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    • 41. 发明申请
    • Implantable Biotelemetry Device
    • 可植入式生物测量装置
    • US20080319280A1
    • 2008-12-25
    • US12057358
    • 2008-03-27
    • Jason AugustRobert GriffinJohn K. StevensPaul Waterhouse
    • Jason AugustRobert GriffinJohn K. StevensPaul Waterhouse
    • A61B5/00
    • A61B5/0031
    • An implantable device for in vivo monitoring of biotelemetry data includes: a waterproof housing completely encasing the implantable device, the waterproof housing constructed from a material with chemical and fatigue resistance plus thermal stability for placement in a living being; a radio frequency modem located inside the housing and operable at a low radio frequency not exceeding one megahertz; an antenna located within the housing and operatively coupled with the radio frequency modem; a fully programmable microprocessor located within the housing and operatively coupled with the modem; at least one sensor located within the housing for detecting the biotelemetric data; a memory; and a connector for connecting to a power source to power the programmable microprocessor.
    • 用于体内监测生物测量数据的可植入装置包括:完全包围可植入装置的防水壳体,防水壳体由具有化学和抗疲劳性加热稳定性的材料构成,用于放置在生活中; 位于壳体内的射频调制解调器,其工作频率不超过1兆赫; 位于壳体内并与射频调制解调器操作耦合的天线; 一个完全可编程的微处理器,位于外壳内并与调制解调器操作耦合; 位于壳体内的至少一个传感器,用于检测生物测焦数据; 记忆 以及用于连接到电源以为可编程微处理器供电的连接器。
    • 43. 发明授权
    • Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules
    • 用于移动和分离核酸和其他带电分子的微电泳芯片
    • US06261430B1
    • 2001-07-17
    • US09505659
    • 2000-02-17
    • Thomas D. YagerPaul WaterhouseAlexandre M. IzmailovBruno C. MaruzzoJohn K. StevensMarina T. Larson
    • Thomas D. YagerPaul WaterhouseAlexandre M. IzmailovBruno C. MaruzzoJohn K. StevensMarina T. Larson
    • G01N2726
    • G01N27/44773G01N27/44704G01N27/44791
    • A microelectrophoresis chip comprises a substrate in which there are formed one or more channels, one channel for each sample to be evaluated. The channels extend for the length of the chip, a distance of generally around 1 cm, and are about 1 to 10 &mgr;m wide and 1 to 10 &mgr;m in depth. The channels are filled with a homogeneous separation matrix which acts as an obstacle to the electrophoretic migration of the charged molecules. Microelectrodes disposed in the channels are used to induce an electric filed within the homogeneous separation medium. When a voltage is applied across two or more of the microelectrodes, the charged molecules are induced to move and separate according to the electric field density, the type of solvent film, and the charge, shape and size of the charged molecule. The chip may further comprise detectors, such as light polarization detectors, fluorescence emission detectors, biosensors, electrochemical sensors or other microcomponents which may include sites for enzymatic or chemical manipulation of the moved or separated charged molecules.
    • 微电泳芯片包括其中形成一个或多个通道的基底,每个待评估样品的通道一个通道。 通道延长芯片的长度,通常约1厘米的距离,宽度约为1至10微米,深度为1至10毫米。 通道充满均匀的分离基质,其作为电荷分子的电泳迁移的障碍。 设置在通道中的微电极用于诱导均匀分离介质内的电场。 当电压施加到两个或更多个微电极上时,根据电场密度,溶剂膜的类型和带电分子的电荷,形状和尺寸,诱导带电分子移动和分离。 芯片还可以包括诸如光偏振检测器,荧光发射检测器,生物传感器,电化学传感器或其它微元件的检测器,其可以包括用于酶或分离带电分子的酶或化学操作的位点。
    • 44. 发明授权
    • Automated electrophoresis and fluorescence detection apparatus and method
    • US6005663A
    • 1999-12-21
    • US849662
    • 1997-08-18
    • Paul WaterhouseJohn A. RenfrewJohn K. Stevens
    • Paul WaterhouseJohn A. RenfrewJohn K. Stevens
    • G01N21/64G01N27/447G01N21/00
    • G01N27/44721
    • Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapted to receive an electrophoresis gel holder; an excitation source of electromagnetic radiation having a frequency effective to induce emission of electromagnetic radiation from the fluorophore; a plurality of optical fibers for delivering electromagnetic radiation from the excitation source to a linear array of excitation/detection sites on the gel holder, optical switching means for sequentially directing electromagnetic radiation into one of several pre-defined groups of the optical fibers; detection means such as a photomultiplier tube, or an array of photomultiplier tubes for detecting emission from the fluorophore induced by a radiation from the excitation source; and means for correlating a detected emission with the switching of the excitation electromagnetic radiation such that a given emission may be linked with the excitation/detection site being irradiated. For example, the optical switching means may alternate between directing radiation from the source into every other optical fiber, or may provide radiation in rotation to every third or fourth fiber. Alternatively, a spot array generation grating can be used for dividing an incident beam of coherent radiation into an array of excitation beamlets and directing each excitation beamlets to an excitation/detection site on the electrophoresis gel. Light emitting diode disposed to deliver excitation energy to an array of excitation/detection sites may also be used. This latter form of the apparatus is particularly advantageous due to the low costs of light emitting diodes (LEDs) compared to coherent light sources (e.g. lasers).
