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41. 发明授权

US09427173B2 Determining mechanical force on aneurysms from a fluid dynamic model driven by vessel blood flow information 有权
标题翻译：从血管血流信息驱动的流体动力学模型确定动脉瘤的机械力
公开(公告)号：US09427173B2
公开(公告)日：2016-08-30
申请号：US12118628
申请日：2008-05-09
申请人： Saad Ahmed Sirohey , Paul E. Licato , Gopal B. Avinash , Tamanna N. Bembenek
发明人： Saad Ahmed Sirohey , Paul E. Licato , Gopal B. Avinash , Tamanna N. Bembenek
IPC分类号： A61B5/05 , A61B5/107 , A61B5/02 , A61B6/03 , A61B6/00 , G06F19/00 , G06T7/00 , G06T15/08
CPC分类号： A61B5/1075 , A61B5/02007 , A61B6/032 , A61B6/481 , A61B6/504 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T15/08 , G06T2207/10081 , G06T2207/10088 , G06T2207/30101 , G16H50/20 , G16H50/50
摘要： Systems, methods and apparatus are provided through which in some implementations changes in an aneurysm in a patient over time are identified by determining temporal differences between segmented aneurysms in a plurality of longitudinal exams and visually presenting the temporal differences.
摘要翻译：提供了系统，方法和装置，在一些实施方式中，通过确定多个纵向检查中的分段动脉瘤之间的时间差异并在视觉上呈现时间差异来识别患者随时间变化的动脉瘤的变化。

42. 发明授权

US08827905B2 Patient initiated on-demand remote medical service with integrated knowledge base and computer assisted diagnosing characteristics 有权
标题翻译：患者启动按需远程医疗服务，具有集成的知识库和计算机辅助诊断特征
公开(公告)号：US08827905B2
公开(公告)日：2014-09-09
申请号：US11324911
申请日：2006-01-04
申请人： Steven Roehm , Ray Liu , Gopal B. Avinash
发明人： Steven Roehm , Ray Liu , Gopal B. Avinash
IPC分类号： G11B20/00 , G11B27/36 , G11B20/18 , A61B5/02 , A61B5/00 , G06F19/00
CPC分类号： A61B5/0002 , A61B5/02 , A61B5/74 , A61B2505/07 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H40/40 , G16H40/63 , G16H50/20 , G16H80/00 , Y10S128/903 , Y10S128/92 , Y10S706/902 , Y10S706/924
摘要： The present invention is a system and method of remote patient monitoring to allow a patient to initiate and activate sensing systems. In the system and method, standard parameters can be sensed, and the information can then be processed and sent to the physician or clinician. The clinician then has the ability to remotely configure or reconfigure the parameters of the sensing system so as to probe for more targeted information based on the initial sensed data.
摘要翻译：本发明是远程患者监测的系统和方法，以允许患者启动和激活感测系统。在系统和方法中，可以检测标准参数，然后可以将信息处理并发送给医师或临床医生。然后，临床医生能够远程配置或重新配置感测系统的参数，以便根据初始感测数据探测更有针对性的信息。

43. 发明授权

US08675929B2 Method and apparatus for synchronizing corresponding landmarks among a plurality of images 有权
标题翻译：用于在多个图像之间同步对应的界标的方法和装置
公开(公告)号：US08675929B2
公开(公告)日：2014-03-18
申请号：US11836636
申请日：2007-08-09
申请人： Saad Ahmed Sirohey , Gopal B. Avinash , Jerome Francois Knoplioch , Laurent Launay , Renaud Capolunghi
发明人： Saad Ahmed Sirohey , Gopal B. Avinash , Jerome Francois Knoplioch , Laurent Launay , Renaud Capolunghi
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , G06T7/33 , G06T2207/30028
摘要： Certain embodiments of the present invention provide a system and method for synchronized viewing of a plurality of images of an object. Corresponding landmarks of an object are synchronized between a first image set and a second image set. In an embodiment, the landmarks are folds of a human colon and the first image set and second images sets are computerized tomography scans, at least one image set being a prone scan of a portion of anatomy and at least one image set being a supine scan of a portion of the anatomy. An indicator for at least a first location in a first image set is displayed. The location of a second location in a second image set of an object is determined, wherein the second location corresponds to the first location of the object. The second location in the second image set is displayed.
摘要翻译：本发明的某些实施例提供了用于同步观看对象的多个图像的系统和方法。对象的对应的地标在第一图像集和第二图像集之间被同步。在一个实施例中，地标是人类冒号的折叠，并且第一图像集和第二图像集合是计算机断层扫描，至少一个图像集合是解剖部分的俯视扫描，并且至少一个图像集合是仰卧扫描的解剖结构的一部分。显示第一图像集中的至少第一位置的指示符。确定对象的第二图像集中的第二位置的位置，其中第二位置对应于对象的第一位置。显示第二个图像集中的第二个位置。

