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41. 发明申请

US20120088789A1 CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 有权
标题翻译： CHROMEN-2-ONE衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20120088789A1
公开(公告)日：2012-04-12
申请号：US13319955
申请日：2010-05-06
申请人： Dan Peters , Elsebet Østergaard Nielsen , Karin Sandager Nielsen , Gordon Munro
发明人： Dan Peters , Elsebet Østergaard Nielsen , Karin Sandager Nielsen , Gordon Munro
IPC分类号： A61K31/439 , A61P29/02 , A61P25/24 , C07D451/12 , A61P25/00
CPC分类号： C07D451/06 , A61K31/46
摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本申请公开了新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基） - 苯并二氢吡喃-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途。在其它方面，申请公开了这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

42. 发明申请

US20120004257A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：US20120004257A1
公开(公告)日：2012-01-05
申请号：US13173178
申请日：2011-06-30
申请人： Dan Peters , Gordon Munro , Elsebet Østergaard Nielsen
发明人： Dan Peters , Gordon Munro , Elsebet Østergaard Nielsen
IPC分类号： A61K31/46 , A61P25/04 , A61P25/24 , C07D451/06 , A61P25/00
CPC分类号： C07D451/06
摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本申请公开了新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基）色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途。在其它方面，申请公开了这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

43. 发明申请

US20110269778A1 NOVEL DIPHENYL PURINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开
标题翻译：新型二苯基衍生物有用作为非丁基乙酰胆碱受体的调节剂
公开(公告)号：US20110269778A1
公开(公告)日：2011-11-03
申请号：US13123259
申请日：2009-10-08
申请人： Antonio Nardi , Jeppe Kejser Christensen , Dan Peters
发明人： Antonio Nardi , Jeppe Kejser Christensen , Dan Peters
IPC分类号： A61K31/52 , C07D487/04 , A61K31/522 , A61K31/519 , A61P25/22 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/24 , A61P25/18 , A61P3/04 , A61P25/14 , A61P25/08 , A61P11/06 , A61P17/00 , A61P25/06 , A61P25/30 , A61P1/00 , C07D473/00
CPC分类号： C07D487/04
摘要： This invention relates to novel (6-phenyl-5-amino/nitro-pyrimidin-4-yl)-phenyl-amines, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及被发现是烟碱乙酰胆碱受体调节剂的新的（6-苯基-5-氨基/硝基 - 嘧啶-4-基） - 苯基胺。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

44. 发明申请

US20110257161A1 NOVEL DIAZA-BICYCLONONYL-PHENYL DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：新型二氮杂双环苯基衍生物及其医药用途
公开(公告)号：US20110257161A1
公开(公告)日：2011-10-20
申请号：US13132366
申请日：2009-12-03
申请人： Dan Peters , Daniel B. Timmermann , Elsebet ?stergaard Nielsen , Jeppe Kejser Christensen , Tino Dyhring
发明人： Dan Peters , Daniel B. Timmermann , Elsebet ?stergaard Nielsen , Jeppe Kejser Christensen , Tino Dyhring
IPC分类号： A61K31/551 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/00 , A61P3/04 , A61P25/16 , A61P25/14 , A61P25/22 , A61P25/08 , A61P25/02 , A61P9/10 , A61P15/06 , A61P1/12 , A61P11/06 , A61P15/10 , A61P29/00 , A61P17/10 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , C07D487/04
CPC分类号： C07D471/08
摘要： This invention relates to novel diazabicyclononyl-phenyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及新的二氮杂双环壬基苯基衍生物及其在制备药物组合物中的用途。发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

45. 发明申请

US20110201656A1 NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开
标题翻译：新型二苯基-1,2,3-三唑衍生物作为非线性乙酰胆碱受体的调节剂有用
公开(公告)号：US20110201656A1
公开(公告)日：2011-08-18
申请号：US13057957
申请日：2009-08-03
申请人： Antonio Nardi , Jeppe Kejser Christensen , Dan Peters
发明人： Antonio Nardi , Jeppe Kejser Christensen , Dan Peters
IPC分类号： A61K31/4192 , C07D249/06 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/16 , A61P25/24 , A61P25/18 , A61P3/04 , A61P25/20 , A61P25/02 , A61P25/08 , A61P9/12 , A61P9/06 , A61P21/00 , A61P1/12 , A61P11/06 , A61P15/00 , A61P5/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P17/00 , A61P17/10 , A61P25/36 , A61P25/30
CPC分类号： C07D249/06
摘要： This invention relates to novel diphenyl 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及新的二苯基1,2,3-三唑衍生物，其被发现是烟碱乙酰胆碱受体的调节剂。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

46. 发明授权

US07960561B2 2-(phenylamino) benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels 有权
标题翻译： 2-（苯基氨基）苯并咪唑衍生物及其作为小电导钙激活钾通道的调节剂的用途
公开(公告)号：US07960561B2
公开(公告)日：2011-06-14
申请号：US11919708
申请日：2006-06-21
申请人： Ulrik Svane Sørensen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
IPC分类号： A61K31/4184 , C07D235/30
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels).In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-（苯基氨基）苯并咪唑衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

