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41. 发明授权

US08079061B2 Authentication system managing method 失效
标题翻译：认证系统管理方法
公开(公告)号：US08079061B2
公开(公告)日：2011-12-13
申请号：US11949159
申请日：2007-12-03
申请人： Kazuhiko Taniguchi , Yoshiaki Isobe , Nariyasu Hamada , Hiroyuki Shimizu
发明人： Kazuhiko Taniguchi , Yoshiaki Isobe , Nariyasu Hamada , Hiroyuki Shimizu
IPC分类号： G06F7/04 , G06F17/30
CPC分类号： G07C9/00166 , G06F21/32 , G06K9/00926 , G06K9/00993 , G07C9/00158
摘要： Inputted information (such as biometric information) is compared to template information (including correlation or authentication) and the result is recorded as log information. According to log information for each of the types of the inputted information (such as information specifying the user who has inputted it and the template), analysis is executed for the inputted information for each of the types. This analysis includes the following aspects. That is, the following states are detected and an alarm is outputted for the accuracy of the corresponding type: when the ratio of negative comparison results (correlation failures) not smaller than a predetermined value is detected within a predetermined period of time; and when a negative result is detected within a predetermined time before an affirmative comparison result is obtained.
摘要翻译：将输入信息（如生物特征信息）与模板信息（包括相关或认证）进行比较，并将结果记录为日志信息。根据输入信息的每种类型（诸如指定输入的用户的信息和模板）的日志信息，针对每种类型的输入信息执行分析。该分析包括以下几个方面。也就是说，检测到以下状态并为相应类型的精度输出报警：当在预定时间段内检测到不小于预定值的负比较结果（相关故障）的比率时; 并且当在获得肯定比较结果之前的预定时间内检测到否定结果时。

42. 发明授权

US08044056B2 Adenine compound 失效
标题翻译：腺嘌呤化合物
公开(公告)号：US08044056B2
公开(公告)日：2011-10-25
申请号：US12531867
申请日：2008-03-19
申请人： Yoshiaki Isobe , Tomoaki Nakamura
发明人： Yoshiaki Isobe , Tomoaki Nakamura
IPC分类号： C07D473/18 , A61K31/522 , C07D241/08 , C07D241/04 , A61P37/08 , A61P11/06 , A61P37/06
CPC分类号： C07D473/18 , C07D473/00
摘要： A novel adenine compound represented by the formula (1): [wherein R1 is substituted or unsubstituted alkyl, etc., X is oxygen, etc., A1 is 4- to 8-membered substituted or unsubstituted saturated nitrogen-containing heterocycle containing 1 to 2 hetero atom(s) selected from 1 to 2 nitrogen(s), 0 to 1 oxygen and 0 to 1 sulfur, etc., A2 is substituted or unsubstituted 6- to 10-membered aryl, etc., L1 and L2 are independently a straight chain or branched chain alkylene, etc.], or a pharmaceutically acceptable salt thereof, which is useful as a medicament.
摘要翻译：由式（1）表示的新型腺嘌呤化合物：其中，R 1为取代或未取代的烷基等，X为氧等，A 1为4〜8元的取代或未取代的饱和含氮杂环， 2个选自1至2个氮，0至1个氧和0至1个硫等的杂原子，A2为取代或未取代的6-至10-元芳基等，L1和L2独立地为直链或支链亚烷基等]或其药学上可接受的盐，其可用作药物。

