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41. 发明授权

US07181283B2 System and method for controlling implantable medical device parameters in response to atrial pressure attributes 有权
标题翻译：用于根据心房压力属性控制植入式医疗装置参数的系统和方法
公开(公告)号：US07181283B2
公开(公告)日：2007-02-20
申请号：US11097408
申请日：2005-03-31
申请人： Douglas A. Hettrick , Todd M. Zielinski , Amber L Jaeger , Nicole M. Campbell
发明人： Douglas A. Hettrick , Todd M. Zielinski , Amber L Jaeger , Nicole M. Campbell
IPC分类号： A61N1/365 , A61B5/021
CPC分类号： A61N1/36564
摘要： In an implantable medical device a real-time left atrial pressure (“LAP”) signal obtained from a patient's heart is used as a feedback control mechanism to adjust one or more device parameters. In one example the device identifies specific characteristics and attributes of the LAP signal that correlate to hemodynamic performance, and adjusts the device parameters to optimize the LAP characteristics and attributes. In a dual-chamber pacing system, the controlled operating parameter may include the atrioventricular pacing delay, and LAP attribute suitable for controlling the atrioventricular pacing delay time intervals of v-wave, a-wave, and/or c-wave characteristics of the LAP signal.
摘要翻译：在可植入医疗装置中，使用从患者心脏获得的实时左心房压力（“LAP”）信号作为反馈控制机构来调节一个或多个装置参数。在一个示例中，设备识别与血液动力学性能相关的LAP信号的特定特征和属性，并且调整设备参数以优化LAP特征和属性。在双室起搏系统中，受控操作参数可以包括房室起搏延迟，并且LAP属性适用于控制LAP的v波，a波和/或c波特征的房室起搏延迟时间间隔信号。

42. 发明授权

US07065398B2 Atrial tachycardia termination sensing 失效
标题翻译：房性心动过速终止感知
公开(公告)号：US07065398B2
公开(公告)日：2006-06-20
申请号：US10260845
申请日：2002-09-30
申请人： Douglas A. Hettrick , Jacqueline Mittelstadt
发明人： Douglas A. Hettrick , Jacqueline Mittelstadt
IPC分类号： A61B5/452
CPC分类号： A61N1/3622 , A61B5/0464
摘要： Techniques for preventing inadvertent detection of AT termination may involve predicting potential undersensing of atrial events, and delaying detection of AT termination when undersensing of atrial events is predicted. For example, an implantable medical device may measure ventricular-atrial (VA) intervals of a heart rhythm using tracked atrial and ventricular events. The device calculates a slope of the series of the VA intervals, and estimates a prospective VA interval using the calculated slope and the most recently measured VA interval. The device determines whether the estimated VA interval is within a threshold range. When the estimated VA interval is outside of the threshold range, the device predicts possible undersensing of atrial events and delays detection of the AT episode termination. The delay detection of AT episode termination improves the accuracy of information collected by event counters.
摘要翻译：用于防止无意识地检测AT终止的技术可能涉及预测心房事件的潜在不足，并且在预测心房事件不足时延迟AT终止的检测。例如，可植入医疗装置可以使用跟踪的心房和心室事件来测量心律的心室（VA）间隔。该装置计算一系列VA间隔的斜率，并使用计算的斜率和最近测量的VA间隔来估计预期的VA间隔。该装置确定估计的VA间隔是否在阈值范围内。当估计的VA间隔超出阈值范围时，该装置预测心房事件可能的不足，并延迟检测AT发作终止。 AT事件终止的延迟检测提高了事件计数器收集的信息的准确性。

43. 发明申请

US20220370112A1 METHODS FOR TREATING EATING DISORDERS IN PATIENTS VIA RENAL NEUROMODULATION 有权
公开(公告)号：US20220370112A1
公开(公告)日：2022-11-24
申请号：US17815509
申请日：2022-07-27
申请人： Gabriel Lazarus , Douglas A. Hettrick
发明人： Gabriel Lazarus , Douglas A. Hettrick
IPC分类号： A61B18/00 , A61F7/12 , G16H20/60 , G16H20/40
摘要： Methods for treating eating disorders and for reducing a risk associated with developing an eating disorder in patients via therapeutic renal neuromodulation and associated systems. Renal sympathetic nerve activity can be attenuated to improve a patient's eating disorder status or risk of developing an eating disorder. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to modulate the renal sympathetic nerve.

44. 发明申请

US20220354581A1 DENERVATION THERAPY 有权
公开(公告)号：US20220354581A1
公开(公告)日：2022-11-10
申请号：US17814757
申请日：2022-07-25
申请人： Paul J. Coates , Douglas A. Hettrick
发明人： Paul J. Coates , Douglas A. Hettrick
IPC分类号： A61B34/10 , A61B6/03 , A61B18/14 , A61B18/06 , A61B18/24 , A61B34/00 , A61B90/00 , A61B5/0536 , A61B5/055 , A61B8/08 , A61B5/20 , A61B5/00 , G16H50/50 , A61B6/00
摘要： Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

