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41. 发明申请

US20110319955A1 REDUCTION OF AV DELAY FOR TREATMENT OF CARDIAC DISEASE 有权
标题翻译：减少AV延迟治疗心脏病
公开(公告)号：US20110319955A1
公开(公告)日：2011-12-29
申请号：US13229948
申请日：2011-09-12
申请人： Joseph M. Pastore , Rodney W. Salo , Julio C. Spinelli , Allan C. Shuros , Andres Belalcazar
发明人： Joseph M. Pastore , Rodney W. Salo , Julio C. Spinelli , Allan C. Shuros , Andres Belalcazar
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译：用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式。取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。

42. 发明申请

US20110319776A1 CARDIAC CONTRACTION DETECTION USING INFORMATION INDICATIVE OF LEAD MOTION 有权
标题翻译：使用指示铅运动的信息进行CARDIAC承包检测
公开(公告)号：US20110319776A1
公开(公告)日：2011-12-29
申请号：US13168507
申请日：2011-06-24
申请人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
发明人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
IPC分类号： A61B5/0245 , A61B5/042 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译：描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由一个心脏。该装置可以包括处理器电路，该处理器电路被配置为确定在所获得的指示可植入引线的运动的信息中包括的指定间隔期间是否发生心脏机械收缩。处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。

43. 发明申请

US20110190840A1 SYMPATHETIC STIMULATION FOR IMPROVED MYOCARDIAL RELAXATION 有权
标题翻译：改善心肌松弛的同步刺激
公开(公告)号：US20110190840A1
公开(公告)日：2011-08-04
申请号：US13019818
申请日：2011-02-02
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Guy Alvarez
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Guy Alvarez
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/365
摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.
摘要翻译：描述了用于在呈现相对正常的收缩功能的心力衰竭患者中用电刺激改善舒张功能的方法和装置。这些患者的特征在于舒张期期间的心肌松弛受损，其在舒张期期间阻止充足的心室充盈，从而降低心输出量。描述了可植入装置，用于促进交感神经系统的战略和周期性刺激，以引发心肌肾上腺素能活化以改善心肌松弛。

44. 发明申请

US20110106197A1 PACEMAKER WITH VAGAL SURGE MONITORING AND RESPONSE 有权
标题翻译：具有VAGAL SURGE监测和响应的PACEMAKER
公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
申请人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译：起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。

45. 发明授权

US07930022B2 System and method to determine hemodynamic tolerability 有权
标题翻译：确定血液动力学耐受性的系统和方法
公开(公告)号：US07930022B2
公开(公告)日：2011-04-19
申请号：US11745016
申请日：2007-05-07
申请人： Yi Zhang , Allan C. Shuros , Dan Li
发明人： Yi Zhang , Allan C. Shuros , Dan Li
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0464 , A61B5/0535 , A61B5/0538 , A61B5/7264
摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.
摘要翻译：可植入医疗装置检测心脏的快速性心律失常。在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。灌注信息也可用于改变快速性心律失常检测或分类。

46. 发明申请

US20100268194A1 DEVICE AND METHOD FOR MODULATING RENAL FUNCTION 失效
标题翻译：用于调节肾功能的装置和方法
公开(公告)号：US20100268194A1
公开(公告)日：2010-10-21
申请号：US12825174
申请日：2010-06-28
申请人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
发明人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
IPC分类号： A61B17/122 , A61N1/36 , A61M25/00
CPC分类号： A61N1/3606 , A61M25/00 , A61N1/05 , A61N1/36007 , A61N1/36135
摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
摘要翻译：肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。在一个实施方案中，来自肾脏的淋巴引流被调节以增加或减少盐和水的管状再吸收。肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。

47. 发明申请

US20100256700A1 METHOD AND APPARATUS FOR ORGAN SPECIFIC INFLAMMATION THERAPY 审中-公开
标题翻译：用于组织特异性炎症治疗的方法和装置
公开(公告)号：US20100256700A1
公开(公告)日：2010-10-07
申请号：US12755041
申请日：2010-04-06
申请人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/365 , A61N1/3702
摘要： A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.
摘要翻译：描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。

48. 发明申请

US20100249860A1 EXTERNAL CARDIAC STIMULATION PATCH 审中-公开
标题翻译：外部心脏刺激贴
公开(公告)号：US20100249860A1
公开(公告)日：2010-09-30
申请号：US12720246
申请日：2010-03-09
申请人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
发明人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译：外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。

49. 发明申请

US20100087881A1 PREFERENTIAL MECHANICAL UNLOADING DURING ANTI-TACHYCARDIA PACING 有权
标题翻译：抗IA IA。。。。。。。。。。。。。。。。。。。
公开(公告)号：US20100087881A1
公开(公告)日：2010-04-08
申请号：US12573520
申请日：2009-10-05
申请人： Allan C. Shuros , Barun Maskara , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Barun Maskara , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/368 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3684 , A61N1/395 , A61N1/3962
摘要： A pacing device and method for operating same is disclosed in which the point of origin of an arrhythmia is estimated in order to more provide more effective treatment. The origin of an arrhythmia may be estimated by analyzing the timing of electrical events as detected at different electrode sites and/or using different sensing vectors. Anti-tachycardia pacing (ATP) may then be delivered to the most appropriate location.
摘要翻译：公开了用于操作的起搏装置和方法，其中估计心律失常的起点，以便更有效地提供治疗。可以通过分析在不同电极位置处检测到的电气事件的定时和/或使用不同的感测向量来估计心律失常的起因。然后将抗心动过速起搏（ATP）送至最合适的位置。

50. 发明申请

US20090264716A1 HEMODYNAMIC MORPHOLOGICAL ANALYSIS FOR RHYTHM IDENTIFICATION 审中-公开
标题翻译：用于RHYTHM识别的HEMODYMM MORPHOLOGICAL ANALYSIS
公开(公告)号：US20090264716A1
公开(公告)日：2009-10-22
申请号：US12425193
申请日：2009-04-16
申请人： Allan C. Shuros , Dan Li
发明人： Allan C. Shuros , Dan Li
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/00 , A61N1/39
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/04525 , A61B5/0464 , A61N1/3962
摘要： This document discusses, among other things, an apparatus comprising an implantable hemodynamic sensor circuit that provides a hemodynamic signal representative of mechanical function of a cardiovascular system of a subject and a controller circuit communicatively coupled to the hemodynamic sensor circuit. The controller circuit includes a detection module configured to detect an onset of tachyarrhythmia, a signal analyzer module configured to determine a measure of morphological variability of the hemodynamic signal during the episode of tachyarrhythmia, and a rhythm discrimination module configured to deem whether the tachyarrhythmia episode is indicative of ventricular tachycardia (VT) according to the measure of morphological variability.
摘要翻译：本文件尤其涉及一种包括可植入血液动力学传感器电路的装置，其提供表示受试者的心血管系统的机械功能的血液动力学信号和通信地耦合到血液动力学传感器电路的控制器电路。所述控制器电路包括检测模块，所述检测模块被配置为检测快速性心律失常的发作，信号分析器模块被配置为确定在快速性心律失常发作期间的血液动力学信号的形态变异性的度量;以及节律辨别模块，其被配置为认为是否发生快速性心律失常发作根据形态变异性的测量指示室性心动过速（VT）。

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