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41. 发明申请

US20100003236A1 USE OF C-GLYCOSIDE DERIVATIVES AS PRO-DESQUAMATING ACTIVE AGENTS 有权
标题翻译：使用C-GLYCOSIDE衍生物作为主动代谢物
公开(公告)号：US20100003236A1
公开(公告)日：2010-01-07
申请号：US12306565
申请日：2007-06-29
申请人： Maria Dalko , Christophe Boulle , Dominique Bernard
发明人： Maria Dalko , Christophe Boulle , Dominique Bernard
IPC分类号： A61K38/47 , A61K31/7004 , A61K38/48 , A61K38/46 , A61P17/02
CPC分类号： A61K8/602 , A61K2800/28 , A61K2800/88 , A61Q5/006 , A61Q19/00 , A61Q19/008
摘要： A cosmetic use of at least one C-glycoside derivative in a composition comprising a physiologically acceptable medium, as a cosmetic agent for promoting the desquamation of the skin and/or the scalp and/or for stimulating epidermal renewal.
摘要翻译：至少一种C-糖苷衍生物在包含生理学上可接受的培养基的组合物中的化妆用途，作为用于促进皮肤脱皮和/或头皮的化妆品和/或用于刺激表皮更新。

42. 发明申请

US20080287537A1 Composition, Particularly a Cosmetic Composition, Comprising ((Dialkylamino)Alkoxy) Ethanol Ester 审中-公开
标题翻译：组合物，特别是包含（（二烷基氨基）烷氧基）乙醇酯的化妆品组合物
公开(公告)号：US20080287537A1
公开(公告)日：2008-11-20
申请号：US11579593
申请日：2005-04-18
申请人： Maria Dalko
发明人： Maria Dalko
IPC分类号： A61K31/221 , A61K31/23 , C07C229/22 , A61Q19/08
CPC分类号： C07C217/08 , A61K8/37 , A61K8/45 , A61Q19/08
摘要： The present invention relates to a process for the cosmetic treatment of wrinkled skin, comprising the topical application to the said skin of a composition comprising, in a physiologically acceptable medium, at least one ester of ((dialkylamino)alkoxy)ethanol of formula (I): It also relates to novel compounds belonging to the formula (I) and corresponding to the formulae (II) and (III): and to the cosmetic compositions comprising them.
摘要翻译：本发明涉及一种皱纹皮肤美容治疗方法，其包括对生理学上可接受的培养基中至少一种式（I（I）的（（二烷基氨基）烷氧基）乙醇的酯，）：它还涉及属于式（I）并对应于式（II）和（III）的新化合物：以及包含它们的化妆品组合物。

43. 发明申请

US20070253924A1 Administration of 4-aminopiperidine compounds for inducing and/or stimulating the growth of keratin fibers and/or preventing loss thereof 审中-公开
标题翻译：施用4-氨基哌啶化合物用于诱导和/或刺激角蛋白纤维的生长和/或防止其损失
公开(公告)号：US20070253924A1
公开(公告)日：2007-11-01
申请号：US11790451
申请日：2007-04-25
申请人： Alexandre Cavezza , Maria Dalko
发明人： Alexandre Cavezza , Maria Dalko
IPC分类号： A61K31/454 , A61K8/49
CPC分类号： A61Q1/10 , A61K8/4926 , A61K31/454 , A61Q7/00
摘要： Agents for inducing and/or stimulating the growth of human keratin fibers and/or preventing their loss and/or increasing their density include at least one 4-aminopiperidine compound of formula (I): in which: Alk1 and Alk2 are each, independently of one another, a linear saturated C1-C10 or unsaturated C2-C10, or branched C3-C10 saturated or unsaturated, alkylene radical (divalent radical); Ph1 and Ph2 are each, independently of one another, a phenyl group optionally substituted with one or more radicals, which may be identical or different, selected from among —F, —CF3, —R1, —OR1 and —NR1R2; R1, R2 and R3 are each, independently of one another, a linear saturated C1-C7 or unsaturated C2-C7, or branched or cyclic C3-C7 alkyl radical; or a salt, optical isomer or solvate thereof.
摘要翻译：用于诱导和/或刺激人角蛋白纤维生长和/或防止其损失和/或增加其密度的试剂包括至少一种式（I）的4-氨基哌啶化合物：其中：Alk 1 ; R 1，R 2和R 3各自彼此独立地是直链饱和的C 1 - C 7或不饱和C 2 -C 7或支链或环状C 3 -C 7 烷基; 或其盐，旋光异构体或溶剂合物。

