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41. 发明授权

US08010177B2 Intraoperative image registration 有权
标题翻译：术中图像注册
公开(公告)号：US08010177B2
公开(公告)日：2011-08-30
申请号：US11739513
申请日：2007-04-24
申请人： Andrew N. Csavoy , Matthew S. Solar , Jeffrey M. Waynik , Mark S. Freas , Thomas I. Miller , Keith Sootsman
发明人： Andrew N. Csavoy , Matthew S. Solar , Jeffrey M. Waynik , Mark S. Freas , Thomas I. Miller , Keith Sootsman
IPC分类号： A61B5/05
CPC分类号： A61B6/5247 , A61B5/055 , A61B6/4441 , A61B34/20 , A61B90/36 , A61B90/37 , A61B2017/00699 , A61B2017/00703 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2034/2055 , A61B2034/256 , A61B2090/363 , A61B2090/364 , A61B2090/365 , A61B2090/367 , A61B2090/376 , G06F19/00
摘要： A system to allow registration of a patient to image space is disclosed. The registration can be performed without touching a plurality of fiducial points on the patient or in the image data. The registration process can eliminate manual steps of image to patient registration and image to image registration.
摘要翻译：公开了允许患者登记到图像空间的系统。可以在不接触患者的多个基准点或图像数据的情况下执行注册。注册过程可以消除图像到患者注册和图像到图像注册的手动步骤。

42. 发明授权

US07981120B2 Trajectory guide with angled or patterned guide lumens or height adjustment 有权
标题翻译：轨迹导轨，带有倾斜或图案化的引导腔或高度调节
公开(公告)号：US07981120B2
公开(公告)日：2011-07-19
申请号：US11738893
申请日：2007-04-23
申请人： Rudy A. Mazzocchi , Matthew S. Solar , Thomas B. Freeman
发明人： Rudy A. Mazzocchi , Matthew S. Solar , Thomas B. Freeman
IPC分类号： A61B19/00
CPC分类号： A61B90/11 , A61B17/3462 , A61B2017/3445 , A61B2017/3449 , A61B2017/3466
摘要： This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.
摘要翻译：本文件讨论了包括仪器指南的轨迹指南，其具有至少一个相对于正交或其它贯穿轴线成角度的内腔。在一个示例中，仪器指南上的图案化流明提供了与目标平面相交的轨迹轴的镜像图案。在另一个示例中，仪器指南的高度调节将这些或其他瞄准技术扩展到三维体积。本文件还描述了制造这种仪器引导件的方法，其也可应用于制造提供平行流明的仪器引导件。

43. 发明授权

US07896889B2 Trajectory guide with angled or patterned lumens or height adjustment 有权
标题翻译：轨迹导轨，带角度或图案流明或高度调节
公开(公告)号：US07896889B2
公开(公告)日：2011-03-01
申请号：US10370090
申请日：2003-02-20
申请人： Rudy A. Mazzocchi , Matthew S. Solar , Thomas B. Freeman
发明人： Rudy A. Mazzocchi , Matthew S. Solar , Thomas B. Freeman
IPC分类号： A61B19/00
CPC分类号： A61B90/11 , A61B17/3462 , A61B2017/3445 , A61B2017/3449 , A61B2017/3466
摘要： This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.
摘要翻译：本文件讨论了包括仪器指南的轨迹指南，其具有至少一个相对于正交或其它贯穿轴线成角度的内腔。在一个示例中，仪器指南上的图案化流明提供了与目标平面相交的轨迹轴的镜像图案。在另一个示例中，仪器指南的高度调节将这些或其他瞄准技术扩展到三维体积。本文件还描述了制造这种仪器引导件的方法，其也可应用于制造提供平行流明的仪器引导件。

44. 发明授权

US07828809B2 Device for immobilizing a primary instrument and method therefor 有权
公开(公告)号：US07828809B2
公开(公告)日：2010-11-09
申请号：US11768554
申请日：2007-06-26
申请人： James G. Skakoon , Robert Wharen , Matthew S. Solar , Kari Parmer , Rudy A. Mazzocchi , John David , Frank Murdock , David Hatcher , Thomas I. Miller , Timothy Alan Parmer , Charles L. Truwit
发明人： James G. Skakoon , Robert Wharen , Matthew S. Solar , Kari Parmer , Rudy A. Mazzocchi , John David , Frank Murdock , David Hatcher , Thomas I. Miller , Timothy Alan Parmer , Charles L. Truwit
IPC分类号： A61B19/00
CPC分类号： A61N1/0539 , A61B34/20 , A61B90/11 , A61B2017/0023 , A61B2017/00398 , A61B2017/00911 , A61B2017/3407 , A61B2017/3409 , A61B2017/3411 , A61B2017/347 , A61B2034/2051 , A61B2034/2055 , A61B2090/103 , A61B2090/363 , A61B2090/374 , A61B2090/3762 , A61B2090/3983 , A61N1/0534
摘要： Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

