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41. 发明申请

US20150133751A1 SYSTEM AND METHOD FOR INTRAOPERATIVE DETECTION OF CANCER MARGINS USING CONFORMAL FILTERS IN A DUAL POLARIZATION CONFIGURATION 有权
标题翻译：在双极化配置中使用合格滤波器对癌症患者进行手术检测的系统和方法
公开(公告)号：US20150133751A1
公开(公告)日：2015-05-14
申请号：US14302225
申请日：2014-06-11
申请人： CHEMIMAGE CORPORATION
发明人： Shona STEWART , Serena AUGUSTINE , Jeffrey COHEN , Ryan PRIORE
IPC分类号： A61B5/1459 , A61B5/1473 , A61B17/00 , G01N21/25 , A61B19/00
CPC分类号： A61B5/1459 , A61B5/1473 , A61B5/4519 , A61B17/00234 , A61B34/30 , A61B2034/302 , G01J3/0224 , G01N21/255 , G01N2201/06113 , H03K19/1735
摘要： Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.
摘要翻译：本文描述了用于区分组织类型的装置，系统和方法。这样的设备和系统可以使用双极化保形过滤器来从目标组织获得图像数据，并且处理器可以创建其中组织之间的对比度被增强的图像。

42. 发明申请

US20140300897A1 SECURITY SCREENING SYSTEMS AND METHODS 审中-公开
标题翻译：安全筛选系统和方法
公开(公告)号：US20140300897A1
公开(公告)日：2014-10-09
申请号：US14246608
申请日：2014-04-07
申请人： CHEMIMAGE CORPORATION
发明人： Patrick J. TREADO , Matthew NELSON , Charles W. GARDNER
IPC分类号： G01J3/51 , G01J3/02
CPC分类号： G01J3/0224 , G01J3/2823 , G01J3/36 , G01J2003/2826
摘要： The present disclosure describes security screening systems and methods for identifying a suspect material in a sample. In general terms, the system and method disclosed herein provide collection optics configured to collect a first plurality of interacted photons from an illuminated sample and generating a first optical signal. The first optical signal is separated into a plurality of optical components where the plurality of optical components are filtered by a plurality of filters. Each filter of the plurality of filters is configured to filter the plurality of optical components into a passband wavelength to generate a plurality of filtered components. The plurality of filtered components are detected by one or more detectors and one or more wavelength specific spectral images are generated. A processor is configured to analyze the one or more wavelength specific spectral images in order to identify the suspect material in the sample. The systems and methods disclosed herein may find particular use in a security setting.
摘要翻译：本公开描述了用于识别样品中的可疑材料的安全性筛选系统和方法。一般来说，本文公开的系统和方法提供了收集光学器件，其被配置为从照明样品收集第一多个相互作用的光子并产生第一光信号。第一光信号被分成多个光学部件，其中多个光学部件被多个滤光器过滤。多个滤波器的每个滤波器被配置为将多个光学部件滤波成通带波长以产生多个滤波分量。多个经滤波的分量由一个或多个检测器检测，并且产生一个或多个波长特定光谱图像。处理器被配置为分析一个或多个波长特定光谱图像，以便识别样品中的可疑材料。本文公开的系统和方法可以在安全设置中发现特定的用途。

43. 发明申请

US20140104607A1 SWIR Targeted Agile Raman System for Detection of Unknown Materials Using Dual Polarization 有权
标题翻译： SWIR目标敏捷拉曼系统，用于利用双极化检测未知材料
公开(公告)号：US20140104607A1
公开(公告)日：2014-04-17
申请号：US13842034
申请日：2013-03-15
申请人： CHEMIMAGE CORPORATION
发明人： Patrick J. Treado , Matthew Nelson , Charles Gardner
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/36 , G01J3/44 , G01N33/22 , G01N2021/1738 , G01N2021/174 , G01N2021/1744 , G01N2201/0833 , G01N2201/0846
摘要： The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.
摘要翻译：本公开提供了用于分析包含至少一种未知材料的样品的系统和方法。可以扫描第一位置以产生SWIR高光谱图像。可以使用双极化技术生成SWIR高光谱图像。可以分析SWIR高光谱图像以瞄准包括未知材料的第二位置。可以使用拉曼光谱技术进一步分析该第二位置，并且可以生成拉曼数据集。可以进一步分析拉曼数据集以将未知材料与知识材料相关联。

