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41. 发明申请

US20130171146A1 DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES 审中-公开
标题翻译：双特异性IL-1A / IL-1B抗体
公开(公告)号：US20130171146A1
公开(公告)日：2013-07-04
申请号：US13591027
申请日：2012-08-21
申请人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
IPC分类号： C07K16/46 , A61K45/06 , C07K16/24 , A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译：本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。本发明的双重特异性抗体也中和人IL-1α和人IL-1beta。本发明还提供了对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。

42. 发明申请

US20100234570A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20100234570A1
公开(公告)日：2010-09-16
申请号：US11501546
申请日：2006-08-08
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

43. 发明申请

US20090082550A1 ANTIBODY COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗体组合物和方法
公开(公告)号：US20090082550A1
公开(公告)日：2009-03-26
申请号：US12186245
申请日：2008-08-05
申请人： Ian Tomlinson , Amrik Basran , Philip Jones
发明人： Ian Tomlinson , Amrik Basran , Philip Jones
IPC分类号： C07K16/18
CPC分类号： C07K16/005 , A61K47/60 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： Provided are concentrated preparations comprising single immunoglobulin variable domain polypeptides that bind target antigen with high affinity and are soluble at high concentration, without aggregation or precipitation, providing, for example, for increased storage stability and the ability to administer higher therapeutic doses.
摘要翻译：提供了包含单一免疫球蛋白可变结构域多肽的浓缩制剂，其以高亲和力结合靶抗原并且可以高浓度溶解，无聚集或沉淀，提供例如提高储存稳定性和施用较高治疗剂量的能力。

44. 发明申请

US20070298041A1 Ligands That Enhance Endogenous Compounds 审中-公开
标题翻译：增强内源化合物的配体
公开(公告)号：US20070298041A1
公开(公告)日：2007-12-27
申请号：US11667393
申请日：2005-11-10
申请人： Ian Tomlinson
发明人： Ian Tomlinson
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： C07K16/241 , A61K47/60 , A61K2039/505 , C07K16/18 , C07K16/2866 , C07K16/2878 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C12N2799/021
摘要： The invention relates to ligands that comprise a moiety (e.g., a dAb) that has a binding site with binding specificity for an endogenous target compound but do not substantially inhibit the activity of said endogenous target compound. Preferably, the ligand does not bind to the active site of an endogenous target compound. The invention relates to the use of such a ligand for the manufacture of a medicament for increasing the half-life, bioavailability, activity or amount of an endogenous target compound to which the ligand binds.
摘要翻译：本发明涉及包含具有对内源靶化合物具有结合特异性但不基本上抑制所述内源性目标化合物的活性的结合位点的部分（例如dAb）的配体。优选地，配体不结合内源目标化合物的活性位点。本发明涉及这种配体在制备用于增加配体结合的内源性目标化合物的半衰期，生物利用度，活性或量的药物中的用途。

45. 发明申请

US20070265450A1 NOVEL PROCESSES FOR THE PREPARATION OF (R)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL 审中-公开
标题翻译：（R）-alPHA-（2,3-二甲氧基苯基）-1- [2-（4-氟代乙基）乙基] -4-哌啶甲醇的制备方法
公开(公告)号：US20070265450A1
公开(公告)日：2007-11-15
申请号：US11782902
申请日：2007-07-25
申请人： Thomas Hilpert , Hans-Wolfram Flemming , Sandra Stolz-Dunn , Jonathan Evans , Ian Tomlinson
发明人： Thomas Hilpert , Hans-Wolfram Flemming , Sandra Stolz-Dunn , Jonathan Evans , Ian Tomlinson
IPC分类号： C07D213/04 , C07D211/04
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
摘要翻译：本发明提供制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的各种方法。

46. 发明申请

US20070093651A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20070093651A1
公开(公告)日：2007-04-26
申请号：US11501522
申请日：2006-08-08
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

47. 发明申请

US20070065440A1 Antibody compositions and methods 审中-公开
标题翻译：抗体组合物和方法
公开(公告)号：US20070065440A1
公开(公告)日：2007-03-22
申请号：US11401745
申请日：2006-04-10
申请人： Ian Tomlinson , Amrik Basran , Philip Jones
发明人： Ian Tomlinson , Amrik Basran , Philip Jones
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/005 , A61K47/60 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： Provided are concentrated preparations comprising single immunoglobulin variable domain polypeptides that bind target antigen with high affinity and are soluble at high concentration, without aggregation or precipitation, providing, for example, for increased storage stability and the ability to administer higher therapeutic doses.
摘要翻译：提供了包含单一免疫球蛋白可变结构域多肽的浓缩制剂，其以高亲和力结合靶抗原并且可以高浓度溶解，无聚集或沉淀，提供例如提高储存稳定性和施用较高治疗剂量的能力。

48. 发明申请

US20060063921A1 Ligand 审中-公开
公开(公告)号：US20060063921A1
公开(公告)日：2006-03-23
申请号：US11217919
申请日：2005-09-01
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.

