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    • 42. 发明授权
    • Dual-function catheter handle
    • 双功能导管手柄
    • US07503914B2
    • 2009-03-17
    • US11173105
    • 2005-07-01
    • James ColemanClaudio Plaza
    • James ColemanClaudio Plaza
    • A61M25/00A61B6/00
    • A61M25/0136
    • A dual function catheter handle is provided for simultaneous movement of two control wires. The catheter handle has a handle housing having proximal and distal ends and a generally hollow interior. A core is mounted in the interior of the handle housing, the core having a longitudinal slot therethrough. A first moveable member is provided with a proximal end mounted in the interior of the handle housing and a distal end extending outside the handle housing. The first moveable member is longitudinally moveable relative to the handle housing. A second moveable member is mounted in the longitudinal slot of the core and is longitudinally moveable relative to the core and handle housing. The second moveable member has a threaded surface. A rotatable member is mounted on the handle housing. The rotatable member has a threaded inner surface that mates with the threaded surface of the second moveable member so that rotation of the rotatable member causes longitudinal movement of the second moveable member. The first moveable member and second moveable member are capable of simultaneously moving proximally relative to the handle housing.
    • 提供双功能导管手柄,用于同时移动两根控制线。 导管手柄具有手柄壳体,其具有近端和远端以及大致中空的内部。 芯部安装在手柄壳体的内部,芯部具有穿过其的纵向狭槽。 第一可移动构件设置有安装在手柄壳体的内部中的近端和延伸到手柄壳体外部的远端。 第一可移动构件相对于手柄壳体可纵向移动。 第二可移动构件安装在芯的纵向狭槽中并且可相对于芯部和手柄壳体纵向移动。 第二可动构件具有螺纹表面。 可旋转构件安装在手柄壳体上。 可旋转构件具有与第二可移动构件的螺纹表面配合的螺纹内表面,使得可旋转构件的旋转引起第二可移动构件的纵向移动。 第一可移动构件和第二可移动构件能够相对于手柄壳体同时向近侧移动。
    • 46. 发明授权
    • Dual-function catheter handle
    • US06913594B2
    • 2005-07-05
    • US10040981
    • 2001-12-31
    • James ColemanClaudio Plaza
    • James ColemanClaudio Plaza
    • A61M25/01A61M37/00A61B5/00A61M25/00A61M25/08A61M25/09
    • A61M25/0136
    • A dual function catheter handle is provided for simultaneous movement of two control wires. The catheter handle has a handle housing having proximal and distal ends and a generally hollow interior. A core is mounted in the interior of the handle housing, the core having a longitudinal slot therethrough. A first moveable member is provided with a proximal end mounted in the interior of the handle housing and a distal end extending outside the handle housing. The first moveable member is longitudinally moveable relative to the handle housing. A second moveable member is mounted in the longitudinal slot of the core and is longitudinally moveable relative to the core and handle housing. The second moveable member has a threaded surface. A rotatable member is mounted on the handle housing. The rotatable member has a threaded inner surface that mates with the threaded surface of the second moveable member so that rotation of the rotatable member causes longitudinal movement of the second moveable member. The first moveable member and second moveable member are capable of simultaneously moving proximally relative to the handle housing.
    • 47. 发明申请
    • Process for the preparation of N-phosphonomethylglycine and derivatives thereof
    • N-膦酰基甲基甘氨酸及其衍生物的制备方法
    • US20050054871A1
    • 2005-03-10
    • US10924265
    • 2004-08-23
    • James ColemanJerry EbnerEric HaupfearPatrick LennonJoseph SchaperSamuel TremontSerge WolfsonPhilip Brodsky
    • James ColemanJerry EbnerEric HaupfearPatrick LennonJoseph SchaperSamuel TremontSerge WolfsonPhilip Brodsky
    • C07F9/28C07F9/38
    • C07F9/3813Y02P20/582
    • N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.
    • N-膦酰基甲胺通过胺底物与卤甲基膦酸或其盐,羟甲基膦酸或其盐或羟甲基膦酸的脱水的自酯二聚物,三聚体或低聚物的反应来制备。 可根据该方法制备的产物是N-膦酰基乙基氨基羧酸,例如(例如)草甘膦,N-膦酰基甲基氨基链烷醇如(例如)羟基乙基氨基甲基膦酸和N-酰基氨基甲基膦酸如(例如)N-氨基甲酰基氨基甲基膦酸。 某些反应用大量过量的胺反应物进行,以驱动转化,同时避免过度形成双(N-膦酰基甲基)胺副产物。 其他反应使用仲胺底物(例如亚氨基二乙酸),并且可以以基本上等摩尔比率的卤代甲基氨基甲基膦酸或羟基氨基甲基膦酸与仲胺反应物进行反应,而不显着形成双(膦酰基甲基)胺副产物。 进一步公开了通过共沸脱水制备羟甲基膦酸自酯二聚体,三聚体和低聚物的方法。