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41. 发明授权

US11518710B2 Sensor formed from conductive nanoparticles and a porous non-conductive substrate 有权
公开(公告)号：US11518710B2
公开(公告)日：2022-12-06
申请号：US16990117
申请日：2020-08-11
申请人： University of Delaware
发明人： Erik Thostenson , Thomas Schumacher
IPC分类号： C08K3/04 , C09D5/44 , C09D7/61 , C03C25/44 , C25D13/02 , C25D13/12 , C25D13/22
摘要： In various aspects, the sensors include a substrate that is porous and non-conductive with nanoparticles deposited onto the substrate within pores of the substrate by an electrophoretic process to form a sensor element. The nanoparticles are electrically conductive. The sensor includes a detector in communication with the sensor element to measure a change in an electrical property of the sensor element. The change in the electrical property may result from alterations in quantum tunneling between nanoparticles within the sensor element, in various aspects.

42. 发明申请

US20220285859A1 High-Gain, Wide-Angle, Multi-Beam, Multi-Frequency Beamforming Lens Antenna 有权
公开(公告)号：US20220285859A1
公开(公告)日：2022-09-08
申请号：US17826057
申请日：2022-05-26
申请人： University of Delaware
发明人： Soumitra Biswas , Howard Jetmundsen , Shawn Rogers , Harold Thomas Cox , Mark Mirotznik
IPC分类号： H01Q25/00 , H01Q5/25 , H01Q21/00 , H01Q3/46 , H01Q15/02 , H01Q15/08 , H01Q19/06
摘要： A high-gain, wide-angle, multi-beam, multi-frequency beamforming lens antenna that includes a Luneburg lens with at least one planar interface in the southern hemisphere of the Luneburg lens and a planar ultrawideband modular antenna (PUMA array) structure. The PUMA array structure is connected to at least one of the planar interfaces of the Luneburg lens and is configured to function as a feed network to illuminate cells of the Luneburg lens simultaneously.

43. 发明授权

US10723684B2 Bisphenol alternative derived from renewable substituted phenolics and their industrial application 有权
公开(公告)号：US10723684B2
公开(公告)日：2020-07-28
申请号：US15313656
申请日：2015-05-27
申请人： UNIVERSITY OF DELAWARE , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY , ROWAN UNIVERSITY
发明人： Kaleigh Havery Reno , Joseph Francis Stanzione, III , Richard Patrick Wool , Joshua M. Sadler , John Joseph Lascala , Eric David Hernandez
IPC分类号： C08G59/24 , C08G59/32 , C08G59/06 , C08L63/10 , C08L63/00 , C08L55/00 , C08L31/02 , C08L31/00 , C08L29/10 , C08L29/00 , C07C69/00 , C07C43/215 , C07C43/20 , C07C43/295 , C08G63/193 , C08G64/06 , C08G59/50 , C08G18/32 , C08G63/547 , C08G64/28 , C07C41/09 , C08F222/10 , C08G18/76
摘要： A compound is provided according to structure 4, (4) wherein n has a value from 0 to 48 and Z is hydroxyl or a benzene ring bearing substituents R11-R15, wherein R1-R15 are each individually selected from the group consisting of H, allyl, alkyl, alkoxy, phenyl, phenoxy, halide, hydroxyl, glycidyl, (meth)acryloyl, 3-(meth)acryloyl-2-hydroxy-1-propoxy, 2,3-epoxypropyl, maleate, and structure (a) wherein at least one of R1-R5, at least one of R6-R10, and at least one of R11-R15 is hydroxyl or an ether or ester derived from it and one of the R6-R10 groups is replaced by a direct bond to the CXY group.

44. 发明授权

US09640826B2 Multiple-membrane multiple-electrolyte redox flow battery design 有权
公开(公告)号：US09640826B2
公开(公告)日：2017-05-02
申请号：US13918452
申请日：2013-06-14
申请人： University of Delaware
发明人： Yushan Yan , Shuang Gu , Ke Gong
IPC分类号： H01M8/20 , H01M2/40 , H01M10/42 , H01M8/18 , H01M8/04 , H01M2/00 , H01M8/04186
CPC分类号： H01M8/20 , H01M2/00 , H01M2/40 , H01M8/04 , H01M8/04186 , H01M8/18 , H01M8/188 , H01M10/4242 , H01M2300/0082 , Y02E60/528 , Y10T29/49108
摘要： A redox flow battery is provided. The redox flow battery involves multiple-membrane (at least one cation exchange membrane and at least one anion exchange membrane), multiple-electrolyte (one electrolyte in contact with the negative electrode, one electrolyte in contact with the positive electrode, and at least one electrolyte disposed between the two membranes) as the basic characteristic, such as a double-membrane, triple electrolyte (DMTE) configuration or a triple-membrane, quadruple electrolyte (TMQE) configuration. The cation exchange membrane is used to separate the negative or positive electrolyte and the middle electrolyte, and the anion exchange membrane is used to separate the middle electrolyte and the positive or negative electrolyte.

