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41. 发明授权

US4073764A Degradable plastic composition 失效
标题翻译：可降解塑料成分
公开(公告)号：US4073764A
公开(公告)日：1978-02-14
申请号：US597269
申请日：1975-07-18
申请人： Heinz-Peter Hemmerich , Gerhard Winter , Hans J. Rosenkranz , Peter Woditsch
发明人： Heinz-Peter Hemmerich , Gerhard Winter , Hans J. Rosenkranz , Peter Woditsch
IPC分类号： C08L23/00 , C08K3/00 , C08K3/22 , C08L1/00 , C08L7/00 , C08L21/00 , C08L27/00 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L67/00 , C08L77/00 , C08L101/00 , C09C1/36 , C08J3/20
CPC分类号： C09C1/36 , C08K3/22 , C01P2002/70 , Y10S260/43
摘要： A plastic composition degradable under the influence of weather or light, comprising a plastic material and finely divided titanium dioxide with a specific surface of more than about 20 m.sup.2 /g. Preferably the titanium dioxide is obtained by hydrolyzing titanium sulfate in aqueous solution, has a predominantly anatase structure, a lightening power of less than about 400, a specific surface of about 60 to 400 m.sup.2 /g and is present in about 0.5 to 5% by weight of the composition, and the plastic material is selected from the group consisting of polyethylene, ethylene-vinyl acetate copolymer, polystyrene, polyvinyl chloride, polyamides and ABS-polymers.
摘要翻译：塑料组合物在天气或光线的影响下可降解，包括塑料材料和比表面积大于约20m2 / g的细分二氧化钛。优选地，二氧化钛通过在水溶液中水解硫酸钛而获得，主要具有锐钛矿结构，小于约400的发光功率，约60至400m 2 / g的比表面积，并且以约0.5至5％的比例存在于约0.5至5％组合物的重量和塑料材料选自聚乙烯，乙烯 - 乙酸乙烯酯共聚物，聚苯乙烯，聚氯乙烯，聚酰胺和ABS-聚合物。

42. 发明申请

US20140371292A1 Method for the controlled intracellular delivery of nucleic acids 审中-公开
标题翻译：核酸控制细胞内递送的方法
公开(公告)号：US20140371292A1
公开(公告)日：2014-12-18
申请号：US14125914
申请日：2012-08-10
申请人： Ahmed Besheer , Matthaus Noga , Gerhard Winter , Ernst Wagner , Daniel Edinger
发明人： Ahmed Besheer , Matthaus Noga , Gerhard Winter , Ernst Wagner , Daniel Edinger
IPC分类号： A61K47/36 , A61K31/713
CPC分类号： A61K47/36 , A61K31/713 , A61K47/59 , A61K47/61
摘要： The present invention relates to a method for the controlled intracellular delivery of nucleic acid molecules into one or more target cells, in particular tumor cells, the method comprising: providing a polymeric complex formed between one or more nucleic acid molecules to be delivered and one or more cationic carrier molecules, wherein at least a part of the one or more carrier molecules in the polymeric complex are covalently attached to hydroxyalkyl starch, and wherein the hydroxyalkyl starch is shielding the polymeric complex; allowing the shielded polymeric complex to get into contact with the one or more target cells; deshielding the polymeric complex by removing the hydroxyalkyl starch; and allowing the deshielded polymeric complex to internalize into the one or more target cells. Removal of the hydroxyalkyl starch can be accomplished enzymatically by exposing the polymeric complex to amylase. The invention also concerns the use of such method for the prevention and/or treatment of a condition selected from the group consisting of cancer, immune diseases, cardiovascular diseases, neuronal diseases, infections, and inflammatory diseases.
摘要翻译：本发明涉及将核酸分子受控的细胞内递送到一个或多个靶细胞，特别是肿瘤细胞中的方法，所述方法包括：提供在待递送的一个或多个核酸分子之间形成的聚合物复合物，更多的阳离子载体分子，其中聚合物络合物中的一个或多个载体分子的至少一部分共价连接到羟烷基淀粉上，并且其中羟烷基淀粉屏蔽聚合复合物; 允许屏蔽聚合物复合物与一个或多个靶细胞接触; 通过除去羟烷基淀粉去除聚合物复合物; 并且允许未屏蔽的聚合物络合物内化到一个或多个靶细胞中。可以通过将聚合物复合物暴露于淀粉酶来酶促去除羟烷基淀粉。本发明还涉及使用这种方法来预防和/或治疗选自癌症，免疫疾病，心血管疾病，神经元疾病，感染和炎性疾病的病症。

