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41. 发明授权

US5892004A Method for preparing PACAP receptor protein 失效
标题翻译：制备PACAP受体蛋白的方法
公开(公告)号：US5892004A
公开(公告)日：1999-04-06
申请号：US855213
申请日：1997-05-13
申请人： Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi
发明人： Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi
IPC分类号： A61K38/00 , C07K14/575 , C07K14/72 , C12N1/21 , C12N15/12 , C12P21/08 , C07K1/14 , C07K1/16
CPC分类号： C07K14/57563 , C07K14/72 , A61K38/00
摘要： The present invention relates to a pituitary adenylate cyclase activating polypeptide (PACAP) receptor protein or a salt thereof which is capable of binding PACAP and a method for preparing said receptor protein or salt thereof.
摘要翻译：本发明涉及能够结合PACAP的垂体腺苷酸环化酶活化多肽（PACAP）受体蛋白或其盐，以及制备所述受体蛋白或其盐的方法。

42. 发明授权

US5891916A Aromatic hydroxamix acid compounds, their production and use 失效
标题翻译：芳香族异羟肟酸化合物，其生产和使用
公开(公告)号：US5891916A
公开(公告)日：1999-04-06
申请号：US662240
申请日：1996-06-14
申请人： Kaneyoshi Kato , Yoshihiro Sugiura , Ken-ichi Naruo , Hideki Takahashi
发明人： Kaneyoshi Kato , Yoshihiro Sugiura , Ken-ichi Naruo , Hideki Takahashi
IPC分类号： C07C259/06 , C07C271/60 , C07D277/30 , C07C239/08 , A61K31/19 , C07D277/00
CPC分类号： C07C271/60 , C07C259/06
摘要： A compound represented by the formula: ##STR1## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group; Q represents an optionally substituted divalent aliphatic hydrocarbon group optionally containing O or S; R.sup.1 represents H, acyl group, etc.; and X represents an electron-withdrawing group, an optionally substituted aromatic group, a group of the formula: ##STR2## wherein R.sup.2 and R.sup.3 independently represent H, acyl group or an optionally substituted hydrocarbon group, etc., etc.; or salts thereof are useful as an excellent anti-neurodegenerative agent.
摘要翻译：由下式表示的化合物：其中Ar 1和Ar 2独立地表示任选取代的芳基; Q表示任选含有O或S的任选取代的二价脂族烃基; R1代表H，酰基等; X表示吸电子基团，可以具有取代基的芳基，下式的基团：其中R2和R3独立地表示H，酰基或任意取代的烃基等; 或其盐可用作优异的抗神经变性剂。

43. 发明授权

US5891087A Mixing syringe 失效
标题翻译：混合注射器
公开(公告)号：US5891087A
公开(公告)日：1999-04-06
申请号：US818679
申请日：1997-03-14
申请人： Seiji Ohtani , Nobuo Tanaka , Katsuyuki Yokokawa , Teruo Matsuda
发明人： Seiji Ohtani , Nobuo Tanaka , Katsuyuki Yokokawa , Teruo Matsuda
IPC分类号： A61M5/28 , A61M5/31 , A61M5/315 , A61M37/00
CPC分类号： A61M5/284 , A61M5/31511 , A61M2005/3101 , A61M2005/3121 , A61M2005/3132 , A61M5/31501 , A61M5/31505
摘要： Behind a slidable end sealing member 3c, there is provided a liquid-absorbing element M which has a liquid-holding function so as to absorb and hold a liquid L flowing out from the end sealing member 3c when the end sealing member passes over a bypass portion 6. As this liquid-absorbent element M, such as a disk-like element D and a cylindrical element R, are typically impregnated with a water-holding and liquid-absorbing accelerator to enhance a leak preventing effect and with an antimicrobial active agent to enhance hygiene.
摘要翻译：在可滑动端部密封构件3c的后面，设置有液体吸收元件M，其具有液体保持功能，以便当端部密封构件通过旁路时吸收并保持从端部密封构件3c流出的液体L. 作为这样的液体吸收元件M，例如圆盘状元件D和圆柱形元件R，通常浸渍有吸水和吸液促进剂，以增强防漏效果，并具有抗微生物活性剂加强卫生。

