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41. 发明授权

US10844407B2 Variant type tetraprenyl-β-curcumene cyclase and method for producing ambrein 有权
公开(公告)号：US10844407B2
公开(公告)日：2020-11-24
申请号：US16080928
申请日：2017-03-03
申请人： NIIGATA UNIVERSITY , ADEKA CORPORATION
发明人： Tsutomu Sato , Kotone Okuno , Toshihiko Takehana , Seiji Koike
IPC分类号： C12P7/04 , C12N9/90 , C12N5/10 , C12N15/09 , C12P7/02 , C12N1/20 , C12N1/32 , C12N9/04 , C12N9/88
CPC分类号： C12P7/04 , C12N1/20 , C12N1/32 , C12N5/10 , C12N9/0006 , C12N9/88 , C12N9/90 , C12N15/09 , C12P7/02 , C12Y101/01034 , C12Y402/01137
摘要： An object of the present invention is to provide a method for preparing ambrein, which can easily obtain the ambrein. The object can be solved by a mutated tetraprenyl-β-curcumene cyclase wherein a fourth amino acid residue of a DXDD motif, aspartic acid, is substituted with an amino acid other than aspartic acid, (a) having a QXXXGX(W/F) motif, and a QXXXX(G/A)X(F/W/Y) motif on the N-terminal side, and a QXXXGX(F/W/Y) motif, and a QXXXGXW motif and a QXXXGX(F/W) motif on the C-terminal side, and not having a QXXXGXW motif at a position separated by 170 amino acid residues or more on the C-terminal side, with respect to the DXDD motif, (b) having 40% or more identity with the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 13, (c) exhibiting ambrein production activity using squalene as a substrate.

42. 发明授权

US10632084B2 Aquaporin 4 function promotor and pharmaceutical composition for neurological disorders 有权
公开(公告)号：US10632084B2
公开(公告)日：2020-04-28
申请号：US16081267
申请日：2017-03-03
申请人： NIIGATA UNIVERSITY
发明人： Tsutomu Nakada , Vincent Huber , Hironaka Igarashi , Yuji Suzuki , Ingrid Kwee
IPC分类号： A61K31/155 , A61K31/443 , A61K31/4439 , A61K31/4433 , A61K31/44 , A61P25/28 , A61P35/00
CPC分类号： A61K31/155 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61P25/28 , A61P35/00
摘要： An aquaporin 4 function promotor contains a compound represented by Formula (1) or (2) or a pharmaceutically acceptable salt thereof, as an active ingredient.

(In the formula, n11 represents an integer of 1 to 10, and R21 represents one selected from the group consisting of an alkyl group having 1 to 10 carbon atoms, an alicyclic heterocyclic group, an aromatic hydrocarbon group, and an aromatic heterocyclic group.)

43. 发明申请

US20190233283A1 METHOD FOR PRODUCING HYDROGEN 审中-公开
公开(公告)号：US20190233283A1
公开(公告)日：2019-08-01
申请号：US16045276
申请日：2018-07-25
申请人： NIIGATA UNIVERSITY
发明人： Tatsuya KODAMA , Nobuyuki GOKON
IPC分类号： C01B3/06
CPC分类号： C01B3/068
摘要： A method for producing hydrogen of the present invention includes thermally reducing a reaction medium in which CeO2 is doped with a metal other than Ce and bringing the thermally reduced reaction medium into contact with water to oxidize the reaction medium and to generate the hydrogen. When a reaction temperature in the thermally reducing the reaction medium is defined as T1 [° C.] and a reaction temperature in the bringing the thermally reduced reaction medium into contact with the water is defined as T2 [° C.], a relation of T1−T2≤150 is satisfied. It is preferred that a series of processes including the thermally reducing the reaction medium and the bringing the thermally reduced reaction medium into contact with the water is repeated.

