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41. 发明授权

US06635468B2 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US06635468B2
公开(公告)日：2003-10-21
申请号：US09907794
申请日：2001-07-17
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C12N121
CPC分类号： C07K14/47 , C07K14/705 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

42. 发明授权

US06472585B1 Cardiotrophin-1 defective mouse 有权
标题翻译：心肌营养素-1缺陷小鼠
公开(公告)号：US06472585B1
公开(公告)日：2002-10-29
申请号：US09648183
申请日：2000-08-25
申请人： David Botstein , Audrey Goddard , David A. Lawrence , Diane Pennica , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Audrey Goddard , David A. Lawrence , Diane Pennica , Margaret Ann Roy , William I. Wood
IPC分类号： A01K67027
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2319/00 , C07K2319/02 , G01N2500/00
摘要： The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的复合和方法。本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

43. 发明申请

US20110207912A1 FGF-19 NUCLEIC ACIDS 审中-公开
标题翻译： FGF-19核酸
公开(公告)号：US20110207912A1
公开(公告)日：2011-08-25
申请号：US13013734
申请日：2011-01-25
申请人： David Botstein , Audrey Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Margaret Ann Roy
发明人： David Botstein , Audrey Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Margaret Ann Roy
IPC分类号： C07K14/50 , C07H21/04 , C12N15/63 , C12N1/19 , C12P21/02 , C12N5/10 , C12N1/21
CPC分类号： C07K14/50 , C07K2317/24 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.
摘要翻译：本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法发明。本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

44. 发明申请

US20080182275A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20080182275A1
公开(公告)日：2008-07-31
申请号：US11786466
申请日：2007-04-10
申请人： Avi J Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Sophia S. Kuo , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , David L. Shelton , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi J Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Sophia S. Kuo , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , David L. Shelton , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： G01N33/53 , C07H21/04 , C12N15/63 , C12N5/06 , C12N5/16 , C12N1/21 , C12N1/19 , C12P21/00 , C07K2/00 , C07K16/46 , C07K16/18 , G01N33/566
CPC分类号： C07K14/47 , G01N33/6872
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

45. 发明授权

US07399834B2 Anti-PRO1558 antibodies 有权
标题翻译：抗PRO1558抗体
公开(公告)号：US07399834B2
公开(公告)日：2008-07-15
申请号：US10013912
申请日：2001-12-10
申请人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
发明人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

46. 发明授权

US07166282B2 Secreted and transmembrane polypeptides and nucleic acids encoding the same 失效
公开(公告)号：US07166282B2
公开(公告)日：2007-01-23
申请号：US09997585
申请日：2001-11-15
申请人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
发明人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , Colin K. Watanabe , William I. Wood
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/52 , C07K14/705 , C07K16/18 , C07K2319/00 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/57484 , G01N33/68 , G01N33/6842 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

47. 发明授权

US07101984B2 Secreted and transmembrane polypeptides and nucleic acids encoding the same 失效
公开(公告)号：US07101984B2
公开(公告)日：2006-09-05
申请号：US10033167
申请日：2001-12-27
申请人： David Botstein , Luc Desnoyers , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Austin L. Gurney , James Pan , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood
发明人： David Botstein , Luc Desnoyers , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Austin L. Gurney , James Pan , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

48. 发明授权

US07098312B2 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US07098312B2
公开(公告)日：2006-08-29
申请号：US10006130
申请日：2001-12-06
申请人： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
发明人： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
IPC分类号： C07K14/00 , C07K19/00 , C07K16/46 , C12N15/62 , C12N15/63
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

49. 发明授权

US07070979B2 Secreted and transmembrane polypeptides and nucleic acids encoding the same 失效
公开(公告)号：US07070979B2
公开(公告)日：2006-07-04
申请号：US09906838
申请日：2001-07-16
申请人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
IPC分类号： C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

50. 发明授权

US07034123B2 Anti-PRO1347 antibodies 有权
标题翻译：抗PRO1347抗体
公开(公告)号：US07034123B2
公开(公告)日：2006-04-25
申请号：US10007236
申请日：2001-12-06
申请人： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
发明人： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

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