43. 发明授权

US08633302B2 Variable tangential flow filtration 有权
标题翻译：可变切向流过滤
公开(公告)号：US08633302B2
公开(公告)日：2014-01-21
申请号：US12668661
申请日：2008-07-15
申请人： Stefan Hepbildikler , Wolfgang Kuhne , Eva Rosenberg , Gerhard Winter
发明人： Stefan Hepbildikler , Wolfgang Kuhne , Eva Rosenberg , Gerhard Winter
IPC分类号： A23J1/00 , C07K1/00 , C07K14/00 , C07K16/00
CPC分类号： C07K1/34 , C07K16/00
摘要： The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.
摘要翻译：本发明报告了通过切向流过滤浓缩免疫球蛋白溶液的方法，其中跨膜压力和交叉流动是可变的。

44. 发明申请

US20120219990A1 PRE-FILTRATION ADJUSTMENT OF BUFFER SOLUTES 有权
标题翻译：缓冲解决方案的预滤波调整
公开(公告)号：US20120219990A1
公开(公告)日：2012-08-30
申请号：US13395893
申请日：2010-08-27
申请人： Stefan Hepbildikler , Wolfgang Kuhne , Eva Rosenberg , Gerhard Winter
发明人： Stefan Hepbildikler , Wolfgang Kuhne , Eva Rosenberg , Gerhard Winter
IPC分类号： C07K1/14 , C07K16/18 , C12P21/00
CPC分类号： C07K1/14 , B01D61/00 , B01D61/14 , C07K1/34 , C07K16/065 , C07K16/18
摘要： Herein is reported a tangential flow filtration method with a pre-filtration solute concentration adjustment in order to ensure a defined concentration of the components of the solution after tangential flow filtration.
摘要翻译：本文报道了具有预过滤溶质浓度调节的切向流过滤方法，以便在切向流过滤之后确保溶液的组分的确定浓度。

45. 发明授权

US08182884B2 Process for application of a hydrophilic coating to fuel cell bipolar plates 有权
标题翻译：将亲水涂层应用于燃料电池双极板的方法
公开(公告)号：US08182884B2
公开(公告)日：2012-05-22
申请号：US11463386
申请日：2006-08-09
申请人： Gerhard Winter , Gayatri Vyas , Thomas A. Trabold , Reena L. Datta
发明人： Gerhard Winter , Gayatri Vyas , Thomas A. Trabold , Reena L. Datta
IPC分类号： C23C16/00 , B05D5/12
CPC分类号： H01M8/0228 , H01M8/0206 , H01M8/0213 , H01M8/0221
摘要： A process comprising: depositing a coating on a fuel cell bipolar plate using plasma assisted chemical vapor deposition.
摘要翻译：一种方法，包括：使用等离子体辅助化学气相沉积在燃料电池双极板上沉积涂层。

46. 发明申请

US20100034823A1 Crystalline anti-hTNFalpha antibodies 有权
标题翻译：结晶抗hTNFalpha抗体
公开(公告)号：US20100034823A1
公开(公告)日：2010-02-11
申请号：US11977677
申请日：2007-10-25
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
IPC分类号： A61K39/395 , C07K1/00 , C07K16/18 , A61P19/10 , A61P19/02 , A61P37/08 , A61P37/06 , A61P11/00 , A61P1/00 , A61P9/00 , A61P19/00 , A61P7/00 , A61P17/00 , A61P11/06 , A61P3/10 , A61P17/06 , A61P25/28 , A61P31/12 , A61P35/00 , A61P27/02
CPC分类号： C07K16/241 , A61K9/50 , A61K39/3955 , C07K2299/00 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译：本发明涉及一种用于使抗hTNFα抗体结晶的分批结晶方法，其允许以工业规模生产所述抗体; 根据所述方法获得的抗体晶体; 含有所述晶体的组合物以及所述晶体和组合物的使用方法。

47. 发明申请

US20070037036A1 Hydrophilic Coating For Fuel Cell Bipolar Plate And Methods Of Making The Same 有权
标题翻译：用于燃料电池双极板的亲水涂层及其制造方法
公开(公告)号：US20070037036A1
公开(公告)日：2007-02-15
申请号：US11463384
申请日：2006-08-09
申请人： Gerhard Winter , Gayatri Vyas , Thomas Trabold , Reena Datta
发明人： Gerhard Winter , Gayatri Vyas , Thomas Trabold , Reena Datta
IPC分类号： H01M8/02 , B05D5/12
CPC分类号： H01M8/0228 , H01M8/0206 , H01M8/0213 , H01M8/0221 , H01M8/0226 , H01M8/023 , H01M8/0234 , H01M8/0241 , H01M8/0243 , H01M8/04291 , H01M2008/1095 , H01M2250/20 , Y02E60/50 , Y02T90/32 , Y10T29/49931
摘要： One embodiment disclosed includes a product comprising: a fuel cell component comprising a substrate and a first coating overlying the substrate, the coating comprising a compound comprising at least one Si—O group, at least one polar group and at least one group including a saturated or unsaturated carbon chain.
摘要翻译：所公开的一个实施方案包括：产品，包括：燃料电池组件，其包含基材和覆盖在基材上的第一涂层，所述涂层包含包含至少一个Si-O基团，至少一个极性基团和至少一个包含饱和或不饱和碳链。

