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41. 发明授权

US5792195A Acceleration sensed safe upper rate envelope for calculating the hemodynamic upper rate limit for a rate adaptive cardiac rhythm management device 失效
标题翻译：加速度感测到用于计算速率适应性心律管理装置的血流动力学上限的安全上限信封
公开(公告)号：US5792195A
公开(公告)日：1998-08-11
申请号：US766339
申请日：1996-12-16
申请人： Gerrard M. Carlson , Bruce R. Jones , Julio C. Spinelli
发明人： Gerrard M. Carlson , Bruce R. Jones , Julio C. Spinelli
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36542
摘要： An implantable cardiac rhythm management device includes an accelerometer along with apparatus for processing the analog signal output from the accelerometer for deriving therefrom the time of occurrence of a selected heart sound in relation to a previously occurring ventricular depolarization event. The thus-derived heart sound information can be used to establish a hemodynamic upper rate limit for a rate adaptive pacemaker.
摘要翻译：植入式心律管理装置包括加速度计以及用于处理从加速度计输出的模拟信号的设备，用于从其中导出相对于先前发生的心室去极化事件的选定心音的发生时间。这样得到的心脏声音信息可用于建立速率适应性起搏器的血液动力学上限速率限制。

42. 发明授权

US08636669B2 Method and apparatus for monitoring of diastolic hemodynamics 有权
标题翻译：用于监测舒张血流动力学的方法和装置
公开(公告)号：US08636669B2
公开(公告)日：2014-01-28
申请号：US12985055
申请日：2011-01-05
申请人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

43. 发明授权

US08317717B2 Method and apparatus for third heart sound detection 有权
标题翻译：第三心音检测方法及装置
公开(公告)号：US08317717B2
公开(公告)日：2012-11-27
申请号：US12283760
申请日：2008-09-16
申请人： Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译：心律管理系统包括提供检测第三心音的心音检测器（S3）。诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。然后从S3检测窗口内的声信号检测S3的出现。

44. 发明授权

US08277389B2 Sensing rate of change of pressure in the left ventricle with an implanted device 有权
标题翻译：用植入装置感测左心室压力变化率
公开(公告)号：US08277389B2
公开(公告)日：2012-10-02
申请号：US13178945
申请日：2011-07-08
申请人： Gerrard M. Carlson , Krzysztof Z. Siejko , Ramesh Wariar , Marina V. Brockway
发明人： Gerrard M. Carlson , Krzysztof Z. Siejko , Ramesh Wariar , Marina V. Brockway
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译：一种用远程位置加速度计监测S1心音的可植入装置和方法。该装置包括将心音转换为电信号的换能器。控制电路耦合到换能器。控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。控制电路还从电信息生成形态数据。形态学数据涉及血流动力学指标，如左心室收缩力。壳体可以包围控制电路。壳体限定与壳体的外表面共同延伸的体积。传感器位于由外壳限定的体积中。

45. 发明授权

US08145590B2 Expert system for patient medical information analysis 有权
标题翻译：患者医疗信息分析专家系统
公开(公告)号：US08145590B2
公开(公告)日：2012-03-27
申请号：US12245215
申请日：2008-10-03
申请人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
发明人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
IPC分类号： G06F9/44 , G06N7/02 , G06N7/06
CPC分类号： G06N5/04 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/7232 , A61B5/7264 , A61B5/7267 , A61B5/7475 , G06F19/00 , G06N7/005 , G16H50/20 , G16H50/30
摘要： A plurality of chronic sensors are used to facilitate diagnosis and medical decision making for an individual patient. An expert system evaluates the sensor data, combines the sensor data with stored probability data and provides an output signal for notification or medical intervention.
摘要翻译：使用多个慢性传感器来促进个体患者的诊断和医学决策。专家系统评估传感器数据，将传感器数据与存储的概率数据组合，并提供用于通知或医疗干预的输出信号。

46. 发明授权

US08103343B2 Automatic modulation of pacing timing intervals using beat to beat measures 有权
标题翻译：使用节拍措施自动调节起搏定时间隔
公开(公告)号：US08103343B2
公开(公告)日：2012-01-24
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

47. 发明授权

US07972275B2 Method and apparatus for monitoring of diastolic hemodynamics 有权
标题翻译：用于监测舒张血流动力学的方法和装置
公开(公告)号：US07972275B2
公开(公告)日：2011-07-05
申请号：US10334694
申请日：2002-12-30
申请人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

48. 发明授权

US07970467B2 Method for exclusion of ectopic events from heart rate variability metrics 有权
标题翻译：排除异位事件与心律变异性指标的方法
公开(公告)号：US07970467B2
公开(公告)日：2011-06-28
申请号：US12235868
申请日：2008-09-23
申请人： John A. Dyjach , Gerrard M. Carlson
发明人： John A. Dyjach , Gerrard M. Carlson
IPC分类号： A61N1/00
CPC分类号： A61B5/0468 , A61B5/4035 , A61N1/3622
摘要： Heart rate variability metrics are derived from the intervals between successive heart beats, referred to as BB intervals. A method implementable by an implantable cardiac device for excluding BB intervals due to ectopic beats based on a function of preceding BB intervals is presented. It is desirable to remove such BB intervals from a BB interval time series used to calculate a heart rate variability metric.
摘要翻译：心率变异性度量是从连续的心跳之间的间隔导出的，称为BB间隔。提出了一种可植入心脏装置的方法，用于根据先前的BB间隔的功能排除由于异位搏动造成的BB间隔。期望从用于计算心率变异性度量的BB间隔时间序列中去除这样的BB间隔。

49. 发明授权

US07953486B2 Maximum pacing rate limiter implemented using the evoked response—T-wave interval 失效
标题翻译：使用诱发响应T波间隔实现最大起搏速率限制器
公开(公告)号：US07953486B2
公开(公告)日：2011-05-31
申请号：US11225712
申请日：2005-09-13
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

50. 发明授权

US07670298B2 Sensing rate of change of pressure in the left ventricle with an implanted device 有权
标题翻译：用植入装置感测左心室压力变化率
公开(公告)号：US07670298B2
公开(公告)日：2010-03-02
申请号：US11142851
申请日：2005-06-01
申请人： Gerrard M. Carlson , Krzysztof Z. Siejko , Ramesh Wariar , Marina Brockway
发明人： Gerrard M. Carlson , Krzysztof Z. Siejko , Ramesh Wariar , Marina Brockway
IPC分类号： A61B5/02 , A61B1/00
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译：一种用远程位置加速度计监测S1心音的可植入装置和方法。该装置包括将心音转换为电信号的换能器。控制电路耦合到换能器。控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。控制电路还从电信息生成形态数据。形态学数据涉及血流动力学指标，如左心室收缩力。壳体可以包围控制电路。壳体限定与壳体的外表面共同延伸的体积。传感器位于由外壳限定的体积中。

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