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41. 发明申请

US20050059885A1 Image guided spinal surgery guide, system and method for use thereof 有权
标题翻译：图像引导脊柱手术指南，系统及其使用方法
公开(公告)号：US20050059885A1
公开(公告)日：2005-03-17
申请号：US10939953
申请日：2004-09-13
申请人： Tony Melkent , Kevin Foley , Bradley Estes , Joseph Chaudoin
发明人： Tony Melkent , Kevin Foley , Bradley Estes , Joseph Chaudoin
IPC分类号： A61B19/00 , A61B1/00 , A61B17/16 , A61B17/17 , A61B17/56 , A61F2/28 , A61F2/44 , A61F2/46 , A61B5/05
CPC分类号： A61F2/4611 , A61B17/1757 , A61B34/20 , A61B34/25 , A61B2034/107 , A61B2034/2055 , A61B2034/2072 , A61B2034/254 , A61F2/442 , A61F2/4455 , A61F2002/2839 , A61F2002/4627 , A61F2002/4632 , Y10S606/907 , Y10S606/909 , Y10S606/912 , Y10S606/914
摘要： A guide is disclosed for use in performing spinal surgery to prepare across a spinal disc and adjacent vertebrae an implantation space. The guide is associated with a computer controlled surgical navigation system employing an energy-detecting array to track positions of the guide in three dimensional space relative to a known reference point. The guide comprises a body for providing protected access to prepare across the spinal disc and into the adjacent vertebrae the implantation space. The body has a passage adapted to receive a bone removal device for forming the implantation space through the body. At least one electrically energizable energy emitter array is attached to the body for use in identifying the location of the guide relative to the adjacent vertebrae. A system and method for using the guide in spinal surgery are also disclosed.
摘要翻译：公开了用于执行脊柱手术以在脊椎盘和相邻椎骨上准备植入空间的引导件。该指南与使用能量检测阵列的计算机控制手术导航系统相关联，以相对于已知的参考点跟踪三维空间中的引导的位置。引导件包括用于提供受保护的通路以准备穿过脊椎盘并进入相邻椎骨的植入空间的主体。身体具有适于接收用于通过身体形成植入空间的骨去除装置的通道。至少一个电激励能量发射器阵列附接到主体以用于识别引导件相对于相邻椎骨的位置。还公开了在脊柱手术中使用该引导件的系统和方法。

42. 外观设计

USD484684S1 Toiletry case 失效
标题翻译：化妆品盒
公开(公告)号：USD484684S1
公开(公告)日：2004-01-06
申请号：US29160467
申请日：2002-05-10
申请人： James B. Eldon, III , David D. McClanahan , Kevin Foley , James S. O'Halloran
设计人： James B. Eldon, III , David D. McClanahan , Kevin Foley , James S. O'Halloran

43. 发明授权

US09090569B2 Triazone compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三嗪类化合物
公开(公告)号：US09090569B2
公开(公告)日：2015-07-28
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

44. 发明授权

US08648104B2 Method for treating proliferative disorders associated with mutations in c-Met 有权
标题翻译：治疗与c-Met突变相关的增殖性疾病的方法
公开(公告)号：US08648104B2
公开(公告)日：2014-02-11
申请号：US12601729
申请日：2008-05-22
申请人： Zhenjian Du , Kevin Foley
发明人： Zhenjian Du , Kevin Foley
IPC分类号： A61K31/4196
CPC分类号： C07D249/12 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/4196 , C07D403/04
摘要： The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating c-Met associated cancers, in a subject in need thereof.
摘要翻译：本发明涉及在有需要的受试者中抑制Hsp90的活性的方法和有需要的受试者中用于治疗c-Met相关癌症的方法。

45. 发明授权

US08504483B2 Electronic trading system supporting anonymous negotiation and indications of interest 有权
标题翻译：电子交易系统支持匿名谈判和兴趣迹象
公开(公告)号：US08504483B2
公开(公告)日：2013-08-06
申请号：US12192253
申请日：2008-08-15
申请人： Kevin Foley , Kim Bang
发明人： Kevin Foley , Kim Bang
IPC分类号： H04K1/00 , H04L9/00 , G06Q40/00
CPC分类号： G06Q40/04 , G06Q20/383
摘要： A system conducts anonymous negotiations and supports indications of interest in trading stock. The system includes a database for storing public orders received from a public stock trading system; and a server for receiving hidden orders from a plurality of users and for conducting anonymous negotiations between first and second users with the hidden orders. The server repeatedly accesses the database to determine a match of any one of the hidden orders with any one of the public orders, and to execute a pair of orders selected from the hidden orders and the public orders. The system also transmits indications of interest (IOI) into a trading environment using the server for processing a trading order from a first user and for maintaining a profile of a user. The profile includes a current IOI setting for controlling transmission of the IOI from the user. The server responds to a toggle command from the first user to control transmission of the IOI opposite to the current IOI setting. The server responds to the IOI setting being set to allow transmission by transmitting the IOI of the first user associated with the trading order.
摘要翻译：一个系统进行匿名谈判，并支持交易股票的兴趣迹象。该系统包括用于存储从公共股票交易系统接收的公共订单的数据库; 以及服务器，用于从多个用户接收隐藏的命令，以及用隐藏的命令进行第一和第二用户之间的匿名协商。服务器重复访问数据库以确定任何一个隐藏的订单与任何一个公共订单的匹配，并执行从隐藏订单和公共订单中选择的一对订单。该系统还使用用于处理来自第一用户的交易订单的服务器将用户感兴趣的指示（IOI）发送到交易环境中并且用于维护用户的简档。配置文件包括用于控制来自用户的IOI传输的当前IOI设置。服务器响应来自第一个用户的切换命令来控制与当前IOI设置相反的IOI传输。服务器响应设置为允许通过传送与交易订单相关联的第一用户的IOI进行传输的IOI设置。