44. 发明授权

US5889009A Method of inhibiting cell adhesion 失效
标题翻译：抑制细胞粘附的方法
公开(公告)号：US5889009A
公开(公告)日：1999-03-30
申请号：US931453
申请日：1997-09-17
申请人： Akio Miyake , Masahira Nakamura , Hideto Fukushi
发明人： Akio Miyake , Masahira Nakamura , Hideto Fukushi
IPC分类号： C07D215/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D513/04 , C07D519/00 , A61K31/495 , A61K31/435 , A61K31/47
CPC分类号： C07D401/04 , C07D215/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D513/04
摘要： A composition comprises a 1,7-disubstituted-4-oxo-3 -quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3 -naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or therapeutic agent for peripheral arterial obstruction, acute myocardial infarction, an antitumor agent, and as a prophylactic and/or therapeutic agent for osteoporosis.
摘要翻译：组合物包含可用作外周动脉阻塞的预防和/或治疗剂的1,7-二取代-4-氧代-3-喹啉羧酸或1,7-二取代-4-氧代-3-萘啶羧酸衍生物，急性心肌梗死，抗肿瘤剂，以及作为骨质疏松症的预防和/或治疗剂。

45. 发明授权

US5885979A N-containing condensed heterocyclic compounds, their production, and their uses 失效
标题翻译：含N的稠合杂环化合物，其制备及其用途
公开(公告)号：US5885979A
公开(公告)日：1999-03-23
申请号：US852292
申请日：1997-05-07
申请人： Hidefumi Yukimasa , Ryuichi Tozawa , Masakuni Kori , Kazuaki Kitano , Yasuo Sugiyama
发明人： Hidefumi Yukimasa , Ryuichi Tozawa , Masakuni Kori , Kazuaki Kitano , Yasuo Sugiyama
IPC分类号： A61K31/395 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/553 , A61K31/554 , C07D267/14 , C07D413/06 , C07D413/12 , A61K31/33
CPC分类号： C07D413/06 , A61K31/395 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/553 , A61K31/554 , C07D267/14 , C07D413/12
摘要： N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.
摘要翻译：公开了含氮，稠合的杂环化合物及其盐，其可用于抑制角鲨烯合成酶和真菌生长，并且其可用于治疗或预防高脂血症。还公开了这些化合物的制造方法。

46. 发明授权

US5854313A Fine particles of high heat resistant polymer and epoxy esters 失效
标题翻译：高耐热聚合物和环氧酯的细颗粒
公开(公告)号：US5854313A
公开(公告)日：1998-12-29
申请号：US845206
申请日：1997-04-21
申请人： Yoshimasa Omori , Hiroya Okumura , Takashi Shibata
发明人： Yoshimasa Omori , Hiroya Okumura , Takashi Shibata
IPC分类号： C08F265/04 , C08F290/06 , C08G59/17 , C08L63/10 , C08K3/20
CPC分类号： C08L63/10 , C08F265/04 , C08F290/064 , C08G59/1466 , Y10S525/922
摘要： Fine particles of high heat resistant polymer obtained by emulsion polymerization or seeded polymerization of at least one epoxy ester (C) having two or more unsaturated bonds in one molecule and at least one reactive monomer (D) having at least one unsaturated double bond in one molecule, in the absence of a water-insoluble inorganic material as a dispersion stabilizer, the epoxy ester (C) being obtained by adding at least one unsaturated monobasic acid (B) to at least one epoxide (A-1) having at least one glycidyl group and one monocyclic hydrocarbon group in one molecule, and/or at least one epoxide (A-2) having at least one cycloaliphatic epoxy group in one molecule. The fine polymer particles have excellent heat resistance and solvent resistance, and an aqueous or alcoholic dispersion of such fine polymer particles is produced therefrom.
摘要翻译：通过在一个分子中具有两个或更多个不饱和键的至少一个环氧酯（C）和至少一个在一个分子中具有至少一个不饱和双键的反应性单体（D）的乳液聚合或接种聚合而获得的高耐热聚合物的细颗粒分子，在不存在作为分散稳定剂的水不溶性无机材料的情况下，环氧酯（C）是通过向至少一种具有至少一个的环氧化物（A-1）的至少一种环氧化物（A-1）加入至少一种不饱和一元酸一个分子中的缩水甘油基和一个单环烃基，和/或至少一个在一个分子中具有至少一个脂环族环氧基的环氧化物（A-2）。聚合物微粒具有优异的耐热性和耐溶剂性，由此生产这种聚合物微粒的水分散体或醇分散体。

