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41. 发明授权

US07243367B2 Method and apparatus for starting up a network or fabric 有权
标题翻译：用于启动网络或结构的方法和设备
公开(公告)号：US07243367B2
公开(公告)日：2007-07-10
申请号：US10062860
申请日：2002-01-31
申请人： James Kleinsteiber , Richard L. Hammons , Shankar Balasubramanian
发明人： James Kleinsteiber , Richard L. Hammons , Shankar Balasubramanian
IPC分类号： G06F7/04 , G06F15/16 , H04L9/00 , H04L12/00
CPC分类号： H04L63/0869 , H04L49/357
摘要： A method and system for starting up a network or network device with particular discussion regarding Fibre Channel networks and switches. The method and system relate to powering on or re-starting a plurality of Fibre Channel switching devices, each of those devices having ports. The system generally calls for the selection of a priority threshold that relates to the importance of tasks in fabric formation. Some embodiments of the system exploit a port authentication procedure to separate the execution of tasks higher in priority than the threshold from tasks lower in priority than the threshold.
摘要翻译：一种用于启动网络或网络设备的方法和系统，具体涉及光纤通道网络和交换机。该方法和系统涉及为多个光纤通道交换设备供电或重新启动，每个设备具有端口。系统通常要求选择与织物形成中的任务的重要性有关的优先级阈值。该系统的一些实施例利用端口认证过程，从优先级低于阈值的任务中分离优先级高于阈值的任务的执行。

42. 发明申请

US20060064743A1 Network security through configuration servers in the fabric environment 审中-公开
公开(公告)号：US20060064743A1
公开(公告)日：2006-03-23
申请号：US11269437
申请日：2005-11-08
申请人： Richard Hammons , James Kleinsteiber , Hung Nguyen , Shankar Balasubramanian , Vidya Renganarayanan
发明人： Richard Hammons , James Kleinsteiber , Hung Nguyen , Shankar Balasubramanian , Vidya Renganarayanan
IPC分类号： H04L9/32 , G06F17/30 , G06F15/16 , G06F7/04 , G06F7/58 , G06K19/00 , G06K9/00
CPC分类号： H04L63/0823 , H04L63/0428 , H04L63/101
摘要： A network configuration device or entity has control of defined management and security functions in the network, or in many embodiments, in a Fibre Channel fabric. The network configuration device may control many functions. Foremost, it may control the recognition, operation and succession procedure for network configuration entities. It may also control user configurable options for the network, rules for interaction between other entities in the network, rules governing management-level access to the network, and rules governing management-level access to individual devices in the network. In addition, the network configuration entity may exploit policy sets to implement its control.

43. 发明申请

US20060035233A1 Recovery of original template 审中-公开
标题翻译：恢复原始模板
公开(公告)号：US20060035233A1
公开(公告)日：2006-02-16
申请号：US10537188
申请日：2003-12-02
申请人： Niall Gormley , Shankar Balasubramanian
发明人： Niall Gormley , Shankar Balasubramanian
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6837 , C12Q2525/301 , C12Q2521/301 , C12Q2521/313
摘要： The present invention relates to methods for regenerating a single-stranded nucleic acid template following its conversion to a double-stranded product, e.g., during a polymerase reaction, and also to regenerating a hairpin or anchoring sequence by removal of the template and its synthesized complement, by design of enzyme restriction sites into the hairpin or anchoring sequence.
摘要翻译：本发明涉及在转化成双链产物之后，例如在聚合酶反应期间再生单链核酸模板的方法，还涉及通过除去模板及其合成的补体来再生发夹或锚定序列通过将酶限制性位点设计到发夹或锚定序列中。

44. 发明授权

US06787308B2 Arrayed biomolecules and their use in sequencing 有权
公开(公告)号：US06787308B2
公开(公告)日：2004-09-07
申请号：US09771708
申请日：2001-01-30
申请人： Shankar Balasubramanian , David Klenerman , David Bentley
发明人： Shankar Balasubramanian , David Klenerman , David Bentley
IPC分类号： C12Q168
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , C12Q2525/301 , C40B40/06 , C40B60/14 , C12Q2521/501 , C12Q2565/507
摘要： A device comprising an array of molecules immobilised on a solid surface is disclosed, wherein the array has a surface density which allows each molecule to be individually resolved, e.g. by optical microscopy. Therefore, the arrays of the present invention consist of single molecules are more spatially distinct than the arrays of the prior art.

45. 发明授权

US09959278B1 Method and system for supporting block-level incremental backups of file system volumes using volume pseudo devices 有权
公开(公告)号：US09959278B1
公开(公告)日：2018-05-01
申请号：US13248408
申请日：2011-09-29
申请人： Vaibhav Khanduja , Shankar Balasubramanian
发明人： Vaibhav Khanduja , Shankar Balasubramanian
IPC分类号： G06F17/30 , G06F11/14
CPC分类号： G06F17/30088 , G06F11/1446
摘要： A method for performing block-level incremental backups of file system volumes using a pseudo device layer of a volume manager. A driver associated with a snapshot backup program is configured to back up the full pseudo disk upon receipt of a backup request, and not automatically performed upon startup. Incremental backups are performed thereafter using a driver that has been modified to include a monitor that tracks writes during backups. The standard I/O routine of the kernel is overwritten with an I/O routine that tracks write operations. The volume manager is called back to perform the incremental backup operations upon each write operation. The going down routine of the kernel is also overwritten to track any updates to the volume manager. If the volume manager is updated, the data structure is cleared and future backups are performed from a subsequent full backup.

