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41. 发明申请

US20070135369A1 Methods of modulating angiogenesis and screening compounds for activity in modulating angiogenesis 有权
标题翻译：调节血管生成和筛选化合物调节血管生成活性的方法
公开(公告)号：US20070135369A1
公开(公告)日：2007-06-14
申请号：US11521787
申请日：2006-09-15
申请人： John Cooke , Martin Ng , Jenny Wu , Edwin Chang
发明人： John Cooke , Martin Ng , Jenny Wu , Edwin Chang
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2320/12
摘要： The present invention provides methods of modulating angiogenesis in an individual, as well as methods of identifying a candidate agent that modulates angiogenesis, where such methods involve modulating and identifying agents that modulate expression of gene products of a subset of genes concordantly-regulated by agonists of nicotinic acetylcholine receptor (nAChR), bFGF receptor, and VEGF receptor.
摘要翻译：本发明提供了调节个体血管生成的方法，以及鉴定调节血管发生的候选试剂的方法，其中这些方法涉及调节和鉴定调节基因产物的基因产物表达的试剂，该基因产物通过烟酰乙酰胆碱受体（nAChR），bFGF受体和VEGF受体。

42. 发明申请

US20060034819A1 Proteins and methods useful for assessing risk of cardiovascular disease 审中-公开
公开(公告)号：US20060034819A1
公开(公告)日：2006-02-16
申请号：US11245171
申请日：2005-10-07
申请人： Robert Balint , John Cooke
发明人： Robert Balint , John Cooke
IPC分类号： A61K38/46 , C12N9/64
CPC分类号： C12N9/78 , C12Q1/34 , C12Y305/03018 , G01N2333/98
摘要： The invention relates to a mutant protein comprising at least a fragment of a mutant dimethylarginine dimethylaminohydrolase (DDAH) enzyme, wherein the fragment possesses an affinity for asymmetric N,N-dimethyl arginine (ADMA) and/or L,N-monomethylarginine (LNMMA), which exists at lower plasma levels than ADMA, and is deficient in hydrolyzing ADMA or LNMMA to citrulline, releasing citrulline, or both.

43. 发明授权

US5536723A S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines 失效
标题翻译：肼基乙酸的S-亚硝基衍生物，1 - [（酰硫基和（巯基）-1-氧代烷基] -1,2,34-四氢喹啉-2-羧酸和丙氨酰脯氨酸和异喹啉
公开(公告)号：US5536723A
公开(公告)日：1996-07-16
申请号：US319414
申请日：1994-10-06
申请人： Joseph Loscalzo , John Cooke
发明人： Joseph Loscalzo , John Cooke
IPC分类号： C07D207/16 , A61K31/50 , A61K31/195 , A61K31/22 , A61K31/40 , A61K31/415 , A61K31/495 , C07D211/30 , C07D239/72
CPC分类号： C07D207/16
摘要： The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier.The invention also relates to methods for treating various pathophysiological conditions including acute myocardial infarction, left ventricular dysfunction without overt heart failure, hypertension, pulmonary hypertension, congestive heart failure, angina pectoris, vascular thrombosis, Raynauds syndrome, scleroderma, toxemia of pregnancy, acute renal failure, diabetic nephropathy, and renal artery stenosis, and to methods of inhibiting ACE and effecting vasodilation comprising administering the S-nitrosothiol derivatives of the ACE inhibitors of the invention to an animal.
摘要翻译：本发明涉及ACE抑制剂的新S-亚硝基衍生物和包含本发明的S-亚硝基硫醇衍生物与药学上可接受的载体的药物组合物。本发明还涉及用于治疗各种病理生理状况的方法，包括急性心肌梗塞，无明显心力衰竭的左心室功能障碍，高血压，肺动脉高压，充血性心力衰竭，心绞痛，血管血栓形成，雷诺氏综合征，硬皮病，怀孕毒血症，急性肾脏失败，糖尿病性肾病和肾动脉狭窄，以及抑制ACE和影响血管舒张的方法，包括将本发明的ACE抑制剂的S-亚硝基硫代衍生物施用于动物。

44. 发明授权

US3991578A Self-advancing mine roof supports 失效
标题翻译：自行开采的屋顶支撑
公开(公告)号：US3991578A
公开(公告)日：1976-11-16
申请号：US560723
申请日：1975-03-21
申请人： John Cooke , Derek Alker
发明人： John Cooke , Derek Alker
IPC分类号： E21D23/16 , E21D15/58 , E21D23/26 , E21D15/44 , F15B21/02
CPC分类号： E21D15/585 , E21D23/26
摘要： A control means, for a mine roof support having hydraulically extensible prop means and some other pressure-fluid-operated component (e.g. a hydraulic ram for advancing the support), comprises a control valve having selectable positions in one of which (the prop extend position) it will select for a supply of hydraulic pressure-fluid to said prop means. The control means also include a valve device having a position in which it will provide for a supply of pressure-fluid to the prop means and having means adapted to cause it to move to that position, when the control valve is operated to the prop extend position, and to keep it in that position even position. the control valve is operated from the prop extend positon. By this arrangement a pressure-fluid supply to the prop means will still be maintained so as to ensure proper setting thereof and to make up any leakage of fluid. The operation of the control valve from the prop extend position may be, for example, to bring it into a neutral position or to a position in which pressure-fluid is supplied to the advancing ram of the support.In one preferred embodiment of the invention the valve device has a pressure-fluid responsive movable member and is adapted to be connected, for its operation, to a pressure-fluid supply via the control valve.
摘要翻译：对于具有液压可伸长支撑装置和一些其它压力流体操作部件（例如，用于推进支撑件的液压柱塞）的矿山屋顶支撑件的控制装置包括控制阀，该控制阀具有可选择的位置，其中一个（支撑延伸位置）将选择供应液压压力流体到所述支承装置。控制装置还包括一个阀门装置，该阀装置具有一个位置，在该位置中，它将提供压力流体供给支承装置并具有适于使其移动到该位置的装置，当控制阀被操作到支柱延伸的位置，并保持在这个位置即使位置。控制阀从支柱延伸位置操作。通过这种布置，仍然保持对支柱装置的压力流体供应，以确保其适当的设定并弥补流体的任何泄漏。控制阀从支柱延伸位置的操作可以是例如使其进入中间位置或将压力流体供应到支撑件的推进柱塞的位置。

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