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41. 发明申请

US20100137300A1 Indolizine Acetic Acid Derivatives as CRTH2 Antagonists 审中-公开
标题翻译： Indolizine乙酸衍生物作为CRTH2拮抗剂
公开(公告)号：US20100137300A1
公开(公告)日：2010-06-03
申请号：US12530929
申请日：2007-03-21
申请人： George Hynd , Nicholas Charles Ray , Harry Finch , John Gary Montana , Michael Colin Cramp , Trevor Keith Harrison , Rosa Arienzo , Paul Blaney , Yann Griffon , David Middlemiss
发明人： George Hynd , Nicholas Charles Ray , Harry Finch , John Gary Montana , Michael Colin Cramp , Trevor Keith Harrison , Rosa Arienzo , Paul Blaney , Yann Griffon , David Middlemiss
IPC分类号： A61K31/5377 , A61K31/435 , A61K31/4709 , C07D413/12 , C07D221/04 , C07D215/14 , A61P1/00 , A61P11/06 , A61P11/00 , A61P1/04
CPC分类号： C07D471/04
摘要： The specific compounds of this list: {7-cyano-2-methyl-1-[4-(morpholine-4-sutfonyl)benzyl]indolizin-3-yl}acetic acid, {1-(3-chloro-4-ethanesulfonylbenzyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro4-(morpholine-4-sulfonyl)benzyl]-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-(3-chloro-4-ethanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro-4-(morpholine-4-sutfonyl)phenylsutfanyl]-7-cyano-2-methylindolizin-3-yl}acetic acid, {7-cyano-1-(6-fluoroquinolin-2-ylmethyl)-2-methylindolizin-3-yl}acetic acid are ligands of the CRTH2 receptor and are useful in the treatment of respiratory diseases.
摘要翻译：该列表的具体化合物：{7-氰基-2-甲基-1- [4-（吗啉-4-磺酰基）苄基]中氮茚-3-基}乙酸，{1-（3-氯-4-乙磺酰基苄基）-7-氰基-2-甲基吲哚啉-3-基}乙酸{1- [3-氯-4-（吗啉-4-磺酰基）苄基] -7-氰基-2-甲基吲哚啉-3-基}乙酸， {1-（3-氯-4-乙磺酰基苯基硫烷基）-7-氰基-2-甲基吲哚啉-3-基}乙酸{1- [3-氯-4-（吗啉-4-磺基）苯基f烷基] 氰基-2-甲基吲哚啉-3-基}乙酸，{7-氰基-1-（6-氟喹啉-2-基甲基）-2-甲基吲哚啉-3-基}乙酸是CRTH2受体的配体，可用于治疗呼吸系统疾病。

42. 发明申请

US20060241106A1 Isoxazole compounds as inhibitors of heat shock proteins 有权
公开(公告)号：US20060241106A1
公开(公告)日：2006-10-26
申请号：US10544443
申请日：2004-02-09
申请人： Martin Drysdale , Brian Dymock , Harry Finch , Paul Webb , Edward McDonald , Karen James , Kwai Cheung , Thomas Matthews
发明人： Martin Drysdale , Brian Dymock , Harry Finch , Paul Webb , Edward McDonald , Karen James , Kwai Cheung , Thomas Matthews
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/42
CPC分类号： A61K31/541 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07D261/08 , C07D261/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D495/04
摘要： Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: (A), (B) wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C═O)—, —(C═S)—, —SO2—, —C(═O)O—, —C(═O)NRA—, —C(═S)NRA—, —SO2NRA—, —NRAC(═O)—, —NRASO2— or —NRA— wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R2 is (i) a group of formula (IA) above or (ii) a carboxamide radical; or (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula -(Alk1)p-(Z)r-(Alk2)s-Q wherein Q, Alk1, Alk2, Z, p, r and s are as defined above in relation to group (IA); and R3 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6 alkenyl, or C1-C6 alkynyl; or a carboxyl, carboxamide, or carboxyl ester group.

43. 发明授权

US5580895A 1,5-benzodiazepine derivatives 失效
标题翻译： 1,5-苯并二氮杂衍生物
公开(公告)号：US5580895A
公开(公告)日：1996-12-03
申请号：US256359
申请日：1994-07-20
申请人： Harry Finch , David G. Trist , Giorgio Tarzia , Aldo Feriani
发明人： Harry Finch , David G. Trist , Giorgio Tarzia , Aldo Feriani
IPC分类号： A61K31/55 , A61K31/551 , A61P1/00 , A61P1/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D243/12 , A61K38/00 , C07D403/12
CPC分类号： C07D243/12
摘要： The present invention relates to compounds of formula (I) which are antagonists of gastrin and CCK-B receptors. The compounds of formula (I) are 1,5-benzodiazepine derivatives. ##STR1##
摘要翻译： PCT No.PCT / EP93 / 00098 Sec。 371日期：1994年7月20日 102（e）日期1994年7月20日PCT 1993年1月15日PCT公布。公开号WO93 / 14074 日期：1993年7月22日本发明涉及作为胃泌素和CCK-B受体拮抗剂的式（I）化合物。式（I）化合物是1,5-苯并二氮杂衍生物。（一）

