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41. 发明申请

US20070073044A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 审中-公开
公开(公告)号：US20070073044A1
公开(公告)日：2007-03-29
申请号：US11550903
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

42. 发明申请

US20070059313A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 审中-公开
公开(公告)号：US20070059313A1
公开(公告)日：2007-03-15
申请号：US11550909
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

43. 发明申请

US20070055053A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 审中-公开
公开(公告)号：US20070055053A1
公开(公告)日：2007-03-08
申请号：US11550879
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

44. 发明申请

US20070054377A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070054377A1
公开(公告)日：2007-03-08
申请号：US11550873
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C12P21/04 , C07H21/04 , C07K14/54
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

45. 发明申请

US20070054374A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070054374A1
公开(公告)日：2007-03-08
申请号：US11550194
申请日：2006-10-17
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C12P21/04 , C07H21/04 , C07K14/54
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

46. 发明申请

US20070048844A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070048844A1
公开(公告)日：2007-03-01
申请号：US11550284
申请日：2006-10-17
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07H21/04 , C12P21/04 , C07K14/54
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

47. 发明申请

US20070048277A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070048277A1
公开(公告)日：2007-03-01
申请号：US11549760
申请日：2006-10-16
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： A61K38/20 , C12P21/04 , C07K14/54
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

48. 发明申请

US20070041936A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070041936A1
公开(公告)日：2007-02-22
申请号：US11550652
申请日：2006-10-18
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： A61K39/42 , C07H21/04 , C12P21/06 , C07K16/10 , C12N5/06
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

49. 发明申请

US20060183851A1 Solvent free aqueous polyurethane dispersions and shaped articles therefrom 审中-公开
标题翻译：无溶剂的水性聚氨酯分散体和其成型制品
公开(公告)号：US20060183851A1
公开(公告)日：2006-08-17
申请号：US11351967
申请日：2006-02-10
申请人： Hong Liu , Carmen Covelli , Douglas Farmer
发明人： Hong Liu , Carmen Covelli , Douglas Farmer
IPC分类号： C08G18/08
CPC分类号： C08G18/0895 , A41B2500/54 , A41C3/0014 , A41D27/245 , B32B5/26 , B32B7/12 , B32B27/12 , B32B27/40 , B32B2255/02 , B32B2255/10 , B32B2255/26 , B32B2307/306 , B32B2307/51 , B32B2307/554 , B32B2437/00 , C08G18/0823 , C08G18/12 , C08G18/4808 , C08G18/4854 , C08G18/6692 , C08G18/7671 , C08G2170/80 , C08J3/05 , C08J2375/04 , D06M15/564 , D06M15/568 , D06M15/572 , D06M17/10 , D06N3/14 , C08G18/302
摘要： An article comprising an adhesive, a stretch member and a substrate wherein the adhesive is used to attach the stretch member to the fabric in a folded hem arrangement. The adhesive can be a tape made from an aqueous polyurethane dispersion and the stretch member can be a spandex fiber.
摘要翻译：一种包括粘合剂，拉伸构件和基底的制品，其中所述粘合剂用于以折叠的布置布置将拉伸构件附接到织物。粘合剂可以是由水性聚氨酯分散体制成的带，并且拉伸构件可以是氨纶纤维。

50. 发明授权

US07078408B2 [1,2,4]-Triazole bicyclic adenosine A2a receptor antagonists 有权
标题翻译： [1,2,4] - 三唑双环腺苷A2a受体拮抗剂
公开(公告)号：US07078408B2
公开(公告)日：2006-07-18
申请号：US10973642
申请日：2004-10-26
申请人： Bernard R. Neustadt , Hong Liu
发明人： Bernard R. Neustadt , Hong Liu
IPC分类号： C07D487/04 , A61K31/519 , A61P25/24 , A61P25/16
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds having the structural formula Iwherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1–C6)-alkyl, halo, CN or —CF3; X is —C(O)—, —O—, —SO0-2—, or optionally substituted methylene, imino, arylene or heteroaryldiyl; Y is —O—, —SO0-2—, or optionally substituted arylene, heteroaryldiyl, or nitrogen-containing heterocycloalkyl, or with certain provisos, a bond; R is optionally substituted-aryl or heteroaryl; and R2 is optionally substituted-aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R2—Y is a fused piperidinyl, substituted piperazinyl or substituted piperidinyl; their use in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations
摘要翻译：具有结构式I的化合物，其中：n为0,1,2或3; A是C（R 1）或N; R 1和R 2是H，（C 1 -C 6 -C 6） - 烷基，卤素，CN或 -CF 3 N 3; X是-C（O） - ， - O - ， - SO 2 - 或任选取代的亚甲基，亚氨基，亚芳基或杂芳基二基; Y是-O-，-SO 0-2 - 或任选取代的亚芳基，杂芳基二基或含氮杂环烷基，或具有一定条件的键; R是任选取代的 - 芳基或杂芳基; R 2是任选取代的 - 芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 2 -Y是稠合的哌啶基，取代的哌嗪基或取代的哌啶基; 其用于治疗帕金森病，单独或与其他治疗帕金森病的药物组合，包含它们的药物组合物和包含组合的组分的试剂盒

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