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41. 发明申请

US20060060027A1 Method for producing magnetic particle, magnetic particle and magnetic material 有权
公开(公告)号：US20060060027A1
公开(公告)日：2006-03-23
申请号：US11258569
申请日：2005-10-25
申请人： Katsumi Okayama , Kaoru Kobayashi , Koichiro Inomata , Satoshi Sugimoto , Yoshihiro Kato
发明人： Katsumi Okayama , Kaoru Kobayashi , Koichiro Inomata , Satoshi Sugimoto , Yoshihiro Kato
IPC分类号： B22F9/24
CPC分类号： B82Y30/00 , B22F1/0018 , B22F1/0059 , B22F9/24 , B22F9/305 , B22F2998/00 , B82Y25/00 , B82Y40/00 , C22C32/0094 , H01F1/0054 , H01F41/30 , H01F41/301 , Y10S977/777 , Y10S977/783 , Y10T428/12146 , Y10T428/254 , Y10T428/256 , Y10T428/257 , Y10T428/29 , Y10T428/2991 , Y10T428/2998 , B22F3/02
摘要： A method for producing a magnetic particle forming a magnetic material for absorbing electromagnetic waves comprises the steps of mixing an organometallic complex or a metal salt with a chain polymer and dissolving the mixture in a solvent (step S1); raising the temperature of the mixture to reaction temperature (step S2), carrying out a reaction at the reaction temperature (step S3); and forming the magnetic particle having a structure that the periphery of each fine particle formed from the organometallic complex or the metal salt is surrounded by the chain polymer and recovering the formed magnetic particle after the reaction (step S4). The magnetic particle has a nanogranular structure to become a magnetic material for absorbing electromagnetic waves. Such a magnetic particle is produced by a wet reaction. Thus, a larger amount of magnetic particle can be produced by one reaction.

42. 发明申请

US20050230788A1 Magnetic shield member, magnetic shield structure, and magnetic memory device 失效
标题翻译：磁屏蔽构件，磁屏蔽结构和磁存储装置
公开(公告)号：US20050230788A1
公开(公告)日：2005-10-20
申请号：US11053650
申请日：2005-02-08
申请人： Yoshihiro Kato , Yoshinori Ito , Tatsushiro Hirata , Katsumi Okayama , Kaoru Kobayashi
发明人： Yoshihiro Kato , Yoshinori Ito , Tatsushiro Hirata , Katsumi Okayama , Kaoru Kobayashi
IPC分类号： H01L23/00 , G11C11/16 , H01L21/8246 , H01L23/552 , H01L27/105
CPC分类号： H01L23/552 , G11C11/16 , H01L2924/0002 , H01L2924/00
摘要： It is an object of the invention to relax magnetic saturation and realize a high-performance magnetic shield effect that is suitable for magnetic devices such as an MRAM. A magnetic shield member of the invention is suitable for a magnetic memory device in which a magnetic random access memory (MRAM) consisting of a TMR element formed by stacking a magnetization fixed layer with a direction of magnetization fixed and a magnetic layer, in which a direction of magnetization can be changed, via a tunnel barrier layer is sealed by a sealing material such as resin. A planar shape or a sectional shape of magnetic shield plates provided on the sealing material in order to magnetically shield the MRAM is a shape in which a side substantially perpendicular to a direction of an outer magnetic field and a side substantially parallel to the direction of an outer magnetic field are not orthogonal to each other, in particular, circular, polygonal, or the like, whereby it is possible to relax magnetic saturation of the magnetic shield plate and keep the magnetic shield effect.
摘要翻译：本发明的目的是松弛磁饱和，实现适用于MRAM等磁性装置的高性能磁屏蔽效果。本发明的磁屏蔽部件适用于磁性随机存取存储器（MRAM），其中磁性随机存取存储器（MRAM）由通过堆积固定磁化方向的磁化固定层形成的TMR元件和磁性层组成，其中，磁化方向可以改变，通过隧道阻挡层被树脂等密封材料密封。设置在密封材料上以磁屏蔽MRAM的磁屏蔽板的平面形状或截面形状是这样的形状，其中，基本上垂直于外部磁场的方向的侧和基本上平行于外部磁场彼此不正交，特别是圆形，多边形等，从而可以缓和磁屏蔽板的磁饱和并保持磁屏蔽效果。

