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41. 发明申请

US20080167715A1 PRIMARY AND SUPPLEMENTAL INTRAOCULAR LENS SYSTEM 审中-公开
标题翻译：主要和补充性眼内镜系统
公开(公告)号：US20080167715A1
公开(公告)日：2008-07-10
申请号：US12041556
申请日：2008-03-03
申请人： Daniel G. Brady , Paul Rockley
发明人： Daniel G. Brady , Paul Rockley
IPC分类号： A61F2/16
CPC分类号： A61F2/1654 , A61F2/1602 , A61F2/1648 , A61F2250/0036
摘要： An intraocular lens system includes a primary intraocular lens configured to correct vision in a patient, and a supplemental intraocular lens configured to modify the correction provided by the primary intraocular lens. The supplemental intraocular lens, which is substantially completely diffractive, is preferably ultrathin. The two lenses may be connected to, or separate from, one another. The supplemental intraocular lens may be implanted at the same time as the primary intraocular lens, or added later.
摘要翻译：眼内透镜系统包括被配置为校正患者视力的初级眼内透镜和被配置为修改由初级眼内透镜提供的校正的补充眼内透镜。基本上完全衍射的补充眼内透镜优选为超薄膜。两个透镜可以彼此连接或分离。补充眼内透镜可以与主要眼内透镜同时植入，或者稍后加入。

42. 发明申请

US20080161913A1 HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 有权
标题翻译：适合摄入镜片
公开(公告)号：US20080161913A1
公开(公告)日：2008-07-03
申请号：US11618325
申请日：2006-12-29
申请人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali
发明人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1681 , A61F2002/169 , A61F2230/0095 , A61F2250/0018
摘要： An intraocular lens is disclosed, with an optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic supports the optic around its equator and couples the optic to the capsular bag of the eye. The region of contact between the optic and the haptic extends into the edge of the optic, similar to the interface between a bicycle tire and the rim that holds it in place. The haptic may be stiffer than the optic. The haptic may have the same refractive index as the optic. The haptic may include a saddle-shaped portion in contact with the adjustable optic, with a convex profile along an optical axis; and a concave profile in a plane perpendicular to the optical axis.
摘要翻译：公开了一种眼内透镜，其具有响应于由眼睛的小环施加的变形力而改变形状的光学元件。触觉件支持其赤道周围的光学器件，并将光学元件耦合到眼睛的囊袋。光学元件和触觉件之间的接触区域延伸到光学元件的边缘，类似于自行车轮胎和将其保持在适当位置的边缘之间的界面。触觉可能比光学元件更硬。触觉可以具有与光学元件相同的折射率。触觉件可以包括与可调节光学元件接触的鞍形部分，具有沿着光轴的凸形轮廓; 以及在垂直于光轴的平面中的凹形轮廓。

43. 发明授权

US06797004B1 Holders for intraocular lenses 失效
标题翻译：眼内透镜支架
公开(公告)号：US06797004B1
公开(公告)日：2004-09-28
申请号：US09517229
申请日：2000-03-02
申请人： Daniel G. Brady , Robert Glick
发明人： Daniel G. Brady , Robert Glick
IPC分类号： A61F216
CPC分类号： A61F2/1648 , A61F2/1629 , A61F2/1664 , A61F2/1694 , A61F2002/009 , A61F2002/1682 , A61F2002/16901 , A61F2002/1699
摘要： An intraocular lens system including one or more intraocular lenses (IOL) and a peripheral holder. The peripheral holder is configured to receive and retain the distal end of a fixation member of the IOL and provide a dynamic interface between the natural capsular bag and fixation member. The holder is preferably annular and flexible and transmits movement of the capsular bag from the surrounding ciliary muscles to the IOL. In this manner, a circumferential surface contact with the capsular bag is provided and accommodation of the IOL is improved. If two IOLs are received in the holder, a spacer may be provided to insure consistent spacing between the IOLs. Alternatively, an IOL system may include two IOLs and a spacer, without the holder. The holder desirably includes a sharp exterior corner to inhibit cell growth and posterior capsular opacification.
摘要翻译：包括一个或多个人工晶状体（IOL）和外围保持器的眼内透镜系统。周边保持器构造成容纳和保持IOL的固定构件的远端，并且在天然囊袋和固定构件之间提供动态界面。保持器优选是环形和柔性的，并且将囊袋从周围的睫状肌的运动传递到IOL。以这种方式，提供与囊袋的圆周表面接触，并且提高了IOL的适应性。如果在支架中接收到两个IOL，则可以提供间隔件以确保IOL之间的一致的间距。或者，IOL系统可以包括两个IOL和没有保持器的间隔件。保持器期望地包括抑制细胞生长和后囊膜混浊的尖锐的外角。

