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41. 发明授权

US06683081B2 Triazolotriazinones and the use thereof 失效
标题翻译：三唑并三嗪酮及其用途
公开(公告)号：US06683081B2
公开(公告)日：2004-01-27
申请号：US10149921
申请日：2002-10-21
申请人： Ulrich Niewöhner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewöhner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
摘要翻译：本发明涉及通式（I）的新型三唑并三嗪酮及其制备方法及其药物用途。

42. 发明授权

US06566360B1 2-phenyl substituted imidatriazinones as phosphodiesterase inhibitors 有权
标题翻译： 2-苯基取代的亚氨基三嗪酮作为磷酸二酯酶抑制剂
公开(公告)号：US06566360B1
公开(公告)日：2003-05-20
申请号：US09943530
申请日：2001-08-30
申请人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A61P1308
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
摘要翻译：通过氯磺化和随后与胺的反应，由相应的2-苯基 - 咪唑并三嗪酮制备在9-位上具有短的非支链烷基的2-苯基取代的咪唑并三嗪酮。所述化合物抑制cGMP代谢磷酸二酯酶，并且适合用作药物中的活性化合物，用于治疗心血管和脑血管障碍和/或泌尿生殖系统疾病，特别是用于治疗勃起功能障碍。

43. 发明授权

US5821222A Cyclic depsipeptides having 18 ring atoms for combating endoparasites 失效
标题翻译：具有18个环原子的环状脱肽用于对抗内寄生虫
公开(公告)号：US5821222A
公开(公告)日：1998-10-13
申请号：US728106
申请日：1996-10-09
申请人： Gerhard Bonse , Michael Londershausen , Erwin Bischoff , Hartwig Muller , Achim Harder , Nobert Mencke , Peter Kurka , Peter Jeschke , Jurgen Scherkenbeck
发明人： Gerhard Bonse , Michael Londershausen , Erwin Bischoff , Hartwig Muller , Achim Harder , Nobert Mencke , Peter Kurka , Peter Jeschke , Jurgen Scherkenbeck
IPC分类号： A61K31/395 , A61P31/00 , A61P33/00 , C07C227/18 , C07C229/06 , C07C229/12 , C07C229/14 , C07C229/22 , C07C229/34 , C07C231/02 , C07C233/36 , C07C235/12 , C07C271/22 , C07D273/00 , A61K38/15 , C07K11/02
CPC分类号： C07D273/00 , C07C229/12 , C07C229/14 , C07C235/12 , C07C271/22
摘要： The present invention relates to the use of cyclic depsipeptides having 18 ring atoms of the general formula (I) ##STR1## in which R.sup.1 to R.sup.6 have the meaning given in the description, and to their optical isomers and racemates, in medicine and veterinary medicine for combating endoparasites, to their preparation, and to new cyclic depsipeptides having 18 ring atoms.
摘要翻译：本发明涉及具有通式（I）的具有18个环原子的环状缩水甘油酯的用途，其中R1至R6具有说明书中给出的含义，以及其在医学上的旋光异构体和外消旋体以及用于对抗内寄生虫及其制备的兽药，以及具有18个环原子的新的环状缩肽。

44. 发明授权

US5374647A Antithrombotic substituted cycloalkano (B) dihydroindole sulphonamides 失效
标题翻译：抗血栓代用环烷基（B）二氢吲哚磺酰胺
公开(公告)号：US5374647A
公开(公告)日：1994-12-20
申请号：US42857
申请日：1993-04-05
申请人： Horst Bohagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
发明人： Horst Bohagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
IPC分类号： C07D209/86 , A61K31/40 , A61K31/403 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P37/08 , C07D209/88 , C07D209/94
CPC分类号： C07D209/88
摘要： Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.
摘要翻译：取代的抗血栓形成取代的环烷基[b]二氢吲哚 - 和吲哚磺酰胺，用于治疗其他基团的血栓形成，血栓栓塞，局部缺血，哮喘和过敏，X是芳基，烷基或CF 3，m和Z各自为1 ，2,3或4，n为0,1或2，A为键或-NH-，Y为OH，烷氧基，芳氧基，氨基或磺酰胺，条件是在所有情况下，两个取代基在m表示数2，Y表示羟基的情况下，R 1 -R 4不是氢，或其盐。

