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41. 发明授权

US07010345B2 Method and apparatus to minimize effects of a cardiac insult 失效
公开(公告)号：US07010345B2
公开(公告)日：2006-03-07
申请号：US09999723
申请日：2001-10-26
申请人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
发明人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.

42. 发明授权

US06922585B2 Method and apparatus for predicting recurring ventricular arrhythmias 有权
标题翻译：用于预测复发性室性心律失常的方法和装置
公开(公告)号：US06922585B2
公开(公告)日：2005-07-26
申请号：US10117465
申请日：2002-04-05
申请人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
发明人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
IPC分类号： A61B5/0452 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61B5/4035 , A61B5/046 , A61B5/0464 , A61N1/3622 , A61N1/3962
摘要： An implantable medical device and method are provided for assessing autonomic tone and risk factors associated with arrhythmias and, based on this assessment, an early recurrence of ventricular tachycardia or ventricular fibrillation is predicted. Specifically, changes in R—R interval, heart rate variability, patient activity, and myocardial ischemia are measured prior to and after a detected an arrhythmia episode. A recurrence score is calculated as a weighted sum of measured parameters and compared to a prediction criterion. The prediction criterion may be a preset threshold score or an individualized episode template based on previously calculated recurrence scores associated with recurring episodes. Stored parameters and episode-related data may be downloaded for offline analyses for optimizing prediction criteria and monitoring patient status.
摘要翻译：提供了一种用于评估与心律失常相关的自主神经和风险因素的可植入医疗装置和方法，并且基于该评估，预测了室性心动过速或心室颤动的早期复发。具体地，在检测到心律失常发作之前和之后测量R-R间期，心率变异性，患者活动和心肌缺血的变化。计算复发得分作为测量参数的加权和并与预测标准进行比较。预测标准可以是基于先前计算的与重复发作相关联的复发评分的预设阈值评分或个体化发作模板。可以下载存储的参数和与剧集相关的数据用于离线分析，以优化预测标准和监测患者状态。

43. 发明授权

US06369568B1 Fast spin echo phase correction for MRI system 失效
标题翻译： MRI系统的快速自旋回波相位校正
公开(公告)号：US06369568B1
公开(公告)日：2002-04-09
申请号：US09325081
申请日：1999-06-03
申请人： Jingfei Ma , Xiaohong Zhou
发明人： Jingfei Ma , Xiaohong Zhou
IPC分类号： G01V300
CPC分类号： G01R33/56554 , G01R33/5617
摘要： A prescan process for an MR fast spin echo (FSE) pulse sequence adjusts the phases of the RF excitation pulse and RF refocusing pulses in the FSE pulse sequence to reduce the spatially invariant phase errors (zeroth order). The prescan process also calculates the value of a readout gradient compensation pulse, a phase-encoding gradient compensation pulse and a slice-select gradient compensation pulse to reduce the first order phase shifts along the readout, phase-encoding, and slice-select gradient axes.
摘要翻译：用于MR快速自旋回波（FSE）脉冲序列的预扫描过程调整FSE脉冲序列中RF激励脉冲和RF重聚焦脉冲的相位，以减少空间不变相位误差（零级）。预扫描过程还计算读出梯度补偿脉冲的值，相位编码梯度补偿脉冲和切片选择梯度补偿脉冲，以减少沿着读出，相位编码和切片选择梯度轴的一阶相移。

44. 发明授权

US06239599B1 Method and apparatus for identifying errors in magnetic resonance imaging examinations 有权
标题翻译：用于识别磁共振成像检查中的误差的方法和装置
公开(公告)号：US06239599B1
公开(公告)日：2001-05-29
申请号：US09316344
申请日：1999-05-21
申请人： Xiaohong Zhou , Joseph K. Maier , Steven J. Huff
发明人： Xiaohong Zhou , Joseph K. Maier , Steven J. Huff
IPC分类号： G01V300
CPC分类号： G01R33/58 , G01R33/56518 , G01R33/56554
摘要： A technique is disclosed for determining errors in MRI sequences resulting from eddy currents generated by pulsed gradient fields. During a calibration sequence, with no phase-encoding, gradient pulses and readout sequences are applied along physical axes of a scanner and data sets are acquired for each combination. A reference data set is acquired with no gradient pulses applied. The resulting data sets are processed by one dimensional Fourier transformation, and the transformed data is analyzed to determine spatially invariant and linear gradient errors. The phase errors may be averaged for each physical axis. The technique is particularly useful in determining errors in diffusion weighted echo planar imaging sequences.
摘要翻译：公开了一种用于确定由脉冲梯度场产生的涡流产生的MRI序列中的误差的技术。在校准序列期间，没有相位编码，沿着扫描仪的物理轴施加梯度脉冲和读出序列，并为每个组合采集数据集。在不施加梯度脉冲的情况下获取参考数据集。通过一维傅里叶变换处理所得到的数据集，并分析变换数据以确定空间不变和线性梯度误差。每个物理轴可以对相位误差进行平均。该技术在确定扩散加权回波平面成像序列中的误差方面特别有用。

