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41. 发明申请

US20110002962A1 Immunogenic PcpA Polypeptides and Uses Thereof 审中-公开
标题翻译：免疫原性PcpA多肽及其用途
公开(公告)号：US20110002962A1
公开(公告)日：2011-01-06
申请号：US12377446
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead , Jeremy Yethon , Joe Wang
发明人： David E. Briles , Susan K. Hollingshead , Jeremy Yethon , Joe Wang
IPC分类号： A61K39/09 , C07K14/195 , A61K39/116 , A61P31/04
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PcpA and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译：本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。更具体地，组合物和方法涉及免疫原性多肽，包括PcpA及其变体的片段，以及编码或表达多肽的核酸，载体和转染的细胞。还描述了制备和使用免疫原性多肽的方法。

42. 发明授权

US07747062B2 Methods, defect review tools, and systems for locating a defect in a defect review process 有权
标题翻译：方法，缺陷评估工具和用于在缺陷评估过程中定位缺陷的系统
公开(公告)号：US07747062B2
公开(公告)日：2010-06-29
申请号：US11270771
申请日：2005-11-09
申请人： Da Chen , Christophe Fouquet , Saibal Banerjee , Santosh Bhattacharyya , Joe Wang , Lian Yao , Mike van Riet , Igor Germanenko
发明人： Da Chen , Christophe Fouquet , Saibal Banerjee , Santosh Bhattacharyya , Joe Wang , Lian Yao , Mike van Riet , Igor Germanenko
IPC分类号： G06K9/00
CPC分类号： G06T7/001 , G01N21/8851 , G01N21/9501 , G01N21/95607 , G06T2207/30148
摘要： Methods, defect review tools, and systems for locating a defect in a defect review process are provided. One method includes acquiring one or more images and data from an inspection tool. The one or more images illustrate an area on a specimen in which a defect to be reviewed is located. The data indicates a position and features of the defect within the area. The method also includes acquiring one or more additional images of the specimen proximate the position of the defect indicated in the data using an imaging subsystem of a defect review tool. In addition, the method includes identifying a portion of the one or more additional images that corresponds to the one or more images. The method further includes determining a position of the defect within the portion of the one or more additional images using the data.
摘要翻译：提供了用于定位缺陷评估过程中的缺陷的方法，缺陷评估工具和系统。一种方法包括从检查工具获取一个或多个图像和数据。一个或多个图像示出了待检查的缺陷所在的样本上的区域。数据表示该区域内缺陷的位置和特征。该方法还包括使用缺陷评估工具的成像子系统获取在数据中指示的缺陷的位置附近的样本的一个或多个附加图像。此外，该方法包括识别对应于一个或多个图像的一个或多个附加图像的一部分。所述方法还包括使用所述数据确定所述一个或多个附加图像的所述部分内的所述缺陷的位置。

43. 发明授权

US07658934B2 Chlamydia antigens and protein vaccine 失效
标题翻译：衣原体抗原和蛋白疫苗
公开(公告)号：US07658934B2
公开(公告)日：2010-02-09
申请号：US12367955
申请日：2009-02-09
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K39/118
CPC分类号： C12N15/85 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/295 , C07K2319/00 , C12N2830/42 , Y02A50/472 , Y02A50/476 , Y10S435/975
摘要： The present invention provides vaccines for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a full-length, 5′-truncated or 3′-truncated 76 kDa protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗。疫苗和方法使用肺炎衣原体菌株的全长5'截短或3'截短的76kDa蛋白质。在本发明的范围内可以进行修改。

44. 发明授权

US07595058B2 Chlamydia antigens and vaccine uses of the protein 失效
标题翻译：衣原体抗原和疫苗用途的蛋白质
公开(公告)号：US07595058B2
公开(公告)日：2009-09-29
申请号：US11118381
申请日：2005-05-02
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K39/118
CPC分类号： C12N15/85 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/295 , C07K2319/00 , C12N2830/42 , Y02A50/472 , Y02A50/476 , Y10S435/975
摘要： The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a full-length, 5′-truncated or 3′-truncated 76kDa protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗和方法。疫苗和方法使用肺炎衣原体菌株的全长5'截短或3'截短的76kDa蛋白。在本发明的范围内可以进行修改。

45. 发明申请

US20090214639A1 OMP P6 VACCINE FOR TREATING AND PREVENTING CHLAMYDIA INFECTION 审中-公开
标题翻译： OMP P6疫苗用于治疗和预防感染CHLAMYDIA
公开(公告)号：US20090214639A1
公开(公告)日：2009-08-27
申请号：US12437159
申请日：2009-05-07
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K9/127 , A61K38/16 , A61K39/02
CPC分类号： C07K14/295 , A61K38/164 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , C07K2319/02 , Y02A50/476
摘要： The present invention provides a vaccine for immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine contains a polypeptide comprising an omp P6 precursor sequence of a strain of C. pneumoniae and variants of the sequence. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗。疫苗含有包含肺炎支原体菌株的omp P6前体序列和序列变体的多肽。在本发明的范围内可以进行修改。

46. 发明申请

US20090142376A1 CHLAMYDIA POLYPEPTIDES AND CORRESPONDING DNA FRAGMENTS AND USES THEREOF 失效
标题翻译： CHLAMYDIA多聚体和相应的DNA片段及其用途
公开(公告)号：US20090142376A1
公开(公告)日：2009-06-04
申请号：US11932276
申请日：2007-10-31
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K39/118 , A61P31/04
CPC分类号： A61K39/118 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/295 , C07K2319/01 , C07K2319/02 , E02D3/02 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98 kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了一种核酸的方法，包括DNA，宿主（包括人）免疫针对由衣原体特异性肺炎衣原体感染引起的疾病，使用含有编码98kDa外膜的核苷酸序列的载体肺炎衣原体菌株的蛋白质和在宿主中表达98kDa外膜蛋白基因的启动子。在本发明的范围内可以进行修改。