45. 发明申请

US20100081914A1 METHOD AND APPARATUS FOR POSITIONING A GUIDE RELATIVE TO A BASE 有权
标题翻译：用于定位相关指南的方法和装置
公开(公告)号：US20100081914A1
公开(公告)日：2010-04-01
申请号：US12239114
申请日：2008-09-26
申请人： Jeffrey M. Waynik , Andrew N. Csavoy , Keith Sootsman , Matthew S. Solar , Thomas I. Miller
发明人： Jeffrey M. Waynik , Andrew N. Csavoy , Keith Sootsman , Matthew S. Solar , Thomas I. Miller
IPC分类号： A61B5/05
CPC分类号： A61B34/20 , A61B17/1739 , A61B2034/107 , A61B2034/2051 , A61B2034/2055
摘要： A system for positioning a guide relative to an anatomy is provided. The system can include a base adapted to be coupled to the anatomy, and a guide that can move relative to the base. The system can include at least one tracking device that can be coupled to the base and the guide, and a tracking system that tracks a position of the tracking device. The system can include a navigation system that determines a position of the base and the guide relative to the anatomy, and whether the position of the base and the guide are in a desired position. The system can include a display, which can display at least one icon superimposed on the image of the anatomy that graphically indicates a manipulation of the guide required to move the guide into the desired position.
摘要翻译：提供了一种用于相对于解剖结构定位导板的系统。系统可以包括适于联接到解剖结构的基座以及可相对于基座移动的引导件。系统可以包括至少一个可以耦合到基座和引导件的跟踪装置，以及跟踪跟踪装置的位置的跟踪系统。该系统可以包括导航系统，该导航系统确定基座和引导件相对于解剖结构的位置，以及基座和引导件的位置是否处于期望位置。该系统可以包括显示器，其可以显示叠加在解剖图像上的至少一个图标，其图形地指示将引导件移动到期望位置所需的引导件的操纵。

46. 发明申请

US20090287141A1 Device and method for delivering therapeutic agents to an area of the body 有权
标题翻译：将治疗剂递送到身体区域的装置和方法
公开(公告)号：US20090287141A1
公开(公告)日：2009-11-19
申请号：US12152280
申请日：2008-05-13
申请人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
发明人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
IPC分类号： A61M5/32 , A61N1/30
CPC分类号： A61B17/34 , A61B17/3478 , A61B2017/00247 , A61B2017/00331 , A61B2018/00392 , A61M37/00 , A61M37/0069
摘要： A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution.
摘要翻译：装置，系统和方法将药剂递送到软质量体，例如身体的区域，更具体地是脑。一个方面包括使用相对较小直径的微创管心针产生组织中的一个或多个通道，隧道或凹槽，然后在输注之前去除探针。探针创造的通道成为增加水力传导性的途径，通过该途径，输注物将倾向于流动并产生可预测的输注模式。输液将以相对较低的阻力进入这些通道，然后从这些通道向外注入周围组织。通过仔细定位这些通道，可以控制和修改分配的首选路径和持续时间。

47. 发明授权

US07575571B2 Indexing cell delivery catheter 有权
标题翻译：索引细胞输送导管
公开(公告)号：US07575571B2
公开(公告)日：2009-08-18
申请号：US10282584
申请日：2002-10-29
申请人： Matthew S. Solar , Kari Parmer , Philip Smith , Frank C. Murdock
发明人： Matthew S. Solar , Kari Parmer , Philip Smith , Frank C. Murdock
IPC分类号： A61M5/00
CPC分类号： A61M25/0097 , A61M25/0009 , A61M25/0045 , A61M25/0662 , A61M2025/0008
摘要： An insertion device and method of using and manufacturing an insertion device is shown, wherein the insertion device is capable of distributing a media over a large distribution volume inside a patient while reducing the amount of tissue disturbed by the procedure. Also shown is a computer-readable medium with instructions stored thereon, the instructions when executed operable to cause generation of a set of data for use with an insertion device. An insertion device and methods are shown that allows a series of iterations to be performed within a single insertion procedure that distributes media, such as cells for cell therapy, over a large volume.
摘要翻译：示出了使用和制造插入装置的插入装置和方法，其中插入装置能够在减少由该过程干扰的组织量的情况下在患者体内分布介质在大分布体积上。还示出了具有存储在其上的指令的计算机可读介质，所述指令被执行时可操作以引起生成用于插入设备的一组数据。示出了插入装置和方法，其允许在单个插入程序中执行一系列迭代，所述插入程序在大体积上分布介质，例如用于细胞治疗的细胞。

