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41. 发明授权

US07956173B2 Nucleic acids coding for humanized antibodies for binding sphingosine-1-phosphate 有权
标题翻译：编码用于结合鞘氨醇-1-磷酸的人源化抗体的核酸
公开(公告)号：US07956173B2
公开(公告)日：2011-06-07
申请号：US12258353
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07H21/04 , C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

42. 发明申请

US20090325893A1 DOXORUBICIN ADJUVANTS TO REDUCE TOXICITY AND METHODS FOR USING THE SAME 有权
标题翻译： DOXORUBICIN ADJUVANTS减少毒性及使用方法
公开(公告)号：US20090325893A1
公开(公告)日：2009-12-31
申请号：US12369657
申请日：2009-02-11
申请人： William A. Garland , Brian D. Frenzel
发明人： William A. Garland , Brian D. Frenzel
IPC分类号： A61K31/704 , A61P35/00 , C07C251/00 , C07C321/00
CPC分类号： A61K31/15 , A61K31/7028 , A61K31/7034 , A61K31/704 , C07C251/30 , C07C321/22 , C07C321/24 , C07C321/26 , C07C323/47 , A61K2300/00
摘要： Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
摘要翻译：提供了使用观察到降低的宿主毒性的多柔比星活性剂的方法。所述方法的方面包括给予受试者有效量的多柔比星活性剂与多柔比星毒性降低佐剂，例如硝酮化合物或硝酮化合物与双二氧代哌嗪化合物的组合。还提供了用于实践本发明方法的组合物。所述方法和组合物可用于各种不同的应用，包括治疗各种不同的疾病状况。

43. 发明授权

US07629131B2 Rabbit monoclonal antibodies against mouse/human Id3 proteins 失效
标题翻译：针对小鼠/人Id3蛋白的兔单克隆抗体
公开(公告)号：US07629131B2
公开(公告)日：2009-12-08
申请号：US11657426
申请日：2007-01-23
申请人： Jung-Shou Chen , William A. Garland
发明人： Jung-Shou Chen , William A. Garland
IPC分类号： G01N33/53 , C07K16/28
CPC分类号： C07K16/18 , G01N2333/4704
摘要： The present invention relates to a rabbit monoclonal antibody that binds to human Id3 protein and/or mouse Id3 protein with high specificity and high affinity. The antibody has a binding constant, measured with respect to human Id3 protein or mouse Id3, of greater than 1×108/molar. The antibody has no substantial cross-reactivity to other family Id proteins such as Id1, Id2, or Id4, or other endogenous proteins present in the cells that express Id3 protein. The specificity and high affinity of the rabbit monoclonal antibodies of the present invention allows sensitive and specific detection and/or quantitation of human or mouse Id3 protein in biological samples. The antibodies are useful in immunochemical-based assays such as ELISA, western blot, and immunohistochemical staining.
摘要翻译：本发明涉及以高特异性和高亲和力结合人Id3蛋白和/或小鼠Id3蛋白的兔单克隆抗体。抗体相对于人Id3蛋白或小鼠Id3测量的结合常数大于1×10 8 /摩尔。该抗体与其它家族Id蛋白如Id1，Id2或Id4或存在于表达Id3蛋白的细胞中存在的其它内源蛋白没有实质的交叉反应性。本发明的兔单克隆抗体的特异性和高亲和性允许生物样品中人或小鼠Id3蛋白的敏感和特异性检测和/或定量。该抗体可用于基于免疫化学的测定，如ELISA，免疫印迹和免疫组织化学染色。

44. 发明申请

US20090130100A1 METHODS OF USING HUMANIZED ANTIBODIES AND COMPOSITIONS FOR BINDING SPHINGOSINE-1-PHOSPHATE 有权
标题翻译：使用人造抗体和组合物结合磷酸肌磷酸1-磷酸的方法
公开(公告)号：US20090130100A1
公开(公告)日：2009-05-21
申请号：US12258355
申请日：2008-10-24
申请人： Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , Steven Tarran JONES , David WILLIAMS
发明人： Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , Steven Tarran JONES , David WILLIAMS
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

