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41. 发明授权

US07879071B2 Closure device and methods for making and using them 有权
公开(公告)号：US07879071B2
公开(公告)日：2011-02-01
申请号：US10435104
申请日：2003-05-09
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

42. 发明授权

US07806904B2 Closure device 有权
标题翻译：封闭装置
公开(公告)号：US07806904B2
公开(公告)日：2010-10-05
申请号：US10787073
申请日：2004-02-24
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Janina Sagastegui, legal representative , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08
CPC分类号： A61B17/064 , A61B17/0057 , A61B17/0644 , A61B17/068 , A61B90/39 , A61B2017/00004 , A61B2017/00668 , A61B2017/00867 , A61B2017/0641
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another. The primary tines are configured such that they are offset from the axes of symmetry of the curved regions from which they extend and are connected to the curved regions by curved or linear regions or are connected directly to the curved regions. The primary tines may overlap the body and may be of different lengths.
摘要翻译：用于接合组织的夹具包括限定平面并围绕垂直于平面延伸的中心轴设置的大致环形的主体。主体包括交替的内部和外部弯曲区域，围绕夹子的周边限定Z字形图案。身体偏向平面构型，该平面构型位于平面内，并可朝向延伸出平面的横向构型偏转。齿从内部弯曲区域延伸，尖齿在平面构型中朝向中心轴线定向，并且在横向构型中平行于中心轴线。尖齿包括比主尖齿短的主要尖齿和次级齿。主尖齿可以设置在相对的内弯曲区域上并且朝向彼此定向。主尖齿被构造成使得它们偏离其延伸的弯曲区域的对称轴线，并且通过弯曲或线性区域连接到弯曲区域，或者直接连接到弯曲区域。主尖齿可能与身体重叠，并且可能具有不同的长度。

43. 发明申请

US20080194956A1 Methods and Apparatus for Testing Disruption of a Vagal Nerve 失效
标题翻译：用于测试迷走神经破坏的方法和装置
公开(公告)号：US20080194956A1
公开(公告)日：2008-08-14
申请号：US12054694
申请日：2008-03-25
申请人： William N. Aldrich , David Miller
发明人： William N. Aldrich , David Miller
IPC分类号： A61N7/00 , A61B5/00
CPC分类号： A61B5/4233 , A61B5/04001 , A61B8/12 , A61B8/445 , A61B17/2202 , A61B18/1477 , A61B2018/00482 , A61N7/02 , A61N7/022
摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.
摘要翻译：用于在胃食管区域中破坏胃迷走神经的方法和装置，并测试迷走神经的功能和破坏。在一个示例性实施例中，治疗装置以高能量级（例如高强度聚焦超声）将超声波应用于迷走神经以将其破坏，然后以较低的能量级别向迷走神经的另一部分超声波，优选地远离胃，以刺激迷走神经。测试迷走神经功能或破坏的其他方法包括使用PCP-GABA，胰多肽，胃内压力变化，胃粘蛋白pH，胃中的染料剂等测试。

44. 发明申请

US20080071173A1 Visualizing Formation of Ablation Lesions 审中-公开
标题翻译：可视化消融病变形成
公开(公告)号：US20080071173A1
公开(公告)日：2008-03-20
申请号：US11532814
申请日：2006-09-18
申请人： William N. Aldrich
发明人： William N. Aldrich
IPC分类号： A61B8/00
CPC分类号： A61B8/4488 , A61B8/12 , A61B2090/378 , A61N7/02
摘要： Systems and methods for visualizing formation of ablation lesions are provided therein. The systems and methods achieve this by alternately performing ultrasound imaging for a short time interval and performing ablation for a short time interval such that the ultrasound imaging appears to show the ablation occurring in real time.
摘要翻译：在其中提供用于可视化消融损伤形成的系统和方法。系统和方法通过在短时间间隔交替执行超声成像并且在短时间间隔内执行消融来实现这一点，使得超声成像似乎实时显示消融。