43. 发明授权

US07754728B2 Adenine compound and use thereof 失效
标题翻译：腺嘌呤化合物及其用途
公开(公告)号：US07754728B2
公开(公告)日：2010-07-13
申请号：US10528343
申请日：2003-09-26
申请人： Yoshiaki Isobe , Haruo Takaku , Haruhisa Ogita , Masanori Tobe , Ayumu Kurimoto , Tetsuhiro Ogino , Hitoshi Fujita
发明人： Yoshiaki Isobe , Haruo Takaku , Haruhisa Ogita , Masanori Tobe , Ayumu Kurimoto , Tetsuhiro Ogino , Hitoshi Fujita
IPC分类号： C07D473/18 , C07D473/16 , A61K31/522 , A61P11/06 , A61P37/08
CPC分类号： A61K31/5377 , A61K31/522 , A61K31/55
摘要： A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents —COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.
摘要翻译：用作局部给药的药物，其作为抗过敏剂有效。用于局部给药的药物含有作为活性成分的由通式（1）表示的腺嘌呤化合物：[其中环A表示6至10元，单或双环，芳族烃或5至10元，单或双环，含有1至3个选自0至2个氮原子，0或1个氧原子和0或1个硫原子的杂原子的芳族杂环; n为0〜2的整数， m为0〜2的整数; R代表卤代，（取代）烷基等; X1代表氧，硫，NR1（R1代表氢或烷基）或单键; Y1表示单键，亚烷基等; Y2表示单键，亚烷基等; Z表示亚烷基; 并且Q1和Q2中的至少一个表示-COOR 10（其中R 10表示（un）取代的烷基等）等）或该化合物的药学上可接受的盐。

44. 发明申请

US20080269240A1 Novel Adenine Compound 审中-公开
标题翻译：新型腺嘌呤复合物
公开(公告)号：US20080269240A1
公开(公告)日：2008-10-30
申请号：US12067446
申请日：2006-09-21
申请人： Kazuki Hashimoto , Tomoaki Nakamura , Kei Nakamura , Shingo Tojo , Ayumu Kurimoto , Yoshiaki Isobe , Hiroki Wada , Roger Bonnert
发明人： Kazuki Hashimoto , Tomoaki Nakamura , Kei Nakamura , Shingo Tojo , Ayumu Kurimoto , Yoshiaki Isobe , Hiroki Wada , Roger Bonnert
IPC分类号： A61K31/522 , C07D473/18 , A61P31/12
CPC分类号： C07D473/18
摘要： An adenine compound useful as a medicine represented by the following formula (1): [wherein R1 is halogen atom, optionally substituted alkyl group, optionally substituted aryl group, etc.; X is oxygen atom, sulfur atom, a single bond, etc.; A1 is optionally substituted and optionally saturated 4 to 8 membered heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom, and 0 to 1 sulfur atom; A2 is optionally substituted 6 to 10 cyclic aromatic hydrocarbon group or optionally substituted 5 to 10 membered heterocyclic aromatic group; L1 and L2 are independently, substituted straight or branched alkylene or a single bond, etc.; L3 is optionally substituted straight or branched alkylene, etc.; R2 is hydrogen atom, optionally substituted alkyl group.] or its pharmaceutically acceptable salt.
摘要翻译：用作下式（1）表示的药物的腺嘌呤化合物：其中R 1是卤素原子，任选取代的烷基，任选取代的芳基等; X是氧原子，硫原子，单键等; 任选被取代的和任选饱和的含有1至2个选自1至3个氮原子，0至1个氧原子和0至1个硫原子的杂原子的4至8元杂环基; 任选取代的6至10个环状芳族烃基或任选取代的5至10元杂环芳基; L 1和L 2独立地为取代的直链或支链亚烷基或单键等; L 3是任选取代的直链或支链亚烷基等; R 2是氢原子，任选取代的烷基。]或其药学上可接受的盐。

45. 发明申请

US20070190071A1 9-Substituted 8-oxoadenine compound 有权
标题翻译： 9-取代的8-氧代腺嘌呤化合物
公开(公告)号：US20070190071A1
公开(公告)日：2007-08-16
申请号：US10593691
申请日：2005-03-24
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/52 , A61K31/522 , C07D473/10
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0〜2的整数，Z 1表示亚烷基，X 2，表示氧原子，硫原子，SO 2，NR 5，CO，CONR 5，NR 5 CO和 Y 1，Y 2和Y 3独立地表示单键或亚烷基，X 1，O 2， >表示氧原子，硫原子，NR 4（R 4）是氢原子或烷基或单键，R 2表示取代或未取代的烷基，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或芳烷基]或其药学上可接受的盐。