46. 发明授权

US09712613B2 Fibre channel fabric copy service 有权
公开(公告)号：US09712613B2
公开(公告)日：2017-07-18
申请号：US10425567
申请日：2003-04-29
申请人： Shankar Balasubramanian , Balakumar N. Kaushik , Richard L. Hammons
发明人： Shankar Balasubramanian , Balakumar N. Kaushik , Richard L. Hammons
IPC分类号： H04L29/08 , H04L29/06
CPC分类号： H04L67/1095 , H04L29/06 , H04L67/1097 , H04L69/329
摘要： Copy capability moved into the SAN fabric and provided as a data mover service. A well-known address is utilized to receive copy commands from the hosts. Each switch in the fabric contains a front end or service interface which receives the copy command and manages access control or zoning and LUN mapping. LUN mapping and zoning are based on shared databases. Assuming correct zoning, the service interface will perform any necessary LUN mapping on the received copy command and forward the command to a copy engine to perform the copy operation. The switch service interface also maintains copy operation status, querying the copy engine if necessary, so that any host status requests are also simply handled. Additionally, if multiple copy engines are present, the switches can communicate to perform load balancing.

47. 发明申请

US20160258014A1 METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION 审中-公开
标题翻译：检测核型修饰的方法
公开(公告)号：US20160258014A1
公开(公告)日：2016-09-08
申请号：US15075370
申请日：2016-03-21
申请人： Michael John Booth , Shankar Balasubramanian
发明人： Michael John Booth , Shankar Balasubramanian
IPC分类号： C12Q1/68 , C01G55/00 , C07H1/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6876 , C01G55/002 , C07H1/00 , C07H21/02 , C07H21/04 , C12Q1/6806 , C12Q1/6827 , C12Q2600/154 , C12Q2523/115 , C12Q2523/125
摘要： This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.
摘要翻译：本发明涉及在样本核苷酸序列中鉴定与胞嘧啶（C）不同的修饰胞嘧啶残基如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。方法可以包括氧化或还原包含样品核苷酸序列的多核苷酸的第一部分; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 识别与样品核苷酸序列中的胞嘧啶残基相对应的第一和第二核苷酸序列中的残基。这些方法可能是有用的，例如在基因组DNA和/或RNA的分析中。

48. 发明授权

US09290807B2 Methods for detection of nucleotide modification 有权
标题翻译：核苷酸修饰检测方法
公开(公告)号：US09290807B2
公开(公告)日：2016-03-22
申请号：US14235707
申请日：2012-07-27
申请人： Michael John Booth , Shankar Balasubramanian
发明人： Michael John Booth , Shankar Balasubramanian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C01G55/002 , C07H1/00 , C07H21/02 , C07H21/04 , C12Q1/6806 , C12Q1/6827 , C12Q2600/154 , C12Q2523/115 , C12Q2523/125
摘要： This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidizing or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidized or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.
摘要翻译：本发明涉及在样本核苷酸序列中鉴定与胞嘧啶（C）不同的修饰胞嘧啶残基如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。方法可以包括氧化或还原包含样品核苷酸序列的多核苷酸的第一部分; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 识别与样品核苷酸序列中的胞嘧啶残基相对应的第一和第二核苷酸序列中的残基。这些方法可能是有用的，例如在基因组DNA和/或RNA的分析中。

49. 发明授权

US09128943B1 Method and system for tracking re-sizing and re-creation of volumes created for making incremental backups 有权
标题翻译：跟踪重新定义和重新创建用于进行增量备份创建的卷的方法和系统
公开(公告)号：US09128943B1
公开(公告)日：2015-09-08
申请号：US13248223
申请日：2011-09-29
申请人： Vaibhav Khanduja , Shankar Balasubramanian , Sureshbabu Murugesan
发明人： Vaibhav Khanduja , Shankar Balasubramanian , Sureshbabu Murugesan
IPC分类号： G06F17/30
CPC分类号： G06F17/30091 , G06F11/1451 , G06F11/1458 , G06F2201/84
摘要： A method for tracking resizing and recreation of volumes in a block-based snapshot backup program. In an embodiment, a record ID is associated with a major and minor number assigned to each volume to be backed up. The record ID maintains a unique reference to the bitmap corresponding to a backed up volume in case the minor number is reused by the volume manager driver during a recreate operation. The length of the volume to be maintained is maintained and compared to the length of the to track any resizing of the volume by the volume manager. In the event of any resizing or recreation, the original bitmap can be replaced with an updated bitmap to ensure proper backup of the resized or recreated volumes.
摘要翻译：在基于块的快照备份程序中跟踪卷的大小和重建的方法。在一个实施例中，记录ID与分配给要备份的每个卷的主号码和次号相关联。记录ID维护对与备份卷相对应的位图的唯一引用，以防在重新创建操作期间由卷管理器驱动程序重复使用次要编号。要维护的卷的长度被维护，并且与卷管理器跟踪卷的任何调整大小的长度进行比较。在任何调整大小或娱乐的情况下，可以使用更新的位图替换原始位图，以确保对已调整大小或重新创建的卷的正确备份。

50. 发明授权

US08623628B2 Polymerases 有权
公开(公告)号：US08623628B2
公开(公告)日：2014-01-07
申请号：US11431939
申请日：2006-05-10
申请人： Tobias William Barr Ost , Geoffrey Paul Smith , Shankar Balasubramanian , Roberto Rigatti , Raquel Maria Sanches
发明人： Tobias William Barr Ost , Geoffrey Paul Smith , Shankar Balasubramanian , Roberto Rigatti , Raquel Maria Sanches
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C12Q1/686 , C12Y207/07007
摘要： Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.

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