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41. 发明授权

US08752722B2 Cap assembly and production method 有权
标题翻译：盖组件和生产方法
公开(公告)号：US08752722B2
公开(公告)日：2014-06-17
申请号：US13120491
申请日：2008-09-29
申请人： Peter Kuhn , Gallus Egli , Philippe Kern , Mario Schüpbach , Ludwig Daniel Weibel
发明人： Peter Kuhn , Gallus Egli , Philippe Kern , Mario Schüpbach , Ludwig Daniel Weibel
IPC分类号： B65D41/02 , B65D17/34 , B65D55/02
CPC分类号： A61M5/5086 , A61M39/20 , A61M2005/3104 , A61M2005/312
摘要： The invention relates to a tip cap assembly for closing a distal opening of a receptacle like a syringe body or a tube in a sealed manner, and to a method for producing the tip cap. A cap assembly according to the invention comprises a frangible tip of a receptacle, preferably a pre-filled receptacle. An upper portion of the tip closes the receptacle respectively a lower tip portion comprising a passage as known from the state of the art. Hence, the receptacle is reliably sealed to prevent contamination or loss of the medication. Compared with the state of the art, a receptacle has a more effectively sealed tip. It is necessary to break the upper tip portion away in order to open the receptacle. A cap element protects the tip on one side. On the other side, unscrewing the cap breaks the upper portion away without hurting a person.
摘要翻译：本发明涉及一种用于以密封的方式封闭容器的远端开口如注射器主体或管的尖端帽组件以及用于制造尖端帽的方法。根据本发明的盖组件包括容器的易碎尖端，优选地是预先填充的容器。尖端的上部分别分别包含从现有技术中已知的通道的下端部分。因此，容器被可靠地密封以防止药物的污染或损失。与现有技术相比，容器具有更有效的密封尖端。为了打开容器，需要将上端部分断开。盖元件保护一侧的尖端。另一方面，拧开盖子会使上部的部分脱落而不会伤害到人身。

42. 发明授权

US08721613B2 Container with hollow needle 有权
标题翻译：集装箱用空心针
公开(公告)号：US08721613B2
公开(公告)日：2014-05-13
申请号：US11914955
申请日：2006-05-18
申请人： Ludwig Weibel-Furer , Dominique Weibel-Furer
发明人： Ludwig Weibel-Furer , Dominique Weibel-Furer
IPC分类号： A61J1/05 , A61J1/20
CPC分类号： B65D35/04 , A61J1/06 , A61J1/067 , A61J1/201 , A61J1/2058 , A61J1/2096 , A61M2207/00 , B65D35/44
摘要： The present invention relates to a container (1, 1′, 1″) for the intake and release of a medicament, in particular a parenteral medicament, the container (1, 1′, 1″) exhibiting a casing (6, 6′) which is sealed, except for an opening (7) for the purpose of releasing the medicament, the container (1, 1′, 1″) being designed in such a way that a release of the medicament is effected by alteration of at least one region of the casing (6, 6′). The casing (6, 6′) is furthermore formed in one piece. The container exhibits a hollow needle (9, 10).
摘要翻译：本发明涉及一种用于吸入和释放药物，特别是胃肠外药物的容器（1,1'，1“），所述容器（1,1'，1”）呈现出壳体（6,6' ），除了用于释放药物的开口（7）之外，所述容器（1,1'，1“）被设计成使得药物的释放至少通过改变至少壳体（6,6'）的一个区域。壳体（6,6'）进一步形成为一体。容器呈现中空针（9,10）。

43. 发明授权

US08263577B2 Water-soluble iron carbohydrate derivative complexes, the preparation thereof, and medicaments comprising them 有权
标题翻译：水溶性碳水化合物碳水化合物衍生物络合物及其制备方法以及包含它们的药物
公开(公告)号：US08263577B2
公开(公告)日：2012-09-11
申请号：US12599343
申请日：2008-05-21
申请人： Stefan Reim , Erik Philipp , Felix Funk , Hans-Martin Mueller , Peter Geisser
发明人： Stefan Reim , Erik Philipp , Felix Funk , Hans-Martin Mueller , Peter Geisser
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/295 , C08B31/00 , C08B31/18 , C08B31/185
摘要： Water-soluble iron-carbohydrate derivative complex obtainable from an aqueous iron(III) salt solution and an aqueous solution of the product of the oxidation and subsequent derivative of one or more maltodextrins with an aqueous hypochlorite solution at an alkaline pH value, wherein when one maltodextrin is used its dextrose equivalent is from 5 to 20 and when a mixture of a plurality of maltodextrins is used the dextrose equivalent of the mixture is from 5 to 20 and the dextrose equivalent of each individual maltodextrin in the mixture is from 2 to 40, and the subsequent derivative is carried out with a suitable reagent, process for the preparation thereof, and medicament for the treatment and prophylaxis of iron deficiency states.
摘要翻译：水溶性铁 - 碳水化合物衍生物复合物可从碱式pH值的铁（III）盐水溶液和一种或多种麦芽糖糊精的氧化和随后衍生物与次氯酸盐水溶液的产物的水溶液获得，其中当一个使用麦芽糖糊精，其葡萄糖当量为5至20，当使用多种麦芽糖糊精的混合物时，混合物的葡萄糖当量为5至20，混合物中各单独的麦芽糖糊精的葡萄糖当量为2至40，并且随后的衍生物用合适的试剂，其制备方法和用于治疗和预防缺铁状态的药物进行。

