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41. 发明授权

US09284330B2 1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof 有权
标题翻译： 1,4-二氢 - 萘啶衍生物及其药物组合物及其用途
公开(公告)号：US09284330B2
公开(公告)日：2016-03-15
申请号：US14362735
申请日：2012-12-07
申请人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
发明人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
IPC分类号： C07D495/14 , C07D471/14 , C07D471/04 , C07D471/12 , C07D491/14
CPC分类号： C07D495/14 , C07D471/04 , C07D471/12 , C07D471/14 , C07D491/14
摘要： Disclosed are 1,4-dihydro-naphthyridine derivatives and pharmaceutical composition and uses thereof. The 1,4-dihydro-naphthyridine derivatives are a compound capable of inhibiting acetylcholinesterase activity and preventing extracellular calcium from flowing into a cell via a calcium channel, i.e., having a dual-activity, which are of potential importance as a pharmaceutical and can be used to prepare the drugs for treating cardiovascular diseases, cerebrovascular diseases and dementia.
摘要翻译：公开了1,4-二氢 - 萘啶衍生物及其药物组合物及其用途。 1,4-二氢 - 萘啶衍生物是能够抑制乙酰胆碱酯酶活性并防止细胞外钙通过钙通道流入细胞的化合物，即具有作为药物具有潜在重要性的双重活性，可以是用于制备治疗心血管疾病，脑血管疾病和痴呆症的药物。

42. 发明授权

US09067965B2 Preparation method of rocuronium 有权
标题翻译：罗库溴铵的制备方法
公开(公告)号：US09067965B2
公开(公告)日：2015-06-30
申请号：US13991316
申请日：2011-01-26
申请人： Zhiwen Zeng , Wenling Zhang , Peng Wang , Xini Zhang
发明人： Zhiwen Zeng , Wenling Zhang , Peng Wang , Xini Zhang
IPC分类号： C07J43/00
CPC分类号： C07J43/003
摘要： A method for preparing rocuronium is disclosed. 2β-(4-Morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α-ol-17β-acetate is used as a starting material and is directly reacted with 3-bromopropene at ambient temperature to produce rocuronium.
摘要翻译：公开了一种制备罗库溴铵的方法。 2＆bgr--（4-吗啉基）-16＆bgr-（1-吡咯烷基）-5α-雄甾烷-3α-醇-17β-乙酸乙酯作为起始原料，并与环境温度下的3-溴丙烯直接反应生成罗库溴铵。

43. 发明授权

US09024013B2 Method for purifying rocuronium bromide 有权
标题翻译：罗库溴铵净化方法
公开(公告)号：US09024013B2
公开(公告)日：2015-05-05
申请号：US14122679
申请日：2011-04-25
申请人： Zhiwen Zeng , Peng Wang , Wenling Zhang , Xini Zhang
发明人： Zhiwen Zeng , Peng Wang , Wenling Zhang , Xini Zhang
IPC分类号： C07J43/00
CPC分类号： C07J43/003 , C07J43/00
摘要： Provided is a method for purifying rocuronium bromide, which comprises: formulating crude rocuronium bromide to be purified into an aqueous solution, distilling off excess residue solvents at reduced pressure, absorbing by adding active carbon or silica gel, then filtrating, quick freezing the filtrate into ice, and then lyophilizing to obtain rocuronium bromide.
摘要翻译：本发明提供了罗苏溴铵的纯化方法，其特征在于，将粗制的罗库溴铵配制成水溶液，减压蒸馏除去过剩的残留溶剂，通过加入活性炭或硅胶吸收，然后过滤，将滤液快速冷冻冰，然后冻干得到罗库溴铵。

