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41. 发明申请

US20080095832A1 Prosaposin as a neurotrophic factor 审中-公开
标题翻译：普罗沙星作为神经营养因子
公开(公告)号：US20080095832A1
公开(公告)日：2008-04-24
申请号：US11787565
申请日：2007-04-16
申请人： John O'Brien , Yasuo Kishimoto
发明人： John O'Brien , Yasuo Kishimoto
IPC分类号： A61K9/127 , A61K38/08 , A61P25/00 , C07K7/08 , C07K7/06 , A61K38/10
CPC分类号： E03B7/074 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/0085 , A61K9/127 , A61K9/19 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/475 , C07K14/52 , C07K14/705 , C07K14/71 , C07K14/715 , Y02A50/465
摘要： Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large, neurons of the brain, including both upper and lower motor neurons.
摘要翻译：皂角苷C和皂角苷C的各种肽片段在体外刺激神经突生长。此外，赞子和皂角蛋白C促进离体髓鞘形成。普罗沙星存在于大脑神经元的大脑中，包括上下运动神经元。

42. 发明申请

US20080049549A1 Method for Mixing A Fluid Dispersion Disposed in a Container Having Either a Cylindrical or Square Shape 有权
标题翻译：用于混合设置在具有圆柱形或正方形的容器中的流体分散体的方法
公开(公告)号：US20080049549A1
公开(公告)日：2008-02-28
申请号：US11928655
申请日：2007-10-30
申请人： Dwight Huckby , James MacDonald , John O'Brien
发明人： Dwight Huckby , James MacDonald , John O'Brien
IPC分类号： B01F9/00
CPC分类号： B01F9/0032 , B01F9/0001 , B01F9/0018 , B01F15/0074 , B01F15/00766 , B01F2215/005 , Y10S366/605
摘要： Apparatus and method for mixing a fluid dispersion disposed in a container having either a cylindrical or a square shape. The apparatus includes a holding structure having a retaining structure connected to a base. The retaining structure prevents lateral movement of the container both when the container has a cylindrical shape and when the container has a generally square shape with a width substantially equal to the diameter of the cylindrical shape. The apparatus rotates the container about at least one axis.
摘要翻译：用于混合设置在具有圆柱形或正方形形状的容器中的流体分散体的装置和方法。该装置包括具有连接到基座的保持结构的保持结构。当容器具有圆柱形形状并且当容器具有基本上等于圆柱形直径的宽度的大致正方形形状时，保持结构防止容器的横向移动。设备围绕至少一个轴线旋转容器。

43. 发明申请

US20080017288A1 Safety tire, method of making and method of improved traffic safety with use thereof 审中-公开
公开(公告)号：US20080017288A1
公开(公告)日：2008-01-24
申请号：US11902399
申请日：2007-09-21
申请人： John O'Brien , Patrick O'Brien
发明人： John O'Brien , Patrick O'Brien
IPC分类号： B60C11/24
CPC分类号： B60C11/24 , Y10T152/10027
摘要： A tire in which a tire manufacturer has determined the tractive capacity at numerous levels of tread wear, the tire having at least one visual warning indicator located at a tread depth corresponding to a percentage loss of tractive capacity. Also, a method of making the tire and a method improving traffic safety through use of such a tire combined with educating the consumer as to proper use of the tire.

44. 发明申请

US20080015636A1 SINGLE DISC INTRALUMINAL PATENT FORAMEN OVALE CLOSURE DEVICE 审中-公开
标题翻译：单碟烧烤专用烤箱封闭装置
公开(公告)号：US20080015636A1
公开(公告)日：2008-01-17
申请号：US11761174
申请日：2007-06-11
申请人： Daniel Olsen , Randy Grishaber , Chao-Chin Chen , Rudolph Cedro , John O'Brien
发明人： Daniel Olsen , Randy Grishaber , Chao-Chin Chen , Rudolph Cedro , John O'Brien
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00615 , A61B2017/00619
摘要： A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.
摘要翻译：用于部署用于封闭身体中的通道的机械闭合装置的装置和方法，例如心脏中的卵孔卵泡（PFO）。单盘机械闭合装置包括由封闭线限制的远端和近端锚，以通过使远侧和近端锚固件沿着闭合线紧密接近来促进机械闭合。

