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41. 发明授权

US4331807A Pyridazine urea plant growth regulators 失效
标题翻译：哒嗪脲植物生长调节剂
公开(公告)号：US4331807A
公开(公告)日：1982-05-25
申请号：US154664
申请日：1980-05-30
申请人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
发明人： Toshihiko Okamoto , Yo Isogai , Koichi Shudo , Soshiro Takahashi
IPC分类号： A01N47/36 , C07D237/20 , C07D237/22 , C07D237/24
CPC分类号： A01N47/36 , C07D237/20
摘要： Plant growth regulators of the N-(4-pyridazinyl)urea and thiourea type are disclosed which exhibit excellent cytokinin-like activities and are useful for regulating plant growth in various manners, such as acceleration and suppression.
摘要翻译：公开了N-（4-哒嗪基）脲和硫脲类的植物生长调节剂，其表现出优异的细胞分裂素样活性，并且可用于以各种方式调节植物生长，例如加速和抑制。

42. 发明授权

US08722730B2 5-membered heterocyclic compound 失效
标题翻译： 5元杂环化合物
公开(公告)号：US08722730B2
公开(公告)日：2014-05-13
申请号：US12673177
申请日：2008-08-14
申请人： Hideaki Muratake , Masayuki Noguchi , Koichi Shudo
发明人： Hideaki Muratake , Masayuki Noguchi , Koichi Shudo
IPC分类号： A61K31/341 , C07D307/40
CPC分类号： A61K31/341 , A61K31/381 , A61K31/401 , A61K31/443 , A61K31/4436 , C07D207/416 , C07D307/54 , C07D307/68 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/12 , C07D409/12
摘要： A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R3 represents hydrogen atom or a C1-10 alkyl group, Z represents —CO—N(R5)— (R5 represents hydrogen atom or a C1-6 alkyl group) or —C(R6)═C(R7)—CO—NH— (R6 and R7 represent hydrogen atom or a C1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R4 represents —COOH, —OCH2—COOH, —CH2—COOH, or —CH2—CH2—COOH], which has a retinoid action and is useful as an active ingredient of a medicament.
摘要翻译：由下列通式（I）表示的化合物：[其中R1和R2表示烷基，X表示-S-，-O-或-NH-，Y表示C或N，R3表示氢原子或C1- 10表示烷基，Z表示-CO-N（R5） - （R5表示氢原子或C1-6烷基）或-C（R6）= C（R7）-CO-NH-（R6和R7表示氢原子或C 1-6烷基），Ar表示芳基二基或杂芳基二基，R 4表示-COOH，-OCH 2 -COOH，-CH 2 -COOH或-CH 2 -CH 2 -COOH]，其具有类视黄醇作用和可用作药物的活性成分。

43. 发明申请

US20140121407A1 DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE 审中-公开
标题翻译：去除苯丙酸衍生物
公开(公告)号：US20140121407A1
公开(公告)日：2014-05-01
申请号：US14126460
申请日：2012-07-04
申请人： Hideaki Muratake , Koichi Shudo , Yohei Amano , Takahiro Toda
发明人： Hideaki Muratake , Koichi Shudo , Yohei Amano , Takahiro Toda
IPC分类号： C07C235/74
CPC分类号： C07C235/74 , C07B59/001 , C07C233/65 , C07C2602/10
摘要： A compound corresponding to 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid in which a part or all of hydrogen atoms in the ethylene group constituting the propionic acid moiety are replaced with deuterium atoms, a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after being absorbed into a living body, which comprises the aforementioned compound, a salt thereof, or an ester thereof as an active ingredient.
摘要翻译：对应于其中部分或全部氢原子的3- [4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯基]丙酸的化合物在构成丙酸部分的亚乙基中被氘原子取代，其盐或其酯，以及用于在被吸收到生物体中后作为活性药物释放的前药，其包含上述化合物，盐或其酯作为活性成分。