45. 发明授权

US06585635B1 Method and system for pericardial modification 失效
标题翻译：用于心包修复的方法和系统
公开(公告)号：US06585635B1
公开(公告)日：2003-07-01
申请号：US09715866
申请日：2000-11-16
申请人： William N. Aldrich
发明人： William N. Aldrich
IPC分类号： A61N1362
CPC分类号： A61B18/148 , A61B17/320708 , A61B2017/00044 , A61B2017/00084 , A61B2017/00243 , A61B2018/00351 , A61B2018/00791 , A61B2018/046 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2210/122
摘要： The invention adapts the pericardium for use as a pump bladder having a pump cavity formed by at least a portion of the pericardial space between the parietal pericardium and the visceral pericardium. The pump bladder is inflated to provide a compressive pressure on the heart and deflated to relieve the pressure. The pericardium is modified under conditions to improve the pumping characteristics of the pericardium as a pump bladder. A portion of the parietal pericardium may be attached to a portion of the visceral pericardium to isolate a portion of the pericardial space to form the pump cavity. The pericardium may be treated by stiffening, strengthening, tightening, shrinking, reshaping, or reducing the compliance or elasticity of the pericardium, or any combination thereof. The treatment may be carried out by heating the pericardium, applying a chemical to the pericardium, plicating the pericardium, or any combination thereof.
摘要翻译：本发明使心包适用于具有由顶壁心包膜和内脏心包膜之间的至少一部分心包空间形成的泵腔的泵囊。泵囊膨胀以在心脏上提供压缩压力并放气以减轻压力。在改善作为泵囊的心包的泵送特性的条件下改变心包。顶叶心包的一部分可以附着到内脏心包的一部分，以隔离一部分心包空间以形成泵腔。心包可以通过加强，加强，收紧，收缩，整形或降低心包的顺应性或弹性或其任何组合来治疗。治疗可以通过加热心包膜，将化学药物施加到心包膜，使心包化合物或其任何组合来进行。

46. 发明授权

US06197042B1 Vascular sheath with puncture site closure apparatus and methods of use 有权
公开(公告)号：US06197042B1
公开(公告)日：2001-03-06
申请号：US09478179
申请日：2000-01-05
申请人： Richard S. Ginn , William N. Aldrich
发明人： Richard S. Ginn , William N. Aldrich
IPC分类号： A61B1704
CPC分类号： A61B17/10 , A61B17/00491 , A61B17/0057 , A61B17/064 , A61B17/083 , A61B17/128 , A61B2017/00637 , A61B2017/00663 , A61B2017/00668 , A61B2017/00862 , A61B2017/0641 , A61M25/0662
摘要： Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes an advanceable resilient spring clip with an expanded delivery configuration in which opposing sides do not contact one another, and an unstressed deployed configuration, in which opposing sides close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The sheath then is withdrawn, thereby causing the clip to resiliently return to its unstressed deployed configuration and draw opposing sides of the puncture together to seal the wound.

47. 发明授权

US5739975A Memory storage module for staring and accessing magnetically encoded data on linear tracks 失效
标题翻译：用于在线性轨道上凝视和访问磁编码数据的存储器存储模块
公开(公告)号：US5739975A
公开(公告)日：1998-04-14
申请号：US606170
申请日：1996-02-23
申请人： A. Harold Parks , James R. W. Clymer , Douglas A. Reim , William N. Aldrich , Ajeet Singh , Albert S. Hoagland , Hi-Dong Chai
发明人： A. Harold Parks , James R. W. Clymer , Douglas A. Reim , William N. Aldrich , Ajeet Singh , Albert S. Hoagland , Hi-Dong Chai
IPC分类号： G11B19/00 , G11B5/008 , G11B5/02 , G11B5/31 , G11B5/48 , G11B5/55 , G11B7/0033 , G11B7/14 , G11B17/04 , G11B17/34 , G11B21/02 , G11B21/08 , G11B21/10 , G11B25/04 , H02K41/035 , G11B5/52
CPC分类号： G11B5/00808 , G11B17/0408 , G11B17/34 , G11B21/02 , G11B21/083 , G11B21/088 , G11B21/10 , G11B25/04 , G11B5/00804 , G11B5/3103 , G11B5/313 , G11B5/488 , G11B5/55 , G11B7/0033 , G11B7/14 , H02K41/0356 , H02K2201/18
摘要： A memory storage module for storing and accessing information which includes a flat storage medium having an X-axis and a Y-axis. A plurality of read/write heads are coupled to a head array assembly which is capable of motion along the X-axis. The head array assembly positions the heads adjacent to the medium. An X-axis motor is coupled to the head array assembly and causes the heads to undergo reciprocating substantially linear motion along the X-axis of the medium. A Y-axis motor creates linear motion between the heads and the medium along the Y-axis of the medium. The heads are controlled to store or access information on the medium as the heads move across the X-axis of the medium. The Y-axis motor moves the heads from track to track along the Y-axis of the medium. The Y-axis motor can be connected to move either the medium or the head array assembly along the Y-axis.
摘要翻译：一种用于存储和访问包括具有X轴和Y轴的平面存储介质的信息的存储器存储模块。多个读/写头耦合到能够沿X轴运动的头阵列组件。磁头阵列组件将磁头定位在与介质相邻的位置。 X轴电动机联接到磁头阵列组件，并使磁头沿着介质的X轴进行往复运动基本上的直线运动。 Y轴电动机沿着介质的Y轴在头部和介质之间产生线性运动。当头部移动到介质的X轴上时，头被控制以存储或访问介质上的信息。 Y轴电动机将磁头从磁道沿介质的Y轴移动到轨道。 Y轴电机可以连接，以沿着Y轴移动介质或头阵列组件。