44. 发明申请

US20130342683A1 System and Method for Detecting Environmental Conditions Using Hyperspectral Imaging 审中-公开
标题翻译：使用高光谱成像检测环境条件的系统和方法
公开(公告)号：US20130342683A1
公开(公告)日：2013-12-26
申请号：US13973769
申请日：2013-08-22
申请人： ChemImage Corporation
发明人： Matthew Nelson , Jeffrey Cohen , Oksana Klueve , Patrick Treado , Charles Gardner
IPC分类号： G01W1/00
CPC分类号： G01W1/00 , G01J3/02 , G01J3/0218 , G01J3/027 , G01J3/0278 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/359
摘要： A system and method for detecting environmental conditions using SWIR hyperspectral imaging. A method may comprise collecting a plurality of interacted photons from at least one location and passing the interacted photons through a tunable filter, filtering the interacted photons into a plurality of wavelength bands. These filtered photons may be detected and analyzed to determine the presence or absence of an environmental condition. A system may comprise at least one collection lens configured to collect at least one plurality of interacted photons from at least one location and a tunable filter for filtering the interacted photons into a plurality of wavelength bands. The system may further comprise a detector configured to detect the filtered photons and generate at least one hyperspectral image representative of the location. The system may further comprise a processor for analyzing the hyperspectral data set and determining the presence or absence of an environmental condition.
摘要翻译：使用SWIR高光谱成像检测环境条件的系统和方法。一种方法可以包括从至少一个位置收集多个相互作用的光子，并将相互作用的光子传递通过可调谐滤波器，将相互作用的光子过滤成多个波长带。可以检测和分析这些过滤的光子以确定环境条件的存在或不存在。系统可以包括配置成从至少一个位置收集至少一个多个相互作用的光子的至少一个集合透镜和用于将相互作用的光子滤波成多个波长带的可调滤波器。该系统还可以包括检测器，其被配置为检测滤波的光子并且生成代表该位置的至少一个高光谱图像。该系统还可以包括用于分析高光谱数据集并确定环境条件的存在或不存在的处理器。

45. 发明申请

US20130321813A1 System and Method for Assessing Tissue Oxygenation Using a Conformal Filter 有权
标题翻译：使用保形过滤器评估组织氧合的系统和方法
公开(公告)号：US20130321813A1
公开(公告)日：2013-12-05
申请号：US13905817
申请日：2013-05-30
申请人： Chemimage Corporation
发明人： Patrick J. Treado , Ryan Priore
IPC分类号： G01J3/51
CPC分类号： G01J3/51 , G01J3/0224 , G01J3/0272 , G01J3/457 , G01J2003/1213 , G01N21/255 , G01N21/33 , G01N21/35 , G01N21/359 , G01N21/65 , G01N21/718 , G01N2021/6471 , G01N2201/0221 , G01N2201/067 , G01N2201/129
摘要： A portable system and method for analyzing biological tissue samples and detecting analytes associated with tissue oxygenation using a conformal filter. A conformal filter, which may comprise a tunable filter, is configured to filter interacted photons conforming to a spectral shape correlated with an analyte of interest. Conformal filter configurations may be selected by consulting a modified look-up table associated with an analyte. An iterative methodology may be used to calibrate a conformal design for an analyte of interest, refine a previous conformal filter design for an analyte of interest, and/or generate a new conformal filter design for an analyte of interest.
摘要翻译：用于分析生物组织样品并使用保形过滤器检测与组织氧合相关的分析物的便携式系统和方法。可以包括可调滤波器的保形滤波器被配置为滤波符合与感兴趣的分析物相关的光谱形状的相互作用的光子。可以通过咨询与分析物相关联的经修改的查找表来选择保形过滤器配置。可以使用迭代方法来校准感兴趣分析物的共形设计，改进目标分析物的先前共形过滤器设计，和/或为感兴趣的分析物生成新的保形过滤器设计。