44. 发明授权

US08633335B2 Retinoid prodrug compound 失效
标题翻译：维甲酸前药化合物
公开(公告)号：US08633335B2
公开(公告)日：2014-01-21
申请号：US12682966
申请日：2007-10-31
申请人： Hideaki Muratake , Koichi Shudo
发明人： Hideaki Muratake , Koichi Shudo
IPC分类号： C07C51/367
CPC分类号： C07C237/52 , C07C233/65 , C07C235/84 , C07C235/88 , C07C237/48 , C07C271/30 , C07C2602/10 , C07F7/081
摘要： A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(COR6)—CO—, —CO—N(COR7)— (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents —Y—CH(R12)—COOH, —CHO, —CH═CH—COOH, or —COOR13 (Y represents a single bond, —CH2—, —CH(OH)—, —CO—, —CO—NH—, or —CO—NH—CH2—CO—NH—, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, —CH(R14)—COOH(R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), —[CH2CH2—O]n—CH2—CH2—OH, —CH2—O—[CH2CH2—O]m—CH2—OH, or —[CH(CH3)—CO—O]p—CH(CH3)—COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
摘要翻译：由以下通式（I）表示的化合物：[R1至R5表示氢原子，烷基或三烷基甲硅烷基，X表示-NH-CO-，-CO-NH-，-N（COR6）-CO - ，-CO-N（COR 7） - （R 6和R 7表示低级烷氧基或羧基取代的苯基）等。 Z表示-Y-CH（R 12）-COOH，-CHO，-CH = CH-COOH或-COOR 13（Y表示单键，-CH 2 - ， - CH（OH） - ， - CO- -NH-或-CO-NH-CH 2 -CO-NH-，R 12表示氢原子或低级烷基，R 13表示氢原子，-CH（R 14）-COOH（R 14表示氢原子，低级烷基，或羟基）， - [CH 2 CH 2 -O] n -CH 2 -CH 2 -OH，-CH 2 -O- [CH 2 CH 2 -O] m -CH 2 -OH或 - [CH（CH 3）-CO-O] CH（CH 3）-COOH（m，n和p表示1〜100的整数））]，其盐或其酯，其在体内吸收后具有转化为类视黄醇的性质。

45. 发明授权

US08232300B2 Tricyclic amide compound 失效
标题翻译：三环酰胺化合物
公开(公告)号：US08232300B2
公开(公告)日：2012-07-31
申请号：US12673207
申请日：2008-08-14
申请人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
发明人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
IPC分类号： C07D333/36 , C07D211/68 , C07D211/80 , C07C63/00 , C07C65/00 , A61K31/38 , A61K31/045
CPC分类号： C07C233/81 , C07C233/65 , C07C311/21 , C07C2603/28 , C07C2603/34 , C07D213/79 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/40
摘要： A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3—or —(CH2)4—, X represents —N(R2)—CO—(R2 represents hydrogen atom or a C1-6 alkyl group), —CO—N(R3)—(R3 represents hydrogen atom or a C1-6 alkyl group), —C(R4)═C(R5)—(R4 and R5 represent hydrogen atom or a C1-6 alkyl group), or —N(R6)—SO2—(R6 represents hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has a retinoid action and is useful as an active ingredient of a medicament.
摘要翻译：由以下通式（I）表示的化合物：其中R 1表示氢原子或C 1-6烷基，A和B表示 - （CH 2）2 - ， - （CH 2）3 - 或 - （CH 2）4 - ，X表示-N（R 2）-CO-（R 2表示氢原子或C 1-6烷基），-CO-N（R 3） - （R 3表示氢原子或C 1-6烷基）， - C R4）= C（R5） - （R4和R5代表氢原子或C1-6烷基）或-N（R6）-SO2-（R6代表氢原子或C1-6烷基），Ar代表芳基二基或杂芳基二基]，其具有类视黄醇作用并且可用作药物的活性成分。