43. 发明申请

US20050226030A1 Magnetic memory device 审中-公开
标题翻译：磁存储器件
公开(公告)号：US20050226030A1
公开(公告)日：2005-10-13
申请号：US10504626
申请日：2003-12-12
申请人： Yoshihiro Kato , Katsumi Okayama , Kaoru Kobayashi , Tetsuya Yamamoto , Minoru Ikarashi
发明人： Yoshihiro Kato , Katsumi Okayama , Kaoru Kobayashi , Tetsuya Yamamoto , Minoru Ikarashi
IPC分类号： G11C11/15 , H01L21/8246 , H01L23/00 , H01L23/495 , H01L23/552 , H01L27/105 , H01L43/02 , H01L43/08 , G11C11/00
CPC分类号： H01L23/49575 , H01L23/552 , H01L2924/0002 , H01L2924/00
摘要： A magnetic memory device in which an MRAM element is magnetically shielded from a large external magnetic field in an satisfactory manner, making it possible to surely achieve an operation free of problems in a magnetic field generated by the environment in which the MRAM element is used. A magnetic random access memory (MRAM) (30) is constituted by a TMR element (10) having a magnetized pinned layer (4), (6) with fixed direction of magnetization and a magnetic layer (memory layer) (2) with changeable direction of magnetization stacked on one another, mounted on a substrate together with another element (38), such as a DRAM, wherein a magnetic shielding layer (33), (34) is formed in a region corresponding to an area occupied by the MRAM element (30) or/and a magnetic shielding layer (33), (34) is with a distance of 15 mm or less between the opposite sides (especially, a length or a width).
摘要翻译：一种磁记录装置，其中MRAM元件以令人满意的方式从大的外部磁场磁屏蔽，使得可以可靠地实现在由使用MRAM元件的环境产生的磁场中没有问题的操作。磁性随机存取存储器（MRAM）（30）由具有固定磁化方向的磁化钉扎层（4），（6）的TMR元件（10）和具有可变形的磁性层（存储层）（2）构成彼此堆叠的磁化方向，与诸如DRAM的另一元件（38）一起安装在基板上，其中在与MRAM占据的区域对应的区域中形成磁屏蔽层（33）（34）元件（30）或/和磁屏蔽层（33），（34）在相对侧（特别是长度或宽度）之间的距离为15mm以下。

44. 发明申请

US20050026908A1 Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient 审中-公开
标题翻译：羧酸衍生物，其制备方法和包含其作为活性成分的药物组合物
公开(公告)号：US20050026908A1
公开(公告)日：2005-02-03
申请号：US10924924
申请日：2004-08-25
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： A61P1/12 , A61P3/12 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/12 , A61P15/00 , A61P15/06 , A61P17/00 , A61P17/02 , A61P17/04 , A61P19/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P37/08 , C07C233/44 , C07C233/55 , C07C235/38 , C07C255/60 , C07C311/51 , C07C323/52 , C07C323/60 , C07D209/18 , C07D213/75 , C07D261/10 , C07D319/18 , C07D333/60 , A61K31/55 , A61K31/40 , A61K31/445
CPC分类号： C07D213/75 , C07B2200/07 , C07C233/44 , C07C233/55 , C07C235/38 , C07C255/60 , C07C311/51 , C07C323/52 , C07C323/60 , C07C2601/02 , C07C2601/10 , C07C2602/10 , C07D209/18 , C07D261/10 , C07D319/18 , C07D333/60
摘要： A carboxylic acid derivative of formula (I) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; R6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.
摘要翻译：式（I）的羧酸衍生物，其中R 1是COOH，COOR 6等; A是亚烷基等; R 2是烷基，烯基，炔基等; B是碳环或杂环; R 4是烷基，环烷基等; R 6是碳环或杂环; 或其无毒盐，其制备方法和包含其作为活性成分的药剂。式（I）化合物可以结合前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，并且可用于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病疾病，癌症。

45. 发明申请

US20050020686A1 Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient 失效
标题翻译：用ep4激动剂作为活性成分治疗骨质量下降的疾病
公开(公告)号：US20050020686A1
公开(公告)日：2005-01-27
申请号：US10484500
申请日：2002-07-22
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K45/00 , A61K31/559 , A61P19/08 , A61P19/10 , C07C405/00 , A61K31/557
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

