专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US06146614A Method for determining lymphocyte distribution and trafficking in mammals using imaging 失效
标题翻译：使用成像确定哺乳动物淋巴细胞分布和贩运的方法
公开(公告)号：US06146614A
公开(公告)日：2000-11-14
申请号：US886578
申请日：1997-07-01
申请人： Robert H. Rubin , Alan J. Fischman , David Baltimore
发明人： Robert H. Rubin , Alan J. Fischman , David Baltimore
IPC分类号： A61K49/04 , A61K49/18 , A61K51/10 , A61K51/12 , A61B5/055
CPC分类号： A61K51/1027 , A61K49/04 , A61K49/1896 , A61K51/1203
摘要： Methods for determining lymphocyte distribution and trafficking in a mammal are described. Either a labeled ligand capable of interacting specifically with the lymphocytes of the mammal is administered to the mammal so that the labeled ligand interacts in vivo with the lymphocytes, resulting in labeled lymphocytes, or, the labeled ligand is contacted with the lymphocytes in vitro so that the labeled ligand interacts with the lymphocytes resulting in labeled lymphocytes, and these labeled lymphocytes are administered to the mammal. The distribution or trafficking of the labeled lymphocytes in the mammal is determined by imaging. Methods for diagnosing the degree of progression of a disease in a mammal by determining the mammal's lymphocyte distribution or trafficking pattern, for monitoring the response to a therapy in mammal having a disease, for evaluating the ability of an agent to alter the distribution or trafficking of lymphocytes, and for identifying an agent useful for treating a mammal having a disease, are also described.
摘要翻译：描述了确定哺乳动物淋巴细胞分布和运输的方法。向哺乳动物施用能够与哺乳动物的淋巴细胞相互作用的标记配体，使得标记的配体在体内与淋巴细胞相互作用，导致标记的淋巴细胞，或者标记的配体在体外与淋巴细胞接触，使得标记的配体与淋巴细胞相互作用，导致标记的淋巴细胞，并且将这些标记的淋巴细胞施用于哺乳动物。通过成像确定哺乳动物中标记的淋巴细胞的分布或运输。用于通过确定哺乳动物的淋巴细胞分布或贩运模式来诊断哺乳动物疾病进展程度的方法，用于监测具有疾病的哺乳动物患有对具有疾病的哺乳动物的治疗的反应，用于评估药剂改变分布或贩运的能力还描述了用于鉴定可用于治疗患有疾病的哺乳动物的药剂的淋巴细胞。

42. 发明授权

US4829051A N-substituted derivatives of 1-desaminovasopressin 失效
标题翻译： 1-取代氨基加压素的N-取代衍生物
公开(公告)号：US4829051A
公开(公告)日：1989-05-09
申请号：US672167
申请日：1984-11-16
申请人： Joseph H. Cort , Alan J. Fischman
发明人： Joseph H. Cort , Alan J. Fischman
IPC分类号： A61K38/00 , C07K7/16
CPC分类号： C07K7/16 , A61K38/00 , Y10S514/807 , Y10S930/15
摘要： Novel analogs of biologically active vasopressin and its synthetic analogs having improved activity are represented by the structural formula: ##STR1## wherein A hydrogen; is hydroxy or lower alkoxy, especially methoxy, B is the peptide residue of phenylalanine (Phe) or isoleucine, Gln represents the peptide residue of glutamine Asn represents the peptide residue of asparagine, E represents the peptide residue of proline (Pro), 4-thioproline (4-thioPro) or 3,4-dehydroproline (3,4-dehydroPro), FNH represents an N-substituted peptide residue of L- or D-lysine (Lys) L or D homolysine (h Lys) or L- or D-orntihine (Orn), X represents a side peptide chain consisting of one or more of Gly, L-Ala, L-Val, L-Leu, or L-Phe, Gly represents the peptide residue of glycine, and G is disulfide (--S--S--) or thioether (--CH.sub.2 S-- or --SCH.sub.2 --).
摘要翻译：具有改善活性的生物活性加压素及其合成类似物的新型类似物由以下结构式表示：其中A氢; 是羟基或低级烷氧基，特别是甲氧基，B是苯丙氨酸（Phe）或异亮氨酸的肽残基，Gln表示谷氨酰胺的肽残基，Asn代表天冬酰胺的肽残基，E表示脯氨酸（Pro）的肽残基，4- 硫代脯氨酸（4-thioPro）或3,4-脱氢脯氨酸（3,4-脱氢Pro），FNH代表L-或D-赖氨酸（Lys）L或D homolysine（h Lys）或L-或 D-orntihine（Orn），X表示由Gly，L-Ala，L-Val，L-Leu或L-Phe中的一种或多种组成的侧肽链，Gly表示甘氨酸的肽残基，G为二硫键（-SS-）或硫醚（-CH 2 S-或-SCH 2 - ）。