44. 发明授权

US4855293A Anti-inflammatory compositions comprising a systemic non-steroidal anti-inflammatory drug and a cyclopentyl ether 失效
标题翻译：包含全身非甾体抗炎药和环戊基醚的抗炎组合物
公开(公告)号：US4855293A
公开(公告)日：1989-08-08
申请号：US111026
申请日：1987-10-21
申请人： Eric W. Collington , Harry Finch , Duncan B. Judd
发明人： Eric W. Collington , Harry Finch , Duncan B. Judd
IPC分类号： A61K45/06 , A61K31/215 , A61K31/235 , A61K31/557 , A61K31/60 , A61P1/04 , A61P25/04 , A61P29/00 , A61P43/00 , C07C69/738
CPC分类号： A61K31/557 , A61K31/60
摘要： The use is described of both (i) a systemic non-steroidal anti-inflammatory drug and (ii) a compound of formula (1) ##STR1## wherein n is 1 or 2;m is 2-5 and X is cis or trans --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; or m is 1-4 and X is --CH.dbd.C.dbd.CH--;R.sup.1 is phenyl, substituted phenyl or naphthyl;Y is substituted or unsubstituted 3-phenoxy-2-hydroxypropyl in the therapy or prophylaxis of inflammatory conditions and for analgesia in humans.Pharmaceutical compositions containing both (i) and (ii) are also described.

45. 发明授权

US4824993A Cyclopentyl ethers and their preparation and pharmaceutical formulation 失效
标题翻译：环戊基醚及其制备及药物配方
公开(公告)号：US4824993A
公开(公告)日：1989-04-25
申请号：US97334
申请日：1987-09-11
申请人： Eric W. Collington , Harry Finch , Duncan B. Judd
发明人： Eric W. Collington , Harry Finch , Duncan B. Judd
IPC分类号： C07C45/58 , C07C45/67 , C07C45/71 , C07C47/277 , C07C49/627 , C07C49/753 , C07C405/00 , C07F7/18 , C07C177/00
CPC分类号： C07C323/00 , C07C405/00 , C07C45/58 , C07C45/673 , C07C45/71 , C07C47/277 , C07C49/627 , C07C49/753 , C07F7/1856
摘要： Compounds are described of formula (I) ##STR1## in which n is 1 or 2;m is 2-5 and X is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; or m is 1-4 and X is --CH.dbd.C.dbd.CH--;R.sup.1 is --H, alkyl, phenalkyl, phenyl, substituted phenyl or naphthyl;Y substituted or unsubstituted 3-phenoxy-2-hydroxypropyl.These compounds inhibit gastric acid secretion and provide gastrointestinal cytoprotection, and may be formulated for use in the treatment of ulcers.
摘要翻译：化合物描述为式（I）其中n为1或2的式（I） m为2-5，X为-CH = CH-或-CH 2 -CH 2 - ; 或m为1-4，X为-CH = C = CH-; R 1是-H，烷基，苯烷基，苯基，取代的苯基或萘基; Y取代或未取代的3-苯氧基-2-羟丙基。这些化合物抑制胃酸分泌并提供胃肠细胞保护作用，并可配制用于治疗溃疡。

46. 发明授权

US4447428A Prostanoid compounds and pharmaceutical compositions 失效
标题翻译：前列腺素化合物和药物组合物
公开(公告)号：US4447428A
公开(公告)日：1984-05-08
申请号：US514261
申请日：1983-07-15
申请人： Eric W. Collington , Harry Finch , Roger F. Newton
发明人： Eric W. Collington , Harry Finch , Roger F. Newton
IPC分类号： C07D317/22 , A61K31/557 , A61K31/5575 , A61P7/02 , A61P11/08 , A61P43/00 , C07C45/71 , C07C67/00 , C07C229/46 , C07C401/00 , C07C405/00 , C07D209/48 , C07D211/48 , C07D241/04 , C07D265/30 , C07D267/08 , C07D267/10 , C07D279/12 , C07D295/096 , C07D295/10 , C07D295/116 , C07D295/14 , C07D295/155 , C07D309/10 , C07D309/12 , C07D311/94 , C07D317/04 , C07D317/16 , C07D405/04 , C07D407/12 , C07D413/12 , A61K31/55 , C07D223/00
CPC分类号： C07D209/48 , C07C247/00 , C07C405/0041 , C07C45/71 , C07D211/48 , C07D295/096 , C07D295/116 , C07D295/155 , C07D309/10 , C07D309/12 , C07D311/94 , C07D317/04 , C07D317/16
摘要： Prostanoid compounds are described having the formula: ##STR1## where A is a cyclopentane ring, which is substituted by oxo and/or hydroxy or etherified hydroxy and may be saturated or unsaturated; X is --CH.dbd.CH--or --(CH.sub.2).sub.2 --; R is alkyl having a terminal --COOH or ester group; and Y is amino or substituted amino, particularly heterocyclic amino.The compounds have bronchodilator activity and/or inhibit blood platelet aggregation.The preparation and pharmaceutical formulation of the compounds is also described.
摘要翻译：描述具有下式的前驱体类化合物：其中A是环戊烷环，其被氧代和/或羟基或醚化的羟基取代并且可以是饱和或不饱和的; X是-CH = CH-或 - （CH 2）2 - ; R是具有末端-COOH或酯基的烷基; Y是氨基或取代的氨基，特别是杂环氨基。该化合物具有支气管扩张剂活性和/或抑制血小板聚集。还描述了化合物的制备和药物制剂。

