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41. 发明授权

US08343526B2 Methods and apparatuses for conducting assays 有权
标题翻译：用于进行测定的方法和装置
公开(公告)号：US08343526B2
公开(公告)日：2013-01-01
申请号：US13275398
申请日：2011-10-18
申请人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
发明人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
IPC分类号： G01N35/08 , G01N33/86 , C12M1/38 , C12M3/00
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
摘要翻译：公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。

42. 发明申请

US20120276656A1 Multiplexed Assay Methods 有权
标题翻译：多重测定方法
公开(公告)号：US20120276656A1
公开(公告)日：2012-11-01
申请号：US13549635
申请日：2012-07-16
申请人： Selen A. Stromgren , Eli N. Glezer
发明人： Selen A. Stromgren , Eli N. Glezer
IPC分类号： G01N21/76
CPC分类号： G01N33/54306 , G01N2333/575 , G01N2333/62 , Y10S436/807 , Y10S436/809
摘要： The present invention is directed to methods for conducting multiplexed assays. The methods are particularly well suited for measuring a plurality of analytes that may be present in very different abundances. The invention also relates to systems, devices, equipment, kits and reagents for use in such methods.
摘要翻译：本发明涉及用于进行多重测定的方法。该方法特别适用于测量可能存在非常不同丰度的多种分析物。本发明还涉及用于这些方法的系统，装置，设备，试剂盒和试剂。

43. 发明授权

US08298834B2 Assay modules having assay reagents and methods of making and using same 有权
标题翻译：具有测定试剂的测定模块及其制备和使用方法
公开(公告)号：US08298834B2
公开(公告)日：2012-10-30
申请号：US12871946
申请日：2010-08-31
申请人： Eli N. Glezer , Bandele Jeffrey-Coker , Jeff D. Debad , Sudeep M. Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
发明人： Eli N. Glezer , Bandele Jeffrey-Coker , Jeff D. Debad , Sudeep M. Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
IPC分类号： G01N33/543
CPC分类号： B01L3/5025 , B01L3/5085 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/105 , G01N33/54366 , G01N33/54393 , Y10S436/809
摘要： We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
摘要翻译：我们描述测定模块（例如，测定板，盒，多孔测定板，反应容器等），其制备方法及其用于进行测定的方法。试剂可以以游离形式存在或在固相上负载，包括测定模块或胶体，珠粒或其它颗粒载体表面的隔室（例如，室，通道，流动池，孔等）的表面。特别地，干试剂可以并入到这些测定模块的隔室中，并根据测定方法在使用之前重构。干燥剂材料可用于在干燥状态下维持和稳定这些试剂。

44. 发明申请

US20120058916A1 DIAGNOSTIC METHODS FOR LIVER DISORDERS 审中-公开
标题翻译：肝脏疾病诊断方法
公开(公告)号：US20120058916A1
公开(公告)日：2012-03-08
申请号：US13319540
申请日：2010-04-29
申请人： Eli N. Glezer , Anu Mathew , Martin Stengelin , Mingyue Wang
发明人： Eli N. Glezer , Anu Mathew , Martin Stengelin , Mingyue Wang
IPC分类号： C40B30/04 , G01N33/566 , C40B30/00
CPC分类号： G01N33/57438 , G01N2333/47 , G01N2333/4725 , G01N2333/70503 , G01N2400/00 , G01N2800/085 , G01N2800/56
摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
摘要翻译：本发明涉及诊断患者肝脏疾病的方法，以及监测肝脏疾病进展的方法和/或监测治疗剂或化疗方案治疗方案的方法。本发明还涉及结合本文所述的诊断方法使用的测定方法。

45. 发明申请

US20120046197A1 BIOMARKERS OF THERAPEUTIC RESPONSIVENESS 审中-公开
标题翻译：治疗应答生物标志物
公开(公告)号：US20120046197A1
公开(公告)日：2012-02-23
申请号：US13318174
申请日：2010-04-29
申请人： Eli N. Glezer , Anu Mathew
发明人： Eli N. Glezer , Anu Mathew
IPC分类号： C40B30/04 , G01N33/566 , G01N33/573 , C40B30/00
CPC分类号： G01N33/543 , G01N33/57438 , G01N2800/52
摘要： The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
摘要翻译：本发明涉及诊断患者肾脏疾病的方法，以及监测肾脏疾病进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。本发明还涉及结合本文所述的诊断方法使用的测定方法。

46. 发明授权

US08012745B2 Assay cartridges and methods of using the same 有权
标题翻译：分析墨盒和使用方法
公开(公告)号：US08012745B2
公开(公告)日：2011-09-06
申请号：US12244133
申请日：2008-10-02
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
摘要翻译：测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。

47. 发明申请

US20100316992A1 DIAGNOSTIC TEST 审中-公开
标题翻译：诊断测试
公开(公告)号：US20100316992A1
公开(公告)日：2010-12-16
申请号：US12818093
申请日：2010-06-17
申请人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： C12Q1/70 , C40B30/04 , G01N33/566
CPC分类号： G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
摘要翻译：公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。还描述了通过管理本发明的测试来监测患者的方法。还描述了通过管理本发明的测试来监测患者治疗的方法。还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。还公开了用于确定分析物的有用性的方法，例如，用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。

48. 发明授权

US07776583B2 Methods and apparatuses for conducting assays 有权
标题翻译：用于进行测定的方法和装置
公开(公告)号：US07776583B2
公开(公告)日：2010-08-17
申请号：US11145528
申请日：2005-06-03
申请人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
发明人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
IPC分类号： C12M1/36 , G01N33/53 , G01N35/08
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
摘要翻译：公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。

49. 发明申请

US20090065357A1 Assay Cartridges and Methods of Using the Same 有权
公开(公告)号：US20090065357A1
公开(公告)日：2009-03-12
申请号：US12244119
申请日：2008-10-02
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC分类号： G01N27/327 , G01N27/30
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

50. 发明授权

US07497997B2 Assay cartridges and methods of using the same 有权
标题翻译：分析墨盒和使用方法
公开(公告)号：US07497997B2
公开(公告)日：2009-03-03
申请号：US10744726
申请日：2003-12-23
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC分类号： B01L9/00 , B01L11/00 , G01N1/00 , G01N21/00 , G01N33/53 , C12Q1/00 , C12Q1/68
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
摘要翻译：测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。

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