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41. 发明申请

US20080193926A1 Device and method for extracting a smear sample 有权
标题翻译：用于提取涂片样品的装置和方法
公开(公告)号：US20080193926A1
公开(公告)日：2008-08-14
申请号：US11599424
申请日：2006-11-15
申请人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
发明人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
IPC分类号： C12M1/26 , C12Q1/68
CPC分类号： B01L3/502715 , A61B10/0051 , A61B10/0096 , B01L3/502738 , B01L3/502761 , B01L3/5029 , B01L2200/027 , B01L2300/042 , B01L2400/0478 , B01L2400/0633 , G01N2001/028
摘要： A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from the cavity through at least one liquid discharge connected to the cavity.
摘要翻译：公开了一种用于提取涂片样品的装置。该装置包括可以引入携带涂片样品的样品载体的空腔。可以通过连接到空腔的至少一个液体进料将液体引入空腔中，并且可以通过连接到空腔的至少一个液体排出物从腔中去除液体。

42. 发明申请

US20070166192A1 Module for processing a biological sample, biochip kit, and use of the module 有权
标题翻译：用于处理生物样品的模块，生物芯片套件和模块的使用
公开(公告)号：US20070166192A1
公开(公告)日：2007-07-19
申请号：US11653230
申请日：2007-01-16
申请人： Thomas Ehben , Walter Gumbrecht , Manfred Stanzel , Christian Zilch
发明人： Thomas Ehben , Walter Gumbrecht , Manfred Stanzel , Christian Zilch
IPC分类号： G01N21/00
CPC分类号： G01N1/40 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2300/0816 , G01N35/0098 , Y10T436/2575
摘要： A module for processing a biological sample for an analysis test is disclosed. The processing module includes, in at least one embodiment, an interface at which the processing module can be connected to a cartridge with a lab-on-a-chip, in which cartridge the analysis steps are carried out. A biochip kit is also disclosed. In at least one embodiment, the biochip kit includes one or more processing modules which are intended for different sample materials and which can be connected to the same cartridge type.
摘要翻译：公开了用于处理用于分析测试的生物样品的模块。处理模块在至少一个实施例中包括接口，在该界面处，处理模块可以与芯片上的实验室连接，其中进行分析步骤。还公开了一种生物芯片套件。在至少一个实施例中，生物芯片套件包括一个或多个处理模块，其用于不同的样品材料并且可以连接到相同的盒式。

43. 发明申请

US20060234236A1 Method and device for pcr-amplification and detection of nucleotide sequences 有权
标题翻译：用于pcr扩增和检测核苷酸序列的方法和装置
公开(公告)号：US20060234236A1
公开(公告)日：2006-10-19
申请号：US10539437
申请日：2003-12-15
申请人： Walter Gumbrecht , Manfred Stanzel
发明人： Walter Gumbrecht , Manfred Stanzel
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34
CPC分类号： C12Q1/686 , C12Q2565/607 , C12Q2565/501
摘要： A DNA-Chip includes a flat carrier and an array of spots containing probe molecules (oligonucleotides) which are arranged on said carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the probe molecules and target molecules (DNA fragments) applied by way of an analyte solution. In order to increase the sensitivity or the binding specific measuring effects of the biochip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing probe molecules and which is permeable to target molecules.
摘要翻译： DNA芯片包括布置在所述载体上的平坦载体和含有探针分子（寡核苷酸）的斑点阵列。每个点与微电极装置相关联，用于阻抗光谱检测在通过分析物溶液施加的探针分子和靶分子（DNA片段）之间发生的结合事件。为了增加生物芯片的灵敏度或结合特异性测量效果，电极布置至少部分地嵌入含有探针分子的亲水性反应层，并且其可渗透靶分子。