47. 发明申请

US20080112965A1 Chlamydia OMP antigen 审中-公开
标题翻译：衣原体OMP抗原
公开(公告)号：US20080112965A1
公开(公告)日：2008-05-15
申请号：US11907155
申请日：2007-10-10
申请人： Andrew Murdin , Raymond Oomen , Joe Wang
发明人： Andrew Murdin , Raymond Oomen , Joe Wang
IPC分类号： A61K39/00 , A61P43/00 , C07K14/00 , C12P21/04
CPC分类号： A61K39/118 , C07K14/295
摘要： The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polypeptides relate to the 98 KDa OMP antigen designated CPN100686 RY 54 (SEQ ID No:14, encoded in one form by SEQ ID NO:1).
摘要翻译：本发明提供了编码衣原体多肽的纯化和分离的多核苷酸分子，其可用于预防，治疗和诊断衣原体感染的方法。在本发明的一种形式中，多肽涉及称为CPN100686 RY 54的98KDa OMP抗原（SEQ ID No：14，以SEQ ID NO：1以一种形式编码）。

48. 发明申请

US20080095793A1 Chlamydia flagellar protein antigen 有权
标题翻译：衣原体鞭毛蛋白抗原
公开(公告)号：US20080095793A1
公开(公告)日：2008-04-24
申请号：US11905430
申请日：2007-10-01
申请人： Andrew Murdin , Raymond Oomen , Joe Wang
发明人： Andrew Murdin , Raymond Oomen , Joe Wang
IPC分类号： A61K31/70 , A61K39/00 , A61P43/00 , C07K14/00 , C12N1/20 , C12N15/00 , C12N15/11
CPC分类号： G01N33/56927 , A61K39/00 , C07K14/295 , C07K2319/00 , Y02A50/472 , Y02A50/476
摘要： The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polynucleotide molecules encode polypeptides CPN100988 RY-68 (SEQ ID Nos:13 and 26).
摘要翻译：本发明提供了编码衣原体多肽的纯化和分离的多核苷酸分子，其可用于预防，治疗和诊断衣原体感染的方法。在本发明的一种形式中，多核苷酸分子编码多肽CPN100988 RY-68（SEQ ID NO：13和26）。

49. 发明授权

US07335370B2 Chlamydia antigens and corresponding DNA fragments and uses thereof 有权
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US07335370B2
公开(公告)日：2008-02-26
申请号：US10897019
申请日：2004-07-23
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K39/118 , A61K39/02 , C07H21/04 , C12N1/20
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K14/295 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The method involves nucleic acid immunization, including DNA immunization, and employs a vector containing a nucleotide sequence which encodes an ATP/ADP translocase of a strain of Chlamydia pneumoniae. The nucleotide sequence is operably linked to a promoter to effect expression of the ATP/ADP translocase in the host. The host may be a human host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了免疫宿主免受衣原体特异性肺炎衣原体感染引起的疾病的方法。该方法包括核酸免疫，包括DNA免疫，并使用含有编码肺炎衣原体菌株的ATP / ADP转位酶的核苷酸序列的载体。核苷酸序列与启动子可操作地连接以在宿主中实现ATP / ADP转位酶的表达。主人可能是一个人的主人。在本发明的范围内可以进行修改。

50. 发明授权

US07297341B1 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US07297341B1
公开(公告)日：2007-11-20
申请号：US09868987
申请日：1999-12-23
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang
IPC分类号： A61K39/11 , A61K39/02 , C12N1/20 , C12P21/04 , C07H21/04
CPC分类号： C07K14/295 , A61K39/00
摘要： The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polynucleotide molecules are selected from DNA that encode polypeptides CPN100686 RY 54 (SEQ ID Nos: 1 and 14), CPN100696 RY-55 (SEQ ID Nos: 2 and 15), CPN100709 RY-57 (SEQ ID Nos: 3 and 16), CPN100710 RY-58 (SEQ ID Nos: 4 and 17), CPN100711 RY-59 (SEQ ID Nos: 5 and 18), CPN100877 RY-61 (SEQ ID Nos: 6 and 19), CPN100325 RY-62 (SEQ ID Nos: 7 and 20), CPN100368 RY-63 (SEQ ID Nos: 8 and 21), CPN100624 RY-64 (SEQ ID Nos:9 and 22), CPN100633 RY-65 (SEQ ID Nos:10 and 23), CPN100985 RY-66 (SEQ ID Nos:11 and 24), CPN100987 RY-67 (SEQ ID Nos:12 and 25) and CPN100988 RY-68 (SEQ ID Nos:13 and 26).
摘要翻译：本发明提供了编码衣原体多肽的纯化和分离的多核苷酸分子，其可用于预防，治疗和诊断衣原体感染的方法。在本发明的一种形式中，多核苷酸分子选自编码多肽CPN100686 RY 54（SEQ ID NO：1和14），CPN100696 RY-55（SEQ ID NO：2和15），CPN100709 RY-57（SEQ 编号3和16），CPN100710 RY-58（SEQ ID NO：4和17），CPN100711 RY-59（SEQ ID Nos：5和18），CPN100877 RY-61（SEQ ID NO：6和19） CPN100325 RY-62（SEQ ID No：7和20），CPN100368 RY-63（SEQ ID NO：8和21），CPN100624 RY-64（SEQ ID NO：9和22），CPN100633 RY-65（SEQ ID NO：：10和23），CPN100985 RY-66（SEQ ID NO：11和24），CPN100987 RY-67（SEQ ID No：12和25）和CPN100988 RY-68（SEQ ID No：13和26）。

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