46. 发明授权

US08329736B2 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US08329736B2
公开(公告)日：2012-12-11
申请号：US13452200
申请日：2012-04-20
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

47. 发明申请

US20110307066A1 Spacer with Height and Angle Adjustments for Spacing Vertebral Members 有权
标题翻译：间隔脊椎成员的高度和角度调整的间隔
公开(公告)号：US20110307066A1
公开(公告)日：2011-12-15
申请号：US13214822
申请日：2011-08-22
申请人： Roy Lim , Kevin Foley
发明人： Roy Lim , Kevin Foley
IPC分类号： A61F2/44
CPC分类号： A61B17/8858 , A61B17/025 , A61B2017/0256 , A61B2017/2939
摘要： A device to space vertebral members that may include a deploying device with a first member with an elongated first shaft and a first body at an end of the first shaft, a second member with an elongated second shaft that extends around the first shaft and a second body at an end of the second shaft, and a third member with an elongated third shaft that extends around the second shaft and a third body at an end of the second shaft. The device may include a first plate positioned on a first side of the deploying device, and a second plate positioned on a second side of the deploying device. First, second, and third jointed linkages may be spaced apart along the deploying device and each having a pair of links and each having a first end attached to the first plate, a second end attached to the second plate, and an intermediate joint connecting the pair of links together and being attached to the deploying device.
摘要翻译：一种用于将脊椎构件放置的装置，其可以包括具有第一构件的展开装置，所述第一构件具有细长的第一轴和在所述第一轴的端部处的第一主体，具有沿所述第一轴延伸的细长的第二轴的第二构件，主体在第二轴的端部，以及第三构件，其具有围绕第二轴延伸的细长的第三轴和在第二轴的端部处的第三主体。该装置可以包括位于展开装置的第一侧上的第一板和位于展开装置的第二侧上的第二板。第一，第二和第三接合连杆可以沿着展开装置间隔开，并且每个具有一对连杆，并且每个连接件具有连接到第一板的第一端，附接到第二板的第二端和连接到第二板的中间接头一对链接在一起并被附接到部署设备。

48. 发明申请

US20110301212A1 METHOD FOR TREATING PROLIFERATIVE DISORDERS ASSOCIATED WITH PROTOONCOGENE PRODUCTS 有权
标题翻译：治疗与PROTOONCOGENE产品相关的增殖性疾病的方法
公开(公告)号：US20110301212A1
公开(公告)日：2011-12-08
申请号：US13211026
申请日：2011-08-16
申请人： Zhenjian Du , Kevin Foley
发明人： Zhenjian Du , Kevin Foley
IPC分类号： A61K31/4196 , A61P35/02 , A61P35/00
CPC分类号： C07D403/04 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4164 , A61K31/4166 , A61K31/4178 , A61K31/4188 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/538 , A61K31/675 , A61K31/685
摘要： The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof.
摘要翻译：本发明涉及在有需要的受试者中抑制Hsp90的活性的方法和在受试者中治疗Bcr-Abl，FLT-3，EGFR，c-Kit，B-raf和NPM-ALK相关癌症的方法需要它。

49. 发明申请

US20100332368A1 MULTICOMPUTER DISTRIBUTED PROCESSING OF DATA REGARDING TRADING OPPORTUNITIES 审中-公开
标题翻译：关于交易机会的数据分发处理
公开(公告)号：US20100332368A1
公开(公告)日：2010-12-30
申请号：US12494438
申请日：2009-06-30
申请人： Dean P. Alderucci , Charles Plott , Mark Miller , Howard W. Lutnick , Andrew Fishkind , Brian Gay , Kevin Foley
发明人： Dean P. Alderucci , Charles Plott , Mark Miller , Howard W. Lutnick , Andrew Fishkind , Brian Gay , Kevin Foley
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A trading platform and trading method that allows access to additional pools of liquidity is described. Other embodiments are also described.
摘要翻译：描述了允许访问额外的流动性池的交易平台和交易方法。还描述了其它实施例。

50. 发明申请

US20100093717A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US20100093717A1
公开(公告)日：2010-04-15
申请号：US12310150
申请日：2007-08-14
申请人： Weiwen Ying , Kevin Foley
发明人： Weiwen Ying , Kevin Foley
IPC分类号： A61K31/4196 , A61K31/5377 , A61K31/519 , A61K31/538 , A61K31/428 , A61P7/00
CPC分类号： A61K31/4196 , A61K31/423 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/472 , A61K31/52 , A61K31/5377 , Y02A50/401
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of treating or inhibiting angiogenesis in a subject in need thereof and methods for blocking, occluding, or otherwise disrupting blood flow in neo vasculature, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中治疗或抑制血管生成的方法以及在有需要的受试者中阻断，阻断或以其它方式破坏新脉管系统中的血液流动的方法，其包括向受试者施用取代的三唑化合物本发明或包含这种化合物的组合物。

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