44. 发明申请

US20070237734A1 ANTI-WRINKLE COSMETIC COMPOSITION 审中-公开
标题翻译：防皱化妆品组合物
公开(公告)号：US20070237734A1
公开(公告)日：2007-10-11
申请号：US11733797
申请日：2007-04-11
申请人： Maria Dalko , Dominique Fagot
发明人： Maria Dalko , Dominique Fagot
IPC分类号： A61K8/73
CPC分类号： A61Q19/08 , A61K8/606
摘要： The present invention relates to adenosine derivatives and methods of treating skin using such derivatives.
摘要翻译：本发明涉及腺苷衍生物和使用这些衍生物治疗皮肤的方法。

45. 发明申请

US20070059260A1 Benzyl-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening 审中-公开
标题翻译：苄基-1,3-噻唑烷-2,4-二酮化合物，用于促进和/或诱导和/或刺激角蛋白材料的着色和/或限制其脱色和/或增白
公开(公告)号：US20070059260A1
公开(公告)日：2007-03-15
申请号：US11476054
申请日：2006-06-28
申请人： Christophe Boulle , Maria Dalko
发明人： Christophe Boulle , Maria Dalko
IPC分类号： A61K8/49
CPC分类号： A61K8/49 , A61Q5/065 , A61Q19/04
摘要： The benzyl-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate thereof: are useful active agents for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or preventing and/or limiting the depigmentation and/or bleaching thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for preventing and/or limiting the canities of human keratin fibers.
摘要翻译：具有结构式（I）的苄基-1,3-噻唑烷-2,4-二酮化合物或其盐和/或溶剂化物：用于促进和/或诱导和/或刺激角蛋白材料着色的有用的活性剂和/或预防和/或限制其脱色和/或漂白，特别是人头发，胡须头发，胡须头发，睫毛和眉毛的脱色和/或漂白，并且有利地是用于预防和/或限制人角蛋白纤维的阴茎的活性剂。

46. 发明授权

US07182949B2 Composition comprising vitamin C prepared during application, use of enzymes for forming vitamin C for topical use, and a cosmetic treatment method 失效
标题翻译：包含在施用期间制备的维生素C，用于形成用于局部使用的维生素C的酶的组合物和美容治疗方法
公开(公告)号：US07182949B2
公开(公告)日：2007-02-27
申请号：US10076418
申请日：2002-02-19
申请人： Maria Dalko , Rui Pereira
发明人： Maria Dalko , Rui Pereira
IPC分类号： A61K9/00 , A61K9/10 , A61K9/48 , A61K9/50 , A61K38/44 , A61K36/00 , A61K35/00
CPC分类号： A61K8/66 , A61K8/0204 , A61K8/11 , A61K8/60 , A61K8/676 , A61K2800/412 , A61K2800/88 , A61Q19/00 , A61Q19/02 , A61Q19/04
摘要： The invention concerns a composition for topical application for extemporaneous preparation, comprising ascorbic acid and a suitable support, the ascorbic acid being obtained by bringing at least one ascorbic acid precursor with the exception of its esters into contact with at least one enzyme that is capable of converting said precursor. It also concerns the use of one or more enzymes selected from L-galactono-1,4-lactone dehydrogenase, L-galactose dehydrogenase, L-sorbosone dehydrogenase, L-gulono-1,4-lactone oxidase and mixtures thereof, or of an extract comprising said enzyme, for the preparation of ascorbic acid for topical use, and a cosmetic method for treating the skin consisting of applying to the skin, either simultaneously or successively, at least one enzyme that can convert an ascorbic acid precursor into ascorbic acid, and at least one ascorbic acid precursor with the exception of its esters.
摘要翻译：本发明涉及用于临时制剂局部施用的组合物，其包含抗坏血酸和合适的载体，所述抗坏血酸是通过使至少一种抗坏血酸前体除了其酯与至少一种能够转化所述前体。还涉及使用一种或多种选自L-半乳糖内酰-1,4-内酯脱氢酶，L-半乳糖脱氢酶，L-山梨糖酮脱氢酶，L-古洛酮-1,4-内酯氧化酶及其混合物的酶，或包含所述酶的提取物，用于制备用于局部使用的抗坏血酸，以及用于治疗皮肤的美容方法，其包括同时或依次施用于皮肤，至少一种可将抗坏血酸前体转化成抗坏血酸的酶，和除了其酯之外的至少一种抗坏血酸前体。

47. 发明申请

US20060223763A1 C-glycoside compounds for stimulating the synthesis of glycosaminoglycans 有权
公开(公告)号：US20060223763A1
公开(公告)日：2006-10-05
申请号：US11373485
申请日：2006-03-13
申请人： Maria Dalko , Lionel Breton
发明人： Maria Dalko , Lionel Breton
IPC分类号： A61K31/7008 , A61K31/7024 , A61K31/70
CPC分类号： A61K8/602 , A61Q19/08 , C07H7/00
摘要： C-glycoside compounds are suited for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes.