44. 发明申请

US20050202556A1 Process and spotting solution for preparing microarrays 审中-公开
标题翻译：制备微阵列的工艺和点样方案
公开(公告)号：US20050202556A1
公开(公告)日：2005-09-15
申请号：US11023372
申请日：2004-12-29
申请人： Walter Gumbrecht , Daniela Kuehn , Manfred Stanzel
发明人： Walter Gumbrecht , Daniela Kuehn , Manfred Stanzel
IPC分类号： B01J19/00 , B05D3/00 , C12M1/34 , C12Q1/68 , C40B60/14 , G01N33/50 , G01N33/543 , G01N33/544
CPC分类号： G01N33/544 , B01J19/0046 , B01J2219/00351 , B01J2219/00639 , B01J2219/00644 , B01J2219/00659 , C40B60/14 , G01N33/54353 , G01N33/5436
摘要： A process is proposed for preparing a microarray including a multiplicity of analytical positions or spots and arranged on a support. The spots include probe molecules and a polymer which has been solidified to give a film. A spot is generated by applying an initially flowable spotting solution to the support, which solution includes a polymer and probe molecules, the polymer being solidified after application to the support. A spotting solution is further proposed which includes, in aqueous solution, probe molecules and a polymer which can be solidified in a non-free radical manner.
摘要翻译：提出了一种制备包含多个分析位置或斑点并布置在载体上的微阵列的方法。斑点包括探针分子和已经固化得到膜的聚合物。通过将初始可流动的点样溶液施加到载体上来产生斑点，该溶液包括聚合物和探针分子，聚合物在施用于载体之后固化。进一步提出了一种检测溶液，其包括在水溶液中，探针分子和可以以非自由基方式固化的聚合物。

45. 发明申请

US20050164199A1 Method for biochemical analysis of dna and arrangement associated therewith 审中-公开
标题翻译： dna生化分析方法及其相关配置
公开(公告)号：US20050164199A1
公开(公告)日：2005-07-28
申请号：US10514019
申请日：2003-05-18
申请人： Manfred Stanzel , Mathias Sprinzl
发明人： Manfred Stanzel , Mathias Sprinzl
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2563/125 , C12Q2527/127
摘要： A system with immobilized DNA is used in the fields of medicine, environmentology or criminology as an analytical tool in the analysis of nucleic acid. The immobilized DNA is provided with a biocatalytically active marker, such as an enzyme, an with an inhibitor substance which reversibly inhibits catalytic activity, or in addition to the immobilized biocatalytic marker, the immobilized DNA is provided with a substance which can reversibly inhibit the catalytic activity of the marker. Alternatively, an immobilized biocatalytically active marker can be provided with DNA as a scavenger which includes a substance as an inhibitor which can reversibly inhibit the activity of the marker. In another alternative, it is possible to use a complex including a molecule binding double-stranded DNA and a substance as an inhibitor which can reversibly inhibit the activity of the marker by interacting with the immobilized biocatalytically active marker. In all cases, the inhibitor or compound including an inhibitor and a molecule which can bind double-stranded DNA interacts with the biocatalytically active marker and defines the inactive state of the system. When the DNA, which is to be analyzed, is bonded, especially hybridized, to the DNA scavengers, the interaction between the biocatalytically active marker and the inhibitor is cancelled as a result of the formation of the double strand. The system is thus shifted from a first state into a second state defining the active state. A carrier with integrated microelectrodes is provided in the associated device, whereby the enzyme is either immobilized therein or is contained in a polymer network in the vicinity of the microelectrodes.
摘要翻译：在医学，环境学或犯罪学领域使用具有固定化DNA的系统作为分析核酸的分析工具。固定化的DNA具有生物催化活性的标记，例如酶，具有可逆抑制催化活性的抑制剂物质，或除了固定化的生物催化标记之外，固定的DNA具有可逆性抑制催化的物质标记的活动。或者，可以提供固定化的生物催化活性标记物作为清除剂，其包括可逆性抑制标记物活性的抑制剂的物质。在另一个替代方案中，可以使用包含分子结合双链DNA和物质作为抑制剂的复合物，其可以通过与固定的生物催化活性标记物相互作用来可逆地抑制标记物的活性。在所有情况下，包括抑制剂和可以结合双链DNA的分子的抑制剂或化合物与生物催化活性标记相互作用，并定义系统的不活动状态。待分析的DNA与DNA清除剂结合，特别是杂交时，生物催化活性标记与抑制剂之间的相互作用由于形成双链而被消除。因此，系统从第一状态转移到定义活动状态的第二状态。在相关装置中提供具有集成微电极的载体，由此将酶固定在其中或者包含在微电极附近的聚合物网络中。

