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41. 发明申请

US20070107919A1 GUIDED POWER TOOL AND METHOD FOR OPERATING A GUIDED POWER TOOL 审中-公开
标题翻译：指导电动工具和操作指导电动工具的方法
公开(公告)号：US20070107919A1
公开(公告)日：2007-05-17
申请号：US11619281
申请日：2007-01-03
申请人： Andreas Strasser , Erhard Hoffmann , Dietmar Hahn
发明人： Andreas Strasser , Erhard Hoffmann , Dietmar Hahn
IPC分类号： B25B21/02
CPC分类号： B25F5/00
摘要： The present invention is based on a method for operating a guided power tool (10), in particular an electric power tool, with a rotatably and/or percussively driven insert tool (36), whereby the insert tool (36) is driven into a work piece (34) in a work process. It is proposed that at least one measured signal detected at the power tool (10) during the work process is evaluated to derive a property of the work piece (34) located in the working direction of the Insert tool (36), and the power tool (10) is operated in accordance with the property. A guided power tool is also proposed.
摘要翻译：本发明基于一种用于操作具有可旋转和/或冲击式驱动的插入工具（36）的引导电动工具（10），特别是电动工具的方法，由此插入工具（36）被驱动成工件（34）在工作过程中。提出在工作过程期间在电动工具（10）处检测到的至少一个测量信号被评估以得出位于插入工具（36）的工作方向上的工件（34）的性质，并且功率工具（10）根据属性进行操作。还提出了一种引导电动工具。

42. 发明申请

US20070029342A1 Laboratory workstation for providing samples 审中-公开
标题翻译：实验室工作站提供样品
公开(公告)号：US20070029342A1
公开(公告)日：2007-02-08
申请号：US10529921
申请日：2002-10-02
申请人： Alexander Cross , Andreas Strasser , Frank Gullich
发明人： Alexander Cross , Andreas Strasser , Frank Gullich
IPC分类号： G01G13/24
CPC分类号： G01N35/0099 , B25J15/10 , G01N2035/00217 , G01N2035/00326
摘要： The present invention relates to a workstation for the handling of chemicals and containers, in particular of containers as used in a laboratory, in combination with a metering device for solids and liquids. The workstation comprises at least: (i) a platform, which has at least one module with at least one reservoir for a sample and at least one module with at least one target container (ii) a metering system for the metering of the sample, (iii) a portal system, which is arranged above the platform and which maneuvers the metering system to all three directions in space, (iv) a control device for controlling the movements of the metering system, and (v) a measuring system for the samples. Thereby, the metering system (ii) has a gripper device for the uptake of a metering tool and/or of the containers, and said metering tool is supported within at least one module on the platform.
摘要翻译：本发明涉及一种用于处理化学品和容器，特别是用于实验室的容器的工作站，与用于固体和液体的计量装置组合。该工作站至少包括：（i）平台，其具有至少一个具有用于样品的至少一个储存器的模块和至少一个具有至少一个目标容器的模块（ii）用于计量样品的计量系统，（iii）入口系统，其设置在平台上方并且将计量系统操纵到空间中的所有三个方向，（iv）用于控制计量系统的运动的控制装置，以及（v）用于样品。因此，计量系统（ii）具有用于吸收计量工具和/或容器的夹持装置，并且所述计量工具被支撑在平台上的至少一个模块中。

43. 发明授权

US09146287B2 XMR sensors with high shape anisotropy 有权
标题翻译：具有高形状各向异性的XMR传感器
公开(公告)号：US09146287B2
公开(公告)日：2015-09-29
申请号：US12946460
申请日：2010-11-15
申请人： Juergen Zimmer , Klemens Pruegl , Olaf Kuehn , Andreas Strasser , Ralf-Rainer Schledz , Norbert Thyssen
发明人： Juergen Zimmer , Klemens Pruegl , Olaf Kuehn , Andreas Strasser , Ralf-Rainer Schledz , Norbert Thyssen
IPC分类号： G01R33/02 , G01R33/09 , H01L43/08 , H01L43/12
CPC分类号： G01R33/0052 , G01R33/09 , G01R33/093 , G01R33/096 , G01R33/098 , H01L27/22 , H01L43/02 , H01L43/08 , H01L43/12
摘要： Embodiments relate to xMR sensors having very high shape anisotropy. Embodiments also relate to novel structuring processes of xMR stacks to achieve very high shape anisotropies without chemically affecting the performance relevant magnetic field sensitive layer system while also providing comparatively uniform structure widths over a wafer, down to about 100 nm in embodiments. Embodiments can also provide xMR stacks having side walls of the performance relevant free layer system that are smooth and/or of a defined lateral geometry which is important for achieving a homogeneous magnetic behavior over the wafer.
摘要翻译：实施例涉及具有非常高的形状各向异性的xMR传感器。实施例还涉及xMR堆叠的新结构化过程，以实现非常高的形状各向异性，而不会在性能相关的磁场敏感层系统中产生化学影响，同时在晶片上提供相对均匀的结构宽度，在实施例中可降低至约100nm。实施例还可以提供具有性能相关自由层系统的侧壁的xMR堆叠，其平滑和/或限定的横向几何形状对于在晶片上实现均匀的磁性行为是重要的。

