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41. 发明授权

US07580185B2 Microscopy system, microscopy method and a method of treating an aneurysm 有权
标题翻译：显微镜系统，显微镜法和治疗动脉瘤的方法
公开(公告)号：US07580185B2
公开(公告)日：2009-08-25
申请号：US10650038
申请日：2003-08-28
申请人： Michael Haisch , Christoph Hauger , Gerhard Gaida , Andreas Raabe
发明人： Michael Haisch , Christoph Hauger , Gerhard Gaida , Andreas Raabe
IPC分类号： G02B21/06
CPC分类号： G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
摘要翻译：显微镜系统和方法允许观察积聚在组织中的荧光物质。可以在可见光和荧光的同时观察组织。可以观察到与可见光图像重叠的一系列先前记录的荧光图像。可以自动确定一系列图像的结束。可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。此外，可以分析荧光图像以识别其相干荧光部分。可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

42. 发明申请

US20090059363A1 MICROSCOPE SYSTEM 审中-公开
标题翻译：微观系统
公开(公告)号：US20090059363A1
公开(公告)日：2009-03-05
申请号：US12205742
申请日：2008-09-05
申请人： Fritz Straehle , Christoph Hauger
发明人： Fritz Straehle , Christoph Hauger
IPC分类号： G02B21/06
CPC分类号： G02B26/0816 , A61B90/20 , A61B90/36 , G02B21/0012 , G02B21/22 , G02B27/642
摘要： A microscope system for imaging an object which can be arranged in an object plane of the microscope system, which includes an imaging system, a displacement device and a controller is described. The imaging system may provide at least one optical imaging path for imaging an imaging field of the object plane. The displacement device may be adapted to translatory displace the imaging field of the imaging system in the object plane. The controller is adapted to determine a desired displacement of the imaging field in the object plane and to correspondingly control the displacement device.
摘要翻译：描述了可以布置在包括成像系统，位移装置和控制器的显微镜系统的物体平面中的物体成像的显微镜系统。成像系统可以提供至少一个光学成像路径，用于对对象平面的成像场进行成像。位移装置可以适于平移位移物体平面中的成像系统的成像场。控制器适于确定物体平面中的成像场的期望位移并且相应地控制位移装置。

43. 发明授权

US07488070B2 Optical measuring system and optical measuring method 有权
标题翻译：光学测量系统和光学测量方法
公开(公告)号：US07488070B2
公开(公告)日：2009-02-10
申请号：US11472030
申请日：2006-06-21
申请人： Christoph Hauger , Peter Reimer
发明人： Christoph Hauger , Peter Reimer
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/1015 , A61B3/1005 , A61B3/102 , A61B3/12 , G01J9/00 , G01N21/47
摘要： An optical measuring system, including at least one radiation source; a first beam splitter; a second beam splitter; an OCT detector; a wavefront detector which is different from the OCT detector; at least one active optical element; and a collimator. The radiation source, the first beam splitter, the second beam splitter, the OCT detector, the wavefront detector, the at least one active optical element, and the collimator are arranged such that a source beam generated by the at least one radiation source is divided into an object illuminating beam and a reference beam by the first beam splitter; the object illuminating beam is directed by the collimator to an object position via the at least one active optical element; radiation emanating from the object position is formed to an object measuring beam by at least the collimator; the object measuring beam is directed to the second beam splitter via the at least one active optical element; the object measuring beam is divided into an OCT measuring beam and a wavefront measuring beam by the second beam splitter; the wavefront measuring beam is directed to the wavefront detector; the OCT measuring beam is directed to the OCT detector; and the reference beam is directed to the OCT detector.
摘要翻译：一种光学测量系统，包括至少一个辐射源; 第一分束器; 第二分束器; OCT检测器与OCT检测器不同的波前检测器; 至少一个有源光学元件; 和准直仪。辐射源，第一分束器，第二分束器，OCT检测器，波前检测器，至少一个有源光学元件和准直器被布置成使得由至少一个辐射源产生的源光束被分割通过第一分束器成为物体照明光束和参考光束; 物体照明光束通过至少一个有源光学元件被准直器引导到物体位置; 从物体位置发出的辐射通过至少准直器形成对象测量光束; 物体测量光束经由至少一个有源光学元件被引导到第二分束器; 物体测量光束由第二分束器分为OCT测量光束和波前测量光束; 波前测量光束被引导到波前检测器; OCT测量光束被引导到OCT检测器; 并且参考光束被引导到OCT检测器。