46. 发明授权

US5763760A Method for calibration of gas measuring sensors for dissolved gasses and method for measuring the concentration of CO.sub.2 in blood with the assistance of such a calibration method 失效
标题翻译：用于校准溶解气体的气体测量传感器的方法和用于测量血液中二氧化碳浓度的方法借助于这种校准方法
公开(公告)号：US5763760A
公开(公告)日：1998-06-09
申请号：US799532
申请日：1997-02-13
申请人： Walter Gumbrecht , Manfred Stanzel
发明人： Walter Gumbrecht , Manfred Stanzel
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1468 , A61B5/1495 , G01N33/49 , G01N37/00 , G01N33/00
CPC分类号： A61B5/14542 , A61B5/14539 , A61B5/1473 , G01N33/4925
摘要： Method for calibrating gas measuring sensors for dissolved gasses and method for measuring the concentration of CO.sub.2 in blood with the assistance of such a calibration method two or more separate calibration fluids in which a gas to be measured is dissolved with respectively different partial pressures are employed. For simplification, another (i.e., a second) calibration fluid is produced from one (i.e., a first) calibration fluid by modifying the partial pressure of the first calibration fluid to a different value, preferably by material transport between the first fluid and a gas phase. Analysis equipment operating with this method, particularly for CO.sub.2 measurement of blood, become simpler, smaller and less expensive.
摘要翻译：用于校准用于溶解气体的气体测量传感器的方法以及用于测量血液中二氧化碳浓度的方法，借助于这种校准方法，采用两种或多种单独的校准流体，其中待测量的气体分别用不同的分压溶解。为了简化，通过将第一校准流体的分压改变为不同的值，优选地通过第一流体和气体之间的材料输送，从一个（即，第一个）校准流体产生另一个（即，第二个）校准流体相。使用这种方法操作的分析设备，特别是对血液进行二氧化碳测量，变得更简单，更小更便宜。

47. 发明授权

US10081831B2 Method and arrangement for calibrating a sensor element 有权
公开(公告)号：US10081831B2
公开(公告)日：2018-09-25
申请号：US12743316
申请日：2008-10-29
申请人： Katja Friedrich , Walter Gumbrecht , Peter Paulicka , Manfred Stanzel , Renee Weber
发明人： Katja Friedrich , Walter Gumbrecht , Peter Paulicka , Manfred Stanzel , Renee Weber
IPC分类号： C12Q1/68 , C12Q1/6837
CPC分类号： C12Q1/6837 , C12Q2527/107
摘要： A method is disclosed for calibrating a sensor element, which has an immobilized probe oligonucleotide, via which the bonding of a target nucleic acid (Z) can be detected by the sensor. In at least one embodiment, the method includes: a) bringing the sensor element into contact with a control nucleic acid (K), the melting temperature Tm(K) of which is less than the melting temperature Tm(Z) of the target nucleic acid (Z); b) hybridizing the control nucleic acid (K) to the probe oligonucleotide at a temperature T[p] Tm(K) and detecting a negative control signal at a temperature T[n]. According to a refinement of at least one embodiment of the invention, a measuring signal of the target nucleic acid (Z) is measured at a measuring temperature T [mess], where Tm(K)