44. 发明授权

US08387460B2 Vibration dosimeter for determining vibrational loading 失效
标题翻译：用于确定振动载荷的振动剂量计
公开(公告)号：US08387460B2
公开(公告)日：2013-03-05
申请号：US12593052
申请日：2008-02-18
申请人： Markus Roth , Andreas Strasser
发明人： Markus Roth , Andreas Strasser
IPC分类号： G01H11/08 , G06F19/00 , G06F17/40
CPC分类号： G01H1/00
摘要： A vibration dosimeter (2) for determining the vibrational loading of people includes a determination device (6) for determining the operating period duration, a calculation device (6) for calculating the permitted work time as a function of a tool-specific characteristic vibration value, a comparison device (6) for comparing the effective operating period duration with the permitted work time, and an interface (3) for reading in the characteristic vibration value from the tool (1).
摘要翻译：用于确定人的振动载荷的振动剂量计（2）包括用于确定操作周期持续时间的确定装置（6），用于根据刀具特有特性振动值计算允许工作时间的计算装置（6），用于将有效运行周期持续时间与允许的工作时间进行比较的比较装置（6）和用于从工具（1）读取特征振动值的接口（3）。

45. 发明申请

US20120321845A1 METHOD FOR PRODUCING HONED SEGMENT BORES IN WORK PIECES AND WORK PIECE HAVING A HONED SEGMENT BORE 审中-公开
标题翻译：在工作中生产有意义的分段钻孔的方法和具有相同部分的钻孔
公开(公告)号：US20120321845A1
公开(公告)日：2012-12-20
申请号：US13516761
申请日：2010-10-25
申请人： Karl Forsch , Marco Schneiders , Guido Stopp , Ralf Burkholder , Andreas Strasser
发明人： Karl Forsch , Marco Schneiders , Guido Stopp , Ralf Burkholder , Andreas Strasser
IPC分类号： B24B33/02 , B32B3/24
CPC分类号： B24B33/02 , Y10T428/24322
摘要： The invention relates to a method for producing a honed segment bore (5-8) in work pieces (1-4), which each have a segment bore (5-8). The work pieces (1-4) are arranged relative to each other such that the segment bores (5-8) of the work pieces (1-4) are aligned to a common longitudinal axis (9) and a closed circle (12) is formed in a projection along the common longitudinal axis (9). The segment bores (5-8) of the work pieces (1-4) arranged relative to each other are then honed together. An elaborate grinding process can thus be replaced by a honing process, in which a plurality of work pieces (1-4) can be processed simultaneously, thus reducing the cycle time.
摘要翻译：本发明涉及一种用于在工件（1-4）中生产珩磨段孔（5-8）的方法，其中每个具有段孔（5-8）。工件（1-4）相对于彼此布置，使得工件（1-4）的段孔（5-8）与公共纵向轴线（9）和闭合圆圈（12）对准，沿着共同纵向轴线（9）形成在突起中。然后将相对于彼此布置的工件（1-4）的段孔（5-8）磨成一体。因此，可以通过珩磨处理来代替精细的研磨工艺，其中可以同时处理多个工件（1-4），从而减少循环时间。

46. 发明申请

US20110256152A1 Methods Of Treating And Preventing Glucose Toxicity 审中-公开
标题翻译：治疗和预防葡萄糖毒性的方法
公开(公告)号：US20110256152A1
公开(公告)日：2011-10-20
申请号：US13021279
申请日：2011-02-04
申请人： Andreas Strasser , Mark McKenzie , Helen Thomas , Janette Allison , Tom Kay
发明人： Andreas Strasser , Mark McKenzie , Helen Thomas , Janette Allison , Tom Kay
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C12N5/00 , A61K35/39 , A61K38/00 , A61K31/7088 , A61P3/10 , A61K35/36 , A61K35/12 , C12N5/02
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/713 , C07K16/22
摘要： The present invention relates to a method for treating and/or preventing a disease associated with glucose toxicity in a subject which may comprise administering to the subject a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell of the subject. Furthermore, provided is a method for culturing cells susceptible to exposure to high concentrations of glucose, which may comprise delivering to the cells, or progenitor cells thereof, a compound that reduces the level of Bim, PUMA and/or Bax activity in the cells.
摘要翻译：本发明涉及用于治疗和/或预防与受试者中葡萄糖毒性相关的疾病的方法，其可包括向受试者施用降低受试者细胞中Bim，PUMA和/或Bax活性水平的化合物。此外，提供了培养容易暴露于高浓度葡萄糖的细胞的方法，所述细胞可以包含向细胞或其祖细胞递送降低细胞中Bim，PUMA和/或Bax活性水平的化合物。