44. 发明授权

US09014423B2 Method and system for catheter tracking in fluoroscopic images using adaptive discriminant learning and measurement fusion 有权
标题翻译：使用自适应判别学习和测量融合的荧光镜图像中导管跟踪的方法和系统
公开(公告)号：US09014423B2
公开(公告)日：2015-04-21
申请号：US13412882
申请日：2012-03-06
申请人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
发明人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
IPC分类号： G06K9/00 , A61B6/00 , A61B6/12 , G06T7/20
CPC分类号： A61B6/487 , A61B6/12 , A61B6/503 , G06T7/246 , G06T2207/10016 , G06T2207/10064 , G06T2207/20076 , G06T2207/20081 , G06T2207/30021 , G06T2207/30048
摘要： A method and system for adaptive discriminant learning and measurement fusion for image based catheter tracking is disclosed. An adaptive discriminant model is trained online based on a tracked object, such as a pigtail catheter tip, in at least one previous frame of a fluoroscopic image sequence. The object is tracked in the current frame of the fluoroscopic image sequence based at least on the adaptive discriminant model trained online. The object may be tracked in the current frame based on a fusion of three types of measurement models including the adaptive discriminant model trained online, an object detection model trained offline, and an online appearance model.
摘要翻译：公开了一种用于基于图像的导管跟踪的自适应判别学习和测量融合的方法和系统。在荧光镜像图像序列的至少一个先前帧中，基于跟踪对象（例如尾纤导管尖端）在线训练自适应判别模型。至少基于在线训练的自适应判别模型，在透视图像序列的当前帧中跟踪对象。基于三种类型的测量模型的融合，可以在当前帧中跟踪对象，包括在线训练的自适应判别模型，离线训练的对象检测模型和在线外观模型。

45. 发明授权

US08806374B2 Electronic device and file manipulation method 有权
标题翻译：电子设备和文件操作方法
公开(公告)号：US08806374B2
公开(公告)日：2014-08-12
申请号：US13593529
申请日：2012-08-24
申请人： Peng Wang
发明人： Peng Wang
IPC分类号： G06F3/048
CPC分类号： G06F3/0486 , G06F3/0488 , G06F3/04883 , G06F3/061 , G06F3/0643 , G06F17/30126 , G06F2206/1008
摘要： An exemplary file manipulation method determines whether the user manipulation on the file or file folder is a moving manipulation. The method then reads a directory structure of each drive from a storage unit when detecting that the user manipulation on the file or file folder is the moving manipulation, determines a maximum folder depth of the directory structure of the one or more drives, and further controls to display a user interface showing the directory structure with the maximum folder depth. Next, the method detects the user manipulation in the user interface, and determines a position where the icon is dragged to is a target position when detecting that the user manipulation is dragging the icon to the position in the ring portion of the sector. The method then moves the manipulated file or file folder to a target drive or file folder corresponding to the target position.
摘要翻译：示例性文件操纵方法确定用户对文件或文件夹的操纵是否是移动操作。然后，当检测到文件或文件夹上的用户操纵是移动操作时，该方法从存储单元读取每个驱动器的目录结构，确定一个或多个驱动器的目录结构的最大文件夹深度，并进一步控制以显示具有最大文件夹深度的目录结构的用户界面。接下来，该方法检测用户界面中的用户操纵，并且当检测到用户操纵将图标拖动到扇区的环形部分中的位置时，确定将图标拖动到的位置是目标位置。然后，该方法将操纵的文件或文件夹移动到与目标位置对应的目标驱动器或文件夹。