45. 发明授权

US6057685A Method for correcting motion-induced errors in MR imaging 失效
标题翻译：用于校正MR成像中运动诱发误差的方法
公开(公告)号：US6057685A
公开(公告)日：2000-05-02
申请号：US987594
申请日：1997-12-09
申请人： Xiaohong Zhou
发明人： Xiaohong Zhou
IPC分类号： G01R33/567 , G01V3/00
CPC分类号： G01R33/56509 , G01R33/5676
摘要： In a method for providing an MR image of a section taken through an object, wherein the section is acquired in the presence of in-plane translational motion of the object, an MR system is operated to acquire a set of imaging data points from the section, the set of imaging data points being contaminated by phase errors resulting from the motion. The MR system is further operated to acquire a plurality of correction data point sets, each correction data point in one of said sets being acquired along an alignment line or other trajectory and at a location coinciding with the location of one of the imaging data points. The imaging data points respectively coinciding with the correction data points comprise, collectively, a subset of the imaging data points. The phase difference between each correction data point set and its corresponding subset of imaging data points is determined, and then used to remove the phase errors from the set of imaging data points.
摘要翻译：在用于提供通过对象拍摄的部分的MR图像的方法中，其中在存在对象的平面内平移运动的情况下获取该部分，操作MR系统以从该部分获取一组成像数据点，该组成像数据点被运动产生的相位误差污染。进一步操作MR系统以获取多个校正数据点集合，其中一个组中的每个校正数据点沿着对准线或其他轨迹以及与一个成像数据点的位置重合的位置获取。分别与校正数据点一致的成像数据点总共包括成像数据点的子集。确定每个校正数据点集合及其对应的成像数据点子集之间的相位差，然后用于从成像数据点集合中去除相位误差。

46. 发明授权

US6011392A Method for reducing Maxwell term artifacts in fast spin echo MR images 失效
标题翻译：用于在快速自旋回波MR图像中降低Maxwell术语伪影的方法
公开(公告)号：US6011392A
公开(公告)日：2000-01-04
申请号：US5768
申请日：1998-01-12
申请人： Xiaohong Zhou , Matthew A. Bernstein , Gousheng Tan
发明人： Xiaohong Zhou , Matthew A. Bernstein , Gousheng Tan
IPC分类号： G01R33/561 , G01R33/565 , G01V3/00
CPC分类号： G01R33/56581 , G01R33/56554 , G01R33/5617
摘要： Fast spin echo pulse sequences are adjusted to reduce, or eliminate image artifacts caused by Maxwell terms arising from the linear imaging gradients. The waveforms of the slice selection, phase encoding and readout gradients are adjusted in shape, size or position to eliminate or reduce the phase error caused by the spatially quadratic Maxwell terms.
摘要翻译：调整快速自旋回波脉冲序列以减少或消除由线性成像梯度引起的麦克斯韦术引起的图像伪像。切片选择，相位编码和读出梯度的波形在形状，大小或位置上进行调整，以消除或减少由空间二次Maxwell项引起的相位误差。

47. 发明授权

US5689186A Method for producing an off-center image using an EPI pulse sequence 失效
标题翻译：使用EPI脉冲序列产生偏心图像的方法
公开(公告)号：US5689186A
公开(公告)日：1997-11-18
申请号：US577000
申请日：1995-12-26
申请人： Joseph Kenneth Maier , Frederick Howard Epstein , Xiaohong Zhou , Lawrence Edward Ploetz , Paul E. Licato
发明人： Joseph Kenneth Maier , Frederick Howard Epstein , Xiaohong Zhou , Lawrence Edward Ploetz , Paul E. Licato
IPC分类号： G01R33/54 , G01V3/00
CPC分类号： G01R33/4833
摘要： An off-center NMR image is produced using an EPI pulse sequence. The offset along the readout gradient axis is achieved by shifting the frequency of an RF reference signal used to demodulate the received NMR echo signals. Phase errors produced by the NMR system and by the shifts in reference signal frequency are corrected in "real time" by also shifting the phase of the RF reference signal.
摘要翻译：使用EPI脉冲序列产生偏心NMR图像。沿读出梯度轴的偏移量通过移位用于解调所接收的NMR回波信号的RF参考信号的频率来实现。由NMR系统产生的相位误差和参考信号频率的偏移通过也移动RF参考信号的相位而以“实时”校正。

48. 发明授权

US08781583B2 Vagal stimulation 有权
公开(公告)号：US08781583B2
公开(公告)日：2014-07-15
申请号：US13353919
申请日：2012-01-19
申请人： Richard N. M. Cornelussen , Xiaohong Zhou , Robert Stadler , Lilian Kornet
发明人： Richard N. M. Cornelussen , Xiaohong Zhou , Robert Stadler , Lilian Kornet
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/36585
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

49. 发明授权

US08781582B2 Vagal stimulation 有权
标题翻译：迷走神经刺激
公开(公告)号：US08781582B2
公开(公告)日：2014-07-15
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/37
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

50. 发明授权

US08620425B2 Nerve signal differentiation in cardiac therapy 有权
标题翻译：心脏治疗神经信号分化
公开(公告)号：US08620425B2
公开(公告)日：2013-12-31
申请号：US12848010
申请日：2010-07-30
申请人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N. M. Cornelussen
发明人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N. M. Cornelussen
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61B5/04001 , A61N1/36114 , A61N1/36514 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
摘要翻译：神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。

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