46. 发明授权

US06486414B2 Through-hole structure and printed circuit board including the through-hole structure 有权
标题翻译：通孔结构和印刷电路板包括通孔结构
公开(公告)号：US06486414B2
公开(公告)日：2002-11-26
申请号：US09921245
申请日：2001-08-01
申请人： Kaoru Kobayashi , Hiroyuki Mori , Kimihiro Yamanaka
发明人： Kaoru Kobayashi , Hiroyuki Mori , Kimihiro Yamanaka
IPC分类号： H05K111
CPC分类号： H05K1/0222 , H05K1/024 , H05K1/0251 , H05K1/115 , H05K3/429 , H05K2201/09063 , H05K2201/09618 , H05K2201/09809
摘要： The present invention provides a through-hole structure for connecting a connector to a printed circuit board, the through-hole structure comprising a signal through-hole having a conductive layer therein for supplying a signal to the printed circuit board, power through-holes having a conductive layer therein for supplying power to the printed circuit board, and dielectric constant adjusting portions formed among the signal through-hole and the power through-holes. Moreover, the present invention provides a printed circuit board having the above-described through-hole structure formed therein.
摘要翻译：本发明提供一种用于将连接器连接到印刷电路板的通孔结构，该通孔结构包括其中具有用于向印刷电路板提供信号的导电层的信号通孔，具有用于向印刷电路板提供信号的电力通孔，用于向印刷电路板供电的导电层，以及形成在信号通孔和电源通孔之间的介电常数调节部。此外，本发明提供一种其中形成有上述通孔结构的印刷电路板。

47. 发明授权

US6068995A Method for producing protein 失效
标题翻译：生产蛋白质的方法
公开(公告)号：US6068995A
公开(公告)日：2000-05-30
申请号：US666435
申请日：1996-09-19
申请人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda , Takao Ohmura
发明人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda , Takao Ohmura
IPC分类号： C07K14/765 , C12N1/19 , C12N1/38 , C12N15/00 , C12N15/12 , C12N15/18 , C12P21/00
CPC分类号： C12N15/00 , C07K14/765 , C12N1/38 , C12P21/00
摘要： A method for producing a desired protein, which comprises growing, by a fed-batch culture, a host cell capable of expressing the desired protein, wherein the specific growth rate of the host cell is changed from the initial rate to a predetermined one by successively changing the rate of addition of a substrate which controls the growth of the host cell. According to the mode of change of the rate of substrate addition to the medium of the present invention, optimal patterns of specific growth rate .mu. and specific production rate .rho. can be realized to optimize the fed-batch culture system. As a consequence of the realization, it is made possible to perform a high density culture of the host cell by fed-batch culture, an the desired protein can be produced efficiently in a short time.
摘要翻译： PCT No.PCT / JP95 / 02186 Sec。 371日期1996年9月19日 102（e）1996年9月19日PCT 1994年10月25日PCT公布。公开号WO96 / 12816 PCT 日期：1996年5月2日一种生产所需蛋白质的方法，其包括通过补料分批培养物生长能够表达所需蛋白质的宿主细胞，其中所述宿主细胞的比生长速率从初始速率改变为通过依次改变控制宿主细胞生长的底物的加入速度来预定的。根据本发明介质的底物添加速度的变化方式，可以实现比生长速度mu和比生产率rho的最佳模式，以优化补料分批培养体系。作为实现的结果，可以通过补料分批培养进行宿主细胞的高密度培养，可以在短时间内有效地产生所需的蛋白质。