46. 发明申请

US20140187942A1 Needle Enhancement in Diagnostic Ultrasound Imaging 有权
标题翻译：针刺增强诊断超声成像
公开(公告)号：US20140187942A1
公开(公告)日：2014-07-03
申请号：US13733310
申请日：2013-01-03
申请人： Peng Wang , Terrence Chen , Ali Kamen , Jeffrey Stoll , Dorin Comaniciu , Sara Good
发明人： Peng Wang , Terrence Chen , Ali Kamen , Jeffrey Stoll , Dorin Comaniciu , Sara Good
IPC分类号： A61B8/08
CPC分类号： A61B8/0841 , A61B8/461 , A61B8/5246
摘要： A needle is enhanced in a medical diagnostic ultrasound image. The image intensities associated with a needle in an image are adaptively increased and/or enhanced by compounding from a plurality of ultrasound images. Filtering methods and probabilistic methods are used to locate possible needle locations. In one approach, possible needles are found in component frames that are acquired at the same time but at different beam orientations. The possible needles are associated with each other across the component frames and false detections are removed based on the associations. In one embodiment of needle detection in an ultrasound component frame, lines are found first. The lines are then searched to find possible needle segments. In another embodiment, data from different times may be used to find needle motion and differences from a reference, providing the features in additional to features from a single component frame for needle detection.
摘要翻译：在医疗诊断超声图像中增强针。通过从多个超声图像的复合来自适应地增加和/或增强与图像中的针相关联的图像强度。使用过滤方法和概率方法来定位可能的针位置。在一种方法中，可以在同时获取但是以不同波束取向获得的分量帧中找到可能的针。可能的针在组件框架之间彼此相关联，并且基于关联来去除错误检测。在超声组件框架中的针检测的一个实施例中，首先找到线。然后搜索线以找到可能的针段。在另一个实施例中，来自不同时间的数据可用于从参考找到针运动和差异，从单个组件框架中提供用于针检测的特征附加的特征。

47. 发明授权

US08737725B2 Method and system for learning based object detection in medical images 有权
标题翻译：医学图像学习基于物体检测的方法与系统
公开(公告)号：US08737725B2
公开(公告)日：2014-05-27
申请号：US13235747
申请日：2011-09-19
申请人： Peng Wang , Terrence Chen , Shaohua Kevin Zhou , Dorin Comaniciu , Martin Ostermeier
发明人： Peng Wang , Terrence Chen , Shaohua Kevin Zhou , Dorin Comaniciu , Martin Ostermeier
IPC分类号： G06K9/62
CPC分类号： G06K9/4614 , G06K9/6257 , G06K9/6282
摘要： Methods and Systems for training a learning based classifier and object detection in medical images is disclosed. In order to train a learning based classifier, positive training samples and negative training samples are generated based on annotated training images. Features for the positive training samples and the negative training samples are extracted. The features include an extended Haar feature set including tip features and corner features. A discriminative classifier is trained based on the extracted features.
摘要翻译：公开了用于训练医学图像中基于学习的分类器和对象检测的方法和系统。为了训练基于学习的分类器，基于注释的训练图像生成正训练样本和负训练样本。提取正训练样本和负训练样本的特征。功能包括扩展的Haar功能集，包括提示功能和角特征。基于提取的特征对歧视性分类器进行训练。

48. 发明授权

US08675914B2 Method and system for needle tracking in fluoroscopic image sequences 有权
标题翻译：透视图像序列中针跟踪的方法和系统
公开(公告)号：US08675914B2
公开(公告)日：2014-03-18
申请号：US12880319
申请日：2010-09-13
申请人： Peng Wang , Marcus Pfister , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Peng Wang , Marcus Pfister , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： A61B6/12
摘要： A method and system for tracking a needle in a fluoroscopic image sequence is disclosed. In order to track a needle in a fluoroscopic image sequence, the needle is initialized in a first frame of the fluoroscopic image sequence. Needle segments are detected in each subsequent frame of the fluoroscopic image sequence, and the needle is detected in each frame of the fluoroscopic image by tracking the needle from a previous frame of the fluoroscopic image sequence based on the detected needle segments in the current frame.
摘要翻译：公开了一种用于在荧光镜像图像序列中跟踪针的方法和系统。为了在透视图像序列中跟踪针，在荧光镜图像序列的第一帧中初始化针。在透视图像序列的每个随后的帧中检测针段，并且基于当前帧中检测到的针段，通过从荧光透视图像序列的先前帧跟踪针来在荧光镜图像的每个帧中检测针。

