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41. 发明申请

US20140211305A1 LASER SCANNING MICROSCOPE 有权
标题翻译：激光扫描显微镜
公开(公告)号：US20140211305A1
公开(公告)日：2014-07-31
申请号：US14227858
申请日：2014-03-27
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Daniel Schwedt , Tiemo Anhut
IPC分类号： G02B21/00
CPC分类号： G02B21/0032 , G02B21/004 , G02B21/006 , G02B21/0076 , G02B21/008
摘要： A laser scanning microscope (LSM) consisting of at least one light source from which an illumination beam path extends in the direction of a sample, at least one detection beam path for transmitting sample light to a detector array, a first pinhole for confocal filtering in front of the detector array, a scanner for causing a relative motion between the illumination light and the sample in at least one direction, and a microscope lens. For illuminating a sample, at least two illumination beams, which the microscope lens focuses as illumination points in a sample plane, are generated in the illumination beam path. The laser scanning microscope is characterized in that in addition to the preferably adjustable, slit-shaped first pinhole, a second, preferably adjustable, slit-shaped pinhole is arranged downstream of the first pinhole so as to create optically conjugate beams arranged between the first and the second pinhole.
摘要翻译：一种激光扫描显微镜（LSM），包括至少一个照明光束路径沿着样本的方向延伸的光源，至少一个用于将样本光传输到检测器阵列的检测光束路径，用于共焦滤光的第一针孔检测器阵列的前面，用于在至少一个方向上引起照明光和样品之间的相对运动的扫描器和显微镜镜头。为了照亮样品，在照明光束路径中产生至少两个照明光束，其中显微镜透镜在样品平面中作为照明点聚焦。激光扫描显微镜的特征在于，除了优选可调节的狭缝状的第一针孔之外，第二优选可调节的狭缝状针孔布置在第一针孔的下游，以便产生光学共轭束，其布置在第一和第第二个针孔。

42. 发明授权

US12055700B2 Light microscope with photon-counting detector elements and imaging method 有权
公开(公告)号：US12055700B2
公开(公告)日：2024-08-06
申请号：US17424293
申请日：2019-01-25
申请人： Carl Zeiss Microscopy GmbH , Ecole Polytechnique Federale de Lausanne
发明人： Tiemo Anhut , Daniel Schwedt , Ivan Michel Antolovic , Claudio Bruschini , Edoardo Charbon
IPC分类号： G02B21/00 , G01N21/64
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0032
摘要： A light microscope has a light source for illuminating a specimen, a photon-counting detector array with a plurality of photon-counting detector elements for measuring detection light coming from the specimen, wherein the photon-counting detector elements are configured to output respective measured photon count rates, and a control device for controlling the photon-counting detector array. The control device is configured to individually influence the measurable photon count rates which are simultaneously measurable with different photon-counting detector elements and/or which are consecutively measurable with the same photon-counting detector element. Furthermore, in an imaging method the measurable photon count rates of photon-counting detector elements are individually influenced to increase the signal-to-noise ratio for the photon-counting detector array.

43. 发明授权

US11921274B2 Method for detecting emission light, detection device and laser scanning microscope 有权
公开(公告)号：US11921274B2
公开(公告)日：2024-03-05
申请号：US18018331
申请日：2021-07-29
申请人： Carl Zeiss Microscopy GmbH
发明人： Daniel Schwedt , Tiemo Anhut , Peter Schacht
IPC分类号： G02B21/00 , G01N21/64
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0032 , G02B21/008
摘要： Detecting emission light, in a laser scanning microscope, wherein the emission light emanating from a sample is guided onto a two-dimensional matrix sensor having a plurality of pixels and being located on an image plane, and a detection point distribution function is detected by the matrix sensor in a spatially oversam pled manner. The emission light emanating from the sample is spectrally separated in a dispersion device; the spectrally separated emission light is detected by the matrix sensor in a spectrally resolved manner; and during the analysis of the intensities measured by the pixels of a pixel region, the spectral separation is cancelled at least for some of said pixels. Additional aspects relate to a detection device for the spectrally resolved detection of emission light in a laser scanning microscope and to a laser scanning microscope.

44. 发明授权

US11880026B2 Microscope and method for light-field microscopy with light-sheet excitation and for confocal microscopy 有权
公开(公告)号：US11880026B2
公开(公告)日：2024-01-23
申请号：US17453075
申请日：2021-11-01
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Tiemo Anhut , Daniel Schwedt , Matthias Wald , Thomas Mehner
IPC分类号： G02B21/00 , G02B21/06 , G02B21/36
CPC分类号： G02B21/0032 , G02B21/06 , G02B21/367
摘要： A microscope, which includes a color splitter that is reflective to excitation radiation, can switch between a first and a second operating mode. A first apparatus can introduce a first cylindrical optical element into the excitation beam path between a light source and the color splitter, when the microscope is in the first operating mode, and a second apparatus can introduce a second cylindrical optical element into the excitation beam path between the color splitter and a scanning apparatus.

