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41. 发明申请

US20070129300A1 Cytotoxic factors for modulating cell death 审中-公开
标题翻译：调节细胞死亡的细胞毒性因子
公开(公告)号：US20070129300A1
公开(公告)日：2007-06-07
申请号：US11485252
申请日：2006-07-13
申请人： Ananda Chakrabarty , Tapas Das Gupta , Vasu Punj , Olga Zaborina
发明人： Ananda Chakrabarty , Tapas Das Gupta , Vasu Punj , Olga Zaborina
IPC分类号： A61K38/16 , C07K14/21
CPC分类号： C07K14/35 , A61K38/00 , C07K14/195 , G01N33/5011 , G01N33/569 , G01N2510/00
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
摘要翻译：公开了用于调节细胞死亡的细胞毒性因子及其在治疗坏死或凋亡相关病症的方法中的用途。本发明还涉及用于鉴定可用于治疗与细胞死亡相关的病症的活性剂的方法。本发明人发现不同的病原体产生具有抗癌活性的不同的细胞毒性因子。基本上纯的细胞毒性因子可用于治疗感染性疾病或癌症的方法。

42. 发明授权

US09969781B2 Compositions and methods to treat cancer with CpG rich DNA and cupredoxins 有权
公开(公告)号：US09969781B2
公开(公告)日：2018-05-15
申请号：US13230055
申请日：2011-09-12
申请人： Tapas Das Gupta , Ananda Chakrabarty
发明人： Tapas Das Gupta , Ananda Chakrabarty
IPC分类号： C07K14/195 , C07K14/21 , A61K38/00
CPC分类号： C07K14/195 , A61K38/00 , C07K14/21
摘要： The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.

43. 发明申请

US20120014877A1 COMPOSITIONS AND METHODS TO TREAT CANCER WITH CpG RICH DNA AND CUPREDOXINS 审中-公开
标题翻译：用CpG Rich DNA和CUPREDOXINS治疗癌症的组合物和方法
公开(公告)号：US20120014877A1
公开(公告)日：2012-01-19
申请号：US13230055
申请日：2011-09-12
申请人： Tapas Das Gupta , Ananda Chakrabarty
发明人： Tapas Das Gupta , Ananda Chakrabarty
IPC分类号： A61K49/00 , A61K31/7088 , A61K35/74 , A61K38/16 , A61P35/00 , C12N1/21 , C07H21/04 , A61K38/00
CPC分类号： C07K14/195 , A61K38/00 , C07K14/21
摘要： The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.
摘要翻译：本发明涉及包含来自绿脓假单胞菌的富含CpG的DNA的组合物。组合物任选地包含铜氧还蛋白。本发明包括来自铜绿假单胞菌的特异性CpG DNA，其可用于治疗患者的癌症和其它病症。这些组合物任选地在药学上可接受的载体中，并且还任选地包含铜氧还蛋白。本发明还涉及在癌细胞附近表达蛋白质的方法。这些方法可以用于表达患有癌症或其他病症的患者中癌细胞附近的治疗或诊断蛋白质，并且还可以用于诊断患者的癌症。该方法使用来自铜绿假单胞菌的azurin基因作为铜绿假单胞菌或异源细胞中的azurin或异源蛋白质的表达系统。

