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41. 发明申请

US20100010556A1 SYSTEMS AND METHODS FOR DELIVERING VAGAL NERVE STIMULATION 有权
标题翻译：用于输送VAGAL NERVE刺激的系统和方法
公开(公告)号：US20100010556A1
公开(公告)日：2010-01-14
申请号：US12487266
申请日：2009-06-18
申请人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
发明人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
摘要翻译：根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界。

42. 发明申请

US20090270960A1 SYSTEMS AND METHODS FOR DELIVERING ELECTRIC CURRENT FOR SPINAL CORD STIMULATION 有权
标题翻译：用于输送脊髓刺激电流的系统和方法
公开(公告)号：US20090270960A1
公开(公告)日：2009-10-29
申请号：US12431607
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.
摘要翻译：各种系统实施例包括具有远端和近端的引线。远端包括多个电极。引线被配置为被馈送到人的背部硬膜外空间到脊柱的期望区域，并且被横向馈送以至少部分地环绕所需区域中的脊髓，以将至少一个刺激电极置于适当位置刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。所需区域可包括颈椎，胸椎或腰椎。一些实施方案刺激T1-T5区域中的脊髓。

43. 发明授权

US08571656B2 Ventricular pacing to augment atrial natriuretic hormone production 有权
公开(公告)号：US08571656B2
公开(公告)日：2013-10-29
申请号：US12966249
申请日：2010-12-13
申请人： Jeffrey E. Stahmann , Ramesh Wariar , Stephen Ruble
发明人： Jeffrey E. Stahmann , Ramesh Wariar , Stephen Ruble
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61N1/36 , A61N1/362 , A61N1/3627 , A61N1/365
摘要： Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.

44. 发明申请

US20130190835A1 SYSTEMS AND METHODS FOR DELIVERING VAGAL NERVE STIMULATION 有权
公开(公告)号：US20130190835A1
公开(公告)日：2013-07-25
申请号：US13796401
申请日：2013-03-12
申请人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
发明人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.

45. 发明授权

US08401640B2 Systems and methods for delivering vagal nerve stimulation 有权
公开(公告)号：US08401640B2
公开(公告)日：2013-03-19
申请号：US13444400
申请日：2012-04-11
申请人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
发明人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.

46. 发明授权

US08386045B2 Systems and methods for selectively stimulating nerve roots 有权
标题翻译：选择性刺激神经根的系统和方法
公开(公告)号：US08386045B2
公开(公告)日：2013-02-26
申请号：US12431621
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36139 , A61N1/3627 , A61N1/365 , A61N1/37241
摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.
摘要翻译：各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。引线具有近端和远端。远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。引线的近端适于连接到外壳。神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。控制器适于控制神经刺激电路以递送神经刺激治疗。

47. 发明授权

US08160701B2 Systems and methods for delivering vagal nerve stimulation 有权
标题翻译：用于输送迷走神经刺激的系统和方法
公开(公告)号：US08160701B2
公开(公告)日：2012-04-17
申请号：US12487266
申请日：2009-06-18
申请人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
发明人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
摘要翻译：根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界。

48. 发明申请

US20100228310A1 SYSTEMS AND METHODS FOR AUTONOMIC NERVE MODULATION 审中-公开
标题翻译：用于自动神经调制的系统和方法
公开(公告)号：US20100228310A1
公开(公告)日：2010-09-09
申请号：US12715862
申请日：2010-03-02
申请人： Allan C. Shuros , Weiying Zhao , Jason J. Hamann , Stephen Ruble
发明人： Allan C. Shuros , Weiying Zhao , Jason J. Hamann , Stephen Ruble
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36117 , A61N1/36185 , A61N1/36585
摘要： According to various embodiments of a method for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, at least one programmed therapy is implemented using an implanted medical device to modulate autonomic neural activity. Implementing the therapy includes increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode in the thoracic duct, and further includes increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode in the desired thoracic lymphatic vessel.
摘要翻译：根据用于调节具有脊髓，锁骨下静脉和包括胸导管和右淋巴管的胸部淋巴管的身体中的自主神经活动的方法的各种实施例，至少一个程序化治疗使用植入的医疗装置调节自主神经活动。实施治疗包括使用胸导管中的第一电极从脊髓的第一区域分支的交感神经中增加或减少交感神经活动，并且还包括增加或减少邻近所需胸部淋巴管或交感神经的副交感神经中的副交感神经活动在所需胸廓淋巴管中使用第二电极从脊髓的第二区域分支的交感神经中的活动。

49. 发明授权

US08452406B2 Automatic selection of lead configuration for a neural stimulation lead 有权
公开(公告)号：US08452406B2
公开(公告)日：2013-05-28
申请号：US13220423
申请日：2011-08-29
申请人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
发明人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36128 , A61N1/36146 , A61N1/36185 , A61N1/37235 , A61N1/37288
摘要： A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity.

50. 发明授权

US08548593B2 Distal end converter for a medical device lead 有权
标题翻译：用于医疗器械引线的远端转换器
公开(公告)号：US08548593B2
公开(公告)日：2013-10-01
申请号：US12613455
申请日：2009-11-05
申请人： David J. Ternes , Stephen Ruble , Jason Hamann
发明人： David J. Ternes , Stephen Ruble , Jason Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/0556 , A61N1/36114
摘要： A system for delivering signals between a pulse generator and tissue includes a lead having a lead body and one or more lead electrodes at a distal end of the lead body. The one or more electrodes are electrically connectable to the pulse generator at a proximal end of the lead body via one or more conductors extending through the lead body. A converter, which is removably securable to the distal end of the lead body, includes one or more converter electrodes. Each converter electrode is connected to an electrical contact that is arranged on the converter to electrically connect the converter electrode to at least one of the one or more lead electrodes.
摘要翻译：用于在脉冲发生器和组织之间递送信号的系统包括具有引线主体和在引线主体的远端处的一个或多个引线电极的引线。一个或多个电极经由穿过引线体延伸的一个或多个导体，电连接到引线主体的近端处的脉冲发生器。转换器可拆卸地固定到引线主体的远端，包括一个或多个转换器电极。每个转换器电极连接到布置在转换器上的电触点，以将转换器电极电连接到一个或多个引线电极中的至少一个。

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