44. 发明授权

US08588486B2 Apparatus and method for isolating a region in an image 有权
标题翻译：用于隔离图像中的区域的装置和方法
公开(公告)号：US08588486B2
公开(公告)日：2013-11-19
申请号：US12487166
申请日：2009-06-18
申请人： Patrick Michael Virtue , Gopal B. Avinash , Zhongmin S. Lin
发明人： Patrick Michael Virtue , Gopal B. Avinash , Zhongmin S. Lin
IPC分类号： G06K9/00
CPC分类号： A61B5/055 , A61B6/032 , A61B6/037 , A61B6/5247 , G01R33/481 , G01R33/5608 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/11 , G06T7/194 , G06T2207/10088 , G06T2207/10104 , G06T2207/30016
摘要： A system, method, and apparatus includes a computer readable storage medium with a computer program stored thereon having instructions that cause a computer to access a first anatomical image data set of an imaging subject acquired via a morphological imaging modality, access a functional image data set of the imaging subject acquired via a functional imaging modality, register the first anatomical image data set to the functional image data set, segment the functional image data set based on the functional image data set, define a binary mask based on the segmented functional image data set, and apply the binary mask to the first anatomical image data set to construct a second anatomical image data set and an image based thereon. The second anatomical image data set is substantially free of image data of the first anatomical image data set correlating to an area outside the region of physiological activity.
摘要翻译：系统，方法和装置包括其上存储有计算机程序的计算机可读存储介质，其上具有使计算机访问经由形态成像模式获取的成像对象的第一解剖图像数据集的指令，访问功能图像数据集通过功能成像模式获取的成像对象，将第一解剖图像数据集登记到功能图像数据集，基于功能图像数据集分割功能图像数据集，基于分割的功能图像数据定义二进制掩码设置并将二进制掩模应用于第一解剖图像数据集以构建第二解剖图像数据集和基于其的图像。第二解剖图像数据集基本上不含与生理活动区域之外的区域相关的第一解剖图像数据集的图像数据。

45. 发明申请

US20120078526A1 APPARATUS, SYSTEM AND METHODS FOR DETERMINING DRUG ATTRIBUTES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA 审中-公开
标题翻译：使用疾病标志物分析和药理学数据确定药物属性的装置，系统和方法
公开(公告)号：US20120078526A1
公开(公告)日：2012-03-29
申请号：US13169594
申请日：2011-06-27
申请人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
发明人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
IPC分类号： G06F19/10
CPC分类号： G16H50/70
摘要： Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example of the inventive apparatus includes a standardizer to at least one of standardize and normalize data related to drug performance for a known disease signature; and a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric associated with the disease signature.
摘要翻译：某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。本发明的装置的实例包括标准化器，用于标准化和标准化与已知疾病特征的药物性能相关的数据中的至少一个; 以及偏差分析器，用于基于多个不同功效度量中的至少一个来分析所述数据，其中，与识别的目标药物相对应的第一数据结果集合与对应于控制的结果的第二数据集之间的量化变化，其中提供所述第一结果数据集用于与所述第二数据结果集进行比较，并且将其之间的偏差与与所述疾病特征相关联的所述至少一个功效度量进行比较。

46. 发明申请

US20120078525A1 APPARATUS, SYSTEM AND METHODS FOR SELECTING DRUG CANDIDATES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA 审中-公开
标题翻译：使用疾病标志分析和药理学数据选择药物候选药物的方法，系统和方法
公开(公告)号：US20120078525A1
公开(公告)日：2012-03-29
申请号：US13169585
申请日：2011-06-27
申请人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
发明人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
IPC分类号： G06F19/00 , G06F7/60
CPC分类号： G16H50/70
摘要： Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes providing a first set of data corresponding to a drug of interest: providing a disease signature; providing a reference set of drug interaction data associated with the disease signature, comparing the first set of data to the reference set using a holistic analysis, and reporting the results of the comparison. An example of the apparatus includes, a standardizer to at least one of standardize and normalize drug interaction data related to a pre-selected disease signature: a deviation analyzer to compare the drug interaction data to data corresponding to a drug under review using a holistic analysis, and a reporter for reporting the output of the deviation analyzer.
摘要翻译：某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。示例性方法包括提供与感兴趣的药物相对应的第一组数据：提供疾病特征; 提供与疾病签名相关联的药物相互作用数据的参考集合，使用整体分析将第一组数据与参考集进行比较，并报告比较结果。该装置的一个实例包括标准化器，其至少标准化和规范与预先选择的疾病特征相关的药物相互作用数据中的至少一个：偏差分析器，以使用整体分析将药物相互作用数据与对应于正在审查的药物的数据进行比较和报告偏差分析仪的输出的记者。