44. 发明申请

US20100278937A1 COMPOSITIONS AND METHODS TO PREVENT AND/OR TREAT CANCER WITH PA-CARD 审中-公开
标题翻译：用PA卡预防和/或治疗癌症的组合物和方法
公开(公告)号：US20100278937A1
公开(公告)日：2010-11-04
申请号：US12709806
申请日：2010-02-22
申请人： Tapas K. Das Gupta , Ananda Chakrabarty , Arsenio Fialho
发明人： Tapas K. Das Gupta , Ananda Chakrabarty , Arsenio Fialho
IPC分类号： A61K33/36 , C07K2/00 , C07K14/21 , A61K38/02 , A61K33/24 , A61K31/497 , A61K31/203 , A61K31/706 , C07H21/04 , A61P35/00 , C12N5/02 , C12N15/63
CPC分类号： C07K14/195 , G01N2333/16
摘要： The present invention relates to methods and materials for killing cancer cells with proteins derived from bacteria. The invention specifically relates to Azurin, Laz, Pa-CARD, and fusion proteins Azu-H.8 and H.8-Azu, and their use in killing leukemia cells and/or ovarian cancer cells.
摘要翻译：本发明涉及用来自细菌的蛋白质杀死癌细胞的方法和材料。本发明具体涉及Azurin，Laz，Pa-CARD和融合蛋白Azu-H.8和H.8-Azu，以及它们在杀死白血病细胞和/或卵巢癌细胞中的用途。

45. 发明申请

US20060040269A1 Cytotoxic factors for modulating cell death 有权
公开(公告)号：US20060040269A1
公开(公告)日：2006-02-23
申请号：US10720603
申请日：2003-11-24
申请人： Ananda Chakrabarty , Tapas Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
发明人： Ananda Chakrabarty , Tapas Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
IPC分类号： A61K38/54 , C12Q1/68
CPC分类号： C07K14/80 , A61K38/164 , A61K38/168 , A61K38/415 , C07K14/195
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.

46. 发明申请

US20140051643A1 ANTICANCER AGENT 有权
标题翻译： ANTICANCER代理
公开(公告)号：US20140051643A1
公开(公告)日：2014-02-20
申请号：US13877304
申请日：2011-09-30
申请人： Anil Suri , Deepika Kanojia , Prabhakar Salunkhe , Sidharth Mahali , Sunil Kumar Manna , Avadhesha Surolia , Ananda Chakrabarty
发明人： Anil Suri , Deepika Kanojia , Prabhakar Salunkhe , Sidharth Mahali , Sunil Kumar Manna , Avadhesha Surolia , Ananda Chakrabarty
IPC分类号： C07K14/45 , C07K14/35
CPC分类号： C07K14/45 , A61K38/164 , C07K14/35
摘要： The present invention thus provides microbial products as anticancer agents and pharmaceutical compositions comprising isolated and purified proteins or synthetic peptides, and methods of using them for the treatment of cancer. It is very important to develop new anticancer bioactive peptides having high activity and low toxicity; given that most currently available anticancer therapies either have significant toxicity, and/or are prone to development of resistance.
摘要翻译：因此，本发明提供作为抗癌剂的微生物产物和包含分离和纯化的蛋白质或合成肽的药物组合物，以及使用它们用于治疗癌症的方法。开发具有高活性和低毒性的新型抗癌生物活性肽是非常重要的; 鉴于大多数目前可用的抗癌疗法具有显着的毒性，和/或易于发展抗药性。

47. 发明授权

US09624277B2 Anticancer agent 有权
公开(公告)号：US09624277B2
公开(公告)日：2017-04-18
申请号：US13877304
申请日：2011-09-30
申请人： Anil Suri , Deepika Kanojia , Prabhakar Salunkhe , Sidharth Mahali , Sunil Kumar Manna , Avadhesha Surolia , Ananda Chakrabarty
发明人： Anil Suri , Deepika Kanojia , Prabhakar Salunkhe , Sidharth Mahali , Sunil Kumar Manna , Avadhesha Surolia , Ananda Chakrabarty
IPC分类号： C07K14/45 , C07K14/35 , A61K38/16
CPC分类号： C07K14/45 , A61K38/164 , C07K14/35
摘要： The present invention thus provides microbial products as anticancer agents and pharmaceutical compositions comprising isolated and purified proteins or synthetic peptides, and methods of using them for the treatment of cancer. It is very important to develop new anticancer bioactive peptides having high activity and low toxicity; given that most currently available anticancer therapies either have significant toxicity, and/or are prone to development of resistance.

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