44. 发明申请

US20190040561A1 METHOD FOR MANUFACTURING SHEET FOR USE IN TONGUE PLAQUE CLEANER 审中-公开
公开(公告)号：US20190040561A1
公开(公告)日：2019-02-07
申请号：US15897539
申请日：2018-02-15
申请人： SHIKIEN CO., LTD. , NIIGATA UNIVERSITY
发明人： Michio TANAKA , Makoto INOUE
IPC分类号： D06C13/08 , B29C71/02 , B26D7/10 , B26D1/00 , A46B9/02
摘要： Provided is a method for manufacturing a sheet for use in a tongue plaque cleaner, capable of reliably cutting loops of thread members provided at a given density, and forming thread members each having a shape with an arc portion sufficient enough to scrape off tongue plaque, through steps that are simple, low-cost and suitable for mass production. A method for manufacturing a sheet 1 for use in a tongue plaque cleaner for scraping off tongue plaque, includes: a step of heating a sheet material having multiple looped thread members 2 protruding from one surface of the sheet material, at a temperature below the melting point of the thread members 2; and a step of forming first thread members 3, 8 and second thread members 4, 9 by cutting loops of the thread members 2 heated.

45. 发明申请

US20180357930A1 MODEL OF VISCERA, TISSUES, OR ORGANS 审中-公开
公开(公告)号：US20180357930A1
公开(公告)日：2018-12-13
申请号：US16060866
申请日：2016-12-02
申请人： SUNARROW LTD , Niigata University
发明人： Yutaka Kuwabara , Atsushi Ogawa , Ken-ichi Mizuno , Hiroki Sato , Shuji Terai
IPC分类号： G09B23/28 , G09B23/30
摘要： Provided is a pseudo visceral model having a specific texture.A model of viscera, tissues, or organs comprising a foam layer containing a hydrogel.

46. 发明申请

US20150297694A1 CANCER DIAGNOSTIC AND THERAPEUTIC METHOD TARGETING MOLECULES EXPRESSED IN CANCER STEM CELLS 审中-公开
标题翻译：癌症诊断和治疗方法指导肿瘤干细胞中表达的分子
公开(公告)号：US20150297694A1
公开(公告)日：2015-10-22
申请号：US14423929
申请日：2013-09-03
申请人： NIIGATA UNIVERSITY , OTSUKA PHARMACEUTICAL CO., LTD.
发明人： Hiroshi KAGAMU , Ichiei NARITA , Yoshihiro GOTO , Takashi HAYASHI
IPC分类号： A61K39/00 , A61K31/17 , C12N9/14 , A61K31/551 , A61K31/4412 , A61K31/404 , G01N33/574 , A61K31/4184
CPC分类号： A61K39/0011 , A61K31/17 , A61K31/404 , A61K31/4184 , A61K31/4412 , A61K31/551 , C12N9/14 , C12Y306/04013 , G01N33/57484 , G01N2333/54 , G01N2333/5406 , G01N2333/57 , G01N2333/914
摘要： The present invention provides a novel method for determining cancer malignancy, a novel cancer diagnostic method, a novel method for determining prognosis, a novel vaccine for cancer treatment, and a novel vaccine for suppressing cancer metastasis. Specifically, the invention provides a cancer malignancy evaluation method that comprises the step of measuring a DDX3X expression level in a cancer tissue, and the step of evaluating malignancy of the cancer tissue by using the DDX3X expression level.
摘要翻译：本发明提供了一种确定癌症恶性肿瘤的新方法，一种新的癌症诊断方法，一种判定预后的新方法，一种用于癌症治疗的新型疫苗，以及一种用于抑制癌症转移的新型疫苗。具体地，本发明提供一种癌症恶性肿瘤评价方法，其包括测定癌组织中DDX3X表达量的步骤，以及使用DDX3X表达水平评价癌组织的恶性程度的步骤。