47. 发明授权

US08098950B2 Method and apparatus for segmentation-based image operations 有权
标题翻译：用于基于分割的图像操作的方法和装置
公开(公告)号：US08098950B2
公开(公告)日：2012-01-17
申请号：US10723189
申请日：2003-11-26
申请人： Gopal B. Avinash
发明人： Gopal B. Avinash
IPC分类号： G06K9/40
CPC分类号： G06T5/50 , G06T7/11 , G06T2207/20012 , G06T2207/30004
摘要： A technique is provided for processing image data based upon determination of whether pixilated data tends to represent or exhibit one characteristic or another. Many such characteristics may be considered, such as whether the pixels probably represent structures or non-structures. Multiple thresholds for the classification of segmentation are used, and pixels falling within an overlapping regions are processed as if they exhibited both characteristics. Subsequent processing may include assignment of values for the overlapping pixels, such as by weighted blending.
摘要翻译：提供了一种基于确定像素化数据是倾向于表示还是呈现一种特征的处理图像数据的技术。可以考虑许多这样的特征，例如像素是否可能表示结构或非结构。使用用于分割分类的多个阈值，并且处理落在重叠区域内的像素，就好像它们表现出两个特征一样。后续处理可以包括对重叠像素的值的分配，例如通过加权混合。

48. 发明授权

US07929746B2 System and method for processing imaging data 有权
标题翻译：用于处理成像数据的系统和方法
公开(公告)号：US07929746B2
公开(公告)日：2011-04-19
申请号：US11464103
申请日：2006-08-11
申请人： Gopal B. Avinash , Kenny Kishan Israni , Baojun Li
发明人： Gopal B. Avinash , Kenny Kishan Israni , Baojun Li
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： G06T7/143 , A61B6/508 , G06T7/11 , G06T7/194 , G06T2207/10112 , G06T2207/10116
摘要： A system and method includes using a point spread function based rule to classify regions in a dataset and processing the dataset based on the point spread function based classification.
摘要翻译：系统和方法包括使用基于点扩散函数的规则来对数据集中的区域进行分类，并且基于基于点扩散函数的分类来处理数据集。

49. 发明授权

US07844317B2 Method and system for estimating three-dimensional respiratory motion 有权
标题翻译：估计三维呼吸运动的方法和系统
公开(公告)号：US07844317B2
公开(公告)日：2010-11-30
申请号：US10723728
申请日：2003-11-26
申请人： Prathyusha K. Salla , Gopal B. Avinash , Jason A. Polzin
发明人： Prathyusha K. Salla , Gopal B. Avinash , Jason A. Polzin
IPC分类号： A61B5/05
CPC分类号： A61B6/5217 , A61B5/0037 , A61B5/055 , A61B5/113 , A61B5/721 , A61B5/7289 , A61B5/7292 , A61B6/503 , A61B6/527 , A61B6/541 , G01R33/28 , G01R33/563
摘要： One or more techniques are provided for measuring the motion of an organ in three dimensions. As provided by the technique, the motion of the organ along each dimension may be determined by a suitable methodology. Where sensor-based motion measurements are suitable, one or more sensors may be placed on a patient to measure internal motion of the organ of interest along one or more perpendicular axes. Where image-based techniques are suitable, the motion of the internal organ along a perpendicular axis may determined using pre-acquisition image data or acquisition image data when suitable. Concurrent motion vectors for all three dimensions may be obtained from the motion data acquired for the perpendicular axes by the disparate methodologies. The concurrent motion vectors may be combined to describe the three-dimensional motion of the organ over time. Validation of the motion data may be performed for each of the one-dimensional motion data sets using motion data acquired by image-based methods, or other image-based methods, for a respective axis.
摘要翻译：提供了一种或多种用于测量器官在三维中的运动的技术。如该技术所提供的，器官沿着每个维度的运动可以通过合适的方法来确定。在基于传感器的运动测量是合适的情况下，可以将一个或多个传感器放置在患者身上以测量沿着一个或多个垂直轴的感兴趣器官的内部运动。在基于图像的技术是合适的情况下，内部器官沿着垂直轴的运动可以在适当时使用预采集图像数据或采集图像数据来确定。可以通过不同的方法从垂直轴获取的运动数据中获得所有三维的并行运动矢量。可以组合并行运动矢量以描述器官随时间的三维运动。运动数据的验证可使用针对相应轴的基于图像的方法或其他基于图像的方法获取的运动数据来针对每个一维运动数据集执行。

50. 发明授权

US07756312B2 Methods and apparatus for noise estimation 有权
标题翻译：用于噪声估计的方法和装置
公开(公告)号：US07756312B2
公开(公告)日：2010-07-13
申请号：US11551109
申请日：2006-10-19
申请人： Jiang Hsieh , Michael Joseph Washburn , Erik Normann Steen , Gopal B. Avinash
发明人： Jiang Hsieh , Michael Joseph Washburn , Erik Normann Steen , Gopal B. Avinash
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： G06T7/0002 , A61B6/508 , A61B6/5258 , A61B6/583 , G06T11/008 , G06T2207/30168
摘要： The method includes estimating a noise level in a reconstructed image using a total attenuation of the reconstructed image.
摘要翻译：该方法包括使用重构图像的总衰减来估计重建图像中的噪声电平。

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