48. 发明授权

US08771609B2 Module for processing a biological sample, biochip kit, and use of the module 有权
标题翻译：用于处理生物样品的模块，生物芯片套件和模块的使用
公开(公告)号：US08771609B2
公开(公告)日：2014-07-08
申请号：US11653230
申请日：2007-01-16
申请人： Thomas Ehben , Walter Gumbrecht , Manfred Stanzel , Christian Zilch
发明人： Thomas Ehben , Walter Gumbrecht , Manfred Stanzel , Christian Zilch
IPC分类号： B01L3/00
CPC分类号： G01N1/40 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2300/0816 , G01N35/0098 , Y10T436/2575
摘要： A module for processing a biological sample for an analysis test is disclosed. The processing module includes, in at least one embodiment, an interface at which the processing module can be connected to a cartridge with a lab-on-a-chip, in which cartridge the analysis steps are carried out. A biochip kit is also disclosed. In at least one embodiment, the biochip kit includes one or more processing modules which are intended for different sample materials and which can be connected to the same cartridge type.
摘要翻译：公开了用于处理用于分析测试的生物样品的模块。处理模块在至少一个实施例中包括接口，在该界面处，处理模块可以与芯片上的实验室连接，其中进行分析步骤。还公开了一种生物芯片套件。在至少一个实施例中，生物芯片套件包括一个或多个处理模块，其用于不同的样品材料并且可以连接到相同的盒式。

49. 发明授权

US08753874B2 Biochip 有权
标题翻译：生物芯片
公开(公告)号：US08753874B2
公开(公告)日：2014-06-17
申请号：US10540208
申请日：2003-12-15
申请人： Walter Gumbrecht , Manfred Stanzel
发明人： Walter Gumbrecht , Manfred Stanzel
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C02F1/40 , B03C5/02 , G01N15/06 , G01N27/00 , G01N33/00 , C07H21/02
CPC分类号： C12M1/34 , G01N27/026 , G01N33/5438
摘要： A biochip includes a flat carrier and an array of spots containing catcher molecules which are arranged on the carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the catcher molecules and the target molecules applied via an analyte solution. In order to increase the sensitivity or the binding-specific measuring effects of the bio-chip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing catcher molecules and which is permeable to target molecules.
摘要翻译：生物芯片包括平坦载体和布置在载体上的含有捕获剂分子的斑点阵列。每个点与微电极布置相关联，用于阻抗光谱检测在捕获剂分子与通过分析物溶液施加的靶分子之间发生的结合事件。为了提高生物芯片的灵敏度或结合特异性的测量效果，电极布置至少部分地嵌入含有捕获剂分子的亲水反应层中，并且其对靶分子是可渗透的。

50. 发明申请

US20140110349A1 ASSEMBLY AND METHOD FOR FILTRATION 审中-公开
标题翻译：装配和过滤方法
公开(公告)号：US20140110349A1
公开(公告)日：2014-04-24
申请号：US14118728
申请日：2012-04-13
申请人： Joachim Bangert , Katja Friedrich , Walter Gumbrecht , Karsten Hiltawsky , Peter Paulicka , Manfred Stanzel
发明人： Joachim Bangert , Katja Friedrich , Walter Gumbrecht , Karsten Hiltawsky , Peter Paulicka , Manfred Stanzel
IPC分类号： A61M1/34 , B01D61/18 , B01D61/22
CPC分类号： A61M1/34 , A61M1/3403 , B01D61/18 , B01D61/22 , B01D67/0032 , B01D71/50 , B01D2311/14 , G01N33/491 , G01N2001/4088
摘要： An assembly and a method for filtration are disclosured, which are suitable in particular for the filtration of cells, for example tumor cells, from a sample, for example a blood sample. In the method, a pressure differential between the pressure upstream and the pressure downstream of a filter is determined; and the pressure differential between upstream and downstream of the filter is adjusted such that the pressure differential does not exceed a predetermined value.
摘要翻译：公开了组合物和过滤方法，其特别适用于从样品例如血液样品过滤细胞，例如肿瘤细胞。在该方法中，确定过滤器下游压力和压力之间的压力差; 并且调节过滤器的上游和下游之间的压力差，使得压差不超过预定值。

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