    • 45. 发明授权
    • Microgels for use in medical diagnosis and methods of making and using
same
    • 用于医学诊断的微凝胶及其制造和使用方法
    • US5885431A
    • 1999-03-23
    • US836269
    • 1997-05-01
    • John A. RenfrewPaul WaterhouseJohn K. StevensHenryk Zaleski
    • John A. RenfrewPaul WaterhouseJohn K. StevensHenryk Zaleski
    • G01N27/447G01N27/26
    • G01N27/44743G01N27/44704G01N27/44747
    • An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The spacer establishes a separation of from 25 to 250 microns between the top substrate and the bottom substrate. A gel compartment is formed by partially sealing the top substrate to the bottom substrate, while leaving an opening for the introduction of unpolymerized gel. The gel compartment is then filled with an unpolymerized gel, which is polymerized in the gel compartment. Electrodes may be printed on the substrates, may be contacts to an exposed edge of gel, or may be applied through windows cut into one of the substrates. One type of gel holder makes use of graded beads having a diameter of 25 to 250 microns slurried in an adhesive such as an acrylate adhesive as the spacer. The slurry is printed onto the surface of one or both substrates to form a spacer of the desired shape, and then hardened using heat or light. If desired, the spacer can establish lanes within the gel.
    • PCT No.PCT / US95 / 14531 Sec。 371日期1997年5月1日 102(e)日期1997年5月1日PCT提交1995年10月31日PCT公布。 出版物WO96 / 日期1996年5月9日在凝胶保持器中形成电泳微凝胶。 凝胶保持器包括顶部基底,底部基底和设置在顶部基底和底部基底之间的间隔物。 间隔物在顶部基底和底部基底之间建立了从25至250微米的间隔。 通过将顶部基底部分地密封到底部基底而形成凝胶室,同时留下用于引入未聚合凝胶的开口。 然后用凝胶隔室填充未聚合的凝胶,其在凝胶隔室中聚合。 电极可以印刷在基底上,可以与凝胶的暴露边缘接触,或者可以通过切割成一个基底的窗口来施加。 一种类型的凝胶保持器使用在诸如丙烯酸酯粘合剂的粘合剂中作为间隔物浆化的直径为25至250微米的分级珠粒。 将浆料印刷到一个或两个基材的表面上以形成所需形状的间隔物,然后使用热或光硬化。 如果需要,间隔物可以在凝胶内建立泳道。
    • 48. 发明授权
    • Evidence tracking
    • 证据跟踪
    • US08013741B2
    • 2011-09-06
    • US13004176
    • 2011-01-11
    • Paul WaterhouseJohn K. StevensJason AugustJessica L. Olson
    • Paul WaterhouseJohn K. StevensJason AugustJessica L. Olson
    • G08B13/14
    • G06K17/00G06K2017/0051
    • A system uses a large loop antenna, connected with a transceiver operating below 1 MHz. The loop antenna is deployed from a spool to surround a crime scene, and may carry indicia communicating that it is a crime scene boundary. The system interrogates devices, including evidence bags and badged personnel, as they enter and leave the scene. The system can optionally log the time of salient events. A second loop antenna can log evidence bags as they enter a vehicle. The devices can be silenced by the transceiver and thus collisions can be reduced and avoided among responses from devices. The system performs “area reads” that would not be possible if higher RF frequencies were employed.