48. 发明授权

US5691451A Method for sterilizing recombinant human serum albumin pharmaceutical preparation 失效
标题翻译：灭菌重组人血清白蛋白药物制剂的方法
公开(公告)号：US5691451A
公开(公告)日：1997-11-25
申请号：US329176
申请日：1994-10-26
申请人： Tomoshi Ohya , Toyoo Ohda , Shinobu Kuwae , Kenji Tomomitsu , Kaoru Kobayashi , Takao Ohmura
发明人： Tomoshi Ohya , Toyoo Ohda , Shinobu Kuwae , Kenji Tomomitsu , Kaoru Kobayashi , Takao Ohmura
IPC分类号： A61K9/08 , A61K38/16 , A61L2/00 , C07K14/765 , C07K1/00 , C12P21/06
CPC分类号： C07K14/765 , A61L2/0023
摘要： A recombinant human serum albumin (rHSA) pharmaceutical preparation is sterilized by subjecting a pharmaceutical preparation of rHSA obtained by gene manipulation techniques packed in a container in an administration unit to heat treatment at 50.degree. to 80.degree. C. for 30 minutes or more. By the disclosed method, rHSA having high safety can be provided since microorganisms contaminated in rHSA pharmaceutical preparations die as a result of the sterilization method of the present invention.
摘要翻译：重组人血清白蛋白（rHSA）药物制剂通过使包装在给药单元的容器中的基因操作技术获得的rHSA药物制剂在50℃至80℃下加热处理30分钟以上而进行灭菌。通过所公开的方法，可以提供具有高安全性的rHSA，因为由rHSA药物制剂中污染的微生物因本发明的灭菌方法而死亡。

49. 发明授权

US5541782A Magnetic recording and playback apparatus capatible with conventional video signal recording format 失效
标题翻译：磁记录和播放设备与传统视频信号记录格式兼容
公开(公告)号：US5541782A
公开(公告)日：1996-07-30
申请号：US425339
申请日：1995-04-18
申请人： Kaoru Kobayashi , Kenji Shibayama
发明人： Kaoru Kobayashi , Kenji Shibayama
IPC分类号： H04N5/92 , H04N5/919 , H04N5/937 , H04N5/78
CPC分类号： H04N5/919 , H04N5/937
摘要： An HD image signal is recorded and reproduced by a tape head system of a conventional home VTR. An HD image signal (bb) which is of a different broadcasting system from a conventional broadcasting system and contains an information whose amount is larger than that contained in a video signal of the conventional broadcasting system is divided by four by first to eighth memories and resultant four signals are recorded on a magnetic tape through a first to fourth recording signal processing circuits and FM modulators, etc. In reproduction, the four signals are reproduced by FM demodulators and a first to fourth reproduced signal processing circuits, etc., and the HD image signal is produced by using the first to eighth memories.
摘要翻译： HD图像信号由常规家用录像机的磁头系统记录和再现。与传统的广播系统不同的广播系统的HD图像信号（bb），其包含大于常规广播系统的视频信号中所包含的信息量的信息被第一至第八存储器除以四，并且得到四个信号通过第一至第四记录信号处理电路和FM调制器等记录在磁带上。在再现中，四个信号由FM解调器和第一至第四再现信号处理电路等以及HD 通过使用第一至第八存储器产生图像信号。

50. 发明授权

US5294699A Inhibition of coloration of human serum albumin 失效
标题翻译：抑制人血清白蛋白着色
公开(公告)号：US5294699A
公开(公告)日：1994-03-15
申请号：US719443
申请日：1991-06-24
申请人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Fuluhata , Kaoru Kobayashi , Shinobu Kuwae , Hirotoshi Fukutsuka , Tomoshi Ohya , Hiroshi Morise
发明人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Fuluhata , Kaoru Kobayashi , Shinobu Kuwae , Hirotoshi Fukutsuka , Tomoshi Ohya , Hiroshi Morise
IPC分类号： A61K38/16 , A61K38/00 , B01D15/00 , B01D15/04 , C07K1/14 , C07K1/20 , C07K14/435 , C07K14/76 , C07K14/765 , C12N15/09 , C12N15/14 , C12N15/81 , C12P21/02 , C12R1/865 , C07K3/28 , A61K45/02
CPC分类号： C07K14/765 , C12N15/81 , A61K38/00 , C07K2319/02
摘要： A method of inhibiting the coloration of human serum albumin expressed by using the gene manipulation technology which method comprises separating coloring contaminants from said human serum albumin before said coloring contaminants bind to the human serum albumin.
摘要翻译：通过使用基因操作技术抑制人血清白蛋白的着色的方法，该方法包括在所述着色污染物与人血清白蛋白结合之前从所述人血清白蛋白中分离着色污染物。

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