44. 发明申请

US20080212171A1 Microscopy System 有权
标题翻译：显微镜系统
公开(公告)号：US20080212171A1
公开(公告)日：2008-09-04
申请号：US12090629
申请日：2006-10-20
申请人： Fritz Strahle , Christoph Hauger
发明人： Fritz Strahle , Christoph Hauger
IPC分类号： G02B21/22
CPC分类号： G02B21/025 , G02B15/14 , G02B17/026 , G02B21/0028 , G02B21/22
摘要： The invention relates to a microscopy system for representing an object that can be placed on an object plane (1) of the microscopy system, the latter comprising a representation system (26) containing several optical elements for providing at least one optical representation path (2a, 2b, 2c, 2d). According to one embodiment of the invention, the optical elements comprise a plurality of optical lenses (4-8, 11, 13, 14), through which the optical representation path(s) (2a-2d) pass(es) in sequence and which represent the object plane (1) in an intermediate image (P). The optical lenses (4-8, 11) are configured in such a way that the representation of the object plane (1) in the intermediate image (P) is reduced a maximum 0.9 times, preferably a maximum 0.8 times, preferably a maximum 0.6 times, with 0.5 times being the preferred maximum reduction.
摘要翻译：本发明涉及一种用于表示可放置在显微系统的物平面（1）上的物体的显微镜系统，后者包括一个表示系统（26），其包含若干光学元件，用于提供至少一个光学表示路径（2） a，2b，2c，2d）。根据本发明的一个实施例，光学元件包括多个光学透镜（4至8,11,13,14），光学表示路径（a2a-2d）通过该光学透镜并且其表示中间图像（P）中的物体平面（1）。光学透镜（4〜8,11）的配置使得中间图像（P）中的物平面（1）的表示最大减少0.9倍，优选地减小最大0.8倍，优选地减小最大0.6 次，优选最大减少量为0.5倍。

45. 发明授权

US07369073B2 Microscopy system and recording method for visualizing fluorescence 有权
标题翻译：显微镜系统和荧光显像的记录方法
公开(公告)号：US07369073B2
公开(公告)日：2008-05-06
申请号：US11544269
申请日：2006-10-06
申请人： Helge Jess , Petra Weinschenk , Martin Schneider , Christoph Hauger , Hans-Joachim Miesner
发明人： Helge Jess , Petra Weinschenk , Martin Schneider , Christoph Hauger , Hans-Joachim Miesner
IPC分类号： H03M1/00
CPC分类号： G02B21/0076 , G01N21/6428 , G01N21/6458
摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.
摘要翻译：图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。电路的增益可调。在记录过程开始时，增益被设置为合适的最大值。如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。

46. 发明授权

US08705042B2 Microscopy system, microscopy method and method of treating an aneurysm 有权
标题翻译：显微镜系统，显微镜法和治疗动脉瘤的方法
公开(公告)号：US08705042B2
公开(公告)日：2014-04-22
申请号：US13479453
申请日：2012-05-24
申请人： Michael Haisch , Christoph Hauger , Harmut Wolf , Joachim Hug , Brigitta Schwarz , Gerhard Gaida , Andreas Raabe
发明人： Michael Haisch , Christoph Hauger , Harmut Wolf , Joachim Hug , Brigitta Schwarz , Gerhard Gaida , Andreas Raabe
IPC分类号： G01J3/45
CPC分类号： G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
摘要： A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series.
摘要翻译：提供显微镜系统和显微镜方法来观察积聚在组织中的荧光物质。显微镜系统包括允许在可见光和荧光的同时观察组织的过滤器。可以观察到与可见光图像重叠的一系列先前记录的荧光图像。可以自动确定一系列图像的结束。可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。

47. 发明授权

US08040599B2 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US08040599B2
公开(公告)日：2011-10-18
申请号：US12162601
申请日：2007-01-30
申请人： Joachim Steffen , Helge Jess , Christoph Hauger
发明人： Joachim Steffen , Helge Jess , Christoph Hauger
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/16 , G02B21/20 , G02B21/22
摘要： A microscope system is for sequential observation of different fluorescent dyes that are accumulated in a tissue in an object plane. An illumination system and an observation system have at least two operating states. In one operating state, illumination radiation has a spectrum that includes an excitation band of a first fluorescent dye and is partly free from an excitation band of another fluorescent dye. In one operating state of the observation system, observation radiation guided in the first observation optical path has a spectrum in sections of the first observation optical path, which includes a first fluorescence band of the first fluorescent dye, while in another operating state observation radiation has a spectrum in at least some sections which is partly free from the first fluorescence band. A controller is configured to selectively switch the illumination system and the observation system into the first and second operating states.
摘要翻译：显微镜系统用于顺序观察积聚在物体平面中的组织中的不同荧光染料。照明系统和观察系统具有至少两个操作状态。在一个操作状态下，照射辐射具有包括第一荧光染料的激发带并且部分没有另一荧光染料的激发带的光谱。在观察系统的一个操作状态下，在第一观察光路中引导的观察辐射具有包括第一荧光染料的第一荧光带的第一观察光路的部分的光谱，而在另一个操作状态下，观察辐射具有在至少部分无第一荧光带的部分的光谱。控制器被配置为选择性地将照明系统和观察系统切换到第一和第二操作状态。

