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41. 发明申请

US20080275029A1 Compounds for Treating Protein-Kinase Mediated Disorders 审中-公开
公开(公告)号：US20080275029A1
公开(公告)日：2008-11-06
申请号：US11718943
申请日：2005-11-09
申请人： Valerio Berdini , Robert George Boyle , Gordon Saxty , Marinus Leendert Verdonk , Steven John Woodhead , Paul Graham Wyatt , Hannah Fiona Sore , David Winter Walker , John Caldwell , Ian Collins
发明人： Valerio Berdini , Robert George Boyle , Gordon Saxty , Marinus Leendert Verdonk , Steven John Woodhead , Paul Graham Wyatt , Hannah Fiona Sore , David Winter Walker , John Caldwell , Ian Collins
IPC分类号： A61K31/517 , C07D239/88 , C07D401/12 , C07D401/04 , A61K31/496 , A61K31/551 , A61P35/00 , C12N5/06 , A61K31/5377 , C07D401/06 , C07D403/12 , C07D413/14
CPC分类号： C07D403/12 , A61K31/505 , C07D239/88 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04
摘要： The invention provides a compound of the formula (I) or a salt, solvate, tautomer or N-oxide thereof for use in the treatment or prophylaxis of a disease state or condition mediated by protein kinase A and/or protein kinase B; wherein the ring Q is a benzene ring; J2-J1 is N═CR7 or R1aN—CO; G is OH or NR5R6; E is CONR7, NR7CO, C(R8)═C(R8) or (X)m(CR8R8a)n where X is O, S or NR7; provided that when J2-J1 is R1aN—CO, E is other than NR7CO; m and n are each 0 or 1, where m+n=1 or 2; A is a bond and R4 and R4a are absent or A is a saturated optionally substituted C1-7 hydrocarbon linker group having a maximum chain length of 5 atoms extending between E and G, one carbon atom in the linker group A being optionally replaced by O or N; R1, R1a, R2, and R3 are each H; halogen; C1-6 hydrocarbyl optionally substituted by halogen, OH or C1-2 alkoxy; CN; CONHR8; NH2; NHCOR10 or NHCONHR10; R4 is H or C1-4 alkyl; R4a is H, C1-4 alkyl or a group R9; R5 and R6 are each selected from H, R9 and C1-4 hydrocarbyl optionally substituted by halogen, C1-2 alkoxy or R9; or NR5R6 forms a saturated 4-7 membered monocyclic heterocyclic group; R7 is H or C1-4 alkyl; R8 and R8a each H or saturated C1-4 hydrocarbyl optionally substituted by fluorine; R9 is a monocyclic or bicyclic carbocyclic or heterocyclic group containing up to 3 ring heteroatoms selected from N, O and S; or R4, R4a and A together form a saturated monocyclic 4-7 membered heterocycle; or NR5R6, R4 and A form a saturated 4-7 membered monocyclic heterocycle; or R4, together with R7 or R8 and A and E form a 4-7 membered saturated monocyclic heterocycle; or NR5R6 and R7 or R8 together with A and E form a 4-7 membered saturated monocyclic heterocycle; and R10 is optionally substituted phenyl or benzyl.

42. 发明申请

US20080044623A1 PROBE CARD FOR TESTING IMAGING DEVICES, AND METHODS OF FABRICATING SAME 审中-公开
标题翻译：用于测试成像装置的探针卡及其制造方法
公开(公告)号：US20080044623A1
公开(公告)日：2008-02-21
申请号：US11465897
申请日：2006-08-21
申请人： John Caldwell , Brett Crump , Phil Byrd
发明人： John Caldwell , Brett Crump , Phil Byrd
IPC分类号： B32B3/10
CPC分类号： G01R3/00 , Y10T428/24322
摘要： Disclosed is a probe card for imager devices, and methods of fabricating same. In one illustrative embodiment, a method of forming a probe card includes performing at least one etching process to define a plurality of light openings in a body of the probe card and forming a plurality of probe pins extending from the body. In another illustrative embodiment, a probe card that includes a body, at least one light opening formed in the body and at least one light conditioning device positioned within the at least one light opening is disclosed.
摘要翻译：公开了一种用于成像装置的探针卡及其制造方法。在一个说明性实施例中，形成探针卡的方法包括执行至少一个蚀刻工艺以在探针卡的主体中限定多个光开口并形成从主体延伸的多个探针。在另一示例性实施例中，公开了一种探针卡，其包括主体，形成在主体中的至少一个开口和位于该至少一个光开口内的至少一个光调节装置。

