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41. 发明申请

US20060123492A1 Methods of identifying modulators of NMUR2-mediated activity 审中-公开
标题翻译：鉴定NMUR2介导活性的调节剂的方法
公开(公告)号：US20060123492A1
公开(公告)日：2006-06-08
申请号：US11332753
申请日：2006-01-13
申请人： Stanley Wiegand , Andrew Murphy , Susan Croll-Kalish , Richard Torres
发明人： Stanley Wiegand , Andrew Murphy , Susan Croll-Kalish , Richard Torres
IPC分类号： A01K67/00 , G01N33/53 , A61K39/395
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/70571 , G01N33/566 , G01N33/6893 , G01N2500/04
摘要： Methods for screening for agents capable of modulating human neuromedin U receptor 2 (NMUR2) activity are provided, as well as therapeutic methods for treating NMUR2-mediated conditions. More specifically, methods are provided for identifying agents capable of inhibiting NMUR2-mediated pain or nociception.
摘要翻译：提供了能够调节人神经介肽U受体2（NMUR2）活性的试剂的筛选方法，以及用于治疗NMUR2介导的病症的治疗方法。更具体地，提供了用于鉴定能够抑制NMUR2介导的疼痛或伤害感受的药剂的方法。

42. 发明申请

US20050144655A1 Methods of modifying eukaryotic cells 审中-公开
标题翻译：改造真核细胞的方法
公开(公告)号：US20050144655A1
公开(公告)日：2005-06-30
申请号：US10415440
申请日：2001-10-31
申请人： Aris Economides , Andrew Murphy , David Valenzuela , David Frendewey , George Yancopoulos
发明人： Aris Economides , Andrew Murphy , David Valenzuela , David Frendewey , George Yancopoulos
IPC分类号： C12N15/00 , A01K67/027 , C12N5/10 , C12N15/09 , C12N15/79 , C12N15/90 , C12Q1/68 , C12N5/06 , C12N15/85
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C12N5/0606 , C12N15/79 , C12N15/907 , C12N2510/00 , C12N2810/10 , C12Q1/6827
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous genes(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
摘要翻译：一种用于工程化和利用大型DNA载体通过同源重组靶向并以任何所需方式修饰真核细胞中的内源基因和染色体基因座的方法。用于真核细胞的这些大的DNA靶向载体，称为LTVEC，衍生自克隆基因组DNA的片段，大于通常用于在真核细胞中进行同源靶向的其它方法通常使用的那些。还提供了检测真核细胞的快速和方便的方法，其中LTVEC已经正确靶向和修饰所需的内源基因或染色体基因座（基因座）以及这些细胞用于产生具有遗传修饰的生物体。

43. 发明申请

US20050096264A1 Methods for treating obesity and related conditions with glycoprotein hormone beta family hormones 审中-公开
标题翻译：用糖蛋白激素β家族激素治疗肥胖症和相关病症的方法
公开(公告)号：US20050096264A1
公开(公告)日：2005-05-05
申请号：US10990058
申请日：2004-11-16
申请人： Lynn MacDonald , Mark Sleeman , Andrew Murphy
发明人： Lynn MacDonald , Mark Sleeman , Andrew Murphy
IPC分类号： A61K38/00 , C07K14/59 , A61K38/22
CPC分类号： C07K14/59 , A61K38/00
摘要： A method of treating or ameliorating an orphan glycoprotein hormone (OGH)-related condition or a condition which responds to OGH administration, comprising administering an OGH-related compound to a subject in need thereof.
摘要翻译：一种治疗或改善孤儿糖蛋白激素（OGH）相关病症或对OGH给药作出反应的病症的方法，包括向有需要的受试者施用OGH相关化合物。

44. 发明申请

US20050059135A1 Methods and compositions for identifying receptor effectors 失效
标题翻译：用于鉴定受体效应物的方法和组合物
公开(公告)号：US20050059135A1
公开(公告)日：2005-03-17
申请号：US10752478
申请日：2004-01-05
申请人： Christine Klein , Andrew Murphy , Dana Fowlkes , James Broach , John Manfredi , Jeremy Paul , Joshua Trueheart
发明人： Christine Klein , Andrew Murphy , Dana Fowlkes , James Broach , John Manfredi , Jeremy Paul , Joshua Trueheart
IPC分类号： C07K14/395 , C12N5/02 , C12N15/81 , C07H21/04 , C07K14/705 , C12N1/18
CPC分类号： C12N15/81 , C07K14/395 , C07K2319/02
摘要： The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
摘要翻译：本发明提供用于筛选和鉴定与细胞受体或离子通道的活性特异性相互作用并调节其活性的药学有效化合物的快速有效的测定。本发明分析使得能够快速筛选文库中的大量多肽以鉴定诱导或拮抗受体生物活性的那些多肽。主题测定特别适用于鉴定孤儿受体的替代配体。

45. 发明授权

US5746689A Method for transverse-fold pop-up 失效
标题翻译：横折弹出方法
公开(公告)号：US5746689A
公开(公告)日：1998-05-05
申请号：US711253
申请日：1996-09-09
申请人： Andrew Murphy
发明人： Andrew Murphy
IPC分类号： B42D15/04 , G09F1/06 , G09F1/08 , B65H45/30
CPC分类号： B42D15/042 , B42D15/045 , G09F1/06 , G09F1/08 , Y10S493/944
摘要： A method of making a pop-up device for a card, book, novelty, or the like with a sandwich-like structure including a base or back (300), a front or cover (200), and a tongue (130) disposed between. All three sections may be of equal length. The three sections are folded onto one another and glued to make the sandwich. The tongue has a protruding tab end (135) for a user to pull; the end distal the tab end is fastened to a portion of the cover. A pull-slot (325) cut out between the cover and back guides the tongue for pulling to eliminate shims. The cover is slit by two parallel cuts (210) and three crosswise creases. The cuts are parallel to the tongue. The creased portion of the cover pops up when the tongue is pulled by a user. The fold lines are perpendicular to the direction of the tongue movement.
摘要翻译：制造具有三明治结构的卡片，书本，新颖性等的弹出装置的方法，包括底座或背部（300），前部或盖子（200）和舌头（130）之间。所有三个部分可能具有相等的长度。三个部分彼此折叠并粘合以制成三明治。舌头具有用于使用者拉动的突出突出端（135）; 突出端的远端的端部被紧固到盖的一部分。在盖和后面之间切出的拉槽（325）引导舌头拉动以消除垫片。盖子通过两个平行的切口（210）和三个横向折痕分开。切口平行于舌头。当用户拉扯舌头时，盖子的褶皱部分会弹起。折线垂直于舌头运动的方向。

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