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41. 发明授权

US09848821B2 Systems and methods to reduce fluid contamination 有权
公开(公告)号：US09848821B2
公开(公告)日：2017-12-26
申请号：US13162315
申请日：2011-06-16
申请人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
IPC分类号： A61B5/00 , B65D33/00 , B65D81/00 , A61D5/00 , A61M1/00 , A61M27/00 , A61B5/145 , A61B5/1459 , A61B5/1495 , A61B5/15 , A61B5/153 , A61B5/157 , A61M5/14 , A61M5/172 , A61M5/145 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/157 , A61B5/6866 , A61M5/1415 , A61M5/1452 , A61M5/1723 , A61M2005/14208 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2230/201
摘要： Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

42. 发明授权

US09414782B2 Fluid component analysis systems and methods for glucose monitoring and control 有权
公开(公告)号：US09414782B2
公开(公告)日：2016-08-16
申请号：US13619825
申请日：2012-09-14
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172 , A61B5/00 , A61B5/155 , A61B5/145 , A61B5/1455 , A61B5/1495 , G06F19/00 , A61M5/168 , A61M5/14 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

43. 发明授权

US07785258B2 System and method for determining a treatment dose for a patient 有权
标题翻译：用于确定患者治疗剂量的系统和方法
公开(公告)号：US07785258B2
公开(公告)日：2010-08-31
申请号：US11316523
申请日：2005-12-21
申请人： James R. Braig , Peter Rule
发明人： James R. Braig , Peter Rule
IPC分类号： A61B5/00 , A61B5/05 , C12M1/34 , C12M3/00 , C12M1/36 , C12M1/00
CPC分类号： G06F19/3468 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/00
摘要： In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
摘要翻译：在某些实施例中，维持患者健康的方法使用分析物检测系统。分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

44. 发明申请

US20090131861A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20090131861A1
公开(公告)日：2009-05-21
申请号：US12249831
申请日：2008-10-10
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

45. 发明授权

US06631282B2 Device for isolating regions of living tissue 失效
标题翻译：用于隔离活组织区域的装置
公开(公告)号：US06631282B2
公开(公告)日：2003-10-07
申请号：US09970021
申请日：2001-10-02
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
IPC分类号： A61B500
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

46. 发明授权

US08140140B2 Analyte detection system for multiple analytes 有权
标题翻译：多种分析物的分析物检测系统
公开(公告)号：US08140140B2
公开(公告)日：2012-03-20
申请号：US11314176
申请日：2005-12-21
申请人： Bernhard B. Sterling , James R. Braig , Kenneth G. Witte , Peter Rule , Richard Keenan , W. Dale Hall
发明人： Bernhard B. Sterling , James R. Braig , Kenneth G. Witte , Peter Rule , Richard Keenan , W. Dale Hall
IPC分类号： A61B5/1455
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过病人结束所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

47. 发明申请

US20110306856A1 SYSTEMS AND METHODS FOR MEASURING MULTIPLE ANALYTES IN A SAMPLE 有权
标题翻译：用于在样品中测量多个分析物的系统和方法
公开(公告)号：US20110306856A1
公开(公告)日：2011-12-15
申请号：US13156295
申请日：2011-06-08
申请人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
IPC分类号： A61B5/157 , A61B6/00
CPC分类号： G01N33/491 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150801 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7275 , A61B2560/0223 , A61B2560/0233 , A61B2560/0437 , A61B2560/0443 , A61B2562/0238 , A61B2562/08 , G01N21/35 , G01N2021/3174 , G01N2201/1215 , G01N2201/1293 , G06F19/00
摘要： Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.
摘要翻译：提供了用于分析流体样品的多个组分的系统和方法。在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分的样品分离后。

48. 发明授权

US07972296B2 Fluid component analysis system and method for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US07972296B2
公开(公告)日：2011-07-05
申请号：US12249831
申请日：2008-10-10
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M31/00
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

49. 发明申请

US20120029329A1 ANALYTE DETECTION SYSTEMS AND METHODS USING MULTIPLE MEASUREMENTS 审中-公开
标题翻译：分析检测系统和使用多个测量的方法
公开(公告)号：US20120029329A1
公开(公告)日：2012-02-02
申请号：US13252596
申请日：2011-10-04
申请人： James R. Braig , Peter Rule
发明人： James R. Braig , Peter Rule
IPC分类号： A61B5/1455
CPC分类号： A61B5/150992 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150854 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/3468 , G16H10/40 , G16H20/17
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

50. 发明申请

US20110264071A1 FLUID COMPONENT ANALYSIS SYSTEMS AND METHODS FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20110264071A1
公开(公告)日：2011-10-27
申请号：US13174610
申请日：2011-06-30
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/168
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

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