45. 发明申请

US20070265431A1 PMMA binding peptides and methods of use 有权
标题翻译： PMMA结合肽及其使用方法
公开(公告)号：US20070265431A1
公开(公告)日：2007-11-15
申请号：US11607732
申请日：2006-12-01
申请人： Scott Cunningham , David Lowe , John O'Brien , Hong Wang , Antoinette Wilkins
发明人： Scott Cunningham , David Lowe , John O'Brien , Hong Wang , Antoinette Wilkins
IPC分类号： C07K14/00
CPC分类号： C07K7/08 , C07K7/06 , C07K14/001
摘要： Combinatorially generated peptides are provided that have binding affinity for polymethylmethacrylate (PMMA). The peptides may be used to deliver benefit agents to various PMMA surfaces.
摘要翻译：提供了对聚甲基丙烯酸甲酯（PMMA）具有结合亲和力的组合产生的肽。肽可以用于将有益剂递送到各种PMMA表面。

46. 发明申请

US20070249805A1 CLAY-BINDING PEPTIDES AND METHODS OF USE 失效
标题翻译：粘合蛋白和使用方法
公开(公告)号：US20070249805A1
公开(公告)日：2007-10-25
申请号：US11696380
申请日：2007-04-04
申请人： Steven Ittel , Scott Cunningham , Pierre Rouviere , Stephen Fahnestock , John O'Brien , Eberhard Schneider , Gregor Schurmann , Peter Wagner
发明人： Steven Ittel , Scott Cunningham , Pierre Rouviere , Stephen Fahnestock , John O'Brien , Eberhard Schneider , Gregor Schurmann , Peter Wagner
IPC分类号： C07K14/00
CPC分类号： C07K7/06 , C07K7/08 , C07K14/001 , C07K17/14
摘要： Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.
摘要翻译：提供了对粘土具有结合亲和力的组合产生的肽。肽可以用于将有益剂递送到各种粘土表面。

47. 发明申请

US20070248868A1 Solid oxide fuel cell stack having an integral gas distribution manifold 有权
标题翻译：具有整体气体分配歧管的固体氧化物燃料电池堆
公开(公告)号：US20070248868A1
公开(公告)日：2007-10-25
申请号：US11406958
申请日：2006-04-19
申请人： Karl Haltiner , James Vordonis , John O'Brien
发明人： Karl Haltiner , James Vordonis , John O'Brien
IPC分类号： H01M8/24 , H01M2/08 , H01M8/02 , H01M8/04
CPC分类号： H01M8/2432 , H01M8/0271 , H01M8/028 , H01M8/0286 , H01M8/04074 , H01M8/242 , H01M8/2425 , H01M8/2465 , H01M8/248 , H01M8/2483
摘要： An SOFC stack module including an integral individual stack manifold containing all of the gas pathways necessary for supply and exhaust of fuel gas and cathode air to and from the stack chimneys. The stack is mounted and hermetically joined directly to the manifold without an intermediate base plate. Flanges at the inlet and outlet ports couple to system distributary manifolds via high temperature sealing joints. The manifold preferably is fabricated of a ferritic stainless steel, and may be formed in a one-piece casting, a combination of multiple castings and stamped plates metallurgically joined (brazed or welded together), or stamped from sheet metal stock. Preferably, the manifold includes fin structures extending into adjacent fuel gas and cathode air chambers to enhance balancing of temperatures by heat exchange therebetween. Heat exchange may be further improved by configuring the manifold to have a plurality of interleaved anode and cathode gas supply chambers.
摘要翻译：一个SOFC堆叠模块，包括一个集成的单独的堆叠歧管，其包含供给和排出燃料气体和向烟囱排出阴极空气所需的所有气体通路。堆叠被安装和气密地直接连接到歧管，而没有中间基板。入口和出口处的法兰通过高温密封接头连接到系统分配歧管。歧管优选地由铁素体不锈钢制成，并且可以以单件铸件形成，多个铸件和冶金接合（钎焊或焊接在一起）上的冲压板的组合，或者由金属板材冲压成型。优选地，歧管包括延伸到相邻燃料气体和阴极空气室中的翅片结构，以通过其间的热交换来增强温度的平衡。可以通过将歧管配置成具有多个交错的阳极和阴极气体供应室来进一步改善热交换。