48. 发明申请

US20110178395A1 IMAGING METHOD AND SYSTEM 审中-公开
标题翻译：成像方法与系统
公开(公告)号：US20110178395A1
公开(公告)日：2011-07-21
申请号：US12756765
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
IPC分类号： A61B6/00
CPC分类号： A61B5/064 , A61B1/00041 , A61B1/0005 , A61B1/0008 , A61B1/00096 , A61B1/00149 , A61B1/00172 , A61B1/042 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/065 , A61B5/445 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B8/12 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B90/20 , A61B90/36 , A61B2090/364 , A61B2562/0242 , G02B21/0012 , G02B21/0024
摘要： Imaging systems and methods are provided herein. An imaging system for imaging a surgical site, may include a macroscopic visualization system; and an imaging apparatus with a probe, the imaging apparatus being adapted to image the observational field and generate second image data; wherein the system is operable to control the macroscopic visualization system and the imaging apparatus to image the site and the observational field respectively at substantially the same time, and to associate the first image data and the second image data. Imaging methods provided herein may include the steps of: imaging the site with a macroscopic visualization system and generating first image data; imaging at substantially the same time an observational field with an imaging apparatus and generating second image data; and associating the first image data and the second image data.
摘要翻译：本文提供成像系统和方法。用于成像外科手术部位的成像系统可以包括宏观可视化系统; 以及具有探针的成像装置，所述成像装置适于对所述观察场进行成像并生成第二图像数据; 其中所述系统可操作以控制所述宏观可视化系统和所述成像装置，以在基本相同的时间分别对所述场地和所述观测场进行成像，并且将所述第一图像数据和所述第二图像数据相关联。本文提供的成像方法可以包括以下步骤：用宏观可视化系统对站点进行成像并产生第一图像数据; 在大体上相同的时间成像具有成像装置的观察场并产生第二图像数据; 以及将所述第一图像数据和所述第二图像数据相关联。

49. 发明申请

US20110170179A1 STEREOSCOPIC MICROSCOPE 有权
公开(公告)号：US20110170179A1
公开(公告)日：2011-07-14
申请号：US13071975
申请日：2011-03-25
申请人： Fritz Strãhle , Christoph Hauger
发明人： Fritz Strãhle , Christoph Hauger
IPC分类号： G02B21/22
CPC分类号： G02B21/22
摘要： A microscope or stereomicroscope for representing an object that can be placed on an object plane of the stereomicroscope provides at least one pair of optical paths and comprises at least one deflection element with a reflecting surface and a representation system containing several optical elements. The optical elements include a plurality of lenses. In addition, the optical elements are configured in such a way that pupil planes of the optical representation paths intersect the reflecting surface of the deflection element or are located at a distance from said reflecting surface less than 1.5 times the diameter of one of the reflecting surfaces along the optical representation paths on the closest lens of the plurality of lenses. An alternative embodiment provides a stereomicroscope with a particularly compact construction, in which at least one pair of optical representation paths is reflected on a first, second, third, and fourth reflecting surface.
摘要翻译：用于表示可以放置在立体显微镜的物平面上的物体的显微镜或立体显微镜提供至少一对光路，并且包括具有反射表面的至少一个偏转元件和包含多个光学元件的表示系统。光学元件包括多个透镜。此外，光学元件被配置成使得光学表示路径的光瞳平面与偏转元件的反射表面相交，或者位于离所述反射表面一定距离处的距离小于反射表面之一的直径的1.5倍沿着多个透镜最近的透镜上的光学表示路径。替代实施例提供具有特别紧凑结构的立体显微镜，其中至少一对光学表示路径在第一，第二，第三和第四反射表面上被反射。

50. 发明申请

US20110090325A1 SYSTEM AND METHOD FOR EXAMINING AN OBJECT 有权
标题翻译：用于检查对象的系统和方法
公开(公告)号：US20110090325A1
公开(公告)日：2011-04-21
申请号：US12757000
申请日：2010-04-08
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：在用于检查包含流体液体的物体的系统和方法中，用测量光照射物体，并且临时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

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