48. 发明授权

US5521774A Memory storage module for storing and accessing 失效
标题翻译：用于存储和访问的存储器存储模块
公开(公告)号：US5521774A
公开(公告)日：1996-05-28
申请号：US215140
申请日：1994-03-18
申请人： A. Harold Parks , James R. W. Clymer , Douglas A. Reim , William N. Aldrich , Ajeet Singh , Albert S. Hoagland , Hi-Dong Chai
发明人： A. Harold Parks , James R. W. Clymer , Douglas A. Reim , William N. Aldrich , Ajeet Singh , Albert S. Hoagland , Hi-Dong Chai
IPC分类号： G11B19/00 , G11B5/008 , G11B5/02 , G11B5/31 , G11B5/48 , G11B5/55 , G11B7/0033 , G11B7/14 , G11B17/04 , G11B17/34 , G11B21/02 , G11B21/08 , G11B21/10 , G11B25/04 , H02K41/035 , G11B5/52
CPC分类号： G11B5/00808 , G11B17/0408 , G11B17/34 , G11B21/02 , G11B21/083 , G11B21/088 , G11B21/10 , G11B25/04 , G11B5/00804 , G11B5/3103 , G11B5/313 , G11B5/488 , G11B5/55 , G11B7/0033 , G11B7/14 , H02K41/0356 , H02K2201/18
摘要： A memory storage module for storing and accessing information which includes a flat storage medium having an X-axis and a Y-axis. A plurality of read/write heads are coupled to a head array assembly which is capable of motion along the X-axis. The head array assembly positions the heads adjacent to the medium. An X-axis motor is coupled to the head array assembly and causes the heads to undergo reciprocating substantially linear motion along the X-axis of the medium. A Y-axis motor creates linear motion between the heads and the medium along the Y-axis of the medium. The heads are controlled to store or access information on the medium as the heads move across the X-axis of the medium. The Y-axis motor moves the heads from track to track along the Y-axis of the medium. The Y-axis motor can be connected to move either the medium or the head array assembly along the Y-axis.
摘要翻译：一种用于存储和访问包括具有X轴和Y轴的平面存储介质的信息的存储器存储模块。多个读/写头耦合到能够沿X轴运动的头阵列组件。磁头阵列组件将磁头定位在与介质相邻的位置。 X轴电动机联接到磁头阵列组件，并使磁头沿着介质的X轴进行往复运动基本上的直线运动。 Y轴电动机沿着介质的Y轴在头部和介质之间产生线性运动。当头部移动到介质的X轴上时，头被控制以存储或访问介质上的信息。 Y轴电动机将磁头从磁道沿介质的Y轴移动到轨道。 Y轴电机可以连接，以沿着Y轴移动介质或头阵列组件。

49. 发明授权

US08758396B2 Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use 有权
标题翻译：血管鞘与生物可吸收性穿刺部位闭合装置及使用方法
公开(公告)号：US08758396B2
公开(公告)日：2014-06-24
申请号：US11411925
申请日：2006-04-27
申请人： Richard S. Ginn , William N. Aldrich
发明人： Richard S. Ginn , William N. Aldrich
IPC分类号： A61D1/00
CPC分类号： A61B17/0643 , A61B17/0057 , A61B17/064 , A61B17/083 , A61B17/1285 , A61B17/3415 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641 , A61M25/0662
摘要： Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes a fastener and an advanceable, deformable clip having a delivery configuration in which opposing sides do not contact one another, and a deployed configuration, in which the fastener causes opposing sides of the deformable clip to close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The clip is then deformed with the fastener to draw opposing sides of the puncture together, and the sheath is withdrawn to seal the wound. The clip and fastener preferably are bioabsorbable.
摘要翻译：提供了用于密封血管穿刺部位的装置和方法。本发明包括具有集成闭合部件的引导器护套。闭合部件包括紧固件和可推进的可变形夹具，其具有相对侧面不彼此接触的输送构造，以及展开构造，其中紧固件使可变形夹的相对侧面彼此靠近。夹子沿护套前进，直到穿刺部位穿过血管壁的相对侧。然后夹子用紧固件变形以将穿刺的相对侧拉在一起，并且将护套取出以密封伤口。夹和紧固件优选是生物可吸收的。

50. 发明授权

US08486108B2 Closure device and methods for making and using them 有权
公开(公告)号：US08486108B2
公开(公告)日：2013-07-16
申请号：US11344891
申请日：2006-02-01
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

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