45. 发明申请

US20160263210A1 LIVE ATTENUATED INFECTIOUS LARYNGOTRACHEITIS VIRUS (ILTV) VACCINES AND PREPARATION THEREOF 审中-公开
标题翻译：感染性感染性喉镜病毒（ILTV）疫苗及其制剂
公开(公告)号：US20160263210A1
公开(公告)日：2016-09-15
申请号：US15032338
申请日：2014-10-29
申请人： Jack GELB , Brian S. LANDMAN , Miguel RUANO , UNIVERSITY OF DELAWARE
发明人： Jack Gelb, JR. , Brian S. Ladman , Miguel Ruano
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2710/16034 , C12N2710/16064 , C12N2710/16334 , C12N2710/16362 , C12N2710/16364
摘要： This disclosure describes a modified live infectious laryngotracheitis virus (ILTV) developed from a strain of ILTV grown at a reduced incubation temperature, vaccines that include the modified live ILTV, methods for producing the live modified ILTV, and methods that include administering the modified ILTV to a subject.
摘要翻译：本公开描述了从在降低培养温度下生长的ILTV菌株开发的经修饰的活的感染性喉气管炎病毒（ILTV），包括修饰的活ILTV的疫苗，用于生产活体修饰的ILTV的方法，以及包括将经修饰的ILTV施用于课程。

46. 发明申请

US20160203261A1 SYSTEMS AND METHODS FOR IDENTIFYING STRUCTURALLY OR FUNCTIONALLY SIGNIFICANT NUCLEOTIDE SEQUENCES 审中-公开
标题翻译：用于识别结构或功能重要核苷酸序列的系统和方法
公开(公告)号：US20160203261A1
公开(公告)日：2016-07-14
申请号：US15076421
申请日：2016-03-21
申请人： University of Delaware , Board of Regents of the Nevada System of Higher Education, on Behalf of the Desert Research Instit
发明人： Joseph J. Grzymski , Adam G. Marsh
IPC分类号： G06F19/22
CPC分类号： G16B30/00
摘要： Provided are methods, systems, and computer readable media for comparing word statistics between a significant amino acid sequence and a significant nucleotide sequence.
摘要翻译：提供了用于比较重要氨基酸序列和重要核苷酸序列之间的词统计的方法，系统和计算机可读介质。

47. 发明申请

US20160203257A1 SYSTEMS AND METHODS FOR IDENTIFYING STRUCTURALLY OR FUNCTIONALLY SIGNIFICANT AMINO ACID SEQUENCES 审中-公开
标题翻译：用于鉴定结构或功能重要氨基酸序列的系统和方法
公开(公告)号：US20160203257A1
公开(公告)日：2016-07-14
申请号：US15076454
申请日：2016-03-21
申请人： University of Delaware , Board of Regents of the Nevada System of Higher Education, on Behalf of the Desert Research Instit
发明人： Adam G. Marsh , Joseph J. Grzymski
IPC分类号： G06F19/18 , G06F19/22
CPC分类号： G16B20/00 , G16B30/00
摘要： Methods and computer readable storage mediums for identifying structurally or functionally significant amino acid sequences encoded by a genome are disclosed. At least one structurally or functionally significant amino acid sequence encoded by a genome may be identified by compiling an observed frequency for each of a plurality of amino acid words encoded by the genome, calculating with a computer an expected frequency for each of the plurality of amino acid words encoded by the genome, and identifying at least one structurally or functionally significant amino acid sequence encoded by the genome based at least in part on the observed and expected frequencies for each of the plurality of amino acid words encoded by the genome.
摘要翻译：公开了用于鉴定由基因组编码的结构或功能上重要的氨基酸序列的方法和计算机可读存储介质。由基因组编码的至少一个结构上或功能上重要的氨基酸序列可以通过编码由基因组编码的多个氨基酸单词中的每一个的观察频率来识别，用计算机计算多个氨基酸中的每一个的预期频率由基因组编码的酸性词，以及至少部分地基于由基因组编码的多个氨基酸词中的每一个的观察和预期的频率，鉴定由基因组编码的至少一个结构或功能上重要的氨基酸序列。