46. 发明申请

US20130268204A1 Invasive Chemometry 审中-公开
标题翻译：侵入化学法
公开(公告)号：US20130268204A1
公开(公告)日：2013-10-10
申请号：US13907544
申请日：2013-05-31
申请人： Chemimage Corporation
发明人： John S. Maier
IPC分类号： G06F19/10
CPC分类号： G16B99/00 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/415 , A61B5/418 , A61B5/4519
摘要： The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest.
摘要翻译：本发明涉及用于评估动物中选定组织的一种或多种组分的方法和装置。本发明允许通过评估动物身体的多个区域以获得感兴趣的组织的光学特征并单独评估一种或多种光学（例如拉曼或NIR），从而对包含多种组织类型的身体结构中的组织成分进行非侵入性评估。表现出感兴趣组织的光学特性的一个或多个区域的组织组分的特征。

47. 发明申请

US20130218480A1 Automation of Ingredient-Specific Particle Sizing Employing Raman Chemical Imaging 审中-公开
标题翻译：使用拉曼化学成像的成分特异性颗粒尺寸自动化
公开(公告)号：US20130218480A1
公开(公告)日：2013-08-22
申请号：US13764374
申请日：2013-02-11
申请人： Chemimage Corporation
发明人： Michael Fuhrman , Ryan Priore , Oksana Olkhovyk , Oksana Klueva
IPC分类号： G01N15/02
CPC分类号： G01N15/0227 , G01J3/02 , G01J3/027 , G01J3/44 , G01N21/65
摘要： A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.
摘要翻译：用于确定样品中颗粒的至少一个几何性质的系统和方法。照射样品从而产生拉曼散射光子。收集这些光子以产生拉曼化学图像。应用第一阈值，其中第一阈值使得检测样品中的所有颗粒。选择样品中的颗粒并施加第二阈值，使得可以确定所选择的颗粒的至少一个几何性质。分析代表所选粒子的至少一个光谱，以确定其是否是感兴趣的粒子。确定第二阈值的步骤可以是经由软件的迭代和自动化，使得应用候选的第二阈值直到达到令人满意的结果。

48. 发明申请

US20230035060A1 SYSTEMS AND METHODS FOR IN SITU OPTIMIZATION OPTIMIZATION OF TUNABLE LIGHT EMITTING DIODE SOURCES 有权
公开(公告)号：US20230035060A1
公开(公告)日：2023-02-02
申请号：US17723186
申请日：2022-04-18
申请人： CHEMIMAGE CORPORATION
发明人： Shawna TAZIK , Alyssa ZRIMSEK , Heather GOMER , Jihang WANG , Patrick J. TREADO
IPC分类号： G01J3/28 , G01J3/10
摘要： Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

49. 发明申请

US20220142457A1 DISCRIMINATION OF CALCULI AND TISSUES WITH MOLECULAR CHEMICAL IMAGING 有权
公开(公告)号：US20220142457A1
公开(公告)日：2022-05-12
申请号：US17582764
申请日：2022-01-24
申请人： CHEMIMAGE CORPORATION
发明人： Jeffrey COHEN , Patrick TREADO , Shona STEWART , Heather GOMER , Arash SAMIEI , Alyssa ZRIMSEK , Jihang WANG
IPC分类号： A61B1/00 , A61B1/04 , A61B1/06
摘要： Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.

50. 发明授权

US11307095B2 Systems and methods for in situ optimization of tunable light emitting diode sources 有权
公开(公告)号：US11307095B2
公开(公告)日：2022-04-19
申请号：US17112393
申请日：2020-12-04
申请人： CHEMIMAGE CORPORATION
发明人： Shawna Tazik , Alyssa Zrimsek , Heather Gomer , Jihang Wang , Patrick J. Treado
IPC分类号： G01J3/10 , G01J3/28
摘要： Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

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