46. 发明申请

US20110213157A1 TRICYCLIC AMIDE COMPOUND 失效
标题翻译：三酰胺化合物
公开(公告)号：US20110213157A1
公开(公告)日：2011-09-01
申请号：US12673207
申请日：2008-08-14
申请人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
发明人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
IPC分类号： C07D213/81 , C07C229/66 , C07D333/38 , C07C317/48
CPC分类号： C07C233/81 , C07C233/65 , C07C311/21 , C07C2603/28 , C07C2603/34 , C07D213/79 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/40
摘要： A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3— or —(CH2)4—, X represents —N(R2)—CO— (R2 represents hydrogen atom or a C1-6 alkyl group), —CO—N(R3)— (R3 represents hydrogen atom or a C1-6 alkyl group), —C(R4)═C(R5)— (R4 and R5 represent hydrogen atom or a C1-6 alkyl group), or —N(R6)—SO2— (R6 represents hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has a retinoid action and is useful as an active ingredient of a medicament.
摘要翻译：由下列通式（I）表示的化合物：[其中R1表示氢原子或C1-6烷基，A和B表示 - （CH2）2-， - （CH2）3-或 - （CH2）4- ，X表示-N（R 2）-CO-（R 2表示氢原子或C 1-6烷基），-CO-N（R 3） - （R 3表示氢原子或C 1-6烷基）， - C R4）= C（R5） - （R4和R5代表氢原子或C1-6烷基）或-N（R6）-SO2-（R6代表氢原子或C1-6烷基），Ar代表芳基二基或杂芳基二基]，其具有类视黄醇作用并且可用作药物的活性成分。

47. 发明授权

US07968600B2 Medicament for preventive and therapeutic treatment of physical dysfunction caused by nerve damage 失效
标题翻译：用于预防和治疗由神经损伤引起的身体功能障碍的药物
公开(公告)号：US07968600B2
公开(公告)日：2011-06-28
申请号：US11670126
申请日：2007-02-01
申请人： Mitsuko Takenaga , Koichi Shudo , Tetsuro Matsuishi , Miwako Ishido
发明人： Mitsuko Takenaga , Koichi Shudo , Tetsuro Matsuishi , Miwako Ishido
IPC分类号： A01N37/10 , A01N31/04 , A01N37/18 , A01N37/12 , A01N37/44 , A61K31/19 , A61K31/07 , A61K31/16 , A61K31/195
CPC分类号： A61K31/19
摘要： A medicament for preventive and/or therapeutic treatment of a physical dysfunction such as motor dysfunction caused by nerve damage resulting from an accident, cerebral crisis and the like, which comprises as an active ingredient a compound or a salt thereof represented by the following general formula (I): wherein R1 to R5 represents hydrogen atom, an alkyl group, or an alkyl-substituted silyl group, X represents —CONH— or —NHCO—, and A represents a carboxylic acid-substituted aromatic group which may be substituted or a tropolonyl group which may be substituted.
摘要翻译：一种用于预防和/或治疗身体功能障碍的药物，所述身体功能障碍例如由事故引起的神经损伤引起的运动功能障碍，脑部危象等，其包含作为活性成分的由以下通式表示的化合物或其盐（I）表示：其中R1至R5表示氢原子，烷基或烷基取代的甲硅烷基，X表示-CONH-或-NHCO-，A表示可被取代的羧酸取代的芳基或可以被取代的对基酮基。

48. 发明申请

US20090299059A1 Novel Compound Having Heterocyclic Ring 失效
标题翻译：具有杂环的新型化合物
公开(公告)号：US20090299059A1
公开(公告)日：2009-12-03
申请号：US12225819
申请日：2007-03-30
申请人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
发明人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
IPC分类号： C07D413/10
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X1 is a single bond, —O—, —S—, —NR2—, —CO—, —CS—, —CONR3—, —NR4CO—, —SO2NR5—, and —NR6SO2— (wherein R2-R6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A任选被取代或稠合并且代表（A-1）含有至少三个N原子的至少七元单环杂环; （A-2）至少含有至少两个N原子和至少一个O原子的6元单环杂环; 或（A-3）至少含有至少两个N原子和至少一个S原子的7元单环杂环; X 1是单键，-O - ， - S - ， - NR 2 - ， - CO - ， - C - ， - CONR 3 - ， - NR 4 CO-，-SO 2 NR 5 - 和-NR 6 SO 2 - 或低级烷基）或其中一个前述基团可以介入的低级亚烷基或低级亚烯基; 环B是任选取代的碳环或任选取代的杂环; R1是氢，或能够与恶唑烷酮抗微生物剂中的恶唑烷酮环的5位结合的有机残基，以及含有该残基的抗菌剂。

