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41. 发明授权

US07601686B2 Hepatitis C virus inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US07601686B2
公开(公告)日：2009-10-13
申请号：US11481536
申请日：2006-07-06
申请人： Piyasena Hewawasam , Min Ding , Li-Qiang Sun , Paul Michael Scola
发明人： Piyasena Hewawasam , Min Ding , Li-Qiang Sun , Paul Michael Scola
IPC分类号： A61K38/00
CPC分类号： C07K5/0808 , A61K38/00
摘要： The present disclosure relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译：本公开涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

42. 发明授权

US07538102B2 Compounds for the treatment of Hepatitis C 有权
标题翻译：用于治疗丙型肝炎的化合物
公开(公告)号：US07538102B2
公开(公告)日：2009-05-26
申请号：US12046030
申请日：2008-03-11
申请人： Kap-Sun Yeung , John A. Bender , Robert G. Gentles , Zhong Yang , Min Ding , Yong Tu , Piyasena Hewawasam , Ying Han , John F. Kadow
发明人： Kap-Sun Yeung , John A. Bender , Robert G. Gentles , Zhong Yang , Min Ding , Yong Tu , Piyasena Hewawasam , Ying Han , John F. Kadow
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

43. 发明授权

US07521441B2 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors 有权
公开(公告)号：US07521441B2
公开(公告)日：2009-04-21
申请号：US11745090
申请日：2007-05-07
申请人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
发明人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
IPC分类号： A61P31/00 , A61K31/407 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

44. 发明申请

US20080226592A1 Compounds for the Treatment of Hepatitis C 有权
标题翻译：用于治疗丙型肝炎的化合物
公开(公告)号：US20080226592A1
公开(公告)日：2008-09-18
申请号：US12046030
申请日：2008-03-11
申请人： Kap-Sun Yeung , John A. Bender , Robert G. Gentles , Zhong Yang , Min Ding , Yong Tu , Piyasena Hewawasam , Ying Han , John F. Kadow
发明人： Kap-Sun Yeung , John A. Bender , Robert G. Gentles , Zhong Yang , Min Ding , Yong Tu , Piyasena Hewawasam , Ying Han , John F. Kadow
IPC分类号： A61K31/55 , C07D487/04 , A61P31/12 , A61K38/21 , A61K38/20
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

45. 发明申请

US20080146537A1 CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS 有权
公开(公告)号：US20080146537A1
公开(公告)日：2008-06-19
申请号：US11942285
申请日：2007-11-19
申请人： John A. Bender , Min Ding , Robert G. Gentles , Piyasena Hewawasam
发明人： John A. Bender , Min Ding , Robert G. Gentles , Piyasena Hewawasam
IPC分类号： A61K31/55 , A61P31/12 , C07D487/04
CPC分类号： C07D487/08 , A61K31/55 , A61K45/06 , C07D471/08 , C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I化合物以及使用该化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

46. 发明申请

US20070287694A1 Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors 有权
标题翻译：环丙基稠合吲哚扎嗪氮芥HCV NS5B抑制剂
公开(公告)号：US20070287694A1
公开(公告)日：2007-12-13
申请号：US11756203
申请日：2007-05-31
申请人： Kap-Sun Yeung , Katharine A. Grant-Young , Min Ding , Robert G. Gentles , John F. Kadow
发明人： Kap-Sun Yeung , Katharine A. Grant-Young , Min Ding , Robert G. Gentles , John F. Kadow
IPC分类号： A61K31/55 , A61K31/553 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括化合物以及使用该化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

47. 发明申请

US20060040246A1 Interactive Toothbrush Game 审中-公开
标题翻译：互动牙刷游戏
公开(公告)号：US20060040246A1
公开(公告)日：2006-02-23
申请号：US11161828
申请日：2005-08-18
申请人： Min Ding , Alexander Shtaerman , Esther Scannell , Ian Almeida , John Romano
发明人： Min Ding , Alexander Shtaerman , Esther Scannell , Ian Almeida , John Romano
IPC分类号： G09B23/28
CPC分类号： G09B19/0084
摘要： A method and system of promoting effective brushing techniques by coupling entertainment value with the brushing of teeth. The method and system provides for the association of brushing techniques with electronic game tasks. The system can include a toothbrush and a position sensor operatively connected to the toothbrush for sensing movement associated with brushing technique. A gaming interface is preferably in operative communication with the position sensor for providing feedback regarding performance of game tasks and for providing prompting regarding performance of game tasks.
摘要翻译：通过将娱乐价值与牙齿刷牙耦合来促进有效刷牙技术的方法和系统。该方法和系统提供了刷牙技术与电子游戏任务的关联。该系统可以包括可操作地连接到牙刷的牙刷和位置传感器，用于感测与刷洗技术相关的运动。游戏界面优选地与位置传感器操作性地通信，用于提供关于游戏任务的性能的反馈并提供关于游戏任务执行的提示。