44. 发明授权

US06679891B2 IOL insertion apparatus and method for making and using same 有权
标题翻译： IOL插入装置及其制造和使用方法
公开(公告)号：US06679891B2
公开(公告)日：2004-01-20
申请号：US10077615
申请日：2002-02-15
申请人： Harish Makker , Shih-Liang S. Yang , Daniel G. Brady , Robert E. Glick
发明人： Harish Makker , Shih-Liang S. Yang , Daniel G. Brady , Robert E. Glick
IPC分类号： A61F900
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译：将眼内透镜（IOL）插入到眼睛中的装置包括中空管，其包括材料并具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口，以及润滑性增强部件物理地固定到所述中空管并且在内壁或其附近集中在有效促进IOL通过中空空间的量的量。

45. 发明授权

US06616692B1 Intraocular lens combinations 有权
标题翻译：人工晶状体组合
公开(公告)号：US06616692B1
公开(公告)日：2003-09-09
申请号：US09390380
申请日：1999-09-03
申请人： Robert E. Glick , Daniel G. Brady
发明人： Robert E. Glick , Daniel G. Brady
IPC分类号： A61F216
CPC分类号： A61F2/1629 , A61F2/1648 , A61F2002/1699 , A61F2250/0053
摘要： Intraocular lens combinations are provided which include a first optic having a negative optical power and being adapted to be placed in a substantially fixed position in a mammalian eye. A second optic having a higher optical power than the first optic is provided. In addition, a movement assembly is provided which is coupled to the second optic and is adapted to cooperate with the eye to effect accommodating movement of the second optic in the eye. Very effective accommodation is provided with the present intraocular lens combination. The present combinations can be effectively positioned to effectively inhibit or reduce the risk of posterior capsular opacification (PCO).
摘要翻译：提供了包括具有负光学功率并适于放置在哺乳动物眼睛中基本上固定的位置的第一光学器件的眼内透镜组合。提供具有比第一光学器件更高的光功率的第二光学器件。另外，提供移动组件，其联接到第二光学元件并且适于与眼睛协作以实现第二光学元件在眼睛中的适应运动。目前的眼内透镜组合提供非常有效的适应。本发明的组合可以有效地定位以有效地抑制或降低后囊膜混浊（PCO）的风险。

46. 发明授权

US06447519B1 Apparatus for holding intraocular lenses and injectors, and methods for using same 失效
标题翻译：用于保持眼内透镜和注射器的装置及其使用方法
公开(公告)号：US06447519B1
公开(公告)日：2002-09-10
申请号：US09532460
申请日：2000-03-22
申请人： Daniel G. Brady , Arlene Gwon , Michael Collinson , Claude A. Vidal , Alan K. Plyley
发明人： Daniel G. Brady , Arlene Gwon , Michael Collinson , Claude A. Vidal , Alan K. Plyley
IPC分类号： A61F900
CPC分类号： A61F2/1691
摘要： Apparatus for holding intraocular lenses and apparatus for holding intraocular lens injectors are provided which provide convenient and effective packaging systems for intraocular lenses and allow convenient and effective transfer of an intraocular lens to an injector in preparation for insertion of the intraocular lens into an eye.
摘要翻译：提供了用于保持眼内透镜的装置和用于保持眼内透镜注射器的装置，其为眼内透镜提供方便和有效的包装系统，并且允许将眼内透镜方便和有效地转移到注射器以准备将眼内透镜插入眼睛。