    • 系统使用大型环形天线,与低于1 MHz的收发器相连。 环形天线从卷轴部署到围绕犯罪现场,并且可以携带指示它是犯罪现场边界的标记。 系统在进入和离开现场时,对装置进行询问,包括证件袋和标识人员。 系统可以选择记录突出事件的时间。 第二个环形天线可以在进入车辆时记录证据袋。 这些设备可以被收发器静音,从而可以减少和避免设备响应之间的冲突。 如果采用较高的射频频率,系统将执行“区域读取”。
    • 49. 发明申请
    • Passive Low Frequency Inductive Tagging
    • 被动低频感应标签
    • US20110163882A1
    • 2011-07-07
    • US12848772
    • 2010-08-02
    • M. Jason AugustPaul WaterhouseJohn K. Stevens
    • M. Jason AugustPaul WaterhouseJohn K. Stevens
    • G08B23/00H04Q5/22
    • A01K11/008A01K11/004A01K15/021G06Q10/08G06Q10/087G06Q50/02G06Q50/30G07C9/00111G07C2009/00777G08B13/2414G08B13/2471
    • A system for detection and tracking of objects which carry low radio frequency tags that comprise an inductive antenna and transceiver operable at a first radio frequency below 1 megahertz, a transceiver operatively connected to that antenna, an ID data storage device, a microprocessor for handling data from the transceiver and data store, and a tag energization inductive antenna which can receive radio frequency energy from an ambient radio frequency field of a second low radio frequency. The system includes a field communication inductive antenna disposed, preferably at a distance of several feet from each object, that permits effective communication therewith at the aforesaid first radio frequency, a data receiver, transmitter and reader data processor in operative communication with the field communication inductive antenna, and a field energization inductive antenna which can produce the ambient radio frequency field at the tag energization inductive antenna.
    • 一种用于检测和跟踪携带低射频标签的物体的系统,所述物体包括可在低于1兆赫兹的第一射频操作的感应天线和收发器,可操作地连接到该天线的收发器,ID数据存储设备,用于处理数据的微处理器 来自收发器和数据存储器以及能够从第二低射频的环境射频场接收射频能量的标签通电感应天线。 该系统包括优选距离每个物体几英尺的距离设置的场通信感应天线,其允许在上述第一射频与其有效通信,数据接收器,发射器和读取器数据处理器与场通信感应 天线和场激励电感天线,其可以在标签通电感应天线处产生环境射频场。
    • 50. 发明申请
    • Evidence Tracking
    • 证据跟踪
    • US20110108321A1
    • 2011-05-12
    • US13004176
    • 2011-01-11
    • Paul WaterhouseJohn K. StevensJason AugustJessica L. Olson
    • Paul WaterhouseJohn K. StevensJason AugustJessica L. Olson
    • H02G3/00
    • G06K17/00G06K2017/0051
    • A system uses a large loop antenna, connected with a transceiver operating below 1 MHz. The loop antenna is deployed from a spool to surround a crime scene, and may carry indicia communicating that it is a crime scene boundary. The system interrogates devices, including evidence bags and badged personnel, as they enter and leave the scene. The system can optionally log the time of salient events. A second loop antenna can log evidence bags as they enter a vehicle. The devices can be silenced by the transceiver and thus collisions can be reduced and avoided among responses from devices. The system performs “area reads” that would not be possible if higher RF frequencies were employed.
    • 系统使用大型环形天线,与低于1 MHz的收发器相连。 环形天线从卷轴部署到围绕犯罪现场,并且可以携带指示它是犯罪现场边界的标记。 系统在进入和离开现场时,对装置进行询问,包括证件袋和标识人员。 系统可以选择记录突出事件的时间。 第二个环形天线可以在进入车辆时记录证据袋。 这些设备可以被收发器静音,从而可以减少和避免设备响应之间的冲突。 如果采用较高的射频频率,系统将执行“区域读取”。