43. 发明申请

US20070245552A1 Probe interposers and methods of fabricating probe interposers 审中-公开
公开(公告)号：US20070245552A1
公开(公告)日：2007-10-25
申请号：US11400583
申请日：2006-04-07
申请人： John Caldwell , Jerry McBride , Brett Crump , Phil Byrd
发明人： John Caldwell , Jerry McBride , Brett Crump , Phil Byrd
IPC分类号： H01L21/302 , H05K3/36
CPC分类号： G01R1/07307 , G01R3/00 , Y10T29/49117 , Y10T29/49126 , Y10T29/49155 , Y10T29/49204 , Y10T29/49222
摘要： The invention includes probe interposers and methods of fabricating pose interposers. In one implementation, a method of fabricating a probe interposer includes providing a substrate having a frontside and a backside. Probe tips are lithographically patterned on the substrate frontside. The probe tips have electrically conductive outer ends configured to mechanically and electrically engage conductive contact surfaces of a circuit substrate to be probed. Mechanical hard stops are lithographically patterned on the substrate frontside. The mechanical hard stops have outer surfaces configured to mechanically engage some surface of the circuit substrate during probe of the circuit substrate with the probe interposer. The invention includes probe interposers independent of method of fabrication.

44. 发明申请

US20070072852A1 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US20070072852A1
公开(公告)日：2007-03-29
申请号：US11010772
申请日：2004-12-13
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter
IPC分类号： A61K31/549 , A61K31/5395 , A61K31/513
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D233/46 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D295/15 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06 , Y02A50/411
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.

45. 发明授权

US06441606B1 Dual zone wafer test apparatus 失效
标题翻译：双区晶圆测试仪
公开(公告)号：US06441606B1
公开(公告)日：2002-08-27
申请号：US09690564
申请日：2000-10-17
申请人： John Caldwell , James Nuxoll , Robert Totorica
发明人： John Caldwell , James Nuxoll , Robert Totorica
IPC分类号： G01R3102
CPC分类号： G01R1/0491 , G01R31/2831 , G01R31/2891
摘要： A wafer cassette includes a stationary dual-zone temperature control base and a removable wafer cassette top. The top includes a main cassette support structure, onto which wafer test electronics, a test interface connector, a wafer interconnect assembly, a wafer test area, a flex film interconnect, and a wafer chuck with evacuation chamber and electric wafer heater, and at least one rough alignment fixture are mounted. A wafer to be tested is inserted, with a pressure-isolating seal, between the wafer chuck and the wafer test area. The base is a stationary fixed portion which includes a first support compartment, a second support compartment and thermal circuits, each of which includes fluid inlet and outlet connections. The fixed portion further includes a heater interconnect to provide connection and external access for a heater element, as well as a vacuum interconnect line to provide external connection to the evacuation chamber. The first and second support compartments are adjacently spaced, and each contains at least one of each of the thermal circuits.
摘要翻译：晶片盒包括固定的双区域温度控制基座和可移除的晶片盒顶部。顶部包括主盒支撑结构，晶片测试电子器件，测试接口连接器，晶片互连组件，晶片测试区域，柔性膜互连和具有抽真空室和电晶片加热器的晶片卡盘，并且至少安装一个粗略对准夹具。在晶片卡盘和晶片测试区域之间插入具有隔离密封的被测试晶片。基座是固定的固定部分，其包括第一支撑室，第二支撑室和热回路，每个包括流体入口和出口连接。固定部分还包括加热器互连件，用于为加热器元件提供连接和外部通路，以及真空互连线，以提供到抽真空室的外部连接。第一和第二支撑室相邻间隔开，并且每个包含每个热回路中的至少一个。

46. 外观设计

USD376938S Chair frame armrest 失效
公开(公告)号：USD376938S
公开(公告)日：1996-12-31
申请号：US021986
申请日：1994-04-28
申请人： John Caldwell
设计人： John Caldwell

47. 外观设计

USD346910S Chair 失效
公开(公告)号：USD346910S
公开(公告)日：1994-05-17
申请号：US665702
申请日：1991-02-06
申请人： John Caldwell
设计人： John Caldwell

48. 外观设计

USD342391S Chair 失效
公开(公告)号：USD342391S
公开(公告)日：1993-12-21
申请号：US781335
申请日：1991-10-18
申请人： John Caldwell
设计人： John Caldwell

49. 外观设计

USD341267S Bench 失效
公开(公告)号：USD341267S
公开(公告)日：1993-11-16
申请号：US704621
申请日：1991-05-23
申请人： John Caldwell
设计人： John Caldwell

50. 外观设计

USD341266S Chair 失效
公开(公告)号：USD341266S
公开(公告)日：1993-11-16
申请号：US771967
申请日：1991-10-02
申请人： John Caldwell
设计人： John Caldwell

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