43. 发明申请

US20100143248A1 METHODS FOR DIAGNOSING AND MONITORING TREATMENT OF ADHD BY ASSESSING THE DOPAMINE TRANSPORTER LEVEL 审中-公开
标题翻译：通过评估多巴胺运输系统水平来诊断和监测ADHD的方法
公开(公告)号：US20100143248A1
公开(公告)日：2010-06-10
申请号：US12490310
申请日：2009-06-23
申请人： Bertha K. Madras , Alan J. Fischman , Peter C. Meltzer
发明人： Bertha K. Madras , Alan J. Fischman , Peter C. Meltzer
IPC分类号： A61K51/00
CPC分类号： A61K51/0448
摘要： A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of ADHD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to the dopamine transporters using PET or SPECT.
摘要翻译：一种通过评估患者中枢神经系统的至少一个区域中的多巴胺转运蛋白的水平来诊断患者的注意力缺陷多动障碍（ADHD）的方法，其中患者的多巴胺转运蛋白水平升高表示ADHD。在本发明的实施方案中，多巴胺转运蛋白水平的评估包括使用PET或SPECT评估多巴胺转运蛋白配体与多巴胺转运蛋白的结合。

44. 发明授权

US06548041B1 Dopamine transporter imaging agents 失效
标题翻译：多巴胺转运蛋白成像剂
公开(公告)号：US06548041B1
公开(公告)日：2003-04-15
申请号：US09568106
申请日：2000-05-10
申请人： Peter C. Meltzer , Paul Blundell , Bertha K. Madras , Alan J. Fischman , Alun G. Jones , Ashfaq Mahmood
发明人： Peter C. Meltzer , Paul Blundell , Bertha K. Madras , Alan J. Fischman , Alun G. Jones , Ashfaq Mahmood
IPC分类号： A61K5100
CPC分类号： A61K31/46 , A61B6/506 , A61K51/0448 , A61K51/0478 , A61K51/0497 , C07D451/02 , C07F13/005
摘要： Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
摘要翻译：公开了放射性药物化合物。托烷化合物通过8-位的N原子连接到能够络合锝或铼的螯合配体，以产生中性标记的复合物，其以比例为10或更高的比例选择性地结合血清素转运蛋白上的多巴胺转运蛋白。这些化合物可以制备成单独的非对映异构体以及非对映异构体的混合物。还公开了用于制备标记的放射性药物化合物的放射性药物试剂盒。

45. 发明授权

US07553478B2 Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level 失效
公开(公告)号：US07553478B2
公开(公告)日：2009-06-30
申请号：US11489394
申请日：2006-07-18
申请人： Bertha K. Madras , Alan J. Fischman , Peter C. Meltzer
发明人： Bertha K. Madras , Alan J. Fischman , Peter C. Meltzer
IPC分类号： A61K49/00
CPC分类号： A61K51/0448
摘要： A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of ADHD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to the dopamine transporters using PET or SPECT.

46. 发明授权

US5792444A Labeled chemotactic peptides to image focal sites of infection or inflammation 失效
标题翻译：标记趋化肽以影像感染或炎症的焦点
公开(公告)号：US5792444A
公开(公告)日：1998-08-11
申请号：US140000
申请日：1993-10-22
申请人： Alan J. Fischman , Howard F. Solomon , Claudia K. Derian , Gary J. Bridger , John D. Higgins, III , Scott K. Larsen , Pedro E. Hernandez , Robert H. Rubin , H. William Strauss , Anthony J. Fuccello , Daniel J. Kroon
发明人： Alan J. Fischman , Howard F. Solomon , Claudia K. Derian , Gary J. Bridger , John D. Higgins, III , Scott K. Larsen , Pedro E. Hernandez , Robert H. Rubin , H. William Strauss , Anthony J. Fuccello , Daniel J. Kroon
IPC分类号： A61K38/00 , A61K38/06 , A61K49/00 , A61K51/00 , A61K51/08 , A61P29/00 , A61P31/00 , C07K20060101 , C07K5/083 , C07K5/103 , C07K7/06
CPC分类号： C07K7/06 , A61K51/08 , A61K51/088 , C07K5/081 , C07K5/101 , C07K5/1013 , A61K2123/00 , A61K38/00 , Y02P20/55
摘要： The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure X--Y--Leu--Phe--�Z!.sub.n --W wherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.
摘要翻译：本发明涉及通过向个体施用诊断或治疗有效量的可检测标记的，治疗性的或治疗上缀合的，可检测地标记的，治疗性的或治疗上缀合的，在个体中检测感染或炎症部位的方法和治疗这种感染或炎症的方法，所述趋化肽基本上在感染或发炎部位积累，所述趋化肽具有通式X-Y-Leu-Phe- [Z] n -W其中：X为氨基保护基，Y为氨基酸残基，Z为间隔序列，n为0或1，W为标记或连接取代基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式