48. 发明申请

US20060211659A9 Novel compounds of the N-acylamino amide family, compositions comprising them and uses thereof 有权
标题翻译： N-酰氨基酰胺家族的新型化合物，包含它们的组合物及其用途
公开(公告)号：US20060211659A9
公开(公告)日：2006-09-21
申请号：US11102812
申请日：2005-04-11
申请人： Maria Dalko , Yann Mahe , Lionel Breton
发明人： Maria Dalko , Yann Mahe , Lionel Breton
IPC分类号： A61K31/66 , C07F9/02 , C07C235/66
CPC分类号： A61K8/44 , A61K8/69 , A61K38/00 , A61K2800/782 , A61Q5/00 , A61Q7/00 , A61Q19/08 , C07K5/06052 , C07K5/06191
摘要： The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin ageing caused by decrease of skin elasticity and/or by collagen degradation in the structure of tissues.
摘要翻译：本发明涉及N-酰基氨基 - 酰胺家族的新化合物，包含它们的组合物，特别是化妆品或药物，以及它们用于治疗身体或面部皮肤老化，无论是时间生物学或光诱导的用途，特别是由降低皮肤弹性和/或通过组织结构中的胶原蛋白降解。

49. 发明申请

US20060167102A1 Compositions comprising cyclopentane derivatives and their use 审中-公开
标题翻译：包含环戊烷衍生物的组合物及其用途
公开(公告)号：US20060167102A1
公开(公告)日：2006-07-27
申请号：US11389166
申请日：2006-03-27
申请人： Jean-Luc Leveque , Maria Dalko , Christophe Boulle
发明人： Jean-Luc Leveque , Maria Dalko , Christophe Boulle
IPC分类号： A61K31/557
CPC分类号： A61K8/36 , A61K8/35 , A61K8/37 , A61K2800/28 , A61Q19/00 , A61Q19/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: in which: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R,″ which may be identical or different, are chosen from a hydrogen atom and saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen atoms, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms; R2 is a radical chosen from linear, branched and cyclic hydrocarbon radicals comprising at least one unsaturation and comprising from 2 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen atoms, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R 1是选自-COOR'，-CONR'R“，-CH” 2 OR'，-COR'，-CH 2 R'，-SO 2 OR'，-PO 3 R' R“和-NHR'，其中可以相同或不同的R'和R”选自氢原子和包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其中任选地被1至5个相同或不同的选自-OR“，-OCOR”'，-SR“'，-SCOR”，NR“'R”'，-NHCOR “，卤素原子，-CN，-COOR”和-COR“，其中R”'和R“'可以相同或不同，选自氢原子，芳基和包含1至4个碳原子的饱和和不饱和的直链和支链烃基; R 2是选自包含至少一个不饱和键并包含2至18个碳原子的直链，支链和环状烃基的基团，其任选被1至5个相同或不同的实体取代，所述实体选自 -OR''，-OCOR''，-SR“'，-SCOR''，NR”'R“'， - NHCOR''，卤素原子，-CN，-COOR” '和-COR''，其中可以相同或不同的R“'和R”'选自氢原子，芳基和饱和和不饱和的直链和支链烃基，其包含1至 4个碳原子以及这些化合物的使用，例如促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

50. 发明授权

US10117816B2 Cosmetic process for treating human body odor using a 4-(3-ethoxy-4-hydroxyphenyl)alkyl ketone or 2-ethoxy-4-hydroxyalkylphenol compound 有权
公开(公告)号：US10117816B2
公开(公告)日：2018-11-06
申请号：US14007853
申请日：2012-03-29
申请人： Maria Dalko
发明人： Maria Dalko
IPC分类号： A61K8/35 , A61K8/34 , A61K8/02 , A61Q15/00
摘要： The present invention relates to a cosmetic process for treating human body odor, in particular underarm odor, which consists in applying to human keratin materials a composition containing, in a cosmetically acceptable medium, at least one 4-(3-ethoxy-4-hydroxyphenyl)alkyl ketone or 2-ethoxy-4-hydroxyalkylphenol compound of formula (I) below: in which: R represents a hydrogen atom, or a linear or branched, saturated or unsaturated (alkyl or alkenyl), C1-C18 hydrocarbon-based radical; R′ represents a linear or branched, saturated or unsaturated (alkyl or alkenyl), C1-C18 hydrocarbon-based radical, optionally substituted with a hydroxyl group; C—X represents C═O or CH—OH. The invention also relates to the cosmetic use of at least one compound of formula (I), as a deodorant active agent.

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