49. 发明授权

US06846634B1 Method to screen phage display libraries with different ligands 有权
标题翻译：用不同配体筛选噬菌体展示文库的方法
公开(公告)号：US06846634B1
公开(公告)日：2005-01-25
申请号：US09511939
申请日：2000-02-24
申请人： Ian Tomlinson , Greg Winter
发明人： Ian Tomlinson , Greg Winter
IPC分类号： G01N33/50 , C07K1/04 , C07K14/705 , C07K14/725 , C07K16/00 , C12N15/09 , C12N15/10 , C12P21/08 , C40B30/04 , C40B40/02 , G01N33/15 , G01N33/68 , G01N33/53 , C07H21/04 , C12Q1/70
CPC分类号： C07K1/047 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/622 , C12N15/1037 , C40B30/04 , C40B40/02 , G01N33/6845 , G01N33/6854
摘要： The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in a second binding site, which generic ligand is capable of binding functional members of the repertoire regardless of target ligand specificity, comprising the steps of: a) contacting the repertoire with the generic ligand and selecting functional polypeptides bound thereto; and b) contacting the selected functional polypeptides with the target ligand and selecting a population of polypeptides which bind to the target ligand. The invention accordingly provides a method by which a polypeptide repertoire is preselected, according to functionality as determined by the ability to bind the generic ligand, and the subset of polypeptides obtained as a result of such preselection is then employed for further selection according to the ability to bind the target ligand.
摘要翻译：本发明提供了从多肽的所有组成部分中选择结合第一结合位点中的靶配体和第二结合位点中的通用配体的功能性多肽群体的方法，该通用配体能够结合包括以下步骤：a）使所述谱系与通用配体接触并选择与其结合的功能性多肽; 和b）使所选择的功能性多肽与靶配体接触并选择结合靶配体的多肽群体。因此，本发明提供了根据通过结合通用配体的能力所确定的官能度来预先选择多肽集合的方法，然后根据能力进一步选择作为这种预选的结果的多肽获得的子集以结合靶配体。

50. 发明授权

US06696245B2 Methods for selecting functional polypeptides 失效
标题翻译：选择功能性多肽的方法
公开(公告)号：US06696245B2
公开(公告)日：2004-02-24
申请号：US09192854
申请日：1998-11-17
申请人： Greg Winter , Ian Tomlinson
发明人： Greg Winter , Ian Tomlinson
IPC分类号： C12Q170
CPC分类号： C07K1/047 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/622 , C12N15/1037 , C40B30/04 , C40B40/02 , G01N33/6845 , G01N33/6854
摘要： The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in a second binding site, which generic ligand is capable of binding functional members of the repertoire regardless of target ligand specificity, comprising the steps of: a) contacting the repertoire with the generic ligand and selecting functional polypeptides bound thereto; and b) contacting the selected functional polypeptides with the target ligand and selecting a population of polypeptides which bind to the target ligand. The invention accordingly provides a method by which a polypeptide repertoire is preselected, according to functionality as determined by the ability to bind the generic ligand, and the subset of polypeptides obtained as a result of such preselection is then employed for further selection according to the ability to bind the target ligand.
摘要翻译：本发明提供了从多肽的所有组成部分中选择结合第一结合位点中的靶配体和第二结合位点中的通用配体的功能性多肽群体的方法，该通用配体能够结合包括以下步骤：a）使所述谱系与通用配体接触并选择与其结合的功能性多肽; 和b）使所选择的功能性多肽与靶配体接触并选择结合靶配体的多肽群体。因此，本发明提供了根据通过结合通用配体的能力确定的官能度来预先选择多肽集合的方法，然后根据该预选的能力进一步选择作为这种预选结果的多肽获得的子集以结合靶配体。

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