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41. 发明授权

US6147051A Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction 失效
标题翻译：用于器官功能减退的预防和/或治疗的方法和组合物
公开(公告)号：US6147051A
公开(公告)日：2000-11-14
申请号：US561096
申请日：1995-11-21
申请人： Toshifumi Watanabe , Mitsuhiro Wakimasu , Chieko Kitada
发明人： Toshifumi Watanabe , Mitsuhiro Wakimasu , Chieko Kitada
IPC分类号： A61K31/19 , A61K31/496 , A61K31/505 , A61K38/04 , A61K38/12
CPC分类号： A61K38/12 , A61K31/19 , A61K31/496 , A61K31/505 , A61K38/04
摘要： Compounds having antagonistic activity on endothelin receptors can be effectively used for prophylaxis and/or treatment of hypofunction of organs which occurs in their surgery or transplant.
摘要翻译：对内皮素受体具有拮抗作用的化合物可以有效地用于预防和/或治疗其手术或移植中出现的器官的功能低下。

42. 发明授权

US5801147A Polypeptides and use thereof 失效
标题翻译：多肽及其用途
公开(公告)号：US5801147A
公开(公告)日：1998-09-01
申请号：US766725
申请日：1996-12-13
申请人： Chieko Kitada , Takuya Watanabe
发明人： Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , C07K1/00 , C07K14/575 , C07K14/00
CPC分类号： C07K1/006 , C07K14/57563 , A61K38/00
摘要： Disclosed are (1) a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof: His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO:13 (I) wherein X is hydrogen atom; or a lower alkyl group which may be substituted with a member selected from the group consisting of hydroxy group, substituted or unsubstituted amino group, carboxyl group, carbamoyl group, and substituted or unsubstituted aromatic group; and Y is one of amino acids or peptides consisting of 1 to 16 amino acid residues counted from the N-terminal side of Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys SEQ ID NO:20, and (2) a pharmaceutical composition comprising a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof, which has remarkable c-AMP activity and is useful as a nerve activating agent.
摘要翻译：公开了（1）式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐：His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr -Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO：13（I）其中X是氢原子; 或可以被选自羟基，取代或未取代的氨基，羧基，氨基甲酰基和取代或未取代的芳基的成员取代的低级烷基; Y是从Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val的N-末端计数的1至16个氨基酸残基组成的氨基酸或肽之一 -Lys-Asn-Lys SEQ ID NO：20，和（2）包含由式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐的药物组合物，其具有显着的c-AMP活性并且是有用的作为神经活化剂。

43. 发明授权

US08778871B2 Metastin derivatives and use thereof 有权
标题翻译： Metastin衍生物及其用途
公开(公告)号：US08778871B2
公开(公告)日：2014-07-15
申请号：US12286671
申请日：2008-10-01
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
摘要翻译：本发明提供具有优异生物活性（癌转移抑制活性，癌生长抑制活性等）的稳定的转铁蛋白衍生物。已经发现通过用特异性修饰基修饰转氨酶的构成氨基酸，具有比天然转移蛋白更多的改善的血液稳定性的转氨酶衍生物，并且显示出优异的癌症转移抑制活性或癌症生长抑制活性。此外，已经发现这些转氨酶衍生物表现出抑制促性腺激素分泌，抑制性激素分泌等的作用，其完全不同于迄今已知的效果。

44. 发明授权

US07625869B2 Metastin derivatives and use thereof 失效
标题翻译： Metastin衍生物及其用途
公开(公告)号：US07625869B2
公开(公告)日：2009-12-01
申请号：US11630698
申请日：2005-06-23
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
摘要翻译：本发明提供具有优异生物活性（癌转移抑制活性，癌生长抑制活性等）的稳定的转铁蛋白衍生物。已经发现通过用特异性修饰基修饰转氨酶的构成氨基酸，具有比天然转移蛋白更多的改善的血液稳定性的转氨酶衍生物，并且显示出优异的癌症转移抑制活性或癌症生长抑制活性。此外，已经发现这些转氨酶衍生物表现出抑制促性腺激素分泌，抑制性激素分泌等的作用，其完全不同于迄今已知的效果。