49. 发明申请

US20080182905A1 MEDICAMENT FOR PREVENTIVE AND THERAPEUTIC TREATMENT OF PHYSICAL DYSFUNCTION CAUSED BY NERVE DAMAGE 失效
标题翻译：预防和治疗由神经损伤引起的身体功能障碍的药物
公开(公告)号：US20080182905A1
公开(公告)日：2008-07-31
申请号：US11670126
申请日：2007-02-01
申请人： Mitsuko Takenaga , Koichi Shudo , Tetsuro Matsuishi , Miwako Ishido
发明人： Mitsuko Takenaga , Koichi Shudo , Tetsuro Matsuishi , Miwako Ishido
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： A medicament for preventive and/or therapeutic treatment of a physical dysfunction such as motor dysfunction caused by nerve damage resulting from an accident, cerebral crisis and the like, which comprises as an active ingredient a compound or a salt thereof represented by the following general formula (I): wherein R1 to R5 represents hydrogen atom, an alkyl group, or an alkyl-substituted silyl group, X represents —CONH— or —NHCO—, and A represents a carboxylic acid-substituted aromatic group which may be substituted or a tropolonyl group which may be substituted.
摘要翻译：一种用于预防和/或治疗身体功能障碍的药物，所述身体功能障碍例如由事故引起的神经损伤引起的运动功能障碍，脑部危象等，其包含作为活性成分的由以下通式表示的化合物或其盐（I）：其中R 1至R 5表示氢原子，烷基或烷基取代的甲硅烷基，X表示-CONH-或-NHCO-， A表示可以被取代的羧酸取代的芳基或可以被取代的聚丙二醇基。

50. 发明授权

US5929069A Compounds activating pharmacological effects of retinoids 失效
标题翻译：激活类维生素A的药理作用的化合物
公开(公告)号：US5929069A
公开(公告)日：1999-07-27
申请号：US710657
申请日：1996-09-20
申请人： Koichi Shudo
发明人： Koichi Shudo
IPC分类号： A61K31/55 , A61K31/553 , C07D243/24 , C07D243/38 , C07D267/02 , C07D267/14 , C07D267/20 , C07D281/08 , C07D281/10 , C07D281/12 , C07D281/16
CPC分类号： C07D243/38 , C07D243/24 , C07D267/14 , C07D267/20 , C07D281/10 , C07D281/16
摘要： A compound represented by the formula (I) or (II) or a salt thereof wherein R.sup.1 represents hydrogen atom or a C.sub.1-6 alkyl group; R.sup.2 and R.sup.3 independently represent a hydrogen atom or a C.sub.1-6 alkyl group, or R.sup.2 and R.sup.3 may combine together to represent a 5- or 6-membered cycloalkyl group; R.sup.4 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; R.sup.5 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group; x represents --NR.sup.7 --, --O--, --CHR.sup.7 -- or --S-- in which R.sup.7 represents, for example, a hydrogen atom or a C.sub.1-6 alkyl group; and Y represents a phenylene group or a pyridinediyl group. The compounds are useful as agents for enhancing the activities of retinoid compounds. ##STR1##
摘要翻译：由式（I）或（II）表示的化合物或其盐，其中R 1表示氢原子或C 1-6烷基; R2和R3独立地表示氢原子或C1-6烷基，或R2和R3可以结合在一起代表5-或6-元环烷基; R4表示例如氢原子或C1-6烷基; R5表示例如氢原子或C1-6烷基; R6表示氢原子或C1-6烷基; x表示-NR 7 - ， - O - ， - CHR 7 - 或-S-，其中R 7表示例如氢原子或C 1-6烷基; Y表示亚苯基或吡啶二基。这些化合物可用作增强类视黄醇化合物活性的试剂。

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