47. 发明申请

US20140315830A1 RICE-PROTEIN COMPOSITION AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：米蛋白组合物及其制备方法
公开(公告)号：US20140315830A1
公开(公告)日：2014-10-23
申请号：US14357873
申请日：2012-11-05
申请人： KAMEDA SEIKA CO., LTD. , NIIGATA UNIVERSITY
发明人： Mikio Fujii , Takamasa Hiratsuka , Motoni Kadowaki
IPC分类号： A61K38/16
CPC分类号： A61K38/168 , A23J1/12 , A23J3/14 , A23L33/185 , A23V2002/00 , A23V2200/3262 , A23V2250/5482
摘要： The objective of the present invention is to provide a high-purity rice-protein composition with improved tongue feel and a melt-in-the-mouth quality, and a method for manufacturing the composition. The rice-protein composition comprises glutelin and prolamine, the protein content with respect to the solid content being at least 90%. Rice protein extracted by an alkaline solution from rice or rice flour is neutralized and coagulated at a temperature no lower than 40 80 DEG C., or is coagulated by adding a divalent metal ion and then neutralized, or glucono-delta-lactone is added and the solution is heated to gel the protein; by therein keeping the pH of the rice-protein composition no lower than 7.0 or no higher than 4.0, a rice-protein composition with extremely good dispersibility and tongue feel can be obtained. Further, by heating to at least 80 DEG C. after adjusting pH, a composition with high water absorbency is achieved.
摘要翻译：本发明的目的是提供一种具有改善的舌头感和口感质量的高纯度米蛋白组合物及其制造方法。稻蛋白组合物包含谷蛋白和谷醇溶蛋白，相对于固体含量的蛋白质含量为至少90％。通过水稻或米粉的碱性溶液提取的大米蛋白被中和并在不低于40℃的温度下凝结，或通过加入二价金属离子凝结，然后中和，或加入葡萄糖酸-δ-内酯，将溶液加热以凝胶化蛋白质; 通过保持米蛋白组合物的pH不低于7.0或不高于4.0，可以获得具有极好的分散性和舌头感的米蛋白组合物。此外，通过在调节pH后加热至至少80℃，获得具有高吸水性的组合物。

48. 发明申请

US20140127233A1 PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIC EVENTS 有权
标题翻译：用于治疗化疗事件的药物组合物
公开(公告)号：US20140127233A1
公开(公告)日：2014-05-08
申请号：US14151507
申请日：2014-01-09
申请人： Niigata University
发明人： Takayoshi SHIMOHATA , Lawrence M. KAUVAR
IPC分类号： A61K39/395 , A61K31/277 , A61K45/06 , A61K38/49
CPC分类号： A61K39/3955 , A61K31/277 , A61K38/177 , A61K38/1866 , A61K38/49 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K16/22
摘要： Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention including thrombolytic agents and an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction are disclosed.
摘要翻译：公开了用于治疗重度缺血事件（包括脑梗塞，心脏梗死或肺栓塞）的方法和药物组合物，其包括溶栓剂介入治疗，包括溶血栓剂和血管内皮生长因子（VEGF）受体介导的信号转导抑制剂。

49. 发明公开

US20240382508A1 REGENERATIVE AGENT FOR BONE TISSUE AND LUNG TISSUE, AND PHARMACEUTICAL COMPOSITION FOR REGENERATING BONE TISSUE AND LUNG TISSUE 审中-公开
公开(公告)号：US20240382508A1
公开(公告)日：2024-11-21
申请号：US18694631
申请日：2022-09-20
申请人： NIIGATA UNIVERSITY
发明人： Tomoki MAEKAWA , Koichi TABETA , Yutaka TERAO , Hikaru TAMURA
IPC分类号： A61K31/7048 , A61K31/7052 , A61P11/00 , A61P19/08
CPC分类号： A61K31/7048 , A61K31/7052 , A61P11/00 , A61P19/08
摘要： A regenerative agent for bone tissue and lung tissue contains a macrolide antimicrobial agent as an active ingredient. The macrolide antimicrobial agent may be one or more selected from the group consisting of erythromycin, azithromycin, and clarithromycin. The regenerative agent for bone tissue and lung tissue may be locally administered to bone tissue or lung tissue. A pharmaceutical composition for regenerating bone tissue and lung tissue contains the regenerative agent for bone tissue and lung tissue, and a pharmaceutically acceptable carrier.

50. 发明公开

US20240009167A1 AGENT FOR ELIMINATING SENESCENT CELLS 审中-公开
公开(公告)号：US20240009167A1
公开(公告)日：2024-01-11
申请号：US18472037
申请日：2023-09-21
申请人： NIIGATA UNIVERSITY , MITSUBISHI TANABE PHARMA CORPORATION
发明人： Tohru MINAMINO
IPC分类号： A61K31/7042 , A61P43/00
CPC分类号： A61K31/7042 , A61P43/00
摘要： The present invention provides an agent or pharmaceutical composition for eliminating senescent cells, comprising an SGLT2 inhibitor.

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