48. 发明申请

US20160154004A1 DEVICE AND METHOD FOR DETERMINING REACTION KINETICS 有权
标题翻译：用于确定反应动力学的装置和方法
公开(公告)号：US20160154004A1
公开(公告)日：2016-06-02
申请号：US14942117
申请日：2015-11-16
申请人： UNIVERSITY OF DELAWARE , AMGEN
发明人： CHRISTOPHER J. ROBERTS , GREGORY V. BARNETT , VLADIMIR I. RAZINKOV , BRUCE A. KERWIN
IPC分类号： G01N33/68
CPC分类号： G01N33/6845 , G01N33/50
摘要： A method of determining the activation energy Ea for degradation of a chemical species includes in sequence the steps of a) simultaneously incubating a plurality of samples of the chemical species in a single unitary device at a plurality of constant temperatures T, in each case for an incubation time t selected to result in loss of at most 20 mol % of the amount originally present; b) quenching each of the samples to stop degradation; c) determining the mole fraction m of the chemical species remaining in each of the quenched samples, relative to the amount present before incubating; d) determining for each sample a reaction rate coefficient kobs according to the equation k obs  ( T ) = 1 - m  ( T ) t ; and e) performing numerical regression of the kobs values obtained in step d) and the corresponding temperatures T in ° K to derive the activation energy Ea according to the following equation k obs = k 0  exp  ( E a R  ( 1 T - 1 T 0 ) ) , or to derive a temperature-dependent activation energy if that is more appropriate for the chemical species of interest.
摘要翻译：确定用于化学物质降解的活化能Ea的方法包括以下步骤：a）在多个恒定温度T下同时将多个化学物质样品在单个整体装置中孵育，在每种情况下为孵育时间t被选择导致最初存在的量的至多20摩尔％的损失; b）淬灭每个样品以停止降解; c）确定每个淬火样品中剩余的化学物质相对于孵育前存在的量的摩尔分数m; d）根据等式k obs（T）= 1-m（T）t确定每个样本的反应速率系数kobs; 和e）对步骤d）中获得的科布值进行数值回归，并以相应的温度T（°K）进行数学回归，以根据以下等式得出活化能Ea（E a R（1 T - 1 T 0）），或者如果这更适合于感兴趣的化学物质，则导出温度依赖性的活化能。

49. 发明授权

US09023758B2 Methods for promoting plant health 有权
标题翻译：促进植物健康的方法
公开(公告)号：US09023758B2
公开(公告)日：2015-05-05
申请号：US14026425
申请日：2013-09-13
申请人： University of Delaware
发明人： Harsh Bais , Amutha Sampath Kumar , Venkatachalam Lakshmanan , Thimmaraju Rudrappa , Darla Janine Sherrier
IPC分类号： A01N25/26 , A01N25/00 , A01N37/36 , A01N35/02 , A01N63/00
CPC分类号： A01N37/36 , A01N35/02 , A01N63/00
摘要： A method for promoting the health of a plant comprises administering malic acid to the plant or the soil in an amount effective to recruit plant growth promoting rhizobacteria (PGPR) to the plant. Administration of malic acid promotes biofilm formation of PGPR on the plant's roots, thereby restricting entry of a foliar pathogen through stomatal pores present in the leaves. Another method for promoting the health of a plant comprises administering acetoin to the plant or the soil in an amount effective to increase pathogen resistance in aerial parts of the plant.
摘要翻译：一种用于促进植物健康的方法包括向植物或土壤施用有效招募植物生长促进根际细菌（PGPR）的苹果酸给植物。苹果酸的施用促进PGPR在植物根部的生物膜形成，从而通过叶中存在的气孔导致叶片病原体的进入。用于促进植物健康的另一种方法包括以有效增加植物地上部分的病原体抗性的量向植物或土壤施用乙偶姻。

50. 发明申请

US20150024381A1 DETECTING AND QUANTIFYING CRYPTIC HIV REPLICATION 有权
标题翻译：检测和定量CRYPIC HIV复制
公开(公告)号：US20150024381A1
公开(公告)日：2015-01-22
申请号：US14382568
申请日：2013-03-07
申请人： UNIVERSITY OF DELAWARE
发明人： Ryan Zurakowski
IPC分类号： G01N33/569
CPC分类号： G01N33/56988 , C12Q1/703 , C12Q2600/136 , G01N2800/52
摘要： The present invention relates to a novel method for detecting efficient cryptic HIV replication in a patient who receives a suppressive antiviral therapy followed by administration of the HIV integrase inhibitor in an effective amount for intensifying the suppressive antiviral therapy, and has undetectable plasma viremia prior to the administration of the HIV integrase inhibitor. The method comprises making a pre-intensification measurement and one or more post-intensification measurements of the concentration of an episomal artifact in samples from the patient, and computing a pre-intensification HIV infection success ratio (R). A pre-intensification HIV infection success ratio (R) sufficiently close to 1 indicates that the patient has the efficient cryptic HIV replication. The method may further comprise quantifying the efficient cryptic HIV replication.
摘要翻译：本发明涉及一种用于在接受抑制性抗病毒治疗，然后以有效量施用HIV整合酶抑制剂的患者中检测有效的隐匿性HIV复制的新方法，用于增强抑制性抗病毒治疗，并且在治疗之前具有不可检测的血浆病毒血症给予HIV整合酶抑制剂。该方法包括对来自患者的样品中的附加型假象的浓度进行预强化测量和一次或多次强化后测量，以及计算强化前HIV感染成功率（R）。强化前艾滋病毒感染成功率（R）足够接近1表示患者具有有效的隐匿性HIV复制。该方法还可以包括量化有效的隐性HIV复制。

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