49. 发明授权

US08634776B2 Communication terminal and pairing method thereof 有权
标题翻译：通信终端及其配对方法
公开(公告)号：US08634776B2
公开(公告)日：2014-01-21
申请号：US13192360
申请日：2011-07-27
申请人： Peng Wang
发明人： Peng Wang
IPC分类号： H04B7/00
CPC分类号： H04M1/7253 , H04M1/22 , H04M2250/02 , H04M2250/52
摘要： A communication terminal includes a request unit, an illuminating unit, a detecting unit, a capturing unit, an analyzing unit, and a pairing unit. The request unit is used for generating a pairing signal when communication pairing function is enabled. The illuminating unit is used for generating predetermined light when communication pairing function is enabled. The detecting unit detects whether the pairing signal from another terminal has been received, and if it has, generates a signal to the capturing unit. The capturing unit is used for capturing an image of the light generated by the illuminating unit of the other terminal. The analyzing unit is used for analyzing the captured image. The pairing unit is used for completing the communication pairing with the other terminal when the captured image of the light includes a predetermined characteristic.
摘要翻译：通信终端包括请求单元，照明单元，检测单元，捕获单元，分析单元和配对单元。当使能通信配对功能时，请求单元用于产生配对信号。当使能通信配对功能时，照明单元用于产生预定的光。检测单元检测来自另一终端的配对信号是否已被接收，并且如果已经接收到，则向捕获单元生成信号。捕获单元用于捕获由另一个终端的照明单元生成的光的图像。分析单元用于分析捕获的图像。当捕获的光图像具有预定特性时，配对单元用于完成与另一终端的通信配对。

50. 发明申请

US20130321897A1 PHOTOREFRACTIVE DEVICES HAVING SOL-GEL BUFFER LAYERS AND METHODS OF MANUFACTURING 审中-公开
标题翻译：具有溶胶缓冲层的光电装置及其制造方法
公开(公告)号：US20130321897A1
公开(公告)日：2013-12-05
申请号：US14000181
申请日：2012-02-17
申请人： Peng Wang , Sergey Simavoryan , Weiping Lin , Wan-Yun Hsieh , Michiharu Yamamoto
发明人： Peng Wang , Sergey Simavoryan , Weiping Lin , Wan-Yun Hsieh , Michiharu Yamamoto
IPC分类号： G02F1/29
CPC分类号： G02F1/293 , G02F1/0126 , G02F1/061 , G02F2202/13 , G02F2202/38 , G03H2001/026 , G03H2001/0264 , G03H2260/36 , G03H2260/54
摘要： A photorefractive device (100) and methods of its manufacture are disclosed. The photorefractive device (100) comprises one or more transparent electrode layers (104), one or more sol-gel buffer layers (113), one or more polymer buffer layers (105), and a photorefractive layer (106). The one or more sol-gel buffer layer (113) is interposed between the one or more polymer buffer layer (105) and the one or more transparent electrode layer (104). When a bias voltage is applied to the device (100), the device (100) exhibits improvement in electric breakdown strength compared to a similar device without the one or more dielectric sol-gel buffer layers (113). The device (100) can operate at high bias levels with quick rising and decay times and shows higher grating performance under single nanosecond pulse recording conditions.
摘要翻译：公开了一种光折射装置（100）及其制造方法。光折变装置（100）包括一个或多个透明电极层（104），一个或多个溶胶 - 凝胶缓冲层（113），一个或多个聚合物缓冲层（105）和光折射层（106）。一个或多个溶胶 - 凝胶缓冲层（113）插入在一个或多个聚合物缓冲层（105）和一个或多个透明电极层（104）之间。当偏置电压施加到器件（100）时，与没有一个或多个电介质溶胶 - 凝胶缓冲层（113）的类似器件相比，器件（100）显示出电击穿强度的提高。器件（100）可以在高的偏置电平下工作，具有快速上升和衰减时间，并且在单纳秒脉冲记录条件下显示更高的光栅性能。

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