48. 发明授权

US06343731B1 Method and device for full thickness resectioning of an organ 有权
公开(公告)号：US06343731B1
公开(公告)日：2002-02-05
申请号：US09813944
申请日：2001-03-22
申请人： Ronald D. Adams , Roy H. Sullivan, III , Lauren O. Main , Peter K. Kratsch , George A. Nunez , Jurgen A. Kortenbach , Matthew S. Solar , Gerhard F. Buess , Marc O. Schurr
发明人： Ronald D. Adams , Roy H. Sullivan, III , Lauren O. Main , Peter K. Kratsch , George A. Nunez , Jurgen A. Kortenbach , Matthew S. Solar , Gerhard F. Buess , Marc O. Schurr
IPC分类号： A61B17068
CPC分类号： A61B17/07207 , A61B17/29 , A61B2017/00353 , A61B2017/07214 , A61B2017/07221 , A61B2017/0725 , A61B2017/2905 , A61B2017/2927 , A61B2090/038 , A61B2090/306
摘要： A full-thickness resection system comprises a flexible endoscope and a stapling mechanism, wherein the endoscope is slidably received through at least a portion of the stapling mechanism. The stapling mechanism comprises an anvil and a stapling head mounted to the anvil so that the anvil and the stapling head are moveable with respect to one another between a tissue receiving position and a stapling position and wherein a gap formed between the stapling head and the anvil is larger in the tissue receiving position than it is in the stapling position. A position adjusting mechanism is provided for moving the anvil and the stapling head between the tissue receiving and stapling positions and a staple firing mechanism sequentially fires a plurality of staples from the stapling head across the gap against the anvil and through any tissue received in the gap and a knife cuts a portion of tissue received within the gap. A control unit which remains outside the body is coupled to the stapling mechanism for controlling operation of the position adjusting mechanism and the staple firing mechanism.

49. 发明授权

US5645075A Jaw assembly for an endoscopic instrument 失效
标题翻译：用于内窥镜仪器的爪组件
公开(公告)号：US5645075A
公开(公告)日：1997-07-08
申请号：US440327
申请日：1995-05-12
申请人： Matthew A. Palmer , Charles R. Slater , Vincent A. Turturro , Matthew S. Solar , Saul Gottlieb , Jose L. Francese , John Jairo Damarati
发明人： Matthew A. Palmer , Charles R. Slater , Vincent A. Turturro , Matthew S. Solar , Saul Gottlieb , Jose L. Francese , John Jairo Damarati
IPC分类号： A61B10/06 , A61B10/00 , A61B10/02 , A61B17/00 , A61B17/28 , A61B17/30 , A61B18/14 , A61B19/00 , A61F2/00
CPC分类号： A61B10/06 , A61B10/0266 , A61B10/02 , A61B17/30 , A61B18/14 , A61B2010/0225 , A61B2017/00398 , A61B2017/00867 , A61B2017/2905 , A61B2017/292 , A61B2017/2926 , A61B2017/2931 , A61B2017/2933 , A61B2017/2937 , A61B2017/2939 , A61B2017/294 , A61B2018/1253 , A61B2018/146 , A61B2090/064 , A61F2210/0019 , A61M2025/0098
摘要： An end effector assembly for an endoscopic instrument includes first and second end effectors, a screw, and optionally a washer. The end effectors have arms which are biased away from each other. The screw has a threaded portion dimensioned to engage the distal end of the endoscopic instrument and a head portion with a pair of arm receiving grooves. In a presently preferred embodiment, the washer extends over the arms of the end effectors which pass through grooves in the head of the screw. In this manner, the arms of the end effectors are captured between the screw and the washer. The grooves are preferably provided with upstanding pins which engage mounting holes in the arms of the end effectors. Where the endoscopic instrument is a biopsy forceps type instrument having a long coil, the threaded portion of the screw mates naturally with the distal end of the coil, and the end effectors, which are normally biased away from each other, are closed by a cylinder which is moved over the arms of the end effectors. Where the endoscopic instrument is a laparoscopic type instrument, an inner rod of the instrument is provided with threads to receive the screw, and the end effectors are closed either by the outer tube of the instrument which is slid over the arms of the end effectors, or by pulling the inner rod into the outer tube.
摘要翻译：用于内窥镜器械的端部执行器组件包括第一和第二端部执行器，螺钉和任选的垫圈。末端执行器具有偏离彼此的臂。螺钉具有螺纹部分，其尺寸适于接合内窥镜器械的远端，头部具有一对臂接收槽。在目前优选的实施例中，垫圈在通过螺钉头部中的凹槽的末端执行器的臂上延伸。以这种方式，末端执行器的臂被捕获在螺钉和垫圈之间。槽优选地设置有直立的销，其接合末端执行器的臂中的安装孔。在内窥镜仪器是具有长线圈的活检钳式仪器的情况下，螺钉的螺纹部分自然地与线圈的远端配合，并且通常被偏压远离的端部执行器被气缸闭合其移动到末端执行器的臂上。在内窥镜仪器是腹腔镜式仪器的情况下，仪器的内杆设置有用于接收螺钉的螺纹，并且末端执行器由仪器的外管封闭，该外管在末端执行器的臂上滑动，或者通过将内杆拉到外管中。