45. 发明授权

US11703670B2 Optical assembly for scanning excitation radiation and/or manipulation radiation in a laser scanning microscope, and laser scanning microscope 有权
公开(公告)号：US11703670B2
公开(公告)日：2023-07-18
申请号：US16641516
申请日：2018-08-23
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Matthias Wald , Daniel Schwedt , Tobias Kaufhold
IPC分类号： G02B21/00 , G02B26/10 , G02B27/28
CPC分类号： G02B21/0048 , G02B21/006 , G02B21/0076 , G02B26/105 , G02B27/283
摘要： An optical assembly in a laser scanning microscope, having an optical scanning unit providing a first pupil plane, a first beam deflecting device, made of a first scanner arranged on the first pupil plane, for scanning excitation radiation in a first coordinate direction, a first focusing device generating a second pupil plane, optically conjugated to the first pupil plane, and a second beam deflecting device for deflecting the excitation radiation. The second deflecting device is arranged on the second pupil plane. A second focusing device to generate a third pupil plane, is optically conjugated to the first pupil plane and the second pupil plane. A third beam deflecting device is arranged on the third pupil plane, and a variable beam deflecting device is provided to switch an optical beam path between a first beam path and a second beam path.

46. 发明申请

US20210157113A1 OPTICAL ASSEMBLY FOR SCANNING EXCITATION RADIATION AND/OR MANIPULATION RADIATION IN A LASER SCANNING MICROSCOPE, AND LASER SCANNING MISCROSCOPE 有权
公开(公告)号：US20210157113A1
公开(公告)日：2021-05-27
申请号：US16641543
申请日：2018-08-23
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Matthias Wald , Daniel Schwedt , Tobias Kaufhold , Beate Böhme
IPC分类号： G02B21/00
摘要： The invention relates to an optical assembly for scanning excitation radiation and/or manipulation radiation in a laser scanning microscope. The optical assembly according to the invention is characterized in that in addition to a first and a second focusing device, a third focusing device is provided in order to generate a third pupil plane which is optically conjugated to a first pupil plane, a third beam deflecting device is arranged on the third pupil plane in order to deflect the excitation radiation and/or manipulation radiation, a first beam deflecting means is provided between the second focusing device and the second pupil plane and the second pupil plane and the third focusing device in order to deflect the excitation radiation and/or manipulation radiation coming from the third focusing device while bypassing the second beam deflecting device in the direction of the second focusing device, a fourth focusing device is provided for generating a fourth pupil plane which is optically conjugated to the third pupil plane, and a variable second beam deflecting means is arranged on the fourth pupil plane in order to switch an optical beam path between a first beam path and a second beam path. The invention additionally relates to a laser scanning microscope.

47. 发明授权

US10031325B2 Method and arrangement for light sheet microscopy 有权
公开(公告)号：US10031325B2
公开(公告)日：2018-07-24
申请号：US15120162
申请日：2015-02-19
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Thomas Kalkbrenner , Daniel Schwedt , Jörg Siebenmorgen , Helmut Lippert
IPC分类号： G02B21/00 , G02B27/00 , H04N5/372 , H04N3/02 , G02B21/16 , G02B21/36
CPC分类号： G02B21/008 , G02B21/0032 , G02B21/0036 , G02B21/006 , G02B21/0076 , G02B21/16 , G02B21/365 , G02B21/367 , G02B27/0075 , H04N3/02 , H04N5/372
摘要： An arrangement for light sheet microscopy that includes a means for scanning a sample volume with a light sheet, which includes an angle δ≠90° with the optical axis of an objective. The light sheet passes through the entire sample volume in the propagation direction, and the depth of field Sobj of the objective is less than the optical-axis depth T of this sample volume. An optical device, disposed downstream of the objective, increases the depth of field Sobj to a depth of field Seff≥the depth T of this sample volume. The arrangement also includes a means for positioning the sample volume within the region of the depth of field Seff. A spatially resolving optoelectronic area sensor is disposed downstream of the optical device, and hardware and software are provided to generate sample-volume images from the electronic image signals output by the area sensor.