46. 发明授权

US5877318A Hydroquinone derivative and pharmaceutical use thereof 失效
标题翻译：对苯二酚衍生物及其药物用途
公开(公告)号：US5877318A
公开(公告)日：1999-03-02
申请号：US113826
申请日：1998-07-10
申请人： Yoshiaki Isobe , Yuso Goto , Masanori Tobe , Osamu Takahashi
发明人： Yoshiaki Isobe , Yuso Goto , Masanori Tobe , Osamu Takahashi
IPC分类号： C07D239/54 , C07D239/545 , C07D405/12
CPC分类号： C07D239/545 , C07D405/12
摘要： Disclosed is a hydroquinone derivative or a pharmaceutically acceptable salt thereof, the hydroquinone derivative being represented by formula (I): ##STR1## wherein R.sup.1 is a phenyl group which is unsubstituted or substituted with a substituent or substituents each independently selected from the group consisting of a halogen atom, a C1-4 alkyl group and a C1-4 alkoxy group;R.sup.2 is a hydrogen atom or a C1-4 alkyl group;each of R.sup.3 and R.sup.4 is independently a hydrogen atom or a C1-4 alkyl group;R.sup.5 is a hydrogen atom or a C1-4 alkyl group;each of R.sup.6, R.sup.7 and R.sup.8 is independently a hydrogen atom or a C1-4 alkyl group;P is a hydroxyl group;Q is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group;P may form together with Q an ether bond;R is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group, provided that when one of said Q and said R is an oxo group, the other is also an oxo group;X is a single bond, an --NR.sup.10 -- group or a --CH.sub.2 --NR.sup.10 -- group in which R.sup.10 is a hydrogen atom or a C1-4 alkyl group;Y is a methylene group or a carbonyl group; anddotted bonds in a six membered ring represent that said six membered ring has the maximum number of double bonds.
摘要翻译：公开了氢醌衍生物或其药学上可接受的盐，氢醌衍生物由式（I）表示：未取代或被各自独立地选自卤素原子，C 1-4烷基的取代基或取代基取代和C 1-4烷氧基; R2是氢原子或C1-4烷基; R 3和R 4各自独立地为氢原子或C 1-4烷基; R5是氢原子或C1-4烷基; R6，R7和R8各自独立地为氢原子或C1-4烷基; P是羟基; Q是羟基，C 1-4烷氧基，C 1-18酰氧基或氧代基; P可与Q形成醚键; R是羟基，C 1-4烷氧基，C 1-18酰氧基或氧代基，条件是当所述Q和所述R中的一个是氧代基时，另一个也是氧代基; X是单键，-NR 10 - 基或-CH 2 -NR 10 - 基，其中R 10是氢原子或C 1-4烷基; Y是亚甲基或羰基; 六元环中的点状键表示所述六元环具有最大数量的双键。

47. 发明授权

US5630034A Three-dimensional image producing method and apparatus 失效
标题翻译：三维图像制作方法及装置
公开(公告)号：US5630034A
公开(公告)日：1997-05-13
申请号：US415941
申请日：1995-04-03
申请人： Michio Oikawa , Koichi Sano , Yoshiaki Isobe
发明人： Michio Oikawa , Koichi Sano , Yoshiaki Isobe
IPC分类号： A61B6/03 , A61B5/055 , G06T1/00 , G06T15/08 , G06F15/00
CPC分类号： G06T15/08
摘要： A three-dimensional image producing method of determining, as display candidates, voxel data having a value exceeding a display threshold set for density, and voxel data of a specified classification selected from among voxel data classified into a plurality of display classifications, and projecting the voxel data as the display candidates onto a projection plane on the basis of predetermined display conditions to form a three-dimensional image.
摘要翻译：一种三维图像产生方法，用于确定具有超过为密度设置的显示阈值的值的体素数据作为显示候选，以及从分类为多个显示分类的体素数据中选择的指定分类的体素数据，并且将基于预定的显示条件将体素数据作为显示候选到投影平面上，以形成三维图像。

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