48. 发明申请

US20060036464A1 Method of Reducing Hypothetical Bias in Jury Studies 审中-公开
标题翻译：减少评估研究中假设偏差的方法
公开(公告)号：US20060036464A1
公开(公告)日：2006-02-16
申请号：US11161636
申请日：2005-08-10
申请人： Daniel Cahoy , Min Ding
发明人： Daniel Cahoy , Min Ding
IPC分类号： G06Q99/00
CPC分类号： G06Q90/00 , G06Q50/188
摘要： A method for reducing hypothetical bias in jury studies. The method utilizes an incentive-based approach to jury studies to help to reduce and/or remove hypothetical bias from these jury studies. The present invention uses an incentive that is to be awarded to an independent third person. This incentive is structured such that the closer the jury's decision comes to the correct result, the greater the amount of the incentive that is to be given to the independent third person. This structure is explained to the jury participating in the jury study such that the jury will desire to increase the amount of the incentive given to the independent third person. Accordingly, some of the previous issues of hypothetical bias, such as laziness, lack of attention to the evidence, and/or personal bias, are reduced or eliminated.
摘要翻译：一种减少陪审团研究中假设偏见的方法。该方法利用基于激励的方式进行陪审团研究，以帮助减少和/或消除这些陪审团研究中的假设偏见。本发明使用授予独立第三人的激励。这种激励的结构使得陪审团的决定越接近正确的结果，给予独立第三人的激励的数量就越多。向参加陪审团研究的陪审团解释了这种结构，使陪审团希望增加对独立第三人的激励金额。因此，以前的一些假设偏见的问题，如懒惰，缺乏对证据的关注和/或个人的偏见，被减少或消除。

49. 发明授权

US08725871B2 Systems and methods for application dependency discovery 有权
标题翻译：用于应用程序依赖关系发现的系统和方法
公开(公告)号：US08725871B2
公开(公告)日：2014-05-13
申请号：US13284350
申请日：2011-10-28
申请人： Min Ding , Vishal Singh , Yueping Zhang , Guofei Jiang
发明人： Min Ding , Vishal Singh , Yueping Zhang , Guofei Jiang
IPC分类号： H04L12/26 , G06F15/173 , G06F17/16 , G06F15/16
CPC分类号： G06F11/3089 , G06F11/3006 , G06F11/3051 , H04L41/12 , H04L41/142 , H04L43/0876
摘要： Systems and methods for discovering a set of applications that run on a network are disclosed. In accordance with one method, aggregate traffic volumes are determined for pairs of nodes on the network over a plurality of time intervals. The method further includes building a traffic matrix denoting each of the pairs of nodes and denoting respective aggregate traffic volume histories of each of the pairs of nodes that are based on the determined traffic volumes. In addition, the traffic matrix is formulated as a combination of bases vectors that model the set of applications. The bases vectors are determined by applying a covariance matrix adaptation evolutionary strategy based on the traffic matrix. An indication of the set of applications based on the bases vectors is output.
摘要翻译：公开了用于发现在网络上运行的一组应用的系统和方法。根据一种方法，在多个时间间隔上为网络上的节点对确定聚合业务量。该方法还包括构建表示每对节点的业务矩阵并且表示基于所确定的业务量的每对节点对应的聚合业务量历史。另外，业务矩阵被形成为对应用集合建模的基本向量的组合。通过应用基于业务矩阵的协方差矩阵适应进化策略来确定基本向量。输出基于基本向量的应用集合的指示。

50. 发明申请

US20120322836A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR STABILIZING THE SAME 审中-公开
标题翻译：药物组合物及其稳定化方法
公开(公告)号：US20120322836A1
公开(公告)日：2012-12-20
申请号：US13600083
申请日：2012-08-30
申请人： Gopal Krishna , Rajeshwar Motheram , Min Ding
发明人： Gopal Krishna , Rajeshwar Motheram , Min Ding
IPC分类号： A61K31/4418 , A61P9/12 , C07D213/80
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/10 , A61K31/435 , A61K31/4418 , A61K2300/00
摘要： Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis.
摘要翻译：描述了药物组合物和稳定具有氯维地平的药物组合物或其任何药学上可接受的盐作为活性成分的方法。该方法包括减缓或抑制氯维地平的氧化途径。这可以通过在制造和储存过程中减少药物组合物暴露于氧和/或光的量来实现。根据该方法，必须除去或更换氧气，或者必须充分阻挡光，使得光能不能达到组合物的活性成分，或者降低到光诱导的氧化反应将氯维地平转化为H324 / 78 被最小化，使得给定组合物样品中H324 / 78的总可检测水平以重量计不超过约0.2％，或者氯维地平与H324 / 78的比例等于或大于约450 至1，以重量为基准。

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