48. 发明授权

US09389402B2 Laser scanning microscope 有权
标题翻译：激光扫描显微镜
公开(公告)号：US09389402B2
公开(公告)日：2016-07-12
申请号：US14227858
申请日：2014-03-27
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Daniel Schwedt , Tiemo Anhut
IPC分类号： G02B21/00
CPC分类号： G02B21/0032 , G02B21/004 , G02B21/006 , G02B21/0076 , G02B21/008
摘要： A laser scanning microscope (LSM) consisting of at least one light source from which an illumination beam path extends in the direction of a sample, at least one detection beam path for transmitting sample light to a detector array, a first pinhole for confocal filtering in front of the detector array, a scanner for causing a relative motion between the illumination light and the sample in at least one direction, and a microscope lens. For illuminating a sample, at least two illumination beams, which the microscope lens focuses as illumination points in a sample plane, are generated in the illumination beam path. The laser scanning microscope is characterized in that in addition to the preferably adjustable, slit-shaped first pinhole, a second, preferably adjustable, slit-shaped pinhole is arranged downstream of the first pinhole so as to create optically conjugate beams arranged between the first and the second pinhole.
摘要翻译：一种激光扫描显微镜（LSM），包括至少一个照明光束路径沿着样本的方向延伸的光源，至少一个用于将样本光传输到检测器阵列的检测光束路径，用于共焦滤光的第一针孔检测器阵列的前面，用于在至少一个方向上引起照明光和样品之间的相对运动的扫描器和显微镜镜头。为了照亮样品，在照明光束路径中产生至少两个照明光束，其中显微镜透镜在样品平面中作为照明点聚焦。激光扫描显微镜的特征在于，除了优选可调节的狭缝状的第一针孔之外，第二优选可调节的狭缝状针孔布置在第一针孔的下游，以便产生光学共轭束，其布置在第一和第第二个针孔。

49. 发明申请

US20150253556A1 Confocal Incident-Light Scanning Microsope For Multipoint Scanning 审中-公开
标题翻译：共聚焦事件光扫描Microsope多点扫描
公开(公告)号：US20150253556A1
公开(公告)日：2015-09-10
申请号：US14432182
申请日：2013-09-27
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Daniel Schwedt , Tiemo Anhut , Tobias Kaufhold
IPC分类号： G02B21/00 , H01J37/28
CPC分类号： G02B21/0032 , G02B21/0024 , H01J37/28
摘要： Confocal multipoint scanning microscopes (1) comprising a multi-beam light source (2), confocal detectors (10) a beam splitter (4) for coupling the illuminating beam path (B) and the detecting beam path (D) into a common beam path (C), and an adjustable deflection unit (5) and a microscope lens (8) have the disadvantage that the properties of the image field cannot be modified in the same way as for a single-point scanning microscope by appropriate activation of the deflection unit, without the relative position of the points changing in relation to one another. The invention proposes solving this problem by having a means (7) for the manipulation of a spatial position of the partial beams or for the manipulation of a phase position of the partial beams relative to one another arranged in the common beam (C) between the main beam splitter (4) and the deflection unit (5). In this way, it is possible to vary image field characteristics without changing the relative position of the points in relation to one another. Confocal microscopy.
摘要翻译：共聚焦多点扫描显微镜（1）包括多光束光源（2），共焦检测器（10），用于将照明光束路径（B）和检测光束路径（D）耦合到公共光束的分束器（4）路径（C）和可调节偏转单元（5）和显微镜（8）的缺点在于，与单点扫描显微镜相同的方式，图像场的性质不能像通过适当的激活偏转单元，没有相对于彼此改变的点的相对位置。本发明提出通过具有用于操纵部分光束的空间位置或者用于操纵部分光束相对于布置在公共光束（C）中的彼此之间的彼此的相位位置的装置（7）来解决该问题。主分束器（4）和偏转单元（5）。以这种方式，可以在不改变点相对于彼此的相对位置的情况下改变图像场特性。共焦显微镜。

50. 发明申请

US20140092460A1 OPTICAL FILTER DEVICE, IN PARTICULAR FOR MICROSCOPES 有权
标题翻译：光学过滤装置，特别是显微镜
公开(公告)号：US20140092460A1
公开(公告)日：2014-04-03
申请号：US14039117
申请日：2013-09-27
申请人： Carl Zeiss Microscopy GmbH
发明人： Daniel Schwedt , Jakow Konradi
IPC分类号： G02F1/01 , G02B21/00
CPC分类号： G02F1/0136 , G02B21/0068 , G02B21/0076 , G02B21/0092 , G02B26/007
摘要： An optical filter device having a polarizing beamsplitter, an achromatic polarization manipulator, and at least one dichroic mirror. The polarization manipulator is arranged optically between a first input/output of the polarizing beamsplitter and the dichroic mirror. The polarization manipulator is also constructed in such a way that it effects a 90-degree rotation of a polarization direction of light which a) exits the polarizing beamsplitter at the first input/output, b) traverses the polarization manipulator, c) is reflected by the dichroic mirror, and d) again traverses the polarization manipulator. The optical filter device can also be used as beamsplitter.
摘要翻译：一种具有偏振分束器，非彩色偏振操纵器和至少一个分色镜的滤光器件。偏振操纵器被光学地布置在偏振分束器的第一输入/输出端与分色镜之间。偏振操纵器也被构造成使得其在第一输入/输出端处离开偏振分束器的光偏振方向90度旋转，b）穿过偏振操纵器，c）被分色镜，d）再次穿过偏振机械手。光滤波器也可用作分束器。

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