44. 发明申请

US20120214803A1 Novel Sulfonaminoquinoline Hepcidin Antagonists 审中-公开
标题翻译：新型磺酰氨基喹啉Hepcidin拮抗剂
公开(公告)号：US20120214803A1
公开(公告)日：2012-08-23
申请号：US13364566
申请日：2012-02-02
申请人： Wilm Buhr , Susanna Burckhardt , Franz Dürrenberger , Felix Funk , Peter O. Geisser , Vincent A. Corden , Stephen M. Courtney , Graham Dawson , Tara Davenport , Mark Slack , Mark P. Ridgill , Chrostopher J. Yarnold , Susan Boyce , Albertus A. Ellenbroek
发明人： Wilm Buhr , Susanna Burckhardt , Franz Dürrenberger , Felix Funk , Peter O. Geisser , Vincent A. Corden , Stephen M. Courtney , Graham Dawson , Tara Davenport , Mark Slack , Mark P. Ridgill , Chrostopher J. Yarnold , Susan Boyce , Albertus A. Ellenbroek
IPC分类号： A61K31/542 , C07D215/40 , C07D215/50 , C07D401/12 , C07D215/46 , A61P7/06 , A61K31/4706 , A61K31/4709 , A61K31/549 , A61K31/497 , A61P3/00 , C07D513/04 , C07D215/42
CPC分类号： C07D513/04 , A61K45/06 , C07D215/40 , C07D215/42 , C07D215/46 , C07D215/50 , C07D333/34 , C07D401/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
摘要翻译：本发明涉及新型的铁调素拮抗剂，包含它们的药物组合物及其作为用于治疗铁代谢紊乱的药物的用途，特别是铁缺乏症和贫血，特别是与慢性炎症有关的贫血疾病

45. 发明申请

US20120214798A1 Novel Ethanediamone Hepcidine Antagonists 审中-公开
标题翻译：新型乙二胺二磷酸拮抗剂
公开(公告)号：US20120214798A1
公开(公告)日：2012-08-23
申请号：US13394201
申请日：2010-09-06
申请人： Franz Dürrenberger , Susanna Burckhardt , Wilm Buhr , Peter O. Geisser , Felix Funk , Vincent A. Corden , Stephen M. Courtney , Tara Davenport , Stefan Jaeger , Mark P. Ridgill , Mark Slack , Christopher J. Yarnold , Wei Tsung Yau
发明人： Franz Dürrenberger , Susanna Burckhardt , Wilm Buhr , Peter O. Geisser , Felix Funk , Vincent A. Corden , Stephen M. Courtney , Tara Davenport , Stefan Jaeger , Mark P. Ridgill , Mark Slack , Christopher J. Yarnold , Wei Tsung Yau
IPC分类号： A61K31/497 , A61K31/5377 , A61P3/02 , A61K31/445 , A61K31/551 , A61K31/496 , A61K31/4545
CPC分类号： C07D401/12 , C07D211/14 , C07D211/58 , C07D211/62 , C07D213/38 , C07D239/42 , C07D241/20 , C07D295/13 , C07D307/24 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
摘要翻译：本发明涉及式（I）的新颖的铁调素拮抗剂，包含它们的药物组合物及其作为药物的用途，特别是用于治疗铁代谢紊乱，特别是铁缺乏症和疾病，特别是贫血与慢性炎性疾病有关（ACD：慢性病贫血和AI：炎症性贫血）。