47. 发明授权

US07818141B2 Vibration dosimeter and method for determining the daily vibration exposure 有权
标题翻译：振动剂量计和确定每日振动暴露的方法
公开(公告)号：US07818141B2
公开(公告)日：2010-10-19
申请号：US11914775
申请日：2007-01-15
申请人： Markus Roth , Andreas Strasser
发明人： Markus Roth , Andreas Strasser
IPC分类号： G06F19/00 , G06F17/40
CPC分类号： G01H1/00
摘要： The invention relates to a vibration dosimeter (2) and a method for determining the daily vibrational loading of persons who are exposed to mechanical oscillations at their place of work due to the operation of a work means and in particular of a manually operated electronic tool (4, 6). What is provided is that the dosimeter (2) comprises a determination device (12, 18) for determining the effective daily operating duration of the work means (4, 6), a computer device (22) for calculating a daily work time until a specified trigger value or exposition limit value of the vibrational loading is reached from a work-means-typical vibration value and the trigger value or exposition limit value, and a comparison device (24) for comparing the determined effective daily operating duration of the work means with the calculated daily work time until the specified trigger value is reached.
摘要翻译：本发明涉及一种振动剂量计（2）和一种用于确定由于工作装置的操作而暴露于其工作地点的机械振荡的人的日常振动负载的方法，特别是涉及一种手动操作的电子工具 4，6）。提供的是剂量计（2）包括用于确定工作装置（4,6）的有效日工作持续时间的确定装置（12,18），计算机装置（22），用于计算直到根据工作装置典型振动值和触发值或曝光极限值达到振动载荷的指定触发值或曝光极限值;以及比较装置（24），用于比较所确定的工作装置的有效日工作持续时间与计算的每日工作时间，直到达到指定的触发值。

48. 发明授权

US07582439B2 Therapeutic molecules 失效
标题翻译：治疗分子
公开(公告)号：US07582439B2
公开(公告)日：2009-09-01
申请号：US11409944
申请日：2006-04-24
申请人： Suzanne Cory , Jerry Adams , David C. S. Huang , Liam O'Connor , Andreas Strasser , Hamsa Puthalakath , Lorraine O'Reilly
发明人： Suzanne Cory , Jerry Adams , David C. S. Huang , Liam O'Connor , Andreas Strasser , Hamsa Puthalakath , Lorraine O'Reilly
IPC分类号： G01N33/536
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
摘要翻译：本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bim”，以及编码它们的遗传序列。本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。

49. 发明授权

US07572900B2 Bcl-2-modifying factor (bmf) sequences and their use in modulating apoptosis 失效
标题翻译： Bcl-2修饰因子（bmf）序列及其在凋亡调控中的应用
公开(公告)号：US07572900B2
公开(公告)日：2009-08-11
申请号：US10479307
申请日：2002-05-30
申请人： Andreas Strasser , Hamsa Puthalakath , Andreas Villunger , Leigh Coultas , Jennifer Beaumont , Lorraine Ann O'Reilly , David Ching Siang Huang
发明人： Andreas Strasser , Hamsa Puthalakath , Andreas Villunger , Leigh Coultas , Jennifer Beaumont , Lorraine Ann O'Reilly , David Ching Siang Huang
IPC分类号： C07H21/04
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00
摘要： The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.
摘要翻译：本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。因此，Bmf被认为是仅BH3分子。本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

50. 发明申请

US20090140154A1 VIBRATION DOSIMETER AND METHOD FOR DETERMINING THE DAILY VIBRATION EXPOSURE 有权
标题翻译：振动剂量计和确定每日振动暴露的方法
公开(公告)号：US20090140154A1
公开(公告)日：2009-06-04
申请号：US11914775
申请日：2007-01-15
申请人： Markus Roth , Andreas Strasser
发明人： Markus Roth , Andreas Strasser
IPC分类号： G01T1/02
CPC分类号： G01H1/00
摘要： The invention relates to a vibration dosimeter (2) and a method for determining the daily vibrational loading of persons who are exposed to mechanical oscillations at their place of work due to the operation of a work means and in particular of a manually operated electronic tool (4, 6). What is provided is that the dosimeter (2) comprises a determination device (12, 18) for determining the effective daily operating duration of the work means (4, 6), a computer device (22) for calculating a daily work time until a specified trigger value or exposition limit value of the vibrational loading is reached from a work-means-typical vibration value and the trigger value or exposition limit value, and a comparison device (24) for comparing the determined effective daily operating duration of the work means with the calculated daily work time until the specified trigger value is reached.
摘要翻译：本发明涉及一种振动剂量计（2）和一种用于确定由于工作装置的操作而暴露于其工作地点的机械振荡的人的日常振动负载的方法，特别是涉及一种手动操作的电子工具 4，6）。提供的是剂量计（2）包括用于确定工作装置（4,6）的有效日工作持续时间的确定装置（12,18），计算机装置（22），用于计算直到根据工作装置典型振动值和触发值或曝光极限值达到振动载荷的指定触发值或曝光极限值;以及比较装置（24），用于比较所确定的工作装置的有效日工作持续时间与计算的每日工作时间，直到达到指定的触发值。

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