47. 发明授权

US06283975B1 IOL insertion apparatus and method for making and using same 有权
标题翻译： IOL插入装置及其制造和使用方法
公开(公告)号：US06283975B1
公开(公告)日：2001-09-04
申请号：US09370009
申请日：1999-08-06
申请人： Robert E. Glick , Harish Makker , Shih-Liang S. Yang , Daniel G. Brady
发明人： Robert E. Glick , Harish Makker , Shih-Liang S. Yang , Daniel G. Brady
IPC分类号： A61F900
CPC分类号： A61F2/1675
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a water soluble lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译：用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及水溶性润滑增强组分物理地固定到所述中空管上，并且以有效促进IOL通过中空空间的量在内壁或其附近集中。

48. 发明授权

US06254607B1 IOL insertion apparatus and method for using same 有权
标题翻译： IOL插入装置及其使用方法
公开(公告)号：US06254607B1
公开(公告)日：2001-07-03
申请号：US09392066
申请日：1999-09-08
申请人： Harish C. Makker , Shih-Liang S. Yang , Daniel G. Brady
发明人： Harish C. Makker , Shih-Liang S. Yang , Daniel G. Brady
IPC分类号： A61F900
CPC分类号： A61F2/167 , A61F2/1678
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.
摘要翻译：将眼内透镜（IOL）插入到眼睛中的装置包括管，具有远端部的杆和由远端部承载的尖端。尖端比杆的远端部分更软。使用这种装置将IOL插入眼睛的方法在本发明的范围内。

49. 发明授权

US09987125B2 Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity 有权
公开(公告)号：US09987125B2
公开(公告)日：2018-06-05
申请号：US14804240
申请日：2015-07-20
申请人： Daniel G. Brady , Scott J. Catlin , Edward P. Geraghty , Huawei Zhao
发明人： Daniel G. Brady , Scott J. Catlin , Edward P. Geraghty , Huawei Zhao
IPC分类号： A61F2/16
CPC分类号： A61F2/1618 , A61F2/1624 , A61F2/1635 , A61F2002/1681 , A61F2002/1682 , A61F2002/1689 , A61F2250/0018
摘要： An intraocular lens for providing a range of accommodative vision, an extended depth of focus, or enhanced performance through the asymmetric transfer of ocular forces to the lens. The intraocular lens contains an optic and a haptic. The shape and/or material of the haptic results in the transmission of ocular forces to particular regions in the optic. Greater forces applied to particular regions result in deformation of that region and increased power.

50. 发明授权

US09278026B2 Capsular membrane treatments to increase accommodative amplitude 有权
标题翻译：荚膜治疗增加调节幅度
公开(公告)号：US09278026B2
公开(公告)日：2016-03-08
申请号：US13043149
申请日：2011-03-08
申请人： Zsolt Bor , Daniel G. Brady , Edward Geraghty , Carina R. Reisin , Douglas S. Cali
发明人： Zsolt Bor , Daniel G. Brady , Edward Geraghty , Carina R. Reisin , Douglas S. Cali
IPC分类号： A61F2/14 , A61B18/18 , A61F9/007 , A61F9/008 , A61F2/16
CPC分类号： A61F9/013 , A61F2/16 , A61F9/00 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F9/0079 , A61F9/008 , A61F9/00838 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895
摘要： Methods and apparatus treat the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion.
摘要翻译：方法和装置处理晶状体囊以增加眼睛的适应性。透镜胶囊的治疗可以包括处理透镜胶囊的一部分，以便加强经处理的部分并改善眼睛的适应性。透镜胶囊的中间部分可以位于透镜胶囊的光学使用的中心部分和与眼睛的小区连接的透镜胶囊的周边部分之间。透镜胶囊的加强的中间部分可以改善透镜胶囊的周边部分与透镜胶囊的中心部分的联接，使得透镜的光学中心部分的调节量增加。当透镜胶囊对设置在透镜胶囊内的透镜的力增加时，透镜可以包括眼睛的天然晶状体或诸如调节性IOL的人造镜片。治疗眼睛以加强中间部分可以包括向中间部分施加一种或多种能量或物质。

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