46. 发明申请

US20120196853A1 Novel Quinoline-Hepcidine Antagonists 审中-公开
标题翻译：新型喹啉 - 肝嘧啶拮抗剂
公开(公告)号：US20120196853A1
公开(公告)日：2012-08-02
申请号：US13390785
申请日：2010-08-19
申请人： Franz Dürrenberger , Susanna Burckhardt , Peter O. Geisser , Wilm Buhr , Felix Funk , Vincent A. Corden , Tara Davenport , Stefan Jaeger , Mark Slack , Christopher J. Yarnold , Wei Tsung Yau , Stephen M. Courtney
发明人： Franz Dürrenberger , Susanna Burckhardt , Peter O. Geisser , Wilm Buhr , Felix Funk , Vincent A. Corden , Tara Davenport , Stefan Jaeger , Mark Slack , Christopher J. Yarnold , Wei Tsung Yau , Stephen M. Courtney
IPC分类号： A61K31/5377 , A61K31/496 , A61P3/00 , A61P7/06 , A61P19/02 , A61P13/12 , A61P9/00 , A61P29/00 , A61P19/04 , A61P1/00 , A61K31/4709 , A61P35/00
CPC分类号： C07D215/28 , C07D215/26 , C07D215/32 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel hepcidin antagonists of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
摘要翻译：本发明涉及通式（I）的新型铁调素拮抗剂，包含它们的药物组合物及其作为药物的用途，特别是用于治疗铁代谢紊乱，特别是铁缺乏症和厌食症与慢性炎症性疾病有关的特异性厌食症（ACD：慢性疾病和AI：炎症性贫血）。

47. 发明申请

US20120052135A1 Phosphate Adsorbent 审中-公开
标题翻译：磷酸盐吸附剂
公开(公告)号：US20120052135A1
公开(公告)日：2012-03-01
申请号：US13202586
申请日：2010-03-01
申请人： Gisela Witzel , Peter O. Geisser , Erik Philipp
发明人： Gisela Witzel , Peter O. Geisser , Erik Philipp
IPC分类号： A61K33/26 , A61P3/12
CPC分类号： A61K33/06 , A61K33/10 , A61K33/26 , A61K2300/00
摘要： Subject of the present invention are compositions comprising a mixture of calcium, magnesium and iron salts for use as a pharmaceutical preparation for adsorbing phosphate, especially for use as pharmaceutical preparations for the treatment of hyperphosphataemia, chronic kidney deficiency as well as for the treatment of haemodialysis patients.
摘要翻译：本发明的主题是包含用于吸附磷酸盐的药物制剂的钙，镁和铁盐的混合物的组合物，特别是用作治疗高磷酸血症的药物制剂，慢性肾脏缺乏以及用于治疗血液透析耐心。

48. 发明申请

US20090169645A1 Iron Sulfate-Based Phosphate Adsorbent 审中-公开
标题翻译：硫酸铁基磷酸盐吸附剂
公开(公告)号：US20090169645A1
公开(公告)日：2009-07-02
申请号：US11571305
申请日：2005-06-21
申请人： Hans-Martin Muller , Erik Philipp , Peter Geisser
发明人： Hans-Martin Muller , Erik Philipp , Peter Geisser
IPC分类号： A61K33/26
CPC分类号： A61K33/26 , A23K20/30 , A23L33/16 , A23V2002/00 , B01J20/0229 , B01J20/06 , B01J2220/46 , C01G49/06 , C02F1/288 , C02F2101/105 , A23V2250/1592
摘要： The present invention relates to a process for the preparation of a novel composition, and to the use of the composition as a phosphate adsorbent, in particular for administration in humans or animals.
摘要翻译：本发明涉及一种制备新型组合物的方法，以及该组合物作为磷酸盐吸附剂的用途，特别是用于给予人或动物。

49. 发明申请

US20080299285A1 Process For The Preparation Of Ferri-Succinylcasein 审中-公开
标题翻译： Ferri-Succinylcasein的制备方法
公开(公告)号：US20080299285A1
公开(公告)日：2008-12-04
申请号：US12096057
申请日：2006-11-28
申请人： Jurgen Klotz , Stefan Reim , Erik Philipp , Hans-Martin Muller , Peter Geisser
发明人： Jurgen Klotz , Stefan Reim , Erik Philipp , Hans-Martin Muller , Peter Geisser
IPC分类号： A23L1/305 , C07K14/47
CPC分类号： C07K14/4732 , A23J3/10 , A23L33/165 , A23V2002/00 , A23V2250/54246 , A23V2250/1592
摘要： The invention is related to a new process for the preparation of ferri-succinylcasein.
摘要翻译：本发明涉及一种制备铁 - 琥珀酰酪蛋白的新方法。

50. 发明公开

US20230212159A1 Process for the Production of Ferroportin Inhibitors 审中-公开
公开(公告)号：US20230212159A1
公开(公告)日：2023-07-06
申请号：US17913631
申请日：2021-03-23
申请人： Vifor (International) AG
发明人： Stefan REIM , Erik PHILIPP , Maria WILHELM , Cyrill BLATTER
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07B2200/13
摘要： The invention relates to a new process for preparing compounds of the formula (I)

and pharmaceutically acceptable salts thereof, which act as ferroportin inhibitors being suitable for the use as medicaments in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or of iron metabolism disorders leading to increased iron levels or increased iron absorption, including iron overload, thalassemia, sickle cell disease and hemochromatosis.

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