47. 发明授权

US07943630B2 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效
标题翻译： 3,9-二氮杂螺[5.5]十一烷衍生物及其作为单胺神经递质再摄取抑制剂的用途
公开(公告)号：US07943630B2
公开(公告)日：2011-05-17
申请号：US11922931
申请日：2006-06-28
申请人： Birgitte L. Eriksen , Dan Peters , Elsebet Ostergaard Nielsen , John Paul Redrobe
发明人： Birgitte L. Eriksen , Dan Peters , Elsebet Ostergaard Nielsen , John Paul Redrobe
IPC分类号： A01N43/42 , A61K31/44 , C07D211/00 , C07D213/00 , C07D215/00 , C07D217/00 , C07D219/00 , C07D221/00
CPC分类号： C07D471/10
摘要： This invention relates to novel 3,9-diaza-spiro[5.5]undecane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型3,9-二氮杂螺[5.5]十一烷衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

48. 发明申请

US20110105478A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS 失效
标题翻译：新的1,4-二氮杂双环[3.2.2]有用的作为非线性乙酰胆碱受体的调节剂的NONYL OXADIAZOLYL衍生物
公开(公告)号：US20110105478A1
公开(公告)日：2011-05-05
申请号：US12921922
申请日：2009-03-09
申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Eva Dam Christoffersen
发明人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Eva Dam Christoffersen
IPC分类号： A61K31/551 , C07D487/08 , A61P25/00 , A61P25/28 , A61P25/24 , A61P25/18 , A61P3/04 , A61P25/16 , A61P29/00 , A61P1/00 , A61P11/06 , A61P17/10
CPC分类号： C07D471/08
摘要： This invention relates to novel N-oxides of a 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivative and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物的新型N-氧化物及其在制备药物组合物中的用途。发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

49. 发明申请

US20110085978A1 NOVEL QUINOLINYLAMIDE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS 审中-公开
标题翻译：新戊酰胺衍生物作为多巴胺和丝氨酸受体的调节剂有用
公开(公告)号：US20110085978A1
公开(公告)日：2011-04-14
申请号：US12922368
申请日：2009-03-13
申请人： Dan Peters , Lars Christian Rønn , Karin Sandager Nielsen , Jørgen Scheel-Krüger
发明人： Dan Peters , Lars Christian Rønn , Karin Sandager Nielsen , Jørgen Scheel-Krüger
IPC分类号： A61K49/00 , C07D401/12 , A61K31/496 , C07D401/14 , A61K31/4709 , A61K31/5513 , A61P25/18 , A61P25/00
CPC分类号： C07D215/38 , C07D401/12
摘要： This invention provides novel quinolinylamide derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, 5HT1A and 5-HT2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.
摘要翻译：本发明提供具有医疗效用的新型喹啉基酰胺衍生物，特别是作为多巴胺和5-羟色胺受体的调节剂，优选为D3,5HT1A和5-HT2A受体亚型，特别可用于治疗神经精神障碍。精神分裂症

50. 发明申请

US20110053984A1 NOVEL 4-BENZHYDRYLOXY-TETRAALKYL-PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
标题翻译：新型4-苄氧基 - 四氢吡啶衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20110053984A1
公开(公告)日：2011-03-03
申请号：US12921030
申请日：2009-02-27
申请人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
发明人： Dan Peters , John Paul Redrobe , Elsebet Østergaard Nielsen
IPC分类号： A61K31/445 , C07D211/46 , A61P25/00 , A61P29/00 , A61P13/00 , A61P15/00
CPC分类号： C07D211/46
摘要： This invention relates to novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives of Formula (I), any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein Ra represents hydrogen or C1-6-alkyl; Rb and Rc independent of each other represent a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, C1-6-alkoxy and methylenedioxo; R′, R″, R′″ and R″″ independent of each other represent C1-6-alkyl; and with the proviso that the compound is not 4-benzhydryloxy-1,2,2,6,6-pentamethyl-piperidine, useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及式（I）的新型4-二苯甲氧基 - 四烷基 - 哌啶衍生物，其任何立体异构体或其立体异构体的任何混合物或其N-氧化物或其药学上可接受的盐，其中R a表示氢或C 1 -6-烷基; Rb和Rc彼此独立地表示苯基，该苯基任选被一个或多个独立地选自卤素，三氟甲基，三氟甲氧基，氰基，C 1-6 - 烷氧基和亚甲基二氧基的取代基取代; R'，R“，R”“和R”“彼此独立地表示C 1-6 - 烷基; 并且条件是该化合物不是4-二苯甲基氧基-1,2,2,6,6-五甲基哌啶，其可用作单胺神经递质再摄取抑制剂。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

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