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41. 发明授权

US07731951B2 Viruses for the treatment of cellular proliferative disorders 有权
公开(公告)号：US07731951B2
公开(公告)日：2010-06-08
申请号：US11557467
申请日：2006-11-07
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K39/285 , C12N7/01
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.

42. 发明授权

US07252817B2 Viruses for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的病毒
公开(公告)号：US07252817B2
公开(公告)日：2007-08-07
申请号：US10418290
申请日：2003-04-18
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K39/425 , C12N7/01
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

43. 发明授权

US07014847B2 Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 失效
公开(公告)号：US07014847B2
公开(公告)日：2006-03-21
申请号：US10401032
申请日：2003-03-28
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K121/00 , A61K39/15 , A61K39/42 , A61K48/00 , C12N7/01
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells.

44. 发明授权

US06703232B2 Method of producing infectious reovirus 有权
标题翻译：产生感染性呼肠孤病毒的方法
公开(公告)号：US06703232B2
公开(公告)日：2004-03-09
申请号：US10337911
申请日：2003-01-08
申请人： Bradley G. Thompson , Matthew C. Coffey
发明人： Bradley G. Thompson , Matthew C. Coffey
IPC分类号： C12Q168
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051
摘要： A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus.
摘要翻译：使用HEK 293细胞开发生产哺乳动物呼肠孤病毒的简单有效的方法。该方法以高产率快速生产呼肠弧病毒。此外，该方法提供了产生的呼肠孤病毒的更简单的纯化程序。

45. 发明授权

US06649157B2 Viruses for the treatment of cellular proliferative disorders 有权
公开(公告)号：US06649157B2
公开(公告)日：2003-11-18
申请号：US09965294
申请日：2001-09-28
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： C12Q170
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.

46. 发明授权

US06565831B1 Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 有权
标题翻译：用于预防呼肠孤病毒识别用于治疗细胞增殖性疾病的方法
公开(公告)号：US06565831B1
公开(公告)日：2003-05-20
申请号：US09636597
申请日：2000-08-10
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K4800
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells.
摘要翻译：本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。

47. 发明授权

US08685734B2 Viral purification methods 有权
标题翻译：病毒纯化方法
公开(公告)号：US08685734B2
公开(公告)日：2014-04-01
申请号：US11736479
申请日：2007-04-17
申请人： Matthew C. Coffey
发明人： Matthew C. Coffey
IPC分类号： C12N5/00 , C12N7/00 , C12N7/02 , C12N1/02 , C12Q1/70 , C12N5/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C07K14/005 , C12N2720/12051 , C12N2720/12222 , C12N2720/12234 , C12N2720/12251
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
摘要翻译：本发明涉及一种纯化病毒，特别是呼肠弧病毒的改进方法。可以用洗涤剂从细胞培养物中提取传染病毒以产生高滴度的病毒，然后可以通过简单的步骤如过滤和柱层析纯化病毒。还提供了包含根据本发明制备的病毒的病毒和组合物。

48. 发明授权

US08609331B2 Use of ribozymes in the detection of adventitious agents 有权
标题翻译：使用核酶检测外来因子
公开(公告)号：US08609331B2
公开(公告)日：2013-12-17
申请号：US13628499
申请日：2012-09-27
申请人： Matthew C. Coffey
发明人： Matthew C. Coffey
IPC分类号： C12Q1/70 , C12Q1/68 , C12P19/34 , A01N43/04 , C07H21/02
CPC分类号： C12Q1/04 , C12N15/1131 , C12N2310/121 , C12Q1/701 , C12Q2521/337
摘要： The present invention provides a method of detecting adventitious agents in a composition comprising a microorganism by using ribozyme-expressing indicator cells, as well as indicator cells useful in such detection.
摘要翻译：本发明提供了通过使用表达核酶的指示剂细胞以及用于这种检测的指示细胞来检测包含微生物的组合物中的外来物质的方法。

49. 发明授权

US08066985B2 Reovirus for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的呼肠孤病毒
公开(公告)号：US08066985B2
公开(公告)日：2011-11-29
申请号：US12323223
申请日：2008-11-25
申请人： Patrick W. K. Lee , James Strong , Matthew C. Coffey
发明人： Patrick W. K. Lee , James Strong , Matthew C. Coffey
IPC分类号： A61K49/00 , A61K39/15
CPC分类号： A61K9/0019 , A61K35/765 , C12N2720/12032 , C12N2720/12232
摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
摘要翻译：公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。增生性疾病包括但不限于赘生物。可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。如果呼肠孤病毒是人呼肠病毒，则可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney）以及呼肠孤病毒的其它血清型或菌株。可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧病毒。可以治疗实体肿瘤或造血赘生物。

50. 发明授权

US06576234B2 Reovirus for the treatment of neoplasia 有权
标题翻译：呼肠孤病毒治疗瘤形成
公开(公告)号：US06576234B2
公开(公告)日：2003-06-10
申请号：US09852017
申请日：2001-05-10
申请人： Patrick W. K. Lee , James Strong , Matthew C. Coffey
发明人： Patrick W. K. Lee , James Strong , Matthew C. Coffey
IPC分类号： A01N6300
CPC分类号： C12N9/1205 , A61K35/765 , C12N7/00 , C12N2720/12232 , C12N2720/12261
摘要： Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other sterotypes or strains of reovirus can be used. Combinations of more than one type and/or strain or reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
摘要翻译：公开了通过向Ras介导的肿瘤施用呼肠孤病毒和使用呼肠孤病毒来制造用于治疗肿瘤的药物的方法。呼肠病毒的施用使其最终直接接触肿瘤细胞。可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。如果呼肠孤病毒是人呼肠病毒，可以使用1型（例如，菌株Lang），2型（例如菌株琼斯），3型（例如，菌株Dearing或菌株Abney）以及其它定向型或呼肠孤病毒菌株。可以使用多于一种类型和/或菌株或呼肠孤病毒的组合，以及来自不同动物种的呼肠病毒。可以治疗实体肿瘤或造血赘生物。

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