47. 发明授权

US08815837B2 Respiratory disease treatment 有权
标题翻译：呼吸系统疾病治疗
公开(公告)号：US08815837B2
公开(公告)日：2014-08-26
申请号：US13537503
申请日：2012-06-29
申请人： Harry Finch , Craig Fox , Mohammed Sajad , Monique Bondil Van Niel , Andrew Forrest
发明人： Harry Finch , Craig Fox , Mohammed Sajad , Monique Bondil Van Niel , Andrew Forrest
IPC分类号： A01N43/00
CPC分类号： A61K31/4439 , A61K9/0075 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： There is provided a pharmaceutical composition that is adapted for pulmonary administration by inhalation, which composition comprises a glitazone, such as pioglitazone or rosiglitazone, and one or more pharmaceutically acceptable carriers and/or excipients, and wherein the glitazone content of the composition consists of at least 95% by weight of the 5R enantiomer and less than 5% by weight of the 5S enantiomer. There is also provided a use and kit.
摘要翻译：提供了适于通过吸入肺部给药的药物组合物，该组合物包含格列酮（如吡格列酮或罗格列酮）和一种或多种药学上可接受的载体和/或赋形剂，并且其中组合物的格列酮含量由至少95重量％的5R对映体和小于5重量％的5S对映异构体。还提供了一个使用和工具包。

48. 发明授权

US08557797B2 Triazolopyridine derivatives and their therapeutic use 失效
标题翻译：三唑并吡啶衍生物及其治疗用途
公开(公告)号：US08557797B2
公开(公告)日：2013-10-15
申请号：US13201716
申请日：2010-02-16
申请人： Harry Finch , John Montana , Monique Bodil Van Niel , Chi-Kit Woo , Jamie Knight , Bohdan Waszkowycz
发明人： Harry Finch , John Montana , Monique Bodil Van Niel , Chi-Kit Woo , Jamie Knight , Bohdan Waszkowycz
IPC分类号： A61K31/535 , A01N43/54 , C07D413/04 , C07D239/02
CPC分类号： C07D471/04
摘要： Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is —O— or —S(O)p— wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C3-C6 divalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(═O)W—; W is a bond, —NH— or —C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl or halo; and R2 is a radical as defined in the claims.
摘要翻译：式（I）化合物是p38MAP激酶的抑制剂，其可用作治疗特别是呼吸道疾病的抗炎剂，其中： R 1是C 1 -C 6烷基，C 3 -C 6环烷基，任选取代的苯基，任选被取代的5-或6-元单环杂芳基，或其中n是1或2的式（II）基团，R 3和R 4是独立地是H或C 1 -C 6烷基，或者R 3和R 4与它们所连接的氮一起形成任选含有另外选自N和O的杂原子的6元杂环; Y是-O-或-S（O）p - ，其中p是0,1或2; A是任选取代的二价亚芳基或单环或双环亚杂芳基或具有5或6个环原子的C 3 -C 6二价亚环烷基或哌啶子基，其中环氮连接至R 2 NHC（= O）W - ; W是键，-NH-或-C（RA）（RB），其中RA和RB独立地是H，甲基，乙基，氨基，羟基或卤素; 并且R 2是如权利要求中所定义的基团。

49. 发明申请

US20130123278A1 PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD 有权
标题翻译：吡嗪衍生物及其在治疗呼吸道疾病如COPD中的应用
公开(公告)号：US20130123278A1
公开(公告)日：2013-05-16
申请号：US13640004
申请日：2011-03-10
申请人： Christine Edwards , Janusz Kulagowski , Harry Finch
发明人： Christine Edwards , Janusz Kulagowski , Harry Finch
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C—R1 or N; -X1-X2- is CR15═N— or —NR19—CO—; and R1-R6, R15 and R16 are as defined in the claims.
摘要翻译：式（I）化合物是嗜中性粒细胞弹性蛋白酶抑制剂，其中A是C-R 1或N; -X1-X2-是CR15 = N-或-NR19-CO-; 并且R 1 -R 6，R 15和R 16如权利要求中所定义。

50. 发明授权

US08426393B2 Inhaled combination therapy 有权
公开(公告)号：US08426393B2
公开(公告)日：2013-04-23
申请号：US12862421
申请日：2010-08-24
申请人： Justian Craig Fox , Mary Frances Fitzgerald , Harry Finch
发明人： Justian Craig Fox , Mary Frances Fitzgerald , Harry Finch
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A61K31/58 , A61K31/52 , A61K2300/00
摘要： There is provided the use of a methylxanthine derivative such as theophylline and a steroid in a synergistic combination for the treatment of chronic obstructive pulmonary disease, wherein the combination is administered by the inhaled route for pulmonary delivery.

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