45. 发明授权

US07517663B2 Rabbit monoclonal antibody against Id1 protein 失效
标题翻译：针对Id1蛋白的兔单克隆抗体
公开(公告)号：US07517663B2
公开(公告)日：2009-04-14
申请号：US11453156
申请日：2006-06-13
申请人： Jung-Shou Chen , William A. Garland
发明人： Jung-Shou Chen , William A. Garland
IPC分类号： C07K16/30 , C12N5/18 , G01N33/53 , G01N33/543 , G01N33/574 , C07H21/04 , C12P21/08
CPC分类号： C07K16/18 , C07K16/32 , C07K2317/92 , G01N33/574 , G01N33/6872
摘要： The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant, measured with respect to human Id1 protein and/or mouse Id1 protein, equal to or greater than 1×108/molar. The antibody has no substantial cross-reactivity with other family Id proteins such as Id2, Id3, or Id4, or other endogenous proteins present in the cells that express Id1 protein. The high specificity and high affinity of the rabbit monoclonal antibodies of the present invention allows sensitive and specific detection and/or quantitation of Id1 protein in biological samples. The antibodies are useful in immunochemical-based assays such as ELISA, western blot, and immunohistochemical staining.
摘要翻译：本发明涉及以高特异性和高亲和力结合人Id1蛋白和/或小鼠Id1蛋白的兔单克隆抗体。针对人Id1蛋白和/或小鼠Id1蛋白测量的抗体具有等于或大于1×10 8 /摩尔的结合常数。该抗体与其它家族Id蛋白如Id2，Id3或Id4或存在于表达Id1蛋白的细胞中存在的其它内源蛋白没有实质的交叉反应性。本发明的兔单克隆抗体的高度特异性和高亲和力使生物样品中Id1蛋白的敏感和特异性检测和/或定量。该抗体可用于基于免疫化学的测定，如ELISA，免疫印迹和免疫组织化学染色。

46. 发明申请

US20080213274A1 COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF FIBROTIC, INFLAMMATORY, AND NEOVASCULARIZATION CONDITIONS OF THE EYE 审中-公开
标题翻译：用于治疗和预防眼睛的炎症，炎症和新生血管状态的组合物和方法
公开(公告)号：US20080213274A1
公开(公告)日：2008-09-04
申请号：US11841363
申请日：2007-08-20
申请人： Roger A. Sabbadini , William A. Garland , Glenn L. Stoller
发明人： Roger A. Sabbadini , William A. Garland , Glenn L. Stoller
IPC分类号： A61K39/395 , A61P27/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for prevention and treatment of ocular diseases and conditions characterized by aberrant fibrogenesis or scarring, inflammation and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against bioactive lipids and which are capable of decreasing the effective concentration of said bioactive lipid. In some embodiments, the immune-derived moiety is a monoclonal antibody that is reactive against sphingosine-1-phosphate (S1P) or lysophosphatidic acid (LPA).
摘要翻译：本发明涉及用于预防和治疗眼部疾病的组合物和方法，其特征在于异常纤维发生或瘢痕形成，炎症和/或异常新生血管形成或血管发生。本发明的组合物和方法利用对生物活性脂质特异性反应并且能够降低所述生物活性脂质的有效浓度的免疫衍生部分。在一些实施方案中，免疫来源的部分是对鞘氨醇-1-磷酸（S1P）或溶血磷脂酸（LPA）具有反应性的单克隆抗体。

47. 发明申请

US20080145360A1 Immune-Derived Moieties Reactive Against Lysophosphatidic Acid 有权
标题翻译：对溶血磷脂酸反应的免疫衍生部分
公开(公告)号：US20080145360A1
公开(公告)日：2008-06-19
申请号：US11755721
申请日：2007-05-30
申请人： Roger A. SABBADINI , William A. Garland , Genevieve Hansen
发明人： Roger A. SABBADINI , William A. Garland , Genevieve Hansen
IPC分类号： A61K39/00 , C07K16/00 , A61K39/395
CPC分类号： G01N33/92 , A61K47/544 , A61K47/60 , A61K47/643 , A61K47/646 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/74
摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
摘要翻译：描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化，吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

48. 发明授权

US08604172B2 Humanized antibody compositions and methods for binding lysophosphatidic acid 失效
标题翻译：人源化抗体组合物和结合溶血磷脂酸的方法
公开(公告)号：US08604172B2
公开(公告)日：2013-12-10
申请号：US12761584
申请日：2010-04-16
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
摘要翻译：描述了制备和使用人源化抗LPA单克隆抗体的组合物和方法及其片段和衍生物。

49. 发明授权

US08361465B2 Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents 有权
标题翻译：抗鞘氨醇-1-磷酸抗体与化学治疗剂的组合使用
公开(公告)号：US08361465B2
公开(公告)日：2013-01-29
申请号：US12690033
申请日：2010-01-19
申请人： Roger A. Sabbadini , William A. Garland
发明人： Roger A. Sabbadini , William A. Garland
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/44 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/24 , A61K2300/00
摘要： The present invention relates to use of anti-S1P antibodies in combination with chemotherapeutic agents for treatment and/or prevention of cancer, tumor growth, metastasis and/or growth of metastatic tumors.
摘要翻译：本发明涉及抗S1P抗体与化学治疗剂组合用于治疗和/或预防转移性肿瘤的癌症，肿瘤生长，转移和/或生长的用途。

50. 发明授权

US08222373B2 Humanized antibodies and compositions for binding sphingosine-1-phosphate 有权
标题翻译：用于结合鞘氨醇-1-磷酸的人源化抗体和组合物
公开(公告)号：US08222373B2
公开(公告)日：2012-07-17
申请号：US12258346
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

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