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41. 发明授权

US07153940B2 C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof 失效
标题翻译：在人前列腺癌中表达的C型凝集素跨膜抗原及其用途
公开(公告)号：US07153940B2
公开(公告)日：2006-12-26
申请号：US10460512
申请日：2003-06-11
申请人： Daniel E. H. Afar , Rene S. Hubert , Aya Jakobovits , Arthur B. Raitano
发明人： Daniel E. H. Afar , Rene S. Hubert , Aya Jakobovits , Arthur B. Raitano
IPC分类号： C07K16/00
CPC分类号： G01N33/574 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/7056 , G01N33/57434 , Y02A50/466
摘要： A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly expressed in prostate cancer. Consequently, PC-LECTIN provides a diagnostic and/or therapeutic target for prostate cancer.
摘要翻译：描述了在前列腺癌及其编码的蛋白质中高度过表达的新基因（称为PC-LECTIN）。正常人组织中的PC-LECTIN仅限于睾丸，但在前列腺癌中高度表达。因此，PC-LECTIN为前列腺癌提供了诊断和/或治疗靶点。

42. 发明授权

US06602501B1 C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof 失效
标题翻译：在人前列腺癌中表达的C型凝集素跨膜抗原及其用途
公开(公告)号：US06602501B1
公开(公告)日：2003-08-05
申请号：US09638203
申请日：2000-08-11
申请人： Daniel E. H. Afar , Rene S. Hubert , Aya Jakobovits , Arthur B. Raitano
发明人： Daniel E. H. Afar , Rene S. Hubert , Aya Jakobovits , Arthur B. Raitano
IPC分类号： A61K39395
CPC分类号： G01N33/574 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/7056 , G01N33/57434 , Y02A50/466
摘要： A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly expressed in prostate cancer. Consequently, PC-LECTIN provides a diagnostic and/or therapeutic target for prostate cancer.

43. 发明授权

US07981624B2 Methods to detect tumors using 20P1F12/TMPRSS2 expression 有权
标题翻译：使用20P1F12 / TMPRSS2表达检测肿瘤的方法
公开(公告)号：US07981624B2
公开(公告)日：2011-07-19
申请号：US12389293
申请日：2009-02-19
申请人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译：描述了衍生自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中，生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。

44. 发明授权

US07951375B2 Methods of inducing an immune response 失效
标题翻译：诱导免疫反应的方法
公开(公告)号：US07951375B2
公开(公告)日：2011-05-31
申请号：US11156231
申请日：2005-06-17
申请人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
发明人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译：图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此，基因 2提供癌症的诊断，预后，预防和/或治疗靶点。图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

45. 发明授权

US07892548B2 121P1F1: a tissue specific protein highly expressed in various cancers 失效
标题翻译： 121P1F1：在各种癌症中高度表达的组织特异性蛋白
公开(公告)号：US07892548B2
公开(公告)日：2011-02-22
申请号：US11952930
申请日：2007-12-07
申请人： Pia M. Challita-Eid , Rene S. Hubert , Steven Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
发明人： Pia M. Challita-Eid , Rene S. Hubert , Steven Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
IPC分类号： A61K39/40 , C07K16/00
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , Y02A50/465 , Y02A50/473
摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译：描述了一种新型基因（称为121P1F1）及其编码的蛋白质。 121P1F1在正常成人组织中表现出组织特异性表达，但其在前列腺，膀胱，肾，脑，骨，子宫颈，子宫，卵巢，乳腺，胰腺，胃，结肠，直肠，白细胞，肝，肺等多种癌症中异常表达癌症因此，121P1F1提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的121P1F1基因或其片段，或其编码的蛋白质或其片段。

46. 发明授权

US07641905B2 Methods of inducing an immune response 有权
标题翻译：诱导免疫反应的方法
公开(公告)号：US07641905B2
公开(公告)日：2010-01-05
申请号：US11154298
申请日：2005-06-15
申请人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
发明人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译：图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此，基因 2提供癌症的诊断，预后，预防和/或治疗靶点。图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

47. 发明授权

US07601825B2 Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的蛋白质121P1F1可用于治疗和检测癌症
公开(公告)号：US07601825B2
公开(公告)日：2009-10-13
申请号：US10087190
申请日：2002-02-28
申请人： Pia M. Challita-Eid , Rene S. Hubert , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Ge Wangmao , Aya Jakobovits
发明人： Pia M. Challita-Eid , Rene S. Hubert , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Ge Wangmao , Aya Jakobovits
IPC分类号： C07H21/04 , C12N7/00 , C12N15/00 , A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/34 , G01N33/574 , Y02A50/466
摘要： A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P1F1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P1F1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P1F1 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为121P1F1）及其编码的蛋白质及其变体，其中121P1F1在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P1F1提供诊断，预后，癌症的预防和/或治疗靶标。 121P1F1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P1F1反应的抗体或T细胞可用于主动或被动免疫。

48. 发明授权

US07569356B2 Diagnosis and therapy of cancer using SGP28-related molecules 失效
标题翻译：使用SGP28相关分子诊断和治疗癌症
公开(公告)号：US07569356B2
公开(公告)日：2009-08-04
申请号：US10992946
申请日：2004-11-18
申请人： Daniel E. H. Afar , Rene S. Hubert , Arthur B. Raitano , Steven Chappell Mitchell , Mary Faris , Aya Jakobovits
发明人： Daniel E. H. Afar , Rene S. Hubert , Arthur B. Raitano , Steven Chappell Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
摘要翻译：本发明涉及用于诊断和治疗前列腺癌的方法和组合物，其利用对应于人SGP28基因的分离的多核苷酸，由SGP28基因及其片段编码的蛋白质，以及能够特异性识别和结合SGP28蛋白质的抗体。

49. 发明授权

US07488479B2 Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的蛋白质125P5C8可用于治疗和检测癌症
公开(公告)号：US07488479B2
公开(公告)日：2009-02-10
申请号：US10099460
申请日：2002-03-13
申请人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后，癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。

50. 发明授权

US07351583B2 Antibodies to G protein-coupled receptor 失效
标题翻译： G蛋白偶联受体的抗体
公开(公告)号：US07351583B2
公开(公告)日：2008-04-01
申请号：US10991028
申请日：2004-11-16
申请人： Arthur B. Raitano , Daniel E. H. Afar , Aya Jakobovits , Mary Faris , Rene S. Hubert , Steven Chappell Mitchell , Douglas Saffran
发明人： Arthur B. Raitano , Daniel E. H. Afar , Aya Jakobovits , Mary Faris , Rene S. Hubert , Steven Chappell Mitchell , Douglas Saffran
IPC分类号： C12N15/85
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/705 , C07K16/3069 , C07K2317/34
摘要： A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.
摘要翻译：描述了在前列腺和其他癌症及其编码的蛋白质中高度过表达的新基因（称为PHOR-1）。 PHOR-1是与涉及嗅觉的受体具有同源性的G蛋白偶联受体。正常人组织中的PHOR-1仅限于前列腺，并且该基因在前列腺癌以及肾，子宫，宫颈，胃和直肠的癌症中高度过度表达。因此，PHOR-1为前列腺癌提供了诊断和/或治疗靶点。

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