45. 发明授权

US07608409B2 Screening assay using G-protein coupled receptor protein OT7T175 失效
标题翻译：使用G蛋白偶联受体蛋白OT7T175的筛选试验
公开(公告)号：US07608409B2
公开(公告)日：2009-10-27
申请号：US11976414
申请日：2007-10-24
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： C07K14/705 , G01N33/53
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
摘要翻译：本发明涉及大鼠小脑衍生和人类脑源性G蛋白偶联受体蛋白或其盐，其部分肽，酰胺，酯或其盐，配体，用于筛选改变结合的化合物的方法/试剂盒配体和G蛋白偶联受体蛋白质之间的性质，通过筛选获得的化合物或其G蛋白偶联受体蛋白质的抗体。

46. 发明授权

US07235531B2 Tachykinin-like polypeptides and use thereof 失效
标题翻译：速激激肽样多肽及其用途
公开(公告)号：US07235531B2
公开(公告)日：2007-06-26
申请号：US10168789
申请日：2000-12-21
申请人： Yasuaki Itoh , Kazunori Nishi , Chieko Kitada
发明人： Yasuaki Itoh , Kazunori Nishi , Chieko Kitada
IPC分类号： A61K38/04 , A61K38/08
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K7/22 , C07K14/475
摘要： The present invention relates to amino acid sequences for novel tachykinin polypeptides and base sequences encoding them, agonists and antagonists of such polypeptides, pharmaceutical compositions comprising them, and the like.
摘要翻译：本发明涉及新型速激肽多肽的氨基酸序列和编码它们的碱基序列，这种多肽的激动剂和拮抗剂，包含它们的药物组合物等。

47. 发明授权

US07064181B1 Physiologically active peptide and its use 失效
标题翻译：生理活性肽及其用途
公开(公告)号：US07064181B1
公开(公告)日：2006-06-20
申请号：US09646078
申请日：1999-03-24
申请人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
发明人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
IPC分类号： C07K14/00
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, a appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译：本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

48. 发明授权

US06699965B1 Peptides that activate the G-protein coupled receptor protein, 0T7T175 失效
标题翻译：激活G蛋白偶联受体蛋白的肽，0T7T175
公开(公告)号：US06699965B1
公开(公告)日：2004-03-02
申请号：US09830428
申请日：2001-04-26
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： C07K1400
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands thereto; a method/kit for screening compounds capable of altering the binding properties of the ligands to the G protein-coupled receptor proteins; the compounds or salts thereof obtained by the above screening; antibodies against the G protein-coupled receptor proteins, etc.
摘要翻译： G起源于大鼠脑干和人脑或其盐附近的蛋白质偶联受体蛋白质，或其肽片段或其酰胺，酯或其盐; 配体; 用于筛选能够改变配体与G蛋白偶联受体蛋白质的结合性质的化合物的方法/试剂盒; 通过上述筛选获得的化合物或其盐; 针对G蛋白偶联受体蛋白的抗体等

49. 发明申请

US20080312155A1 Metastin Derivatives and Use Thereof 失效
标题翻译： Metastin衍生物及其用途
公开(公告)号：US20080312155A1
公开(公告)日：2008-12-18
申请号：US11630698
申请日：2005-06-23
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
IPC分类号： A61K38/08 , C07K7/06 , A61P35/00 , A61P3/10
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
摘要翻译：本发明提供具有优异生物活性（癌转移抑制活性，癌生长抑制活性等）的稳定的转铁蛋白衍生物。已经发现通过用特异性修饰基修饰转氨酶的构成氨基酸，具有比天然转移蛋白更多的改善的血液稳定性的转氨酶衍生物，并且显示出优异的癌症转移抑制活性或癌症生长抑制活性。此外，已经发现这些转氨酶衍生物表现出抑制促性腺激素分泌，抑制性激素分泌等的作用，其完全不同于迄今已知的效果。

50. 发明申请

US20060155109A1 Novel physiologically active peptide and its use 失效
标题翻译：新型生理活性肽及其用途
公开(公告)号：US20060155109A1
公开(公告)日：2006-07-13
申请号：US11376694
申请日：2006-03-15
申请人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
发明人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译：本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

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