48. 发明申请

US20070065387A1 Method for enhancing the effect of particulate benefit agents 审中-公开
标题翻译：增强颗粒有益剂效果的方法
公开(公告)号：US20070065387A1
公开(公告)日：2007-03-22
申请号：US11514804
申请日：2006-09-01
申请人： William Beck , John O'Brien , Hong Wang
发明人： William Beck , John O'Brien , Hong Wang
IPC分类号： A61K8/73 , A61K8/64
CPC分类号： A61K8/64 , A61K8/11 , A61K8/8111 , A61K8/8117 , A61K8/8123 , A61K8/8152 , A61K8/88 , A61Q5/02 , A61Q5/065 , A61Q5/12 , C07K7/08
摘要： A method for applying a particulate benefit agent to a body surface is provided. The method employs a particulate benefit agent coated with a polymer. The polymer-coated benefit agent is applied to a body surface such as hair or skin, in the presence of a composition comprising a peptide having affinity for the polymer. The presence of the polymer-binding peptide in the application serves to extend the binding longevity of the coated particulate benefit agent on the body surface.
摘要翻译：提供了一种将颗粒有益剂施用于身体表面的方法。该方法使用涂覆有聚合物的颗粒有益剂。在包含对聚合物具有亲和性的肽的组合物的存在下，将聚合物涂覆的有益试剂施用于身体表面如毛发或皮肤。该应用中聚合物结合肽的存在用于延长涂覆的颗粒有益剂在身体表面上的结合寿命。

49. 发明申请

US20070014584A1 Calibration apparatus and method for charging unit of image forming device 有权
标题翻译：图像形成装置的充电装置的校准装置和方法
公开(公告)号：US20070014584A1
公开(公告)日：2007-01-18
申请号：US11179731
申请日：2005-07-13
申请人： Gerald Fletcher , John O'Brien , Bruce Parks , Eliud Robles-Flores , Alfred Claflin , Jerry Adams
发明人： Gerald Fletcher , John O'Brien , Bruce Parks , Eliud Robles-Flores , Alfred Claflin , Jerry Adams
IPC分类号： G03G15/02
CPC分类号： G03G15/0266 , G03G2215/027
摘要： System and methods may calibrate an AC rms voltage applied to a coronode of a charging device to achieve a predefined operating current at a target value of DC shield voltage. The target value of DC shield voltage may be set to be substantially below an over-voltage condition. System and methods may use a calibration routine that may determine a minimum AC voltage required to achieve the target value of DC shield voltage. Systems and methods may alternatively, or additionally, sense current and adjust the applied voltage to obtain a target current.
摘要翻译：系统和方法可以校准施加到充电装置的冠状体的AC均方根电压，以在DC屏蔽电压的目标值下实现预定义的工作电流。 DC屏蔽电压的目标值可以被设置为基本上低于过电压状态。系统和方法可以使用可以确定实现DC屏蔽电压的目标值所需的最小AC电压的校准程序。系统和方法可以替代地或另外地感测电流并且调整所施加的电压以获得目标电流。

50. 发明授权

US07162957B2 Redundant signal transmission system and development method 有权
标题翻译：冗余信号传输系统及开发方法
公开(公告)号：US07162957B2
公开(公告)日：2007-01-16
申请号：US11407556
申请日：2006-04-19
申请人： John O'Brien , Thomas A. Nadeau , Timothy J. O'Brien , A. Jonathan Bawabe , Stephen W. Bartholomew , Raymond G. Niederwerfer
发明人： John O'Brien , Thomas A. Nadeau , Timothy J. O'Brien , A. Jonathan Bawabe , Stephen W. Bartholomew , Raymond G. Niederwerfer
IPC分类号： C06C5/04
CPC分类号： F42D1/043 , C06C5/04 , F42D1/04
摘要： Percussive signal transmission tubes, of contrasting color, are joined along adjacent longitudinally extending portions by an adhesive bead of polymeric material. The tubes can be separated in the field and are provided on spools without any sheath. A small diameter (0.10 inch) tube can be used to reduce the size of the spool, or increase the length of tubing wound on the spool. An apparatus for assembling the product is also disclosed.
摘要翻译：具有对比色的冲击信号传输管通过聚合材料的粘合剂珠沿相邻的纵向延伸部分连接。管可以在现场分离并且在没有任何鞘的线轴上提供。可以使用小直径（0.10英寸）的管子来减小阀芯的尺寸，或增加缠绕在阀芯上的管道的长度。还公开了一种用于组装产品的装置。

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