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41. 发明授权

US06612897B2 Musical toy with a motor driven display 失效
标题翻译：具有电机驱动显示的音乐玩具
公开(公告)号：US06612897B2
公开(公告)日：2003-09-02
申请号：US10058793
申请日：2002-01-30
申请人： Michael Greenberg
发明人： Michael Greenberg
IPC分类号： A63H352
CPC分类号： A63H33/00 , A63H5/00
摘要： A toy includes a housing, a plurality of buttons arranged to initiate playback of a tune or other sounds, a transparent enclosure containing a plurality of balls, an agitator extending into the enclosure, a motor mounted within the housing for causing the agitator to oscillate and propel balls that encounter the agitator against the walls of the enclosure, a sound generator and speaker, and control circuitry for causing the sound generator to play selected sounds upon pressing of one of the buttons, and for intermittently activating the agitator during playback of the sounds. The housing of the toy may be arranged to resemble a piano, and the buttons may be configured to resemble keys of the piano.
摘要翻译：玩具包括壳体，多个按钮，用于启动曲调或其他声音的回放，包含多个球的透明外壳，延伸到外壳中的搅拌器，安装在壳体内的电机，用于使搅拌器振荡;以及将与搅拌器相遇的球推向靠近外壳的墙壁，发声器和扬声器，以及控制电路，用于在按压其中一个按钮时使声音发生器播放所选择的声音，并且在播放声音期间间歇地激活搅拌器。玩具的壳体可以被布置为类似于钢琴，并且按钮可以被配置为类似于钢琴的键。

42. 发明授权

US5994054A cDNA cloning methods for the identification of a CD8+ T-lymphocytes suppressor factor capable of inhibiting HIV-1 replication 失效
标题翻译：用于鉴定能够抑制HIV-1复制的CD8 + T淋巴细胞抑制因子的cDNA克隆方法
公开(公告)号：US5994054A
公开(公告)日：1999-11-30
申请号：US486810
申请日：1995-06-07
申请人： Dani P. Bolognesi , Chin-Ho Chen , Michael Greenberg , Kent Weinhold , Simon F. Lacey
发明人： Dani P. Bolognesi , Chin-Ho Chen , Michael Greenberg , Kent Weinhold , Simon F. Lacey
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C07K14/52 , C12N5/08 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/48 , C12Q1/66 , C12Q1/68 , C12Q1/70 , C12R1/91 , G01N33/53
CPC分类号： C12Q1/703 , C07K14/4703 , C12Q1/6897 , A61K38/00
摘要： The present invention relates to a bioactive molecule, herein referred to as the CD8.sup.+ suppressor molecule, that is produced by the CD8.sup.+ subset of human T-lymphocytes and suppresses type-1 human immunodeficiency virus (HIV-1) replication through inhibition of viral transcription. The invention relates to isolation of clonal CD8.sup.+ cells lines that produce the antiviral activity and the development of an assay system for detection of the antiviral activity. The clonal cell lines and the assay system, described herein, may be utilized to purify, characterize and clone the CD8.sup.+ suppressor molecule. The CD8.sup.+ suppressor molecule may have therapeutic applications for treatment of diseases associated with HIV-1 infection.
摘要翻译：本发明涉及由人T淋巴细胞的CD8 +亚群产生并通过抑制病毒转录抑制1型人类免疫缺陷病毒（HIV-1）复制的生物活性分子（本文中称为CD8 +抑制分子）。本发明涉及产生抗病毒活性的克隆CD8 +细胞系的分离和用于检测抗病毒活性的测定系统的开发。本文所述的克隆细胞系和测定系统可用于纯化，表征和克隆CD8 +抑制分子。 CD8 +抑制分子可能具有用于治疗与HIV-1感染相关的疾病的治疗应用。

43. 发明授权

US5860007A Automated software modification facilitator 失效
标题翻译：自动软件修改辅助器
公开(公告)号：US5860007A
公开(公告)日：1999-01-12
申请号：US536547
申请日：1995-09-29
申请人： Dilip Soni , Michael Greenberg
发明人： Dilip Soni , Michael Greenberg
IPC分类号： G06F9/44 , G06F7/00
CPC分类号： G06F8/70 , G06F8/71
摘要： Analysis, planning and interrelated modifications of a software system across modular architectural, language and documentation levels are automated and facilitated by use of the Change Assistant (CA). CA automatically analyzes the impact of the intended change on all levels, identifying related changes that may be needed to achieve the programmer's goal. When the plan is finalized and approved, CA automatically performs the change, modifying the code, as needed, to make it consistent with the changed architecture. Thereby, the need for human intervention in maintaining software is significantly reduced and the possibility of error minimized.
摘要翻译：通过使用Change Assistant（CA），可以自动化并通过模块化架构，语言和文档级别对软件系统进行分析，规划和相互关联的修改。 CA自动分析预期变更对所有级别的影响，确定实现程序员目标可能需要的相关变更。当计划完成并批准时，CA会自动执行更改，根据需要修改代码，使其与更改的架构保持一致。因此，人为干预维护软件的需求显着减少，误差最小化的可能性。

44. 发明授权

US5814519A Supressor of HIV-1 replication and transcription 失效
标题翻译： HIV-1复制和转录的抑制因子
公开(公告)号：US5814519A
公开(公告)日：1998-09-29
申请号：US488527
申请日：1995-06-07
申请人： Dani P. Bolognesi , Chin-Ho Chen , Michael Greenberg , Kent Weinhold , Simon F. Lacey
发明人： Dani P. Bolognesi , Chin-Ho Chen , Michael Greenberg , Kent Weinhold , Simon F. Lacey
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C07K14/52 , C12N5/08 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/48 , C12Q1/66 , C12Q1/68 , C12Q1/70 , C12R1/91 , C12N5/22
CPC分类号： C12Q1/703 , C07K14/4703 , C12Q1/6897 , A61K38/00
摘要： The present invention relates to a bioactive molecule, herein referred to as the CD8.sup.+ suppressor molecule, that is produced by the CD8.sup.+ subset of human T-lymphocytes and suppresses type-1 human immunodeficiency virus (HIV-1) replication through inhibition of viral transcription. The invention relates to isolation of clonal CD8.sup.+ cells lines that produce the antiviral activity and the development of an assay system for detection of the antiviral activity. The clonal cell lines and the assay system, described herein, may be utilized to purify, characterize and clone the CD8.sup.+ suppressor molecule. The CD8.sup.+ suppressor molecule may have therapeutic applications for treatment of diseases associated with HIV-1 infection.
摘要翻译：本发明涉及由人T淋巴细胞的CD8 +亚群产生并通过抑制病毒转录抑制1型人类免疫缺陷病毒（HIV-1）复制的生物活性分子（本文中称为CD8 +抑制分子）。本发明涉及产生抗病毒活性的克隆CD8 +细胞系的分离和用于检测抗病毒活性的测定系统的开发。本文所述的克隆细胞系和测定系统可用于纯化，表征和克隆CD8 +抑制分子。 CD8 +抑制分子可能具有用于治疗与HIV-1感染相关的疾病的治疗应用。

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