45. 发明授权

US5190971A Substituted dibenz-oxa-thiocinones, -12-oxides and -12,12-dioxides, a process for their preparation and their use in medicaments 失效
标题翻译：取代的二苯氧基 - 氧杂环己烷，-12-氧化物和-12,12-二氧化物，其制备方法及其在药物中的用途
公开(公告)号：US5190971A
公开(公告)日：1993-03-02
申请号：US798386
申请日：1991-11-26
申请人： Peter Fey , Klaus Frobel , Jan-Bernd Lenfers , Andreas Knorr , Johannes-Peter Stasch , Erwin Bischoff , Hans-Georg Dellweg , Martin Beuck
发明人： Peter Fey , Klaus Frobel , Jan-Bernd Lenfers , Andreas Knorr , Johannes-Peter Stasch , Erwin Bischoff , Hans-Georg Dellweg , Martin Beuck
IPC分类号： A61K31/39 , A61P9/00 , C07D327/02
CPC分类号： C07D327/02
摘要： The invention relates to substituted dibenz-oxa-thiocinone-12-oxides and -12,12-dioxides of the general formula I ##STR1## in which R.sup.1 to R.sup.6 and Y have the meaning indicated in the description, to processes for their preparation and to their use in medicaments, in particular in circulation-influencing medicaments.
摘要翻译：本发明涉及通式Ⅰ的取代二苄氧羰硫酮12-氧化物和-12,12-二氧化物，其中R1至R6和Y具有说明书中所示的含义，其制剂和用于药物，特别是在循环影响药物中的用途。

46. 发明授权

US5185348A Phenylsulphonamide substituted pyridinealkene- and -aminooxyalkanecarboxylic acid derivatives 失效
标题翻译：苯磺酰胺取代的吡啶烯基 - 和 - 氨基氧烷基羧酸衍生物
公开(公告)号：US5185348A
公开(公告)日：1993-02-09
申请号：US887208
申请日：1992-05-21
申请人： Ulrich Niewohner , Ulrich E. Muller , Elisabeth Perzborn , Erwin Bischoff , Hans-Georg Dellweg
发明人： Ulrich Niewohner , Ulrich E. Muller , Elisabeth Perzborn , Erwin Bischoff , Hans-Georg Dellweg
IPC分类号： C07D213/53 , C07D213/55 , C07D213/71
CPC分类号： C07D213/53 , C07D213/55 , C07D213/71
摘要： The compounds according to the invention can be prepared by reaction of the corresponding amines with sulphonic acid derivatives, or in the case of the aminooxy compounds by reacton of ketones with aminooxy compounds or alkylation of hydroxylamines, or in the case of the alkene compounds by reaction of ketones with phosphorusylides. The phenylsulphonamide substituted pyridinealkene- and -aminooxyalkencarboxylic acid derivatives can be used for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, allergies and asthma.
摘要翻译：根据本发明的化合物可以通过相应的胺与磺酸衍生物反应来制备，或者在氨基氧化合物的情况下通过酮与氨氧基化合物的反应或羟胺的烷基化反应，或在烯烃化合物的情况下通过反应的含有二酰亚胺的酮。苯基磺酰胺取代的吡啶基烯基 - 和 - 氨基氧代羧酸衍生物可用于治疗血栓栓塞性疾病，局部缺血，动脉硬化，过敏和哮喘。

47. 发明授权

US5185326A Efomycins A, E and G as antiinflammatory agents 失效
标题翻译： EFOMYCINS A，E和G作为抗炎药
公开(公告)号：US5185326A
公开(公告)日：1993-02-09
申请号：US709902
申请日：1991-06-03
申请人： Hartwig Muller , Erwin Bischoff , Burkhard Fugmann , Karlheinz Weber , Klaus Frobel , Bruno Rosen , Rudi Grutzmann , Guenther Karmann , Christian Kohlsdorfer
发明人： Hartwig Muller , Erwin Bischoff , Burkhard Fugmann , Karlheinz Weber , Klaus Frobel , Bruno Rosen , Rudi Grutzmann , Guenther Karmann , Christian Kohlsdorfer
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P29/00 , C07H17/04
CPC分类号： A61K31/70
摘要： A method of treating a patient to reduce or prevent an acute or chronic inflammation or an ischaemic state which comprises administering to such patient an effective amount therefor of efomycin A, E or G.
摘要翻译：一种治疗患者以减少或预防急性或慢性炎症或缺血状态的方法，其包括向该患者施用有效量的依托霉素A，E或G.