48. 发明授权

US06346274B1 Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof 失效
标题翻译：以微粒形式的含多肽的药物给药形式及其制备方法
公开(公告)号：US06346274B1
公开(公告)日：2002-02-12
申请号：US08894796
申请日：1998-01-05
申请人： Hans Koll , Gerhard Winter , Thomas Kissel , Michael Morlock
发明人： Hans Koll , Gerhard Winter , Thomas Kissel , Michael Morlock
IPC分类号： A61K916
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K38/1816
摘要： The invention concerns parenteral pharmaceutical forms of administration containing polypeptide in the form of microparticles and a process for the production thereof. The microparticles according to the invention contain as a biodegradable polymer an ABA triblock copolymer the A block of which is a copolymer of lactic and glycolic acid and the B block of which represents a polyethylene glycol chain, together with additives that are selected from the group comprising serum proteins, polyamino acids, cyclodextrins, cyclodextrin derivatives, saccharides, amino sugars, amino acids, detergents or carboxylic acids as well as mixtures of these additives. The microparticles according to the invention continuously release the polypeptide over a relatively long time period even when the amounts of polypeptide they include are small or susceptible to aggregation.
摘要翻译：本发明涉及含有微粒形式的多肽的肠胃外药物给药形式及其生产方法。根据本发明的微粒包含作为生物可降解聚合物的ABA三嵌段共聚物，其中A嵌段是乳酸和乙醇酸的共聚物，其B嵌段代表聚乙二醇链，以及选自以下的添加剂：血清蛋白，聚氨基酸，环糊精，环糊精衍生物，糖，氨基糖，氨基酸，去污剂或羧酸，以及这些添加剂的混合物。根据本发明的微粒在相对长的时间段内连续地释放多肽，即使它们包括的多肽的量很小或易于聚集。

49. 发明授权

US06303113B1 Process for the production of pharmaceutical preparations containing human protein for infusion or injection purposes 失效
标题翻译：用于生产含有用于输注或注射目的的人蛋白质的药物制剂的方法
公开(公告)号：US06303113B1
公开(公告)日：2001-10-16
申请号：US08593579
申请日：1996-01-30
申请人： Heinrich Woog , Werner Gruber , Hans-Jörg Markl , Gerhard Winter , Fritz Demmer
发明人： Heinrich Woog , Werner Gruber , Hans-Jörg Markl , Gerhard Winter , Fritz Demmer
IPC分类号： A61K3819
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1816 , A61K38/193 , A61K47/10 , A61K47/14 , Y10S530/829
摘要： The present invention concerns a process for the production of well-tolerated, preserved injection or infusion solutions containing human protein.
摘要翻译：本发明涉及生产含有人蛋白质的耐受良好，保留的注射或输注溶液的方法。

50. 发明授权

US5788544A Multi-pole variable SMD terminal arrangement and method for its mounting on a circuit substrate 失效
标题翻译：多极可变SMD端子布置及其安装在电路基板上的方法
公开(公告)号：US5788544A
公开(公告)日：1998-08-04
申请号：US709282
申请日：1996-09-06
申请人： Karl-Gerd Drekmeier , Gerhard Winter
发明人： Karl-Gerd Drekmeier , Gerhard Winter
IPC分类号： H01R12/57 , H01R43/02 , H01R43/16 , H05K1/02 , H05K3/32 , H05K3/34 , H01R9/24
CPC分类号： H01R12/57 , H01R43/0263 , H05K3/3426 , H05K1/0271 , H05K2201/10757 , H05K2201/1084 , Y02P70/613 , Y10T29/49147 , Y10T29/49149
摘要： A multi-pole, variable SMD terminal arrangement mountable on a circuit substrate has a stamped metallic element with at least three terminal poles connected with one another by means of a common connecting strip that can be removed after the soldering, the terminal poles having variably formed contact areas on the substrate side that are respectively deflected on one side from the plane of the connecting strip in basically z-shaped fashion, so that the contact areas deflected towards opposite sides form a support base for the terminal arrangement during assembly and soldering. The contact areas comprise end areas that form a contact plane that is coplanar to the substrate during assembly and soldering.
摘要翻译：安装在电路基板上的多极可变SMD端子布置具有冲压的金属元件，其具有至少三个端子极，其通过可在焊接之后被去除的公共连接条彼此连接，端子极可变地形成基板侧的接触区域分别以基本上z形的方式从连接条的平面偏转在一侧，使得朝向相对侧偏转的接触区域在组装和焊接期间形成用于端子装置的支撑基座。接触区域包括在组装和焊接期间形成与基底共面的接触平面的端部区域。

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