45. 发明授权

US09713701B2 Using multiple diagnostic parameters for predicting heart failure events 有权
公开(公告)号：US09713701B2
公开(公告)日：2017-07-25
申请号：US12184003
申请日：2008-07-31
申请人： Shantanu Sarkar , Douglas A. Hettrick , Robert W. Stadler
发明人： Shantanu Sarkar , Douglas A. Hettrick , Robert W. Stadler
IPC分类号： A61N1/365 , A61M37/00 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/11
CPC分类号： A61B5/0422 , A61B5/0205 , A61B5/021 , A61B5/046 , A61B5/0464 , A61B5/0537 , A61B5/0538 , A61B5/08 , A61B5/1118 , A61B2562/0219 , A61M5/1723 , A61M37/00 , A61M2230/04 , A61M2230/42 , A61N1/36585
摘要： Techniques for using multiple physiological parameters to provide an early warning for worsening heart failure are described. A medical device monitors a primary diagnostic parameter that is indicative of worsening heart failure, such as intrathoracic impedance or pressure, and one or more secondary diagnostic parameters. The medical device detects worsening heart failure in the patient based on the primary diagnostic parameter when an index that is changed over time based on the primary diagnostic parameter value is outside a range of values, termed the threshold zone. When the index is within the threshold zone, the medical device detects worsening heart failure in the patient based on the one or more secondary diagnostic parameters. Upon detecting worsening heart failure, the medical device may, for example, provide an alert that enables the patient to seek medical attention before experiencing a heart failure event.

46. 发明授权

US09037237B2 Algorithm to modulate atrial-ventricular delay and rate response based on autonomic function 有权
标题翻译：基于自主功能调制心房延迟和速率反应的算法
公开(公告)号：US09037237B2
公开(公告)日：2015-05-19
申请号：US12787058
申请日：2010-05-25
申请人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
发明人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365 , A61B5/0456
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

47. 发明授权

US08914101B2 System and method to localize changes in intrathoracic fluid content using measured impedance in an implantable device 有权
标题翻译：使用可植入装置中测量的阻抗来定位胸腔内液体含量变化的系统和方法
公开(公告)号：US08914101B2
公开(公告)日：2014-12-16
申请号：US12261131
申请日：2008-10-30
申请人： Douglas A. Hettrick , Shantanu Sarkar , Todd M. Zielinksi , Kevin P. Knox
发明人： Douglas A. Hettrick , Shantanu Sarkar , Todd M. Zielinksi , Kevin P. Knox
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/0536 , A61B5/0537 , A61B5/0538 , A61B5/4878
摘要： An implantable medical device and associated methods monitor thoracic fluid status and discriminate thoracic fluid conditions. Intrathoracic impedance is measured along multiple intrathoracic measurement vectors using implanted electrodes. A map of thoracic conductivity is computed using the measured intrathoracic impedances. A thoracic fluid condition is detected in response to the computed map.
摘要翻译：可植入医疗器械和相关方法监测胸腔液状态并辨别胸腔液体状况。使用植入电极沿多个胸腔内测量载体测量胸内阻抗。使用测量的胸腔内阻抗计算胸导电图。根据计算的图检测胸部液体状况。

48. 发明授权

US08831721B2 Pressure and impedance based discrimination of hemodynamic stability 有权
标题翻译：基于压力和阻抗的区分血流动力学稳定性
公开(公告)号：US08831721B2
公开(公告)日：2014-09-09
申请号：US12108785
申请日：2008-04-24
申请人： Douglas A. Hettrick , Kevin P. Vincent , Shantanu Sarkar , Yong K. Cho , Todd M. Zielinski
发明人： Douglas A. Hettrick , Kevin P. Vincent , Shantanu Sarkar , Yong K. Cho , Todd M. Zielinski
IPC分类号： A61N1/00 , A61N1/365 , A61B5/053 , A61N1/39 , A61B5/00
CPC分类号： A61N1/36585 , A61B5/0535 , A61B5/0538 , A61B5/7264 , A61N1/00 , A61N1/36521 , A61N1/36564 , A61N1/3962
摘要： An implantable cardioverter defibrillator evaluates the hemodynamic stability of an arrhythmia to determine whether or not to defibrillate. The device obtains cardiac pressure and cardiac impedance data and evaluates a phase relationship between these parameters. Hemodynamically stable rhythms will result in an out of phase relationship.
摘要翻译：植入式心律转复除颤器评估心律失常的血液动力学稳定性，以确定是否除颤。该装置获得心脏压力和心脏阻抗数据，并评估这些参数之间的相位关系。血液动力学稳定的节律将导致异相关系。

49. 发明申请

US20130030319A1 CARDIAC MONITORING USING SPINAL CORD STIMULATION ELECTRODES 审中-公开
标题翻译：使用脊髓刺激电极进行心脏监测
公开(公告)号：US20130030319A1
公开(公告)日：2013-01-31
申请号：US13562112
申请日：2012-07-30
申请人： Douglas A. Hettrick , Pascalle Reiters , Shantanu Sarkar , Todd M. Zielinski
发明人： Douglas A. Hettrick , Pascalle Reiters , Shantanu Sarkar , Todd M. Zielinski
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0215 , A61B5/0537 , A61B5/0826 , A61B5/4875 , A61B5/686 , A61N1/0551 , A61N1/36114
摘要： Methods and systems for use in cardiac monitoring may periodically measure intrathoracic impedance using one or more pairs of electrodes and analyze measured impedance values to identify changes in the patient's thoracic fluid content for use in cardiac monitoring. The intrathoracic impedance is measured using at least one spinal cord stimulation electrode.
摘要翻译：用于心脏监测的方法和系统可以使用一对或多对电极周期性地测量胸内阻抗，并分析测量的阻抗值以识别用于心脏监测的患者胸腔内容物的变化。使用至少一个脊髓刺激电极测量胸内阻抗。

50. 发明授权

US07856269B2 System and method for determining phsyiologic events during pacing mode operation 有权
标题翻译：用于在起搏模式操作期间确定phsyiologic事件的系统和方法
公开(公告)号：US07856269B2
公开(公告)日：2010-12-21
申请号：US11461162
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

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