47. 发明授权

US5852177A Basic fibroblast growth factor (bFGF) muteins 失效
标题翻译：碱性成纤维细胞生长因子（bFGF）突变蛋白
公开(公告)号：US5852177A
公开(公告)日：1998-12-22
申请号：US301460
申请日：1989-01-24
申请人： Masaharu Senoo , Reiko Sasada , Tsutomu Kurokawa , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Tsutomu Kurokawa , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , C07K14/55 , C07K16/22
CPC分类号： C07K16/22 , C07K14/503 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.
摘要翻译：碱性成纤维细胞生长因子（bFGF）的突变蛋白具有成纤维细胞生长促进活性，毛细血管内皮细胞生长刺激活性和血管生成活性，稳定性高，毒性低。因此，本发明的突变蛋白有利地用作燃烧等的愈合促进剂，血栓形成治疗药等，以及细胞培养促进剂。

48. 发明授权

US5851990A bFGF mutein and its production 失效
标题翻译： bFGF突变蛋白及其生产
公开(公告)号：US5851990A
公开(公告)日：1998-12-22
申请号：US231894
申请日：1994-04-22
申请人： Akira Fujishima , Tsunehiko Fukuda
发明人： Akira Fujishima , Tsunehiko Fukuda
IPC分类号： A61K38/00 , A61K38/22 , A61P7/02 , A61P9/10 , A61P17/00 , A61P17/02 , A61P43/00 , C07K14/50 , C07K14/52 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , A61K38/18
CPC分类号： C07K14/503 , A61K38/00
摘要： A mutein resulting from substitution of cysteins for at least one of the constitutional amino acids has a high stability, and can serve well as a pharmaceutical, such as a healing promoting agent for wounds.
摘要翻译：由至少一种结构氨基酸取代半胱氨酸而产生的突变蛋白具有高稳定性，可作为药物如伤口愈合促进剂起作用。

49. 发明授权

US5783635A Unsaturated polyester resin composition 失效
标题翻译：不饱和聚酯树脂组合物
公开(公告)号：US5783635A
公开(公告)日：1998-07-21
申请号：US841556
申请日：1997-04-30
申请人： Koichi Akiyama , Kenichi Morita , Hideki Terada
发明人： Koichi Akiyama , Kenichi Morita , Hideki Terada
IPC分类号： C04B26/18 , C08F2/44 , C08F283/01 , C08G63/52 , C08K3/00 , C08K3/22 , C08K7/20 , C08L67/06 , C08F8/00
CPC分类号： C08F283/01 , C08L67/06
摘要： An unsaturated polyester resin composition which comprises 100 parts by weight of a resin mixture comprising 25 to 80 parts by weight of an unsaturated polyester, 20 to 60 parts by weight of a comonomer and 1 to 10 parts by weight of a particulate crosslinked polymer and 100 to 400 parts by weight of an inorganic filler and in which the difference in refractive index between a product of copolymerization of the unsaturated polyester with the comonomer and the inorganic filler is 0.02 or below; and molded articles produced by curing the resin composition by heating under pressure. The resin composition has a high productivity, exhibits a texture excellent in both light transmittance and gloss, and is excellent in water resistance and which is suitable for the production of artificial marble.
摘要翻译：不饱和聚酯树脂组合物，其包含100重量份的树脂混合物，其包含25至80重量份的不饱和聚酯，20至60重量份的共聚单体和1至10重量份的交联聚合物颗粒和100 至400重量份的无机填料，其中不饱和聚酯与共聚单体和无机填料的共聚产物之间的折射率差为0.02以下; 以及通过在加压下加热使树脂组合物固化而制成的成型品。树脂组合物具有高的生产率，具有优异的透光性和光泽性，并且耐水性优异，适用于生产人造大理石。

50. 发明授权

US5767121A Pyridine derivatives, their production and use 失效
公开(公告)号：US5767121A
公开(公告)日：1998-06-16
申请号：US717022
申请日：1996-09-20
申请人： Muneo Takatani , Taketoshi Saijo , Kiminori Tomimatsu
发明人： Muneo Takatani , Taketoshi Saijo , Kiminori Tomimatsu
IPC分类号： C07D213/68 , C07D213/70 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61K31/535 , C07D401/06
CPC分类号： C07D213/70 , C07D213/68 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D417/14
摘要： There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.4 may be independently attached to A to form a ring, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or diluent.

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