48. 发明授权

US4927810A Efomycin G and it's use as yield promoter in animals 失效
标题翻译： Efomycin G，它用作动物的产量促进剂
公开(公告)号：US4927810A
公开(公告)日：1990-05-22
申请号：US22915
申请日：1987-03-06
申请人： Klaus Frobel , Hartwig Muller , Erwin Bischoff , Olga Salcher , Anno de Jong , Friedrich Berschauer , Martin Scheer
发明人： Klaus Frobel , Hartwig Muller , Erwin Bischoff , Olga Salcher , Anno de Jong , Friedrich Berschauer , Martin Scheer
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K35/74 , A61P3/00 , C07H7/06 , C07H15/26 , C07H17/04 , C12P19/12 , C12P19/44 , C12R1/465
CPC分类号： C12R1/465 , C07H15/26 , C07H17/04 , C07H7/06 , C12P19/12 , Y10S435/886
摘要： An animal growth promoter, efomycin G, is obtained by culturing Streptomycetes strain BS 1261. Efomycin G has the following properties:(a) The empirical formula: C.sub.53 H.sub.86 O.sub.18(b) The mass spectrum (fast atom bombardment) Molecular weight+Na.sup.+ : 1033(c) The .sup.1 H-nuclear magnetic resonance spectrum, stated in parts per million, shown in FIG. 1.(d) The .sup.13 C-nuclear magnetic resonance spectrum, stated in parts per million shown in FIG. 2, with chemical shifts of the CC-NMR signals as follows:______________________________________ 170.0 77.9 65.9 32.9 7.0 145.4 73.4 48.5 19.4 144.7 71.2 43.6 19.1 131.9 70.6 41.9 16.8 121.1 70.1 41.1 16.7 99.6 69.9 38.8 15.1 99.5 66.9 38.5 13.4 93.6 66.5 36.2 9.0 93.3 66.4 33.0 8.9 ______________________________________ (ppm values are relative to tetramethylsilane at 0 ppm) (e) A UV absorption maximum at 251-254 nm in methanolic solution(f) The structure according to FIG. 3.
摘要翻译：通过培养链霉菌菌株BS1261获得动物生长促进剂efomycin G。Efomycin G具有以下性质：（a）经验式：C53H86O18（b）质谱（快速原子轰击）分子量+ Na +：1033（ c）1H-核磁共振谱，以百万分之几表示，如图1所示。（d）13C-核磁共振谱，以图1所示的百万分之几表示。 2，CC-NMR信号的化学位移如下：-170.0 77.9 65.9 32.9 7.0 -145.4 73.4 48.5 19.4 -144.7 71.2 43.6 19.1 -131.9 70.6 41.9 16.8 -121.1 70.1 41.1 16.7 -99.6 69.9 38.8 15.1 -99.5 66.9 38.5 13.4 -93.6 66.5 36.2 9.0 -93.3 66.4 33.0 8.9 - （ppm值相对于四甲基硅烷在0ppm） - （e）在甲醇溶液中在251-254nm处的UV吸收最大值（f）根据图1的结构。 3。

49. 发明申请

US20080096880A1 Novel use of imidazotriazinones 审中-公开
标题翻译：新型使用咪唑并三嗪酮
公开(公告)号：US20080096880A1
公开(公告)日：2008-04-24
申请号：US10519129
申请日：2003-06-24
申请人： Helmut Haning , Erwin Bischoff , Ulrich Niewohner , Maria Niewohner
发明人： Helmut Haning , Erwin Bischoff , Ulrich Niewohner , Maria Niewohner
IPC分类号： A61K31/5377 , A61K31/53 , A61P25/00 , A61P3/00 , A61P9/00 , C07D413/14 , C07D487/04
CPC分类号： A61K31/53
摘要： The invention relates to novel uses of imidazo[1,2,4]triazinones for producing a medicament for the treatment and/or prophylaxis of coronary cardiopathy, heart failure, pulmonary hypertension, bladder complaints, prostatic hyperplasia, nitrate-induced tolerance, or diseases of the eye, such as glaucoma, for the treatment or prophylaxis of central, retinal or posterior ciliary artery occlusion, central retinal vein occlusion, optical neuropathy, such as anterior ischaemic optical neuropathy and glaucomatous optical neuropathy, in addition to macular degeneration, diabetes, in particular diabetic gastroparesis, for the treatment of dysperistalsis of the stomach and oesophagus, female infertility, premature contractions, pre-eclampsia, alopecia, psoriasis associated with renal syndrome, cystic fibrosis, cancer and for improving cognition, powers of concentration, learning skills or hypermnesia, in particular if the disorder is a symptom of dementia.
摘要翻译：本发明涉及咪唑并[1,2,4]三嗪酮在制备用于治疗和/或预防冠状动脉心脏病，心力衰竭，肺动脉高压，膀胱反应，前列腺增生，硝酸盐诱导的耐受或疾病的药物中的新用途的眼睛，如青光眼，用于治疗或预防中枢，视网膜或后睫状动脉闭塞，视网膜中央静脉阻塞，光学神经病变，如前部缺血性视神经病变和青光眼性视神经病变，以及黄斑变性，糖尿病，特别是糖尿病性胃轻瘫，用于治疗胃和食道的dysperistalsis，女性不孕症，早产，先兆子痫，脱发，与肾综合征相关的牛皮癣，囊性纤维化，癌症和改善认知，集中力，学习技能或特别是如果该疾病是痴呆的症状。

50. 发明授权

US07173037B2 Carbamate-substituted pyrazolopyridines 有权
标题翻译：氨基甲酸酯取代的吡唑并吡啶
公开(公告)号：US07173037B2
公开(公告)日：2007-02-06
申请号：US10513869
申请日：2003-04-25
申请人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
发明人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
IPC分类号： C07D471/04 , A61K31/506 , C07D231/38
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
摘要翻译：本发明涉及刺激可溶性鸟苷酸环化酶，其制备及其作为药物的用途，特别是作为用于治疗心血管疾病和/或性功能障碍的药物的化合物。

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