen, R.sup.2 is hydrogen or --COR.sup.3 and R.sup.3 is C.sub.1 -C.sub.20 alkyl, m is 1, 2 or 3, n is 0, 1, 2, 3 or 4 and the sum of m and n is not more than 5, and A is selected from the group of radicals consisting of halogen, cyano or structural units of the formulae III to VIII ##STR2## in which R.sup.4 and R.sup.6 independently of one another are hydroxyl, ##STR3## or glycidyl groups of the formula IXa or IXb ##STR4## R.sup.5 and R.sup.7 independently of one another are C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen, o and q independently of one another are 0, 1, 2 or 3, p and r independently of one another are 0, 1,2,3, 4 or 5, it being necessary for the totals o+p and q+4 to be not more than 5, R.sup.8 is hydrogen, C.sub.1 -C.sub.20 -alkyl, a glycidyl radical of formula IXa or a radical of formula VI, R.sup.9 is hydrogen, C.sub.1 -C.sub.20 -alkyl, cycloalkyl having 5-7 ring C atoms, phenyl, naphthyl or benzyl, R.sup.10 is hydrogen, C.sub.1 -C.sub.20 - or a glycidyl radical of the formula IXa, and the groups R.sup.11 and R.sup.12 independently of one another are hydrogen, C.sub.1 -C.sub.20 -alkyl, cycloalkyl having 5-7 ring C atoms, aryl or aralkyl which is substituted or unsubstituted or a glycidyl radical of the formula IXa, or, together with the common nitrogen atom, form a five-membered or six-membered, non-aromatic, heterocyclic ring, and R.sup.13 and R.sup.14 independently of one another are hydrogen or methyl, it being possible for the radicals R.sup.1 to R.sup.14 and A of a polymer molecule to be different, within the definitions given.The compounds are distinguished by high glass transition temperatures and good flexibility and can be employed as binders in photoresist systems. The representatives containing glycidyl groups can also be used as self-crosslinking epoxide resins.

48. 发明授权

US4594400A Thioxanthonecarboxylic acids, esters thioesters and amides with reactive functional groups and polymers prepared therefrom and having thioxanthone radicals as side chains 失效
标题翻译：噻吨酮羧酸，酯硫酯和具有反应性官能团的酰胺和由其制备的聚合物，并具有噻吨酮基团作为侧链
公开(公告)号：US4594400A
公开(公告)日：1986-06-10
申请号：US652683
申请日：1984-09-19
申请人： Vratislav Kvita , Hans Zweifel , Martin Roth , Louis Felder
发明人： Vratislav Kvita , Hans Zweifel , Martin Roth , Louis Felder
IPC分类号： C07D209/48 , C07D335/16 , C07D409/12 , C08F2/00 , C08F2/50 , C08F20/38 , C08G63/688 , C08G85/00 , C08K5/45 , C08L23/02 , C09D11/00 , C09D11/10 , G03F7/031 , G03F7/032 , G03F7/038 , C08F26/06 , C08F28/06
CPC分类号： C07D209/48 , C07C323/00 , C07D335/16 , C08F2/50 , C08F20/38 , C08G63/688 , C08G85/00 , C08G85/004 , C08K5/45 , C08L23/02 , G03F7/031 , G03F7/032 , G03F7/0388 , Y10S522/904
摘要： Thioxanthone carboxylic acid esters, thioesters and amides with reactive functional groups of the formula ##STR1## in which X, Y, Z, n and Q are as defined in the patent claim and Q is, for example, --OCH.dbd.CH.sub.2, --OCH.sub.2 CH.dbd.CH.sub.2, --SCH.sub.2 CH.dbd.CH.sub.2 or --NHCH.sub.2 CH.dbd.CH.sub.2 (n=1), --OH, --SH, --NH.sub.2, --COOH, --COCl or --OCO--C(R").dbd.CH.sub.2, in which R" is methyl or hydrogen (n=2), are suitable for the preparation of polymers with thioxanthone radicals in side chains. The compounds (I) and also the polymers which can be prepared therefrom can be employed as sensitizers for photocrosslinkable polymers or as initiators, if desired in a mixture with amines, for the photopolymerization of ethylenically unsaturated compounds or for the photochemical crosslinking of polyolefines.
摘要翻译：具有式（I）的反应性官能团的噻吨酮羧酸酯，硫酯和酰胺，其中X，Y，Z，n和Q如专利权利要求和Q中所定义，是例如-OCH = CH 2 ，-OCH 2 CH = CH 2，-SCH 2 CH = CH 2或-NHCH 2 CH = CH 2（n = 1），-OH，-SH，-NH 2，-COOH，-COCl或-OCO-C（R“ R“是甲基或氢（n = 2），适用于在侧链中制备具有噻吨酮基团的聚合物。化合物（I）以及可以由其制备的聚合物可以用作光可交联聚合物的敏化剂，或者如果需要，与胺的混合物用作烯键式不饱和化合物的光聚合或用于聚烯烃的光化学交联的引发剂。