50. 发明授权

US5643251A Fibert optic guide wire and support catheter therefor 失效
标题翻译：光纤导丝及支撑导管
公开(公告)号：US5643251A
公开(公告)日：1997-07-01
申请号：US539079
申请日：1995-10-04
申请人： Cecily M. Hillsman , Kevin D. Taylor , Daniel J. Kasprzyk , Matthew S. Solar
发明人： Cecily M. Hillsman , Kevin D. Taylor , Daniel J. Kasprzyk , Matthew S. Solar
IPC分类号： A61B18/20 , A61B17/22 , A61B18/24 , A61B19/00 , A61L27/00 , A61L29/00 , A61M25/00 , A61M25/01 , A61M25/09 , A61N5/06 , A61B17/36
CPC分类号： A61B18/245 , A61M25/09 , A61B2017/22038 , A61B90/39 , A61M2025/09166 , A61M2025/09175 , A61M25/0009 , A61M25/0108 , A61M25/0905
摘要： A guide wire for a catheter has a tubular portion with a flexible body fixed to its distal end. The distal end of the body may be composed of a radiopaque material. Optical fibers are disposed within the assembly and terminate in a radiopaque tip at the distal end of the body. The guide wire may have a longitudinal marker wire or mandrel for providing stiffness and radioscopic tracking characteristics, as well as providing torsional control and tip shaping capabilities. The guide wire has a proximal end attached to the tube and a distal end that also terminates in the tip. The wire may be maneuvered in a vascular area like a conventional guide wire and may be used in conjunction with a support catheter to increase its maneuverability. Then, laser energy is conveyed to the vascular area by the optical fibers to ablate an obstruction. The proximal end of the guide wire is then removed and a larger catheter may then be slid over the guide wire to continue the ablation operation. Employing plastic tubing, a wire coil, or a combination of these two for the distal body, the guide wire may be used in peripheral or coronary angioplasty applications. The guide wire may be used in conjunction with a support catheter which is used to direct the guide wire to a treatment site and provides improved tracking characteristics.
摘要翻译：用于导管的引导线具有管状部分，其柔性主体固定到其远端。身体的远端可以由不透射线的材料组成。光纤布置在组件内并终止于身体远端的不透射线的尖端。引导线可以具有用于提供刚度和放射线跟踪特性的纵向标记线或心轴，以及提供扭转控制和尖端成形能力。引导线具有附接到管的近端和也终止在尖端中的远端。电线可能像传统的导丝线一样在血管区域中操作，并且可以与支撑导管结合使用以增加其机动性。然后，激光能量被光纤传送到血管区域以消除阻塞。导线的近端然后被移除，然后可以在引导线上滑动较大的导管以继续消融操作。使用塑料管，线圈或这两个组合用于远端主体，导丝可以用于外周或冠状血管成形术应用中。引导线可以与用于将导丝引导到治疗部位并提供改进的跟踪特征的支撑导管结合使用。

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