49. 发明授权

US4506083A Thioxanthonecarboxylic acid esters, thioesters and amides 失效
标题翻译：噻吨酮羧酸酯，硫酯和酰胺
公开(公告)号：US4506083A
公开(公告)日：1985-03-19
申请号：US392922
申请日：1982-06-28
申请人： Vratislav Kvita , Hans Zweifel , Martin Roth , Louis Felder
发明人： Vratislav Kvita , Hans Zweifel , Martin Roth , Louis Felder
IPC分类号： C08K5/00 , C07D209/48 , C07D335/16 , C07D409/06 , C08F2/00 , C08F2/48 , C08F2/50 , C08F4/00 , C08J3/24 , C08J3/28 , C08K5/36 , C08K5/45 , C08L7/00 , C08L21/00 , C08L23/00 , C08L101/00 , C09D133/00 , G03F7/031
CPC分类号： C07D209/48 , C07C323/00 , C07D335/16 , C08F2/50 , G03F7/031 , Y10S430/123
摘要： Thioxanthonecarboxylic acid esters, thioesters or amides of the formula I ##STR1## in which X and Z are hydrogen or one of the substituents defined in more detail in claim 1 and Y is --OR.sub.1, --SR.sub.1 or --N(R.sub.1)(R.sub.2), in which R.sub.1 is C.sub.1-24 alkyl and R.sub.2 is H or R.sub.1, are suitable, if desired together with amines, as initiators for the photopolymerization of ethylenically unsaturated compounds or for photochemical crosslinking of polyolefines. They are also used an sensitizers for photocrosslinkable polymers. They can be prepared by methods known per se, for example by cyclization of phenylthio-phthalic, -isophthalic or -terephthalic acids, which can be correspondingly substituted, and subsequent reaction with suitable alcohols, thiols or amines.
摘要翻译：其中X和Z是氢或式（1）中更详细地定义的取代基之一的式I化合物（I）的噻吨酮羧酸酯，硫酯或酰胺是-OR1，-SR1或-N（R1）（R2），其中R 1为C 1-4烷基且R 2为H或R 1，如果需要，与胺一起适用作为烯键式不饱和化合物光聚合的引发剂或聚烯烃的光化学交联。它们也用于光致交联聚合物的敏化剂。它们可以通过本身已知的方法制备，例如通过苯基硫代邻苯二甲酸，间苯二甲酸或对苯二甲酸的环化，其可以相应地取代，随后与合适的醇，硫醇或胺反应。

50. 发明授权

US4179444A Process for the manufacture of iso-imides or mixtures of iso-imides and imides 失效
标题翻译：制备异氰酰亚胺或异氰酰亚胺和酰亚胺混合物的方法
公开(公告)号：US4179444A
公开(公告)日：1979-12-18
申请号：US908338
申请日：1978-05-22
申请人： Martin Roth
发明人： Martin Roth
IPC分类号： C07D207/44 , C07D207/452 , C07D307/34 , C07D307/90 , C07D403/10
CPC分类号： C07D207/452 , C07D307/34 , C07D307/90
摘要： A process for the manufacture of iso-imides or mixtures of iso-imides and imides by reacting corresponding amide-acids with ketene at temperatures of about -10.degree. C. to +80.degree. C. is described. According to the process of the invention, the iso-imides or mixtures of iso-imides and imides can be manufactured in a simple, economical manner and in good to very good yields. The acetic anhydride formed during the reaction with the ketene can easily be recovered.
摘要翻译：描述了通过在约-10℃至+ 80℃的温度下使相应的酰胺酸与乙烯酮反应制备异亚胺或异亚胺和酰亚胺的混合物的方法。根据本发明的方法，异亚胺或异亚胺和酰亚胺的混合物可以以简单，经济的方式制备，并以良好至非常好的